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1. 发明申请

WO2014025976A1 HETEROAROMATIC COMPOUNDS AS BRUTON'S TYROSINE KINASE (BTK) INHIBITORS 审中-公开
标题翻译：作为BRUTON的酪氨酸激酶（BTK）抑制剂的异种化合物
公开(公告)号：WO2014025976A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/054096
申请日：2013-08-08
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, XI and Y are defined herein, which are suitable for the treatment of a disease chosen from rheumatoid arthritis, systemic lupus erythromatosis, scleroderma, asthma, allergic rhinitis, allergic eczema, B cell lymphoma, multiple sclerosis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, graft versus host disease, psoriatic arthritis, ankylosing spondylitis and uveitis.
摘要翻译：本发明包括式（I）化合物，其中基团A，Cy，XI和Y在本文中定义，其适用于治疗选自类风湿性关节炎，系统性红斑狼疮，硬皮病，哮喘，过敏性鼻炎，过敏性湿疹，B细胞淋巴瘤，多发性硬化，青少年类风湿关节炎，幼年型特发性关节炎，炎性肠病，移植物抗宿主病，牛皮癣关节炎，强直性脊柱炎和葡萄膜炎。

2. 发明申请

WO2014152114A1 HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS 审中-公开
标题翻译：异构化合物作为BTK抑制剂
公开(公告)号：WO2014152114A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026966
申请日：2014-03-14
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOSANAC, Todd , DISALVO, Darren , HORAN, Joshua Courtney , LIANG, Shuang , ZINDELL, Renee M.
发明人： BOSANAC, Todd , DISALVO, Darren , HORAN, Joshua Courtney , LIANG, Shuang , ZINDELL, Renee M.
IPC分类号： C07D487/04 , A61K31/519 , A61P19/02 , A61P11/06
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of the formula (I), wherein the groups X and Cy are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
摘要翻译：本发明包括式（I）化合物，其中本文定义的基团X和Cy，其适用于治疗与BTK相关的疾病，制备方法，含有化合物的药物制剂及其使用方法。

3. 发明申请

WO2010056585A2 HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS 审中-公开
标题翻译：用作MMP-13抑制剂的杂芳基二酰胺化合物
公开(公告)号：WO2010056585A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/063343
申请日：2009-11-05
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , FARROW, Neil Alexander , GAO, Donghong A. , HEIM-RIETHER, Alexander , KEENAN, Lana Louise Smith , LIANG, Shuang , TAYLOR, Steven John , WELLENZOHN, Bernd , WIEDENMAYER, Dieter , XIONG, Zhaoming , ZHANG, Qiang , SCHLYER, Sabine
发明人： FARROW, Neil Alexander , GAO, Donghong A. , HEIM-RIETHER, Alexander , KEENAN, Lana Louise Smith , LIANG, Shuang , TAYLOR, Steven John , WELLENZOHN, Bernd , WIEDENMAYER, Dieter , XIONG, Zhaoming , ZHANG, Qiang , SCHLYER, Sabine
IPC分类号： C07D231/14 , C07D263/16 , C07D277/56 , C07D307/68 , C07D401/04 , C07D407/10
CPC分类号： C07D407/10 , C07D231/14 , C07D263/16 , C07D277/56 , C07D307/68 , C07D401/04 , C07D407/14 , C07D411/12 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
摘要翻译：公开了如本文所述的式（I）化合物和组合物，其是MMP-13的抑制剂。还公开了使用和制备式（I）化合物的方法。

4. 发明申请

WO2010045190A1 FUSED HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS 审中-公开
标题翻译：用作MMP-13抑制剂的FUSED HETEROARYL DIAMIDE化合物
公开(公告)号：WO2010045190A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060439
申请日：2009-10-13
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , HEIM-RIETHER, Alexander , LIANG, Shuang , SCHLYER, Sabine
发明人： HEIM-RIETHER, Alexander , LIANG, Shuang , SCHLYER, Sabine
IPC分类号： C07D405/04 , C07D405/14 , C07D471/04 , A61K31/404 , A61K31/4184 , A61K31/5355 , A61K31/541 , A61P9/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P35/04
CPC分类号： C07D405/04 , C07D405/14 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
摘要翻译：公开了本文所述的式I化合物和组合物，其是MMP-13的抑制剂。还公开了使用和制备式I化合物的方法。

