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1. 发明申请

WO1984004331A1 METHOD AND REAGENT FOR THE DETERMINATION OF ANGIOTENSIN CONVERTI NG ENZYME 审中-公开
标题翻译：用于测定血管紧张素转化酶的方法和试剂
公开(公告)号：WO1984004331A1
公开(公告)日：1984-11-08
申请号：PCT/EP1984000127
申请日：1984-04-28
申请人： BOEHRINGER MANNHEIM GMBH , SCHARPE, Simon, L. , VAN SANDE, Marc, E. , NEELS, Hugo, M.
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12Q01/36
CPC分类号： C12Q1/37 , G01N2333/96486
摘要： A sample containing an angiotensin-converting enzyme (ACE) is mixed with hippuryl-glycyl-glycine or hippuryl-L-histidyl-L-leucine as substrates, and is deproteinized and the released amount of glycil-glycine, respectively L-histidyl-L-leucine, is determined. Such determination is preferably carried out by arylation by means of nitrobenzin derivatives such as for example trinitrobenzinsulfonic acid or 1-fluoro-2, 4-dinitrobenzin and the arylated products are determined by photometry. A reagent for implementing such process and containing as ACE substrates hippuryl-glycil-glycine or hippuryl-L-histidyl-L-leucine is also disclosed.
摘要翻译：将含有血管紧张素转换酶（ACE）的样品与马尿酰甘氨酰 - 甘氨酸或马尿酰-L-组氨酰-L-亮氨酸作为底物混合，并将其去蛋白，甘草分泌量分别为L-组氨酰-L 亮氨酸，是确定的。这种测定优选通过硝基苯并衍生物例如三硝基苯并苯磺酸或1-氟-2,4-二硝基苯并
萘的芳基化进行，并且通过光度法测定芳基化产物。还公开了用于实施这种方法并作为ACE底物包含马普里基 - 甘氨酸 - 甘氨酸或马尿酰-L-组氨酰-L-亮氨酸的试剂。

2. 发明申请

WO1998027195A1 RECEPTACLE FOR CELL CULTURES AND USE OF MULTIPLE DISHES FOR CULTURING ANTITUMOUR CELLS 审中-公开
标题翻译：细胞培养容器和多皮渣育种杀伤肿瘤细胞的使用
公开(公告)号：WO1998027195A1
公开(公告)日：1998-06-25
申请号：PCT/EP1997007095
申请日：1997-12-17
申请人： BOEHRINGER MANNHEIM GMBH , KUBBIES, Manfred , KOCH, Stefan , GOLLER, Bernhard
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12M01/20
CPC分类号： C12M23/08 , B01L3/5085 , C12M23/34
摘要： The invention relates to a receptacle for cell cultures (10) used to culture an antitumour cell transplant for gene and cell therapy. Said receptacle comprises a base part (12) with a plurality of support points (12b), which form a support plane (E) for supporting the cell culture receptacle (10) on a substantially level lower surface. Said receptacle further comprises an upper surface (12c), which runs substantially parallel to the support plane (E) and has a plurality of culturing recesses (16), and a lid (14) for covering the base part (12). At least one culturing recess (16) of the cell culture receptacle (12) progressively narrows from the upper surface (12c) of the base part (12) towards the bottom of the recess (16a, 16b), i.e. the cross-sectional surface area of said recess (16) decreases from the upper surface (12c) of the base part (12) towards the bottom (16a, 16b) in such a way that the cells, during multiplication, can expand not only towards upward but also sideways. Each culturing recess (16) has a volume of at least 1 ml. In addition, the base part (12) and lid (14) are connected such that they are liquid proof.
摘要翻译：用于生长的抗肿瘤细胞移植的基因和细胞治疗，包括具有多个支撑点的基座部分（12）的细胞培养容器（10）（12B），其包括一个支撑平面（E），用于支撑所述的细胞培养容器（10）一个基本上为平面的基板上跨度，以及基本上与用于覆盖基部支撑平面（E）的上表面（12c）的在多个生长阱（16）形成，并且盖（14）平行（12 ）。这种细胞培养容器中的至少一个育种凹部（16）（12）从所述基部（12），用于槽底（16A，16B）下，即，上表面（12c）的逐渐变细该横截面面积，所述至少一个凹部（16）从所述基部（12）的上表面（12c）的增加的底部（16A，16B）朝向这样断，使得细胞在生殖不仅向上而且在横向方向上可以传播。每个培养孔（16）的具有至少为1毫升的体积。此外，基座部分（12）和所述盖（14）液密地连接到彼此。

