专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011088580A1 APPARATUS AND METHODS FOR CHARACTERIZATION OF LUNG TISSUE BY RAMAN SPECTROSCOPY 审中-公开
标题翻译：拉曼光谱法鉴定肺组织的装置及方法
公开(公告)号：WO2011088580A1
公开(公告)日：2011-07-28
申请号：PCT/CA2011/050040
申请日：2011-01-21
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH , ZENG, Haishan , SHORT, Michael , LAM, Stephen , MCWILLIAMS, Annette
发明人： ZENG, Haishan , SHORT, Michael , LAM, Stephen , MCWILLIAMS, Annette
IPC分类号： A61B1/267 , A61B6/00 , G01N21/65
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , G01N21/65
摘要： Near-infrared Raman spectroscopy can be applied to identify preneoplastic lesions of the bronchial tree. Real-time in vivo Raman spectra of lung tissues may be obtained with a fiber optic catheter passed down the instrument channel of a bronchoscope. Using prototype apparatus, preneoplastic lesions were detected with sensitivity and specificity of 96 and 91 % respectively. The use of Raman spectroscopy apparatus and methods in conjunction with other bronchoscopy imaging modalities can substantially reduce the number of false positive results.
摘要翻译：近红外拉曼光谱可用于鉴定支气管树瘤的肿瘤前病变。肺组织的实时体内拉曼光谱可以通过向下穿过支气管镜的仪器通道的光纤导管获得。使用原型装置，分别检测到96和91％的敏感性和特异性的癌前病变。使用拉曼光谱设备和方法与其他支气管镜检查成像模式联合可以大大减少假阳性结果的数量。

2. 发明申请

WO2014063257A1 METHODS AND APPARATUS FOR COLONIC NEOPLASIA DETECTION WITH HIGH FREQUENCY RAMAN SPECTRA 审中-公开
标题翻译：高频拉曼光谱法检测大肠杆菌的方法及装置
公开(公告)号：WO2014063257A1
公开(公告)日：2014-05-01
申请号：PCT/CA2013/050812
申请日：2013-10-25
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： SHORT, Michael , TAI, Isabella , ZENG, Haishan , WANG, Wenbo
IPC分类号： A61B6/00
CPC分类号： A61B5/0075
摘要： Raman spectroscopy at higher Raman shifts, for example, Raman shifts exceeding 1000 cm -1 is applied for characterizing tissues of the colon. Characterization may comprise comparisons of peaks in the Raman spectrum and/or multivariate analysis. Compact, cost effective and disposable Raman probes may be provided. In one embodiment a Raman probe comprises a single pair of optical fibers having beveled ends.
摘要翻译：拉曼光谱在较高的拉曼位移，例如，超过1000 cm -1的拉曼位移被用于表征结肠组织。表征可以包括拉曼光谱和/或多变量分析中的峰的比较。可以提供紧凑的，成本有效的和一次性的拉曼探头。在一个实施例中，拉曼探针包括具有倾斜端部的单对光纤。

3. 发明申请

WO2014124531A1 INTEGRATED SPECTRAL PROBE FOR RAMAN, REFLECTANCE AND FLUORESCENCE SPECTRAL MEASUREMENTS 审中-公开
标题翻译：用于拉曼，反射和荧光光谱测量的综合光谱探测
公开(公告)号：WO2014124531A1
公开(公告)日：2014-08-21
申请号：PCT/CA2014/050093
申请日：2014-02-11
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： ZENG, Haishan , SHORT, Michael , ZHAO, Jianhua
IPC分类号： G01J3/28 , G01J3/12 , A61B6/00
CPC分类号： G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B2560/0285 , G01J3/0213 , G01J3/0221 , G01J3/4406 , G01N21/64 , G01N21/645 , G01N2021/6417 , G01N2021/6484 , G01N2201/08 , G01N2201/0833 , G01N2201/084
摘要： Examples of a spectroscopy probe for performing measurements of Raman spectra, reflectance spectra and fluorescence spectra are disclosed. The integrated spectral probe can comprise one or more light sources to provide a white light illumination to generate reflectance spectra, an excitation light to generate an UV/visible fluorescence spectra and a narrow band NIR excitation to induce Raman spectra. The multiple modalities of spectral measurements can be performed within 2 seconds or less. Examples of methods of operating the integrated spectroscopy probe disclosed.
摘要翻译：公开了用于进行拉曼光谱，反射光谱和荧光光谱测量的光谱探针的实例。集成光谱探测器可以包括一个或多个光源以提供白光照明以产生反射光谱，产生UV /可见荧光光谱的激发光和窄带NIR激发以诱导拉曼光谱。光谱测量的多种方式可以在2秒以内进行。所公开的集成光谱探测器的操作方法的实例。