5. 发明申请

WO2015160654A1 COMPOUNDS AS MODULATORS OF ROR GAMMA 审中-公开
标题翻译：化合物作为ROR GAMMA的调节剂
公开(公告)号：WO2015160654A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/025328
申请日：2015-04-10
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BAKONYI, Johanna , BRUNETTE, Steven Richard , COLLIN, Delphine , HUGHES, Robert Owen , LI, Xiang , LIANG, Shuang , SIBLEY, Robert , TURNER, Michael Robert , WU, Lifen , ZHANG, Qiang
发明人： BAKONYI, Johanna , BRUNETTE, Steven Richard , COLLIN, Delphine , HUGHES, Robert Owen , LI, Xiang , LIANG, Shuang , SIBLEY, Robert , TURNER, Michael Robert , WU, Lifen , ZHANG, Qiang
IPC分类号： C07D475/10 , A61K31/33
CPC分类号： C07D475/00 , A61K31/33 , C07D475/10 , C07D487/04
摘要： The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
摘要翻译：本发明包括式（I）的化合物，其中本文所定义的变量适用于RORγ的调节和治疗与RORγ调节有关的疾病。本发明还包括制备式（I）化合物和含有它们的药物制剂的方法。

6. 发明申请

WO2015035032A1 BICYLIC COMPOUNDS AS MODULATORS OF RORGAMMA 审中-公开
标题翻译：作为RORGAMMA的调节剂的双酚化合物
公开(公告)号：WO2015035032A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054070
申请日：2014-09-04
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , COOK, Brian Nicholas , HUBER, John D. , HUGHES, Robert Owen , KIRRANE, Thomas Martin, Jr. , LASOTA, Celina , LI, Xiang , LIANG, Shuang , MUGGE, Ingo Andreas , ZHANG, Qiang
发明人： COOK, Brian Nicholas , HUBER, John D. , HUGHES, Robert Owen , KIRRANE, Thomas Martin, Jr. , LASOTA, Celina , LI, Xiang , LIANG, Shuang , MUGGE, Ingo Andreas , ZHANG, Qiang
IPC分类号： C07D209/96 , C07D209/10 , C07D417/10 , C07D413/10 , C07D403/04 , C07D401/10 , C07D401/02 , C07D401/04 , A61K31/403 , A61K31/404 , A61K31/416 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/506
CPC分类号： C07D209/96 , C07D209/08 , C07D209/10 , C07D401/02 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D413/10 , C07D417/10
摘要： The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
摘要翻译：本发明包括式（I）的化合物：其中本文定义的变量适用于调节RORC和治疗与RORC调节有关的疾病。本发明还包括制备式（I）化合物和含有它们的药物制剂的方法。

7. 发明申请

WO2015017335A1 AZAINDOLE COMPOUNDS AS MODULATORS OF RORC 审中-公开
标题翻译：作为RORC的调节剂的AZAINDOLE化合物
公开(公告)号：WO2015017335A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048444
申请日：2014-07-28
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , COOK, Brian, Nicholas , HUBER, John, D. , HUGHES, Robert, Owen , LI, Xiang , LIANG, Shuang , MUGGE, Ingo, Andreas , TURNER, Michael, Robert , ZHANG, Qiang
发明人： COOK, Brian, Nicholas , HUBER, John, D. , HUGHES, Robert, Owen , LI, Xiang , LIANG, Shuang , MUGGE, Ingo, Andreas , TURNER, Michael, Robert , ZHANG, Qiang
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
摘要翻译：本发明包括式（I）的化合物，其中本文所定义的变量适用于调节RORC和治疗与RORC调节相关的疾病。本发明还包括制备式（I）化合物和含有它们的药物制剂的方法。