3. 发明申请

WO1998023961A1 ANTIGEN-SPECIFIC IgG DETECTION 审中-公开
标题翻译：抗原特异性IgG PROOF
公开(公告)号：WO1998023961A1
公开(公告)日：1998-06-04
申请号：PCT/EP1997006582
申请日：1997-11-26
申请人： BOEHRINGER MANNHEIM GMBH , FAATZ, Elke , SCHMITT, Urban
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： G01N33/68
CPC分类号： G01N33/543 , G01N33/6854 , Y10S435/965 , Y10S530/866
摘要： The invention relates to a method for determining antigen-specific antibodies of immunoglobulin class G in the presence of immunoglobulins of class M in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors, wherein a bonding partner in monomer form is a substantial constituent of R2. The invention also relates to a reagent for determining an antigen-specific antibody of immunoglobulin class G and the use of bonding partners in monomer form for determining an antigen-specific antibody of immunoglobulin class G.
摘要翻译：本发明涉及一种用于在体液M级的免疫球蛋白的存在的免疫球蛋白G类的抗原特异性抗体的测定方法通过培养用至少两种不同的受体R1和R2和任选地另外的受体，其中R 2的主要部分是单体形式结合伴侣，用于确定所述免疫球蛋白G类的抗原特异性抗体，以及在以单体形式使用结合伴侣的用于确定G.免疫球蛋白类的抗原特异性抗体的试剂

4. 发明申请

WO1998022483A1 NEW PHOSPHONATES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS 审中-公开
标题翻译：新膦酸酯，方法用于生产和药物
公开(公告)号：WO1998022483A1
公开(公告)日：1998-05-28
申请号：PCT/EP1997006365
申请日：1997-11-14
申请人： BOEHRINGER MANNHEIM GMBH , KUCZNIERZ, Ralf , LEINERT, Herbert , VON DER SAAL, Wolfgang , NEIDLEIN, Richard , KEHR, Christiane
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C07F09/59
CPC分类号： C07F9/5532 , C07F9/572 , C07F9/59
摘要： Compounds have the formula (I), in which R , R are the same or different and represent a hydrogen atom, an alkyl group, a cycloalkyl group, an hydroxyalkyl group, an alkenyl group, an alkinyl group or an aralkyl group or R and R form together an alkylene radical which forms with the bonded oxygen atoms and the phosphorus atom that carries the oxygen atoms a saturated 5- to 8-membered ring; R is an optionally substituted amino group, an alkyl group, a cycloalkyl radical or an optionally substituted aryl radical; n is an integer between 1 and 4. Also disclosed are hydrates, solvates and physiologically tolerable salts of these compounds, their optically active forms, processes for preparing the same and medicaments with factor Xa-inhibiting properties containing these compounds.
摘要翻译：式（I）的平均化合物，其中R <1>，R <2>是相同的或不同的，并且是氢原子，烷基，环烷基，羟烷基，链烯基，炔基或芳烷基，或R <1>，和 [R <2> zusammem是亚烷基，其与结合的氧原子和氧原子轴承磷原子形成形成饱和的5-至8-元环; [R <3>表示任选被取代的氨基，烷基，环烷基或任选取代的芳基; n是1和4之间的整数，装置以及水合物，溶剂合物和生理学上可接受的盐，它们的光学活性形式，与因子Xa抑制性质，含有这些化合物及其制备方法和药物。

