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1. 发明申请

WO1996037190A1 STABLE, CONCENTRATED, LOCALLY-TOLERATED ERYTHROMYCYLAMINE SOLUTIONS 审中-公开
标题翻译：稳定，集中，局部兼容红霉素SOLUTIONS
公开(公告)号：WO1996037190A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002117
申请日：1996-05-17
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , LEINER, Stefan , SCHLEICHER, Werner , HASSEL, Bernhard
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： A61K09/08
CPC分类号： A61K31/7048 , Y02A50/473 , Y02A50/481
摘要： The invention concerns a stable, buffered, concentrated, locally-tolerated erythromycylamine solution.
摘要翻译：本发明涉及一种稳定的，缓冲的，重点突出，局部可接受的红霉素胺溶液。

2. 发明申请

WO1993024215A1 PROCESS AND DEVICE FOR PRODUCING GRANULATES FROM POWDERY MATERIAL 审中-公开
标题翻译：方法和一种用于产生粉末材料的颗粒
公开(公告)号：WO1993024215A1
公开(公告)日：1993-12-09
申请号：PCT/EP1993001328
申请日：1993-05-27
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , SCHLEICHER, Werner , LEINER, Stefan , BEDNAREK, Detlef , HASSEL, Bernhard , SPÄTH, Philipp
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： B01J02/00
CPC分类号： B01J2/16 , A23K40/10 , B01J2/006
摘要： A process is disclosed for constructively granulating a powdery material in a fluidized bed equipment. The granulating liquid containing a binder is sprayed downwards on the fluidized bed of material to be granulated in countercurrent to the fluidized bed-generating gas by means of two-component fan jet nozzles. With charge quantities on the order of about 1000 kg, very uniform and dust-free granulates can thus be obtained.

3. 发明申请

WO1995026191A1 INJECTABLE SOLUTIONS OF DIRITHROMYCIN 审中-公开
标题翻译：注射液红霉素
公开(公告)号：WO1995026191A1
公开(公告)日：1995-10-05
申请号：PCT/EP1995001096
申请日：1995-03-23
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , LEINER, Stefan , HASSEL, Bernhard
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： A61K31/71
CPC分类号： A61K31/70 , A61K9/0019 , A61K47/10 , A61K47/14
摘要： The invention concerns stable injectable solutions of dirithromycin.
摘要翻译：本发明涉及地红霉素的稳定可注射溶液。

4. 发明申请

WO1997007232A1 ANTIGENIC PREPARATIONS 审中-公开
标题翻译：抗原制剂
公开(公告)号：WO1997007232A1
公开(公告)日：1997-02-27
申请号：PCT/EP1996003535
申请日：1996-08-09
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , FARNOW, Dieter , KARLE, Joachim , POLIAKOV, Igor, D. , IVANOVA, Ludmilla, G.
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： C12P21/00
CPC分类号： C12R1/725 , A61K39/00 , A61K39/0002 , C07K2/00 , C08B37/00 , C12P19/04 , C12P21/005 , Y10S435/911 , Y10S435/922
摘要： The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, processes for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccines, including but not limited to, the prophylaxis and treatment of allergy, as well as for modulating the immune response.
摘要翻译：本发明涉及包含可从角质嗜性真菌以及酵母制备的多糖和/或糖肽的抗原制剂，制备这些抗原制剂的方法，它们作为药物的用途以及它们作为疫苗的用途，包括但不限于，过敏的预防和治疗，以及调节免疫反应。

5. 发明申请

WO1998015284A2 MYCOSIS VACCINES 审中-公开
标题翻译： MYCOSIS疫苗
公开(公告)号：WO1998015284A2
公开(公告)日：1998-04-16
申请号：PCT/EP1997005181
申请日：1997-09-22
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM VETMEDICA GMBH , POLIAKOV, Igor Dimitrievich , IVANOVA, Ludmilla
发明人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： A61K39/00
CPC分类号： C12R1/645 , A61K39/0002 , C12R1/725
摘要： The present invention pertains to vaccines comprising homogenised inactivated yeast blastospores and homogenised inactivated dermatophyte microconidia or antigenic material of said pores, methods for their production and their use for the prophylaxis and/or treatment of mycoses in mammals, preferably humans. The vaccines according to the present invention are especially useful for the prophylaxis and/or treatement of skin mycosis, preferably Dermatomycosis and/or Candidosis and/or Onychomycosis.
摘要翻译：本发明涉及包含均质灭活的酵母胚泡和均质灭活的皮肤癣菌微生物或所述孔的抗原物质的疫苗，其生产方法及其用于预防和/或治疗哺乳动物，优选人类中的霉菌病的疫苗。根据本发明的疫苗特别可用于预防和/或治疗皮肤真菌病，优选皮肤真菌病和/或念珠菌病和/或甲真菌病。

