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1. 发明申请

WO2010059894A1 OCULAR FORMULATIONS OF NORKETOTIFEN 审中-公开
标题翻译：北卡罗来纳州的奥斯卡制剂
公开(公告)号：WO2010059894A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065252
申请日：2009-11-20
申请人： BRIDGE PHARMA, INC. , ABERG, A.K. Gunnar , JOHNSON, Keith
发明人： ABERG, A.K. Gunnar , JOHNSON, Keith
IPC分类号： A61K31/445
CPC分类号： A61K31/4436 , A61K9/0048 , A61K9/0051 , A61K9/127 , A61K31/436 , A61K31/4465 , A61K31/575 , A61K38/13 , Y10S514/912
摘要： Ophthalmic compositions containing norketotifen and methods of making the same and the use thereof are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof topical ophthalmic compositions containing norketotifen.
摘要翻译：本发明公开了含有诺托芬芬的眼用组合物及其制备方法及其应用。所述方法还包括向有需要的哺乳动物的眼睛施用含有诺托芬芬的局部眼用组合物。

2. 发明申请

WO2017066052A1 FORMULATIONS AND METHODS FOR TREATING HIGH INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于治疗高眼压的制剂和方法
公开(公告)号：WO2017066052A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/055404
申请日：2016-10-05
申请人： BRIDGE PHARMA, INC.
发明人： ABERG, A. K. Gunnar , CIOFALO, Vincent B. , JOHNSON, Keith
IPC分类号： A61K31/4535 , A61K9/00 , A61P27/06
CPC分类号： A61K31/4535 , A61K9/0043 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K9/107 , A61K45/06 , A61K47/10 , A61K47/183 , A61K47/26
摘要： Disclosed herein are methods of treating a mammal in need of a reduction in intraocular pressure by administering an intraocular formulation including a therapeutically effective amount of norketotifen for the reduction of intraocular pressure to the eye of the mammal in need thereof, wherein the intraocular formulation includes about 0.02 wt% to about 1.0 wt% norketotifen or a salt or an isomer thereof, calculated as the norketotifen free base. In certain aspects, the intraocular formulation is free from any added preservative and the intraocular formulation is self-preserving. Also included herein is a method of treating a human in need of a reduction in intraocular pressure by administering an intranasal formulation that includes a therapeutically effective amount of norketotifen for the reduction of intraocular pressure to the eye of the human in need thereof. Also, the beneficial effects of known drugs for high IOP are improved by co-administration with norketotifen.
摘要翻译：本文公开了治疗需要降低眼内压的哺乳动物的方法，其通过施用包含治疗有效量的诺酮替哌的眼内制剂用于将眼内压降低至有需要的哺乳动物的眼睛其中所述眼内制剂包含约0.02重量％至约1.0重量％的诺卡替芬或其盐或其异构体，以诺酮替芬游离碱计算。在某些方面，眼内制剂不含任何添加的防腐剂，并且眼内制剂是自我保存的。本文还包括通过施用鼻内制剂来治疗需要降低眼内压力的人的方法，所述鼻内制剂包含治疗有效量的诺酮替哌，用于将眼内压降低至有需要的人的眼睛。此外，已知药物对于高IOP的有益效果通过与诺卡替芬共同施用而得到改善。

3. 发明申请

WO2007038325A2 FORMULATIONS OF INDANYLAMINES AND THE USE THEREOF AS LOCAL ANESTHETICS AND AS MEDICATION FOR CHRONIC PAIN 审中-公开
标题翻译：印度胺的制剂及其作为本地麻醉品的用途和作为慢性疼痛的药物
公开(公告)号：WO2007038325A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037070
申请日：2006-09-22
申请人： BRIDGE PHARMA, INC. , ABERG, Gunnar, A., K. , JOHNSON, Keith
发明人： ABERG, Gunnar, A., K. , JOHNSON, Keith
IPC分类号： A61K9/70
CPC分类号： A61K9/12 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/02 , A61K9/7015
摘要： Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided. Also provided are solutions of 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine for injection, characterized by short onset time and long duration of activity. Formulations containing both 2-[2-(N-phenyl-N-2-indanyl) aminoethyl] piperidine and capsaicin are also provided.
摘要翻译：提供2- [2-（N-苯基-N-2-茚满基）氨基乙基]哌啶的皮肤和粘膜制剂，其特征在于快速的皮肤和粘膜吸收和长的治疗活性持续时间。还提供了用于注射的2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶的溶液，其特征在于起始时间短和活性持续时间长。还提供含有2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶和辣椒素的制剂。

4. 发明申请

WO2010047681A1 TREATING XEROPHTHALMIA WITH NORKETOTIFEN 审中-公开
标题翻译：用诺卡方治疗西药
公开(公告)号：WO2010047681A1
公开(公告)日：2010-04-29
申请号：PCT/US2008/014056
申请日：2008-12-24
申请人： BRIDGE PHARMA, INC. , ABERG, A.K., Gunnar , JOHNSON, Keith
发明人： ABERG, A.K., Gunnar , JOHNSON, Keith
IPC分类号： A01N43/04
CPC分类号： A61K31/4535
摘要： Methods of using a cycloheptathiophene compound for the treatment of xerophthalmia are described, as are formulations and compositions for such treatment.
摘要翻译：描述了使用环庚噻吩化合物治疗干眼症的方法，以及用于这种治疗的制剂和组合物。

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