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1. 发明申请

WO2006036926A3 EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES 审中-公开
公开(公告)号：WO2006036926A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/034511
申请日：2005-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY , MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
发明人： MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02
摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. Formula (I). These compounds can be useful as factor Xa inhibitors.

2. 发明申请

WO2006036926A2 EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES 审中-公开
标题翻译： 4,5-二羟基 - 吡唑并[3,4-C]吡啶-2-酮的有效合成
公开(公告)号：WO2006036926A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034511
申请日：2005-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY , MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
发明人： MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
CPC分类号： C07D471/04
摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. Formula (I). These compounds can be useful as factor Xa inhibitors.
摘要翻译：描述了由合适的苯肼制备下列所示类型的4,5-二氢 - 吡唑并[3,4-c]吡啶-2-酮的新方法及其中间体。式（I）。这些化合物可用作因子Xa抑制剂。

3. 发明申请

WO2005016904A1 PROCESS FOR PREPARING 4-ALKYL-OR 4-ARYL-OXYCARBONYL PACLITAXEL ANALOGS AND NOVEL INTERMEDIATES 审中-公开
标题翻译：制备4-烷基 - 或4-芳基 - 氧代羰基苯并噻唑类似物和新型中间体的方法
公开(公告)号：WO2005016904A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/025204
申请日：2004-08-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , GIBSON, Frank, S. , KANT, Joydeep , DESHPANDE, Rajendra, P. , TENHUISEN, Karen, L. , LIANG, Jing , LI, Jun , BOETTGER, Susan, D. , GUBLO, Edward, J. , DHOKTE, Ulhas, P.
发明人： GIBSON, Frank, S. , KANT, Joydeep , DESHPANDE, Rajendra, P. , TENHUISEN, Karen, L. , LIANG, Jing , LI, Jun , BOETTGER, Susan, D. , GUBLO, Edward, J. , DHOKTE, Ulhas, P.
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.
摘要翻译：提供了一种制备4-烷基 - 或4-芳基 - 氧羰基紫杉醇类似物的方法，其包括使用亲电保护基如苯甲酰氧基羰基将紫杉醇转化为C-7酰基保护的紫杉醇的步骤，并将C-7保护的类似物进入4-烷氧基羰基或4-芳氧基羰基紫杉醇类似物。还提供了在该方法中生产的新型中间体。

4. 发明申请

WO2004052310A2 PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1ALPHA, 3 ALPHA, 4 BETA)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLO 审中-公开
标题翻译：制备抗病毒剂的方法[1S-（1ALPHA，3 ALPHA，4ABA）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-甲基烯基
公开(公告)号：WO2004052310A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039554
申请日：2003-12-10
申请人： BRISTOL-MYERS SQUIBB COMPANY , BANERJEE, Amit , KUCERA, David, J. , PENDRI, Yadagiri, R. , CHEN, Chung-Pin, H. , PATEL, Sunil, S. , EVANS, Jeffrey, M. , LIANG, Jing , KRONENTHAL, David, R. , POWERS, Gerald, L. , PRASAD, Siva, Josyula , BIEN, Jeffrey, T. , SHI, Zhongping , PATEL, Ramesh, N. , CHAN, Yeung, Y. , RIJHWANI, Sushil, K. , SINGH, Ambarish, K. , WANG, Shaopeng , STOJANOVIC, Milan , POLNIASZEK, Richard , LEWIS, Charles , THOTTATHIL, John , KRISHNAMURTY, Dhileepkumar , ZHOU, Maotang, X. , VEMISHETTI, Purushotham
发明人： PENDRI, Yadagiri, R. , CHEN, Chung-Pin, H. , PATEL, Sunil, S. , EVANS, Jeffrey, M. , LIANG, Jing , KRONENTHAL, David, R. , POWERS, Gerald, L. , PRASAD, Siva, Josyula , BIEN, Jeffrey, T. , SHI, Zhongping , PATEL, Ramesh, N. , CHAN, Yeung, Y. , RIJHWANI, Sushil, K. , SINGH, Ambarish, K. , WANG, Shaopeng , STOJANOVIC, Milan , POLNIASZEK, Richard , LEWIS, Charles , THOTTATHIL, John , KRISHNAMURTY, Dhileepkumar , ZHOU, Maotang, X. , VEMISHETTI, Purushotham
IPC分类号： A61K
CPC分类号： C07F7/1856 , C07D473/18 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/0827 , C07F7/083
摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
摘要翻译：公开了制备抗病毒剂恩替卡韦的方法。还公开了用于恩替卡韦的分离和纯化的树脂吸附方法。还公开了可用于制备恩替卡韦的各种中间体。

