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1. 发明申请

WO2010121122A2 BIOMECHANICAL INDUCTION OF HEMATOPOIESIS 审中-公开
标题翻译：生物化学诱导HEMATOPOIESIS
公开(公告)号：WO2010121122A2
公开(公告)日：2010-10-21
申请号：PCT/US2010031382
申请日：2010-04-16
申请人： BRIGHAM & WOMENS HOSPITAL , CHILDRENS MEDICAL CENTER , DALEY GEORGE , NAVEIRAS OLAIA , GARCIA-CARDENA GUILLERMO , ADAMO LUIGI
发明人： DALEY GEORGE , NAVEIRAS OLAIA , GARCIA-CARDENA GUILLERMO , ADAMO LUIGI
IPC分类号： A61K35/28 , A61K35/14 , A61P7/00 , C12N5/078
CPC分类号： C12N5/0634 , C12N2506/02 , C12N2521/00
摘要： The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical stimulus. More specifically, the application of shear stress to hematopoietic progenitor cells or endothelial cells stimulates hematopoiesis, with or without concurrent application of other extrinsic modulators of hematopoiesis.
摘要翻译：本发明提供通过将细胞暴露于至少一种外部生物力学刺激来增加造血祖细胞，血管细胞和/或血液内皮细胞群的造血潜能的方法和组合物。更具体地说，剪切应力对造血祖细胞或内皮细胞的应用刺激造血，有或没有同时使用造血造血的其他外源调节剂。

2. 发明申请

WO2008021465A8 METHOD AND APPARATUS FOR MICROFLUIDIC INJECTION 审中-公开
标题翻译：微流体注射的方法和装置
公开(公告)号：WO2008021465A8
公开(公告)日：2008-08-28
申请号：PCT/US2007018204
申请日：2007-08-16
申请人： MASSACHUSETTS INST TECHNOLOGY , ADAMO ANDREA , ADAMO LUIGI , JENSEN KLAVS F
发明人： ADAMO ANDREA , ADAMO LUIGI , JENSEN KLAVS F
IPC分类号： C12M3/00 , C12N15/89
CPC分类号： C12M35/02
摘要： A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission direction of the jet or droplet) to produce a jet of liquid from the nozzle. The jet or droplet of liquid may be introduced through a cell membrane and into the cell interior in such a way that damage to the cell membrane that would cause cell death is avoided. An electrode may be formed adjacent a fluid channel by conducting a liquid material, such as solder, from a reservoir and into an electrode portion of an electrode channel to a location adjacent the fluid channel. A passageway between the electrode channel and the fluid channel may prevent flow of the liquid electrode material into the fluid channel during electrode formation.
摘要翻译：一种用于生产液体的射流或液滴的方法和装置。注射器装置可以包括与喷嘴流体连通的储存器，并且可以在储存器中产生压力梯度（例如，通过垂直于射流或液滴的排放方向的初始方向上的压电元件）产生压力梯度，以产生来自喷嘴的液体喷射。液体的射流或液滴可以通过细胞膜引入细胞内部，从而避免细胞膜的损伤，导致细胞死亡。可以通过将液体材料（例如焊料）从储存器传导到电极通道的电极部分到与流体通道相邻的位置而邻近流体通道形成电极。在电极形成期间，电极通道和流体通道之间的通道可以防止液体电极材料流入流体通道。

3. 发明申请

WO2008021465A3 METHOD AND APPARATUS FOR MICOFLUIDIC INJECTION 审中-公开
标题翻译：微型注射的方法和装置
公开(公告)号：WO2008021465A3
公开(公告)日：2008-05-22
申请号：PCT/US2007018204
申请日：2007-08-16
申请人： MASSACHUSETTS INST TECHNOLOGY , ADAMO ANDREA , ADAMO LUIGI , JENSEN KLAVS F
发明人： ADAMO ANDREA , ADAMO LUIGI , JENSEN KLAVS F
IPC分类号： C12M3/00 , C12N15/89
CPC分类号： C12M35/02
摘要： A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission direction of the jet or droplet) to produce a jet of liquid from the nozzle. The jet or droplet of liquid may be introduced through a cell membrane and into the cell interior in such a way that damage to the cell membrane that would cause cell death is avoided. An electrode may be formed adjacent a fluid channel by conducting a liquid material, such as solder, from a reservoir and into an electrode portion of an electrode channel to a location adjacent the fluid channel. A passageway between the electrode channel and the fluid channel may prevent flow of the liquid electrode material into the fluid channel during electrode formation.
摘要翻译：一种用于生产液体的射流或液滴的方法和装置。注射器装置可以包括与喷嘴流体连通的储存器，并且可以在储存器中产生压力梯度（例如，通过横向于射流或液滴的排放方向的初始方向的压电元件）产生压力梯度，以产生来自喷嘴的液体喷射。液体的射流或液滴可以通过细胞膜引入细胞内部，从而避免细胞膜对细胞死亡的破坏。可以通过将诸如焊料的液体材料从储存器引导到电极通道的电极部分到与流体通道相邻的位置而邻近流体通道形成电极。在电极形成期间，电极通道和流体通道之间的通道可以防止液体电极材料流入流体通道。

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