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1. 发明申请

WO2014197699A1 GENERATION OF AMPHIPHILIC NETWORK WITH AN ABILITY TO DISTINGUISH THE TRANSPORT OF IGG AND INSULIN 审中-公开
标题翻译：具有辨别IGG和胰岛素运输能力的电泳网络的生成
公开(公告)号：WO2014197699A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/041100
申请日：2014-06-05
申请人： CAKMAK, Mukerrem , NUGAY, Turgut , NUGAY, Nihan , KENNEDY, Joseph , THE UNIVERSITY OF AKRON
发明人： CAKMAK, Mukerrem , NUGAY, Turgut , NUGAY, Nihan , KENNEDY, Joseph
IPC分类号： C08G77/12
CPC分类号： C08G77/20 , C08G77/12 , C08L83/04 , C08L83/00
摘要： A method of preparing an amiphiphilic co-network comprising preparing a molecularly-bimodal crosslinkable amphiphilic graft by polymerizing a dihydrocarbylacrylamide monomer in the presence of a first asymmetric-telechelic polydihydrocarbylsiloxane monomer mixture and a second asymmetric-telechelic polydihydrocarbylsiloxane monomer mixture where the molar mass ratio between average molar mass of the first asymmetric-telechelic monomer mixture polydihydrocarbylsiloxane and average molar mass of the second asymmetric-telechelic monomer mixture polydihydrocarbylsiloxane is between 1:2 and 1:20; and crosslinking the molecularly-bimodal crosslinkable amphiphilic graft with a siloxane compound that includes at least two Si-H bonds.
摘要翻译：一种制备亲水性共网络的方法，包括通过在第一不对称 - 遥爪聚二烃基硅氧烷单体混合物和第二不对称遥爪聚二烃基硅氧烷单体混合物存在下聚合二烃基丙烯酰胺单体制备分子双峰可交联的两亲性接枝物，其中摩尔质量比第一不对称遥爪单体混合物聚二烃基硅氧烷的平均摩尔质量和第二不对称遥爪单体混合物聚二烃基硅氧烷的平均摩尔质量为1:2至1:20; 并将分子双峰可交联的两亲性接枝物与包含至少两个Si-H键的硅氧烷化合物交联。

2. 发明申请

WO2014138001A1 PHOTOCHEMICAL PREPARATION OF HYDROXYL-TERMINATED POLYISOBUTYLENES AND RELATED METHODS AND USES 审中-公开
标题翻译：羟基封端的聚异丁烯的光化学制备及其相关方法和用途
公开(公告)号：WO2014138001A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/020180
申请日：2014-03-04
申请人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan , THE UNIVERSITY OF AKRON
发明人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan
IPC分类号： C08F110/10 , C08G75/04
CPC分类号： C08G18/696 , C08F8/00 , C08F8/02 , C08F8/26 , C08F8/34 , C08F110/10 , C08F2810/30 , C08F2810/40 , C08G18/4063 , C08G18/6204 , C08G18/758 , C08G75/04 , C08J3/28 , C08K5/5403 , C08L81/04 , C08G18/12 , C08G18/3206 , C08F4/16 , C08F2/38
摘要： The present invention relates to novel hydroxyl-terminated polyisobutylenes and methods of making and using them. The hydroxyl-terminated polyisobutylenes contain a sulfur unit, -S-, within each terminal end group. The well-defined, sulfur containing, primary hydroxyl-terminated polyisobutylenes of the present invention can be simply, rapidly, and essentially quantitatively obtained by subjecting the unsaturated telechelic PIBs and mercapto alcohols to UV light-activated thiol-ene reactions. The resultant sulfur containing, primary hydroxyl-terminated polyisobutylenes can then be used in the production of polyurethanes and like materials.
摘要翻译：本发明涉及新的羟基封端的聚异丁烯及其制备和使用方法。羟基封端的聚异丁烯在每个末端基团中含有硫单元-S-。通过使不饱和的遥爪PIB和巯基醇经受UV光活化的硫醇 - 烯反应，可以简单，快速地并且基本上定量地获得本发明的含硫的主要羟基封端的聚异丁烯。所得到的含硫的伯羟基封端的聚异丁烯然后可用于生产聚氨酯和类似材料。