5. 发明申请

WO2022251116A1 MODIFIED HERBAL COMPOSITIONS FOR NEUROMODULATION 审中-公开
公开(公告)号：WO2022251116A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030545
申请日：2022-05-23
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , LIANG, Jing
发明人： LIANG, Jing
IPC分类号： A61F13/02 , A61K31/05 , A61K31/125
摘要： Herbal compositions comprising dihydromyricetin (DHM) and methods of use. The herbal compositions include DHM in combination with other ingredients to form compositions that can significantly improve the quality and duration of sleep, reduce the time for onset of improved sleep quality and duration, and treat or alleviate the symptoms of sleep-related disorders and neurological conditions. The composition is a therapeutic alternative to drugs to alleviate sleep disorders and related symptoms and ailments.

6. 发明申请

WO2012078998A1 SLOW REBOUND FOAM PADDED SPORTS SHIRT 审中-公开
标题翻译：慢慢发泡泡沫运动衫
公开(公告)号：WO2012078998A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/064189
申请日：2011-12-09
申请人： STORELLI SPORTS, LLC , STORELLI, Claudio , LIANG, Jing
发明人： STORELLI, Claudio , LIANG, Jing
IPC分类号： A41D13/05
CPC分类号： A63B71/12 , A41D13/0518 , A41D2600/10 , A63B2071/1208 , A63B2102/18 , A63B2243/0025 , A63B2243/0066 , A63B2243/007
摘要： A novel chest pad is attached to or incorporated into the chest area of a jersey, loose undershirt or compression undershirt to help goalkeepers or other players gain control of balls that hit their chests. The novel chest pad is effective to reduce the velocity of a rebounding ball after its impact with the chest while providing protection against impact and abrasion. The slow-rebound foam layer has the property that once compressed, it returns to its pre-compression state slowly relative to other foams. In the context of catching or controlling a soccer ball, this slow-rebound property reduces the foam's pressure on the rebounding ball, thus decreasing its rebounding velocity and allowing a player to catch or control the ball more easily, especially hard shots. A soccer field player wearing a shirt with the chest pad may also find it helpful for trapping soccer balls with their chest.
摘要翻译：一个新颖的胸垫附着或并入到球衣，松散的汗衫或压缩汗衫的胸部区域，以帮助守门员或其他玩家获得控制击中胸部的球。新颖的胸垫可有效降低反弹球与胸部撞击后的速度，同时提供防止冲击和磨损的保护。缓慢回弹的泡沫层具有一旦被压缩的性质，相对于其它泡沫体缓慢返回到其预压缩状态。在捕捉或控制足球的背景下，这种缓慢反弹的属性可以减少泡沫在反弹球上的压力，从而降低其反弹速度，并允许玩家更容易地抓住或控制球，特别是硬射门。穿着胸垫的衬衫的足球运动员也可能会发现有助于将足球与胸部相扣合。

