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1. 发明申请

WO1995034573A1 IDENTIFICATION OF POLYCYSTIC KIDNEY DISEASE GENE, DIAGNOSTICS AND TREATMENT 审中-公开
标题翻译：多科性杀虫病基因鉴定，诊断和治疗
公开(公告)号：WO1995034573A1
公开(公告)日：1995-12-21
申请号：PCT/US1995007079
申请日：1995-06-02
申请人： BRIGHAM AND WOMEN'S HOSPITAL , MILLENIUM PHARMACEUTICALS, INC.
发明人： BRIGHAM AND WOMEN'S HOSPITAL , MILLENIUM PHARMACEUTICALS, INC. , REEDERS, Stephen , SCHNEIDER, Michael , GLUCKSMANN, Sandra
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to the identification of the autosomal dominant polycystic kidney disease (PKD) gene and high throughput assays to identify compounds that interfere with PKD activity. Interfering compounds that inhibit the expression, synthesis and/or bioactivity of the PKD gene product can be used therapeutically to treat polycystic kidney disease.
摘要翻译：本发明涉及常染色体显性多囊肾病（PKD）基因的鉴定和高通量测定以鉴定干扰PKD活性的化合物。抑制PKD基因产物的表达，合成和/或生物活性的干扰化合物可用于治疗性治疗多囊肾病。

2. 发明申请

WO1996005861A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF BODY WEIGHT DISORDERS, INCLUDING OBESITY 审中-公开
标题翻译：用于治疗身体重量疾病的组合物和方法，包括肥胖
公开(公告)号：WO1996005861A1
公开(公告)日：1996-02-29
申请号：PCT/US1995010918
申请日：1995-08-23
申请人： MILLENIUM PHARMACEUTICALS, INC.
发明人： MILLENIUM PHARMACEUTICALS, INC. , TARTAGLIA, Louis, A.
IPC分类号： A61K39/395
CPC分类号： C07K14/5759 , A01K2217/05 , A61K38/00 , Y10S930/12
摘要： The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.
摘要翻译：本发明涉及用于治疗体重障碍的方法和组合物，包括但不限于肥胖症。具体地，本发明鉴定并描述了相对于在正常或非体重紊乱状态下表达和/或响应于与食欲和/或体重调节相关的操作而在体重紊乱状态下差异表达的基因。此外，本发明通过其基因产物与涉及体重紊乱和/或食欲和/或体重调节的基因产物相互作用的能力来鉴定和描述基因。此外，本发明提供了用于鉴定和治疗使用化合物作为体重紊乱治疗的方法。此外，本发明描述了各种体重障碍的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。

3. 发明申请

WO1998000711A1 DETECTION OF CANCER BY ASSAYING FOR CANCER-SPECIFIC ANTIGENS HAVING LINKED OLIGOSACCHARIDES WHICH ARE AT LEAST TRIANTENNARY 审中-公开
标题翻译：通过测定具有至少三倍体连锁寡糖的癌症特异性抗原来检测癌症
公开(公告)号：WO1998000711A1
公开(公告)日：1998-01-08
申请号：PCT/US1997010444
申请日：1997-06-13
申请人： MILLENIUM PHARMACEUTICALS, INC.
发明人： MILLENIUM PHARMACEUTICALS, INC. , ROBBINS, Phillips, W. , PRAKASH, Sadhana
IPC分类号： G01N33/48
CPC分类号： G01N33/57488 , G01N33/57434 , G01N2333/42 , G01N2333/4724 , G01N2333/96455
摘要： A process for assaying for cancer of the prostate, comprising assaying a sample derived from a human for prostate specific antigen having a linked oligosaccharide which is at least triantennary. The assay may employ a binding molecule which binds to oligosaccharides that are at least triantennary, but does not bind to oligosaccharides that are monoantennary or diantennary. Such binding molecule may be a lectin such as PHA-L or an antibody to an oligosaccharide that is at least triantennary.
摘要翻译：一种用于测定前列腺癌症的方法，包括测定来自人类的具有至少三临界连接的寡糖的前列腺特异性抗原的样品。该测定可以使用结合分子，该结合分子与至少三天生的寡糖结合，但不结合作为单一或双螺旋的寡糖。这样的结合分子可以是凝血素如PHA-L或至少为三进制的寡糖的抗体。

4. 发明申请

WO1996030389A1 COMPOSITIONS FOR THE DIAGNOSIS, PREVENTION, AND TREATMENT OF TUMOR PROGRESSION 审中-公开
标题翻译：用于诊断，预防和治疗肿瘤进展的组合物
公开(公告)号：WO1996030389A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004413
申请日：1996-03-29
申请人： MILLENIUM PHARMACEUTICALS, INC.
发明人： MILLENIUM PHARMACEUTICALS, INC. , SHYJAN, Andrew, W.
IPC分类号： C07H21/04
CPC分类号： C07K14/82 , A01K2217/05 , A01K2217/075 , A61K38/00 , C12N15/1034 , C12N15/1072
摘要： The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung tumors, and neoplastic conditions such as leukemias and lymphomas. Genes are identified that are differentially expressed in benign (e.g., non-malignant) tumor cells relative to malignant tumor cells exhibiting a high metastatic potential. Genes are also identified via the ability of their gene products involved in the progression to, and/or aggressiveness of, neoplastic tumor disease states.
摘要翻译：本发明涉及用于诊断，预防和治疗涉及人肿瘤的细胞如黑素瘤，乳腺癌，胃肠道，肺肿瘤和肿瘤性疾病如白血病和淋巴瘤的肿瘤进展的方法和组合物。鉴定出相对于表现出高转移潜能的恶性肿瘤细胞，在良性（例如，非恶性）肿瘤细胞中差异表达的基因。基因也通过其涉及肿瘤肿瘤疾病状态进展和/或侵袭性的基因产物的能力来鉴定。

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