3. 发明申请

WO2019018495A1 HIGH-STRENGTH LOW-CREEP THERMOPLASTIC ELASTOMER 审中-公开
公开(公告)号：WO2019018495A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/042636
申请日：2018-07-18
申请人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan , THE UNIVERSITY OF AKRON
发明人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan
IPC分类号： C07C13/32 , C07C13/44 , C07C23/18
摘要： A polystyrene- g -(polyisobutylene-b-polystyrene) is taught. The polystyrene- g -(polyisobutylene- b -polystyrene) is synthesized by first providing a polystyrene backbone. Once the polystyrene backbone is provided, the polystyrene backbone is acetylated to provide acetyl groups on the polystyrene backbone. Next, the acetyl groups are converted to -C(CH 3 ) 2 OH groups. Finally, the living polymerization of isobutylene is initiated, which is then followed by the living block polymerization of styrene. A polymer network of polystyrene- g -(polyisobutylene- b -polystyrene)s is also provided.

4. 发明申请

WO2014138017A1 PREPARATION OF POLYISOBUTYLENE-BASED POLYMER NETWORKS BY THIOL-ENE CHEMISTRY 审中-公开
标题翻译：通过THIOL-ENE化学制备基于聚异丁烯的聚合物网络
公开(公告)号：WO2014138017A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/020208
申请日：2014-03-04
申请人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan , THE UNIVERSITY OF AKRON
发明人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan
IPC分类号： C08F110/10 , C08G75/04
CPC分类号： C08F110/10 , C08F10/10 , C08F299/00 , C08G75/04 , C08G75/045 , C08K5/37 , C08F4/16 , C08F2/10
摘要： A PIB-based polymer network includes at least one sulfur containing segment and at least two PIB polymer segments. The at least two PIB polymer segments each include a core and at least two polyisobutylene polymer chains extending therefrom. The at least one sulfur containing segment includes at least one sulfur atom that is located between any two polyisobutylene polymer chains from two different PIB polymer segments, so that the sulfur containing segment connects those two different PIB polymer segments together. The PIB-based polymer network is produced by the thiol-ene reaction in the presence of light or heat. The reaction products include at least two polyisobutylene polymer precursor moieties, each polyisobutylene polymer precursor moiety having at least two end group selected from the end groups -CH 2 -CH(CH 3 )=CH 2 , -CH 2 =C(CH 3 ) 2 , and -CH 2 -CH=CH 2 ;and at least one multi-functional thiol.
摘要翻译：基于PIB的聚合物网络包括至少一个含硫段和至少两个PIB聚合物链段。所述至少两个PIB聚合物链段各自包含芯和从其延伸的至少两个聚异丁烯聚合物链。至少一个含硫部分包含位于来自两个不同PIB聚合物链段的任何两个聚异丁烯聚合物链之间的至少一个硫原子，使得含硫链段将那两个不同的PIB聚合物链段连接在一起。基于PIB的聚合物网络通过在光或热存在下的硫醇 - 烯反应制备。反应产物包括至少两个聚异丁烯聚合物前体部分，每个聚异丁烯聚合物前体部分具有至少两个选自端基-CH 2 -CH（CH 3）= CH 2，-CH 2 = C（CH 3）2和-CH 2 -CH = CH 2;和至少一个多官能硫醇。

5. 发明申请

WO2014025986A3 NOVEL POLYISOBUTYLENE-BASED THERMOPLASTIC ELASTOMERS 审中-公开
公开(公告)号：WO2014025986A3
公开(公告)日：2014-02-13
申请号：PCT/US2013/054111
申请日：2013-08-08
申请人： THE UNIVERSITY OF AKRON , KENNEDY, Joseph P. , NUGAY, Turgut , NUGAY, Nihan
发明人： KENNEDY, Joseph P. , NUGAY, Turgut , NUGAY, Nihan
IPC分类号： C08F216/16
摘要： The present invention is directed to a new class of thermoplastic elastomers (TPEs) and processes for making them. In some embodiments of the present invention, the end groups of the multi-arm PIB copolymer is a conjugated diene, whereas the other component is a multi-functional dienophile. The components of the TPE of the present invention are chemically connected via the well-known Diels-Alder reaction which is thermally reversible (by the retro-Diels-Alder reaction) at moderately elevated temperatures. The reversibility of the Diels-Alder retro-Diels-Alder reactions allows the recovery of the original components of the TPE and thus its recyclability and also gives the TPE the ability to be reshaped or reformed.

