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1. 发明申请

WO2010059894A1 OCULAR FORMULATIONS OF NORKETOTIFEN 审中-公开
标题翻译：北卡罗来纳州的奥斯卡制剂
公开(公告)号：WO2010059894A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065252
申请日：2009-11-20
申请人： BRIDGE PHARMA, INC. , ABERG, A.K. Gunnar , JOHNSON, Keith
发明人： ABERG, A.K. Gunnar , JOHNSON, Keith
IPC分类号： A61K31/445
CPC分类号： A61K31/4436 , A61K9/0048 , A61K9/0051 , A61K9/127 , A61K31/436 , A61K31/4465 , A61K31/575 , A61K38/13 , Y10S514/912
摘要： Ophthalmic compositions containing norketotifen and methods of making the same and the use thereof are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof topical ophthalmic compositions containing norketotifen.
摘要翻译：本发明公开了含有诺托芬芬的眼用组合物及其制备方法及其应用。所述方法还包括向有需要的哺乳动物的眼睛施用含有诺托芬芬的局部眼用组合物。

2. 发明申请

WO2007038325A2 FORMULATIONS OF INDANYLAMINES AND THE USE THEREOF AS LOCAL ANESTHETICS AND AS MEDICATION FOR CHRONIC PAIN 审中-公开
标题翻译：印度胺的制剂及其作为本地麻醉品的用途和作为慢性疼痛的药物
公开(公告)号：WO2007038325A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037070
申请日：2006-09-22
申请人： BRIDGE PHARMA, INC. , ABERG, Gunnar, A., K. , JOHNSON, Keith
发明人： ABERG, Gunnar, A., K. , JOHNSON, Keith
IPC分类号： A61K9/70
CPC分类号： A61K9/12 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/02 , A61K9/7015
摘要： Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided. Also provided are solutions of 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine for injection, characterized by short onset time and long duration of activity. Formulations containing both 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine and capsaicin are also provided.
摘要翻译：提供2- [2-（N-苯基-N-2-茚满基）氨基乙基]哌啶的皮肤和粘膜制剂，其特征在于快速的皮肤和粘膜吸收和长的治疗活性持续时间。还提供了用于注射的2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶的溶液，其特征在于起始时间短和活性持续时间长。还提供含有2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶和辣椒素的制剂。

3. 发明申请

WO2010047681A1 TREATING XEROPHTHALMIA WITH NORKETOTIFEN 审中-公开
标题翻译：用诺卡方治疗西药
公开(公告)号：WO2010047681A1
公开(公告)日：2010-04-29
申请号：PCT/US2008/014056
申请日：2008-12-24
申请人： BRIDGE PHARMA, INC. , ABERG, A.K., Gunnar , JOHNSON, Keith
发明人： ABERG, A.K., Gunnar , JOHNSON, Keith
IPC分类号： A01N43/04
CPC分类号： A61K31/4535
摘要： Methods of using a cycloheptathiophene compound for the treatment of xerophthalmia are described, as are formulations and compositions for such treatment.
摘要翻译：描述了使用环庚噻吩化合物治疗干眼症的方法，以及用于这种治疗的制剂和组合物。

4. 发明申请

WO2017066052A1 FORMULATIONS AND METHODS FOR TREATING HIGH INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于治疗高眼压的制剂和方法
公开(公告)号：WO2017066052A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/055404
申请日：2016-10-05
申请人： BRIDGE PHARMA, INC.
发明人： ABERG, A. K. Gunnar , CIOFALO, Vincent B. , JOHNSON, Keith
IPC分类号： A61K31/4535 , A61K9/00 , A61P27/06
CPC分类号： A61K31/4535 , A61K9/0043 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K9/107 , A61K45/06 , A61K47/10 , A61K47/183 , A61K47/26
摘要： Disclosed herein are methods of treating a mammal in need of a reduction in intraocular pressure by administering an intraocular formulation including a therapeutically effective amount of norketotifen for the reduction of intraocular pressure to the eye of the mammal in need thereof, wherein the intraocular formulation includes about 0.02 wt% to about 1.0 wt% norketotifen or a salt or an isomer thereof, calculated as the norketotifen free base. In certain aspects, the intraocular formulation is free from any added preservative and the intraocular formulation is self-preserving. Also included herein is a method of treating a human in need of a reduction in intraocular pressure by administering an intranasal formulation that includes a therapeutically effective amount of norketotifen for the reduction of intraocular pressure to the eye of the human in need thereof. Also, the beneficial effects of known drugs for high IOP are improved by co-administration with norketotifen.
摘要翻译：本文公开了治疗需要降低眼内压的哺乳动物的方法，其通过施用包含治疗有效量的诺酮替哌的眼内制剂用于将眼内压降低至有需要的哺乳动物的眼睛其中所述眼内制剂包含约0.02重量％至约1.0重量％的诺卡替芬或其盐或其异构体，以诺酮替芬游离碱计算。在某些方面，眼内制剂不含任何添加的防腐剂，并且眼内制剂是自我保存的。本文还包括通过施用鼻内制剂来治疗需要降低眼内压力的人的方法，所述鼻内制剂包含治疗有效量的诺酮替哌，用于将眼内压降低至有需要的人的眼睛。此外，已知药物对于高IOP的有益效果通过与诺卡替芬共同施用而得到改善。