8. 发明申请

WO2013012844A1 ARYLPYRAZOLE ETHERS AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开
标题翻译： ARYLPYRAZOLE ETHERS作为紫苏酮A4水解酶的抑制剂
公开(公告)号：WO2013012844A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047024
申请日：2012-07-17
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , HEIM-RIETHER, Alexander , LIANG, Shuang , PADYANA, Anil Kumar , TAYLOR, Steven John , ZHANG, Qiang
发明人： HEIM-RIETHER, Alexander , LIANG, Shuang , PADYANA, Anil Kumar , TAYLOR, Steven John , ZHANG, Qiang
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D513/04 , C07D231/12 , A61K31/415 , A61K31/4155 , A61P9/00
CPC分类号： C07D403/12 , C07D231/12 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein A 1 , A 2 , A 3 , L 1 , L 2 and D are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A 4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中A1，A2，A3，L1，L2和D如本文所定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

9. 发明申请

WO2012100750A1 BUSINESS MASHUP 审中-公开
标题翻译：商务服务
公开(公告)号：WO2012100750A1
公开(公告)日：2012-08-02
申请号：PCT/CN2012/070747
申请日：2012-01-30
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , ZHOU, Yuchen , WANG, Xining , LIU, Xinpeng , XUE, Liang , LIANG, Xiaoxing , LIANG, Shuang , SUN, Changhua
发明人： ZHOU, Yuchen , WANG, Xining , LIU, Xinpeng , XUE, Liang , LIANG, Xiaoxing , LIANG, Shuang , SUN, Changhua
IPC分类号： G06F9/44
CPC分类号： G06F8/38 , G06Q10/067
摘要： A business mashup method is provided, which comprises: generating a business application logic corresponding to a desired business according to requirements of the business, wherein the business application logic includes Web services and Widgets; mashing up the Widgets in the business application logic to create a Widget mashup application; establishing an adaptation relationship between the Web services and the Widgets in the Widget mashup application; generating a business process for the business based on the business application logic and the adaptation relationship; and generating a mashup Widget application based on the Widget mashup application and the adaptation relationship. The business mashup method of the invention provides an Off-Premise business process development platform to enable non-professional users to develop the desired business process without coding. The method of the invention enables the business process to support the mashup Widget application, and establishes a bi-directional linkage between the business process and the Widgets. A corresponding business mashup system is also provided.
摘要翻译：提供了一种商业混搭方法，其包括：根据业务的要求生成与期望业务相对应的业务应用逻辑，其中业务应用逻辑包括Web服务和小部件; 将业务应用程序逻辑中的小部件混合以创建一个Widget mashup应用程序; 在Web服务和Widget Mashup应用程序中的Widget之间建立适应关系; 根据业务应用逻辑和适应关系为业务生成业务流程; 并根据Widget mashup应用程序和适应关系生成一个Mashup Widget应用程序。本发明的商业混搭方法提供了一种非外部业务流程开发平台，以使非专业用户能够开发不需要编码的所需业务流程。本发明的方法使得业务流程能够支持混搭小组件应用，并且在业务流程和小部件之间建立双向链接。还提供了相应的业务混搭系统。

10. 发明申请

WO2010090873A2 POLYPEPTIDES AND THEIR USE AS ADJUVANTS 审中-公开
标题翻译：多肽及其作为佐剂使用
公开(公告)号：WO2010090873A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/021650
申请日：2010-01-21
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE , HAJISHENGALLIS, Georgios , CONNELL, Terry, D. , LIANG, Shuang
发明人： HAJISHENGALLIS, Georgios , CONNELL, Terry, D. , LIANG, Shuang
IPC分类号： C07K14/195 , C12N15/31 , C07K19/00 , A61K39/02 , A61P37/02
CPC分类号： C07K14/245 , A61K39/00 , A61K39/092 , A61K2039/55544 , Y02A50/487
摘要： This document provides methods and materials relating to a B subunit polypeptide from a Type II heat-labile enterotoxin that contain at least one amino acid modifications. Methods and materials for stimulating the immune system of a mammal are also provided.
摘要翻译：本文提供了与来自含有至少一个氨基酸修饰的II型热不稳定肠毒素的B亚基多肽有关的方法和材料。还提供了刺激哺乳动物免疫系统的方法和材料。

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