6. 发明申请

WO1996003514A1 PICORNAVIRUS L PROTEINASE AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： PICORNAVIRUS L蛋白酶及其制备和使用方法
公开(公告)号：WO1996003514A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002742
申请日：1995-07-13
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH , SKERN, Timothy , KIRCHWEGER, Regina , ZIEGLER, Elisabeth , BLAAS, Dieter , LIEBIG, Hans-Dieter , LAMPHEAR, Barry , WATERS, Debora , RHOADS, Robert , SOMMERGRUBER, Wolfgang , AHORN, Horst
IPC分类号： C12N15/57
CPC分类号： C12N9/506 , C07K14/4705
摘要： Methods of making and using Picornavirus (foot-and-mouth disease virus) L proteinase peptides (PLPPs) are provided, including, but not limited to, expression of DNA encoding all or a portion thereof, such as a Picornavirus L proteinase (PLP) and variants thereof, as well as methods for determining active sites and inhibitors of a PLP.
摘要翻译：提供制备和使用微小RNA病毒（口蹄疫病毒）L蛋白酶肽（PLPP）的方法，包括但不限于编码其全部或部分的DNA，例如微小RNA病毒L蛋白酶（PLP）及其变体，以及用于确定PLP的活性位点和抑制剂的方法。

7. 发明申请

WO1993007894A1 DERMATOMYCOSIS VACCINE 审中-公开
标题翻译：真菌病疫苗
公开(公告)号：WO1993007894A1
公开(公告)日：1993-04-29
申请号：PCT/EP1992002391
申请日：1992-10-17
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , POLYAKOV, Igor, Dimitriesich , IVANOVA, Ludmilla
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： A61K39/00
CPC分类号： C12R1/645 , A61K39/0002 , A61K2039/545 , A61K2039/552
摘要： The invention concerns the production of vaccines and their use in the preparation of agents specifically for the prevention and treatment of dermatomycosis infections.
摘要翻译：本发明涉及疫苗的生产及其在制备专门用于预防和治疗皮肤真菌感染的药剂中的用途。

8. 发明申请

WO1990006299A1 NEW PHENYLETHANOLAMINES 审中-公开
标题翻译：新型苯乙烯胺
公开(公告)号：WO1990006299A1
公开(公告)日：1990-06-14
申请号：PCT/EP1988001083
申请日：1988-11-29
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , HURNAUS, Rudolf , REIFFEN, Manfred , SAUTER, Robert , GRELL, Wolfgang , RUPPRECHT, Eckhard
发明人： BOEHRINGER INGELHEIM VETMEDICA GMBH
IPC分类号： C07C91/16
CPC分类号： C07C255/00 , C07C229/38
摘要： New phenylethanolamines of general formula (I), in which A is a straight-chain or branched alkylene group, B is a bond, an alkylene group, a carbonyl or hydroxymethylene group, R1 is a hydrogen atom, a halogen atom or a trifluormethyle group, R2 is a hydrogen atom or an amino group, R3 is a cyano group, a hydrogen, chlorine or bromine atom, R4 is a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group, substituted in an end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group, their optical isomers and their diastereomers and acid addition salts. The new compounds, their optical isomers, diastereomers and addition salts, in particular physiologically acceptable acid addition salts with inorganic and organic acids, possess useful pharmacological properties, namely an effect on the metabolism, preferably reduction of the blood sugar level and body fat. They can also be used to promote performance in animals. The new compounds can be produced by processes known per se.
摘要翻译： A为直链或支链亚烷基的通式（I）的新的苯乙醇胺，B为键，亚烷基，羰基或羟基亚甲基，R 1为氢原子，卤原子或三氟甲基，R2是氢原子或氨基，R3是氰基，氢，氯或溴原子，R4是氢或卤原子，烷基，羟基，烷氧基，羧基，烷氧基羰基，氨基羰基，烷基氨基羰基或二烷基氨基羰基羧基，烷氧基羰基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，羟基，烷氧基，氨基，烷基氨基，二烷基氨基，吡咯烷子基，哌啶子基或六亚甲基亚氨基，其光学异构体及其非对映异构体和酸加成盐。新化合物，它们的光学异构体，非对映异构体和加成盐，特别是与无机和有机酸形成的生理上可接受的酸加成盐，具有有用的药理学性质，即对代谢的影响，优选降低血糖水平和体脂肪。它们也可用于促进动物表现。新化合物可以通过本身已知的方法制备。

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