7. 发明申请

WO2012068418A1 SOCCER GOALKEEPER GLOVE 审中-公开
公开(公告)号：WO2012068418A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/061277
申请日：2011-11-17
申请人： STORELLI SPORTS, LLC , STORELLI, Claudio , LIANG, Jing
发明人： STORELLI, Claudio , LIANG, Jing
IPC分类号： A41D19/00
CPC分类号： A63B71/148 , A41D19/01523 , A63B71/143
摘要： Sports gloves include a multilayer palm section that includes an outer layer and one or more inner layers, at least one of which is a layer of slow rebound, open cell polyurethane to provide a glove with better impact control and protection while also providing a user with better feel for a ball striking the palm.
摘要翻译：运动手套包括多层手掌部分，其包括外层和一个或多个内层，其中至少一层是缓慢回弹层，开孔聚氨酯，以提供具有更好冲击控制和保护的手套，同时还为使用者提供更好地感觉到一个击球的球。

9. 发明申请

WO2010144236A1 LATENT HARDENER FOR EPOXY COMPOSITIONS 审中-公开
标题翻译：环氧组合物的最佳硬化剂
公开(公告)号：WO2010144236A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/035905
申请日：2010-05-24
申请人： TRILLION SCIENCE, INC. , YING, Yurong , MCNAMARA, John, J. , LIANG, Jing , LIANG, Rong-chang
发明人： YING, Yurong , MCNAMARA, John, J. , LIANG, Jing , LIANG, Rong-chang
IPC分类号： C08G59/14
CPC分类号： C08G59/184 , C08G59/182 , C08G59/4007
摘要： Disclosed herein is a curing agent for epoxy resins that is comprised of the reaction product of an amine, an epoxy resin, and an elastomer epoxy adduct. Additionally disclosed is a process comprising agitating a solution of an amine, an epoxy resin, and an elastomer epoxy adduct as a dispersant at an elevated temperature in an organic medium.
摘要翻译：本文公开了一种由胺，环氧树脂和弹性体环氧加合物的反应产物组成的环氧树脂固化剂。另外公开了一种方法，该方法包括在高温下在有机介质中搅拌胺，环氧树脂和弹性体环氧加合物作为分散剂的溶液。

10. 发明申请

WO2010036131A1 PRODUCTION OF TITANIUM ALLOYS IN PARTICULATE FORM VIA SOLID STATE REDUCTION PROCESS 审中-公开
标题翻译：通过固态还原方法生产颗粒形式的钛合金
公开(公告)号：WO2010036131A1
公开(公告)日：2010-04-01
申请号：PCT/NZ2009/000202
申请日：2009-09-25
申请人： TITANOX DEVELOPMENT LIMITED , LIANG, Jing
发明人： LIANG, Jing
IPC分类号： C22B9/14 , C22B34/12 , C22C14/00
CPC分类号： C22C14/00 , B22F9/20 , B22F2998/10 , B22F2999/00 , C22B34/1286 , B22F2201/11 , B22F1/0085 , B22F9/04
摘要： The invention relates to a method for the production of titanium alloy particulate materials, in particular the invention relates to a process for producing titanium metal alloys via a Solid State Reduction (SSR) process from Titanium oxide (TiO 2 ) and alloying metal oxides and / or elemental metals. A variety of particulate titanium alloys, such as Ti-6Al-4V, Ti-55Ni,γ -Ti-48Al, α 2 -Ti 3 Al, Ti-28Nb, Ti-24Nb-3Al, can be produced by mixing metal oxides and / or elemental metals with calcium hydride (CaH 2 ) and heating to carry out a solid state reduction.
摘要翻译：本发明涉及一种生产钛合金颗粒材料的方法，特别是本发明涉及一种通过固体还原（SSR）工艺生产钛金属合金的方法，该工艺由氧化钛（TiO 2）和合金金属氧化物和/或元素金属。各种微粒钛合金，如Ti-6Al-4V，Ti-55Ni，？ -Ti-48Al，a2-Ti3Al，Ti-28Nb，Ti-24Nb-3Al可以通过将金属氧化物和/或元素金属与氢化钙（CaH 2）混合并加热来进行固态还原来制备。

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