5. 发明申请

WO2003018157A1 TOY AIRPLANE ASSEMBLY HAVING A MICROPROCESOR FOR ASSISTING FLIGHT 审中-公开
标题翻译：具有助理飞行器的微型飞机的玩具飞机组件
公开(公告)号：WO2003018157A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/026483
申请日：2002-08-21
申请人： SPIN MASTER TOYS , REHKEMPER, Jeffrey , GOULD, Bret , GRISOLA, Nicholas , FLOROV, Alexey , JOHNSON, Keith
发明人： REHKEMPER, Jeffrey , GOULD, Bret , GRISOLA, Nicholas , FLOROV, Alexey , JOHNSON, Keith
IPC分类号： A63H27/00
CPC分类号： A63H27/02 , A63H30/04
摘要： A toy airplane assembly (31) is provided that is easy to fly, inexpensive, and durable. The toy plane assembly includes a plane having a radio receiver (73) and a microprocessor (71). Batteries (19) housed in the fuselage (12) power the printed circuit board (14) to which the microprocessor (71) and radio receiver (73) are attached. The radio receiver (73) receives signals from a hand-held remote control radio transmitter (51) and are transmitted to the microprocessor (71). The microprocessor (71) decodes the signals and, in response thereto, distributes power to the motors (8,8A) for driving the propellers (2,2A). All movement of the plane is controlled by the microprocessor (71), thereby providing microprocessor assisted flight. The plane fuselage (12) is a one-piece molded part, made of a foam material to provide a durable plane.
摘要翻译：提供了一种易于飞行，便宜且耐用的玩具飞机组件（31）。玩具平面组件包括具有无线电接收器（73）和微处理器（71）的平面。容纳在机身（12）中的电池（19）为微处理器（71）和无线电接收器（73）所附接的印刷电路板（14）供电。无线电接收机（73）从手持式遥控无线电发射机（51）接收信号并发送给微处理器（71）。微处理器（71）对信号进行解码，响应于此，将电力分配给用于驱动螺旋桨（2,2A）的马达（8,8A）。平面的所有运动由微处理器（71）控制，从而提供微处理器辅助飞行。平面机身（12）是一体成形件，由泡沫材料制成，以提供耐用的平面。

6. 发明申请

WO2010108090A1 WATER CLUSTERS CONFINED IN NANO-ENVIRONMENTS 审中-公开
标题翻译：纳米环境中的水库
公开(公告)号：WO2010108090A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027963
申请日：2010-03-19
申请人： HYDRO ELECTRON VENTURES , PRICE-GALLAGHER, Matthew , JOHNSON, Keith
发明人： PRICE-GALLAGHER, Matthew , JOHNSON, Keith
IPC分类号： C10L1/32
CPC分类号： C01B5/00 , C01B5/02
摘要： The disclosure describes a method including providing a nano-environment; and confining heavy or light water in the nano-environment such that at least one water cluster forms.
摘要翻译：本公开描述了一种包括提供纳米环境的方法; 并将重或轻水限制在纳米环境中，使得形成至少一个水簇。

7. 发明申请

WO2009075854A2 EFFECTIVE QUANTITATION OF COMPLEX PEPTIDE MIXTURES IN TISSUE SAMPLES AND IMPROVED THERAPEUTIC METHODS 审中-公开
标题翻译：组织样品中复合肽混合物的有效定量和改进的治疗方法
公开(公告)号：WO2009075854A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013590
申请日：2008-12-10
申请人： PEPTIMMUNE INC. , BALDWIN, Sam , BONNIN, Dustan , JOHNSON, Keith , KRIEGER, Jeff , RASMUSSEN, James , YU, Bei , ZANELLI, Eric , ZHANG, Jianxin , COLLINS, Kathryn, H. , GENOVA, Michelle , KOVALCHIN, Joseph
发明人： BALDWIN, Sam , BONNIN, Dustan , JOHNSON, Keith , KRIEGER, Jeff , RASMUSSEN, James , YU, Bei , ZANELLI, Eric , ZHANG, Jianxin , COLLINS, Kathryn, H. , GENOVA, Michelle , KOVALCHIN, Joseph
IPC分类号： A61K38/07 , A61P37/00 , A61P37/06
CPC分类号： A61K38/16
摘要： The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation.
摘要翻译：本发明提供了检测和定量组织样品中复合肽混合物的方法以及这种复合肽混合物施用结果的功能性读出方法。本发明还提供了向有需要的受试者施用复合肽混合物的方法，基于上述检测和定量方法确定的剂量方案和量。