5. 发明申请

WO1998018327A1 BLEND OF APPROPRIATE PRESERVATIVE AGENTS FOR ANALYSIS INSTRUMENTS WITH ION-SELECTIVE ELECTRODES 审中-公开
标题翻译：适用于选择性电极离子分析KONSERVIERUNGSMITTELMIX DEVICES
公开(公告)号：WO1998018327A1
公开(公告)日：1998-05-07
申请号：PCT/EP1997006011
申请日：1997-10-30
申请人： BOEHRINGER MANNHEIM GMBH , PRINZING, Urban , SCHMIDT, Axel
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A01N43/76
CPC分类号： A01N43/90 , A01N37/18 , A01N43/76 , A01N2300/00
摘要： The inventive preservative agent for reagents intended for the diagnostic determination of electrolytes by means of ion-selective electrodes contains a compound which triggers the cleavage of formaldehyde, possibly combined with chloracetamide. The present invention also relates to this blend of preservative agents as well as to the preserved reagents.
摘要翻译：根据本发明的防腐剂用于电解质的含有释放甲醛的化合物，任选地与氯乙酰胺的离子选择性电极的装置的确定诊断试剂。此外，本发明的目的是使用防腐剂混合物和保守的试剂。

6. 发明申请

WO1998016637A1 FANCONI GENE 1 审中-公开
标题翻译：范可尼-GEN我
公开(公告)号：WO1998016637A1
公开(公告)日：1998-04-23
申请号：PCT/EP1997005543
申请日：1997-10-08
申请人： BOEHRINGER MANNHEIM GMBH , KUBBIES, Manfred , MACHL, Andreas , PLANITZER, Simone
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K16/18 , C12N9/16
摘要： The present invention relates to a pathophysiologically relevant gene associated with Fanconi Anaemia (FA), a polypeptide coded thereby, an antibody directed against the polypeptide, as well as the pharmaceutical use of the nucleic acid, polypeptide and antibody.
摘要翻译：本发明涉及一种病理生理学相关的范可尼贫血（FA）-assoziiertes基因，其编码的多肽，针对多肽的抗体和药物用途的多肽和抗体的核酸的抗体。

7. 发明申请

WO1998012350A1 IMPROVED METHOD FOR DETERMINING LIPASE 审中-公开
标题翻译：改进法测定脂肪酶
公开(公告)号：WO1998012350A1
公开(公告)日：1998-03-26
申请号：PCT/EP1997005051
申请日：1997-09-16
申请人： BOEHRINGER MANNHEIM GMBH , SCHELLONG, Lieselotte , ZIELENSKI, Ralf , PRINZING, Urban
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12Q01/44
CPC分类号： C12Q1/44 , Y10S435/968
摘要： The invention concerns a method and a reagent for determining lipase in the presence of a colored substrate and at least one N-substituting carboxamide derivative or a mixture of the general formula (I) or (Ia), in which R and R independently represent hydrogen or a saturated or non-saturated, substituting or non-substituting hydrocarbon residue with 2 to 24 carbon atoms, Z a saturated or non-saturated, substituting, cyclic or linear-chain hydrocarbon residue with 1 to 10 carbon atoms, X an atom or atom group with positive charge and n a figure ranging from 1 to 3. Specially tetranatrium-N-(1,2-dicarboxylethyl)-N-alkyl-sulfo-succinamide or a mixture containing such compound has proven to be quite advantageous in eliminating unspecified reactions during the determination of lipase in a biological test sample.
摘要翻译：本发明涉及一种用于脂肪酶在彩色底物的存在的确定和至少一种N-取代的羧酸酰胺衍生物或通式（I）或（Ia）的化合物，其中R <1>和R <2>的方法和试剂彼此独立地为氢或饱和或不饱和的，取代或未取代的烃基，其具有碳原子数2〜24，Z为碳原子数1〜10的饱和或不饱和的，取代的，环状或直链烃残基，X表示的原子或具有正电荷的原子团和 n表示1〜3 用于消除的生物样品中脂肪酶的非特异性测定反应，特别的，四钠N-（1,2-二dicarboxylethyl）-N-烷基sulfosuccinamid或含有这种化合物的混合物已被发现是有利的。