6. 发明申请

WO2014018509A1 POLYISOBUTYLENE-BASED POLYURETHANES CONTAINING ORGANICALLY MODIFIED MONTMORILLONITE 审中-公开
标题翻译：含有有机改性蒙脱土的聚异丁烯基聚氨酯
公开(公告)号：WO2014018509A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051634
申请日：2013-07-23
申请人： THE UNIVERSITY OF AKRON , KENNEDY, Joseph , NUGAY, Nihan , NUGAY, Turgut
发明人： KENNEDY, Joseph , NUGAY, Nihan , NUGAY, Turgut
IPC分类号： C08K3/34 , C08K9/00 , C08K9/04
CPC分类号： C08G18/3895 , C08G18/10 , C08G18/12 , C08G18/4825 , C08G18/4854 , C08G18/5024 , C08G18/6204 , C08G18/73 , C08G18/831 , C08K9/04 , C08L75/04 , C08L75/02 , C08L75/08
摘要： The present invention generally relates to polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas, and to a process for making such compounds. In one embodiment, the polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas also include at least one flexible hydrogen bond acceptor chain extender (HACE). In another embodiment, amine telechelic and hydroxyl telechelic polyisobutylenes are utilized with at least one at least one flexible hydrogen bond acceptor chain extender (HACE) to produce polyurethane-polyureas having various desired mechanical properties in combination with various desired oxidative/hydrolytic stability.
摘要翻译：本发明一般涉及聚异丁烯基聚氨酯，聚脲和/或聚氨酯 - 聚脲，以及制备这些化合物的方法。在一个实施方案中，聚异丁烯基聚氨酯，聚脲和/或聚氨酯 - 聚脲还包括至少一个柔性氢键受体扩链剂（HACE）。在另一个实施方案中，将胺遥爪和羟基遥爪聚异丁烯与至少一种柔性氢键受体扩链剂（HACE）一起使用，以产生具有各种所需机械性能的聚氨酯 - 聚脲，并结合各种所需的氧化/水解稳定性。

7. 发明申请

WO2018004797A1 APPARATUS AND METHOD FOR ZERO ORDER DRUG DELIVERY FROM MULTILAYER AMPHIPHILIC CO-NETWORKS 审中-公开
标题翻译：用于从多层两亲联合网络零药物递送的装置和方法
公开(公告)号：WO2018004797A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/029074
申请日：2017-04-24
申请人： CAKMAK, Mukerrem , GUZMAN CARDOZO, Gustavo Andres , ORGE, Frank , NUGAY, Turgut , THE UNIVERSITY OF AKRON
发明人： CAKMAK, Mukerrem , GUZMAN CARDOZO, Gustavo Andres , ORGE, Frank , NUGAY, Turgut
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7007 , A61F13/02 , A61K9/0051 , A61K9/51 , A61K45/06 , A61K47/32 , A61K47/34 , G02B1/043
摘要： In one or more embodiments the present invention provides a three layer bimodal amphiphilic co-network (β-APCN) based drug delivery device and methods for its making and use. In various embodiments, the system is based on a three-layer scheme. A center layer is composed of a β-APCN matrix containing a high drug loading and exhibiting high drug diffusivity and two outer layers which are also β-APCN-based, contain no-drug and are instead loaded with a diffusional barrier such as vitamin E, which considerably slows drug diffusion through these outer layers. Both modeling and experimental data demonstrates that the combined effect of non-uniform distribution of drug loading and diffusion constants within the three-layer systems of various embodiments of the present invention is capable of maintaining a low local drug concentration at the polymer-fluid interface, thus achieving zero-order kinetics.
摘要翻译：在一个或多个实施方案中，本发明提供了基于三层双峰双亲共网络（β-APCN）的药物递送装置及其制造和使用方法。在各种实施例中，该系统基于三层方案。中心层由含有高药物负载量并表现出高药物扩散性的β-APCN基质和也是基于β-APCN的两个外层组成，不含药物，而是装载有扩散屏障例如维生素E ，这大大减缓了通过这些外层的药物扩散。建模和实验数据都表明，本发明各种实施方案的三层体系内药物加载量和扩散常数的不均匀分布的组合效应能够维持聚合物 - 流体界面处的低局部药物浓度，从而实现零级动力学。