4. 发明申请

WO2010083484A2 SYSTEM AND METHOD FOR CHARACTERIZATION OF ORAL, SYSTEMIC AND MUCOSAL TISSUE UTILIZING RAMAN SPECTROSCOPY 审中-公开
标题翻译：用拉曼光谱法表征口腔，系统和粘膜组织的系统和方法
公开(公告)号：WO2010083484A2
公开(公告)日：2010-07-22
申请号：PCT/US2010/021315
申请日：2010-01-18
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BRITISH COLUMBIA CANCER AGENCY BRANCH , GUZE, Kevin , SHORT, Michael , ZENG, Haishan , SONIS, Stephen
发明人： GUZE, Kevin , SHORT, Michael , ZENG, Haishan , SONIS, Stephen
IPC分类号： G01N33/483
CPC分类号： G01N21/65 , A61B5/0088 , A61B5/682 , G01N2021/656
摘要： A method and system for characterizing tissue includes a probe connected to a red LASER source and a Raman spectroscope. The probe includes at least excitation fiber and one or more emission fibers that connect the probe with the LASER source and the Raman spectroscope. The excitation fiber is connected to the red LASER source and terminates in the first end of the probe adjacent the tip of the probe. The emission fibers are connected to the Raman spectroscope and terminate in the first end of the probe adjacent the tip of the probe. In one embodiment, the excitation fiber extends through the central portion of the probe and one or more emission fibers are arranged around the excitation fiber. The tip of the probe is intended to come in contact with the tissue to be examined. The tip includes a central opening to allow red LASER radiation to project out of the end of the red excitation fiber on to the tissue and to permit Raman spectra to enter the emission fiber(s) and travel to the Raman spectroscope. The tip is constructed to have a predefined focal length to position the first end of the probe a predefined distance from the surface of the tissue being examined. The tip can be removable and tips having different focal lengths can be used to accommodate different types of tissues and examinations. A detector can convert the Raman spectra into signals and data for analysis by a computer system. The Raman spectra for tissue in a predefined location can be profiled such that the system can distinguish between healthy and diseased tissue.
摘要翻译：用于表征组织的方法和系统包括连接到红色激光源和拉曼分光镜的探针。探头至少包括激发光纤和一根或多根将探头与激光源和拉曼分光镜连接的发射光纤。激发光纤连接到红色LASER光源，并终止在探头尖端附近的探头第一端。发射光纤连接到拉曼分光镜，并终止在探针尖端附近的探针第一端。在一个实施例中，激发光纤延伸穿过探针的中心部分并且一个或多个发射光纤布置在激发光纤周围。探针的尖端旨在与要检查的组织接触。尖端包括中心开口，以允许红色LASER辐射从红色激发光纤的端部伸出到组织上，并允许拉曼光谱进入发射光纤并前往拉曼分光镜。尖端构造成具有预定义的焦距，以将探针的第一端定位成与正在检查的组织的表面相距预定距离。尖端可以拆卸，并且可以使用具有不同焦距的尖端来适应不同类型的组织和检查。检测器可以将拉曼光谱转换成信号和数据供计算机系统分析。可以对预定位置处的组织的拉曼光谱进行分析，使得该系统可以区分健康组织和患病组织。

5. 发明申请

WO2014124537A1 METHOD AND APPARATUS FOR OPTICAL MEASUREMENTS UNDER AMBIENT LIGHT CONDITIONS 审中-公开
标题翻译：光环境条件下光学测量的方法与装置
公开(公告)号：WO2014124537A1
公开(公告)日：2014-08-21
申请号：PCT/CA2014/050100
申请日：2014-02-14
申请人： VERISANTE TECHNOLOGY, INC. , BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： ZENG, Haishan , ZHAO, Jianhua , SHORT, Michael , BRAUN, Thomas Andrew
IPC分类号： G01J3/02 , A61B6/00 , F21V33/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/742 , A61B2560/0247 , F21K9/60 , G01J3/10 , G01J3/44 , G01J2003/104
摘要： Examples of a spectroscopy system with a specially design ambient illumination system are disclosed. The ambient illumination system comprises one or more light emitting diodes (LEDs) that provide illumination light in the wavelength of 400 - 785 nm. The ambient illumination system can further comprise a filter to block light above 785nm. The filter can be placed directly in front of LED emitters. The LEDs can be white LEDs or RGB LEDs. The spectroscopy system can further comprise a control system that can receive a signal from the spectral probe when the spectral measurements commence and can instantaneously send a signal to automatically switch off the ambient illumination system and to receive a signal from the spectral probe when the spectral measurements are terminated and automatically switch on the ambient illumination system. Examples of methods of operating the spectroscopy system and the ambient illumination system are disclosed.
摘要翻译：公开了具有特别设计的环境照明系统的光谱系统的实例。环境照明系统包括提供400-785nm波长的照明光的一个或多个发光二极管（LED）。环境照明系统还可以包括用于阻挡高于785nm的光的滤光器。滤波器可以直接放在LED发射器的前面。 LED可以是白色LED或RGB LED。光谱系统还可以包括一个控制系统，当光谱测量开始时可以从光谱探测器接收信号，并且可以瞬时发送一个信号以自动切断环境照明系统，并在光谱测量时接收来自光谱探测器的信号被终止并自动打开环境照明系统。公开了操作光谱系统和环境照明系统的方法的实例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式