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2. 发明申请

WO2005047858A3 ON-LINE APPARATUS AND METHOD FOR DETERMINING ENDOTOXIN LEVELS 审中-公开
标题翻译：用于确定内毒素水平的在线装置和方法
公开(公告)号：WO2005047858A3
公开(公告)日：2005-07-21
申请号：PCT/US2004037097
申请日：2004-11-08
申请人： CAMBREX BIO SCIENCE WALKERSVIL , BONEN MATTHEW RICHARD , BERZOFSKY RONALD NORMAN , RICHARDSON BRUCE J , LATHROP ROBERT L III , DEN DULK BRUCE RODNEY
发明人： BONEN MATTHEW RICHARD , BERZOFSKY RONALD NORMAN , RICHARDSON BRUCE J , LATHROP ROBERT L III , DEN DULK BRUCE RODNEY
IPC分类号： C12M1/34 , G01N20060101 , G01N1/18 , G01N31/00 , G01N33/53 , G01N33/554 , G01N33/569 , G01N35/10
CPC分类号： G01N1/18 , G01N33/5302 , G01N35/1097 , G01N2035/103
摘要： An apparatus and method for on-line testing for the presence of an endotoxin within a fluid sample from a fluid line. The apparatus is positioned in fluid communication with a fluid line to perform the on-line fluid testing for the presence of at least one endotoxin. The apparatus can include a housing and a fluid sampling system positioned in fluid communication with the fluid line. The fluid sampling system can comprise a valve for controlling the fluid flow from the fluid line into the fluid sampling system. A fluid flow well is positioned within the housing and in fluid communication with the fluid sampling system. A removable assembly can also be secured within the housing. The removable assembly comprises a plurality of wells for receiving used and unused fluid carrying members that can receive samples from the fluid flow well, a plurality of fluid sample receiving wells, and a plurality of vessel retention positions comprising recesses for securely receiving portions of respective fluid vessels. A detecting system is provided for testing a control sample and a sample of the fluid from the fluid line. The results of these tests are compared in order to determine if the fluid sample is carrying any endotoxins. In an embodiment, fluorescence testing of the sample is compared to that of the control in order to determine if the sample includes an endotoxin.
摘要翻译：一种用于在线测试来自流体管线的流体样本内存在内毒素的装置和方法。该设备被定位成与流体管线流体连通以对至少一种内毒素的存在进行在线流体测试。该装置可以包括壳体和定位成与流体管线流体连通的流体采样系统。流体采样系统可以包括用于控制流体从流体管线流入流体采样系统的阀。流体流动井位于壳体内并与流体采样系统流体连通。可拆卸组件也可以固定在外壳内。可移除组件包括用于接收可以从流体流动井中接收样本的已使用和未使用的流体承载构件的多个井，多个流体样本接收井和多个容器保持位置，所述多个容器保持位置包括用于将各个流体船只。提供检测系统用于测试来自流体管线的对照样品和流体样品。比较这些测试的结果以确定流体样本是否携带任何内毒素。在一个实施方案中，将样品的荧光测试与对照的测试进行比较以确定样品是否包含内毒素。

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