8. 发明申请

WO2017127642A1 NOVEL INITIATORS FOR LIVING CARBOCATIONIC POLYMERIZATION 审中-公开
标题翻译：新型起居剂用于活性碳阳离子聚合
公开(公告)号：WO2017127642A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014280
申请日：2017-01-20
申请人： KENNEDY, Joseph , NUGAY, Turgut , THE UNIVERSITY OF AKRON
发明人： KENNEDY, Joseph , NUGAY, Turgut
IPC分类号： C07C13/32 , C07C13/44 , C07C23/18
CPC分类号： C07C13/44 , C07C23/18 , C07C23/32 , C07C33/36 , C07C35/31 , C07C35/37 , C07C35/44 , C07C43/188 , C07C211/27 , C07C2602/06 , C07C2603/08 , C07C2603/40
摘要： In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is directed to methods for using these novel compositions as initiators for isobutylene (IB) and other cationically polymerizable monomers, such as styrene and its derivatives. In still other embodiments, the present invention is directed to structurally new, allyl (and chlorine) telechelic PIBs formed from these new initiator compositions and their derivatives (in particular, hydroxyl telechelic PIB and amine telechelic PIB). In yet other embodiments, the present invention is directed to structurally new polyurethanes, polyureas, and polyurethane ureas made using telechelic PIBs formed from these new initiator compositions.
摘要翻译：在各种实施方案中，本发明涉及用于生产明确定义的远螯PIB（通过异丁烯的LC + P）的新型低成本引发剂组合物。在各种其它实施方案中，本发明涉及使用这些新型组合物作为异丁烯（IB）和其它阳离子可聚合单体如苯乙烯及其衍生物的引发剂的方法。在其他实施方案中，本发明涉及由这些新引发剂组合物及其衍生物（特别是羟基遥爪PIB和胺遥爪PIB）形成的结构新颖的烯丙基（和氯）遥爪PIB。在其他实施方案中，本发明涉及使用由这些新型引发剂组合物形成的遥爪PIB制备的结构上新的聚氨酯，聚脲和聚氨酯脲。

9. 发明申请

WO2022031895A1 SYNTHESIS OF HIGH MOLECULAR WEIGHT AND STRENGTH POLYISOBUTYLENE-BASED POLYURETHANES AND USE THEREOF 审中-公开
公开(公告)号：WO2022031895A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/044616
申请日：2021-08-05
申请人： THE UNIVERSITY OF AKRON , CAMBRIDGE ENTERPRISE LIMITED
发明人： KENNEDY, Joseph , NUGAY, Turgut , NUGAY, Nihan , DEODHAR, Tejal , MOGGRIDGE, Geoff , PATEL, Ruhi
IPC分类号： C08G18/40 , C08G18/62 , A61L27/18 , A61L27/34
摘要： A method of preparing a polyisobutylene-based polyurethane for making heart valves is disclosed, wherein the method includes providing a polyisobutylene (PIB) polymer, freshly distilling a diisocyanate compound to create a freshly distilled diisocyanate and providing a chain extender. When the polyisobutylene polymer, the freshly distilled diisocyanate, and the chain extender are combined together by mixing, the created polyisobutylene-based polyurethane exhibits a higher number average molecular weight, a higher ultimate strength, a higher elongation, and a greater toughness than a polyisobutylene-based polyurethane made without a freshly distilled diisocyanate, which makes the polymer particularly useful as a bioprosthetic heart valve.

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