8. 发明申请

WO1998010065A1 BREAST CARCINOMA-ASSOCIATED GENE 审中-公开
标题翻译：乳腺癌相关基因
公开(公告)号：WO1998010065A1
公开(公告)日：1998-03-12
申请号：PCT/EP1997004785
申请日：1997-09-02
申请人： BOEHRINGER MANNHEIM GMBH , WEIDLE, Ulrich , SCHIEMANN, Sabine
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N15/12
CPC分类号： C07K14/4748 , A61K38/00
摘要： A pharmaceutical composition is disclosed, as well as its use in tumour diagnosis, therapy and prevention, methods for diagnosing, treating and preventing tumours, and antibodies and their use.
摘要翻译：本发明涉及一种药物组合物，其用途为肿瘤的诊断，治疗和预防，用于肿瘤的诊断，治疗和预防的方法，以及抗体和它们的用途。

9. 发明申请

WO1998006386A2 DERIVATES FROM BISARYLTETRACARBONACID, AND PHARMARCEUTICAL PRODUCT CONTAINING THEM 审中-公开
标题翻译： BISARYLTETRACARBONSÄUREDERIVATE和含有药物
公开(公告)号：WO1998006386A2
公开(公告)日：1998-02-19
申请号：PCT/EP1997004348
申请日：1997-08-09
申请人： BOEHRINGER MANNHEIM GMBH , DICKHAUT, Joachim
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , C07C233/81 , C07C311/64 , C40B40/00
摘要： The invention pertains to combinatorial libraries of general formula (I), to be found in form of mixtures, use thereof for tests intended to reveal biologically active compounds, individual compounds of general formula (I), preparation processes thereof and pharmaceutical products containing them. In formula (I), X, R1, R2, R3 and R4 have the meaning given in the description.
摘要翻译：本发明的目的是通式（I），其是存在的混合物，使用在测定这些混合物的发现生物活性化合物，所述通式的个人（I）化合物，其中X，R1，R2，R3，和的组合文库 R4在说明书所指出的，它们的制备方法和含有这些化合物的药物组合物。

10. 发明申请

WO1997045534A1 CELL CULTIVATION PROCESS 审中-公开
标题翻译：方法为培养细胞
公开(公告)号：WO1997045534A1
公开(公告)日：1997-12-04
申请号：PCT/EP1997002475
申请日：1997-05-15
申请人： BOEHRINGER MANNHEIM GMBH , GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH , KUBBIES, Manfred , DÖRMER, Peter , MEISSNER, Petra
发明人： BOEHRINGER MANNHEIM GMBH , GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH
IPC分类号： C12N05/08
CPC分类号： C12N5/0647 , C12N2502/1394
摘要： A process for cultivating a first mammary cell which makes contact for cultivation with cell surface proteins of a second mammary cell, in which said mammary cell is cultivated in the presence of an immobilised vesicle of the second mammary cell forming part of the natural surface of the second mammary cell, is of advantage for the multiplication of mammary cells.
摘要翻译：一种用于在第一哺乳动物细胞的培养方法，这使得接触与第二哺乳动物细胞培养的细胞表面蛋白，其特征在于，所述第一哺乳动物细胞包含在第二哺乳动物细胞，其第二哺乳动物细胞的自然表面的部分是培养的固定化囊泡的存在，是有利的哺乳动物细胞的繁殖。

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