8. 发明申请

WO2007078443A2 METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS 审中-公开
标题翻译：随机共聚物治疗疾病的方法
公开(公告)号：WO2007078443A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/044699
申请日：2006-11-17
申请人： PEPTIMMUNE, INC. , RASMUSSEN, James , ZHANG, Jianxin , BALDWIN, Sam , ZANELLI, Eric , YU, Bei , BONNIN, Dustin , JOHNSON, Keith , KRIEGER, Jeff
发明人： RASMUSSEN, James , ZHANG, Jianxin , BALDWIN, Sam , ZANELLI, Eric , YU, Bei , BONNIN, Dustin , JOHNSON, Keith , KRIEGER, Jeff
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译：本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。本发明还涉及治疗自身免疫性疾病如多发性硬化症，并且涉及在治疗方案中给予无规共聚物，所述无规共聚物包含以高于24小时的间隔给药的制剂，或者涉及在一段时间内给予共聚物的持续释放制剂大于24小时。本发明进一步涉及进行制药业务的方法，包括制造，许可或分发包含或涉及本文所述的无规共聚物的制剂或给药方案的试剂盒。

9. 发明申请

WO2009049120A3 VIBRONIC INTERACTIONS OF WATER CLUSTERS AND USES THEREFOR 审中-公开
公开(公告)号：WO2009049120A3
公开(公告)日：2009-04-16
申请号：PCT/US2008/079469
申请日：2008-10-10
申请人： HYDROELECTRON VENTURES INC. , JOHNSON, Keith , PRICE-GALLAGHER, Matthew
发明人： JOHNSON, Keith , PRICE-GALLAGHER, Matthew
IPC分类号： C02F1/70
摘要： The present disclosure provides methods wherein water-clusters' molecular vibrations in the 0.5 - 32 terahertz (THz) frequency range are coupled to the clusters' electronic states, generally referred to 'vibronic interactions', to promote water clusters as active agents in a range of applications. The present disclosure also describes the various natural and engineered systems where these water clusters are present and/or produced and whose unique vibronic interactions can be activated to carry out the desired applications. In addition, methods and systems of using the vibronic interactions of water clusters are disclosed, including applications for environmental remediation, clean energy production, terahertz radiation technologies, chemical synthesis and reactivity, and pharmaceutical and biomedical technologies.

10. 发明申请

WO2013123675A1 PROVIDING BUILDING INFORMATION MODELING DATA 审中-公开
标题翻译：提供建筑信息建模数据
公开(公告)号：WO2013123675A1
公开(公告)日：2013-08-29
申请号：PCT/CN2012/071587
申请日：2012-02-24
申请人： HONEYWELL INTERNATIONAL INC. , CHEN, Enyi , KIFF, Liana M. , RAYMOND, Michelle , JOHNSON, Keith , PLOCHER, Tom , FOSLIEN, Wendy
发明人： CHEN, Enyi , KIFF, Liana M. , RAYMOND, Michelle , JOHNSON, Keith , PLOCHER, Tom , FOSLIEN, Wendy
IPC分类号： G06F9/44
CPC分类号： G06F17/5009 , G06Q10/067
摘要： Devices, methods, and systems for providing building information modeling data are described herein. One system includes a database having complete building information modeling data associated with a building, and a computing device coupled to the database. The computing device is configured to receive, from a user of the computing device, a request for a particular scope of building information modeling data associated with the building, retrieve, from the database, the building information modeling data in the database that corresponds to the particular scope of building information modeling data requested by the user, and provide, to the user, the building information modeling data that corresponds to the particular scope of building information modeling data requested by the user.
摘要翻译：本文描述了用于提供建筑物信息建模数据的设备，方法和系统。一个系统包括具有与建筑物相关联的完整建筑物信息建模数据的数据库，以及耦合到数据库的计算设备。计算设备被配置为从计算设备的用户接收对与建筑物相关联的建筑物信息建模数据的特定范围的请求，从数据库检索数据库中对应于建筑物的建筑物信息建模数据，构建用户请求的信息建模数据的特定范围，并向用户提供对应于由用户请求的建筑物信息建模数据的特定范围的建筑物信息建模数据。

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