专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019010381A1 A METHOD TO MEASURE TISSUE TEXTURE USING NMR SPECTROSCOPY TO IDENTIFY CHEMICAL SPECIES OF COMPONENT TEXTURAL ELEMENTS IN A TARGETED REGION OF TISSUE 审中-公开
公开(公告)号：WO2019010381A1
公开(公告)日：2019-01-10
申请号：PCT/US2018/041035
申请日：2018-07-06
申请人： BIOPROTONICS, LLC
发明人： PARKER, Ian , CHASE, David, R. , JAMES, Timothy, W. , JAMES, Kristin
IPC分类号： A61B5/00 , G01R33/48 , G01R33/54
摘要： A method for identifying the chemical species of various textural elements in a targeted region of tissue wherein a volume of interest (VOI) is selectively excited and a k-encode gradient pulse is applied to induce phase wrap to create a spatial encode for a specific k-value and orientation. The specific k-value is selected based on anticipated texture within the VOI. Multiple sequential samples of the NMR RF signal encoded with the specific k-value are recorded as signal data. The Fourier Transform of the acquired signal data is then taken, wherein for each k-encode, the signal recorded is indicative of the spatial frequency power density at that point in k-space. Each peak in the NMR spectrum is then evaluated, whereby the relative contribution to the texture of tissue in the VOI at a k-value for each chemical species is determined.

2. 发明申请

WO2017062882A1 SELECTIVE SAMPLING FOR ASSESSING STRUCTURAL SPATIAL FREQUENCIES WITH SPECIFIC CONTRAST MECHANISMS 审中-公开
标题翻译：用特定对比机制评估结构性空间频率的选择性采样
公开(公告)号：WO2017062882A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/056147
申请日：2016-10-07
申请人： BIOPROTONICS LLC
发明人： CHASE, David, R. , JAMES, Timothy, W. , JAMES, Kristin, E.
IPC分类号： A61B5/055 , G01R33/48 , G01R33/385 , G01R33/54
CPC分类号： A61B5/055 , A61B5/0033 , A61B5/4842 , G01R33/4833 , G01R33/561 , G01R33/56509
摘要： The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k- values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in- vivo resolution than is obtainable with current MRI techniques.
摘要翻译：所公开的实施例提供了一种用于以分辨率低至几十微米获取MR数据的方法，用于体内诊断和监测病理学，其中精细组织纹理的变化可用作疾病发作和进展的标志。骨病，肿瘤，神经系统疾病和涉及纤维化生长和/或破坏的疾病都是目标病态。此外，该技术可以用于需要非常高分辨率表征精细尺度形态的任何生物或物理系统中。该方法提供在k空间中快速获取所选择的值，并且以定义的组织体积内的微秒数量级的时间尺度上采集的各个k值的多次连续采集，以及以这种方式的多个测量的后续组合以使SNR最大化。缩小的采集量以及沿所选方向仅在k空间中的选择值的获取使得比目前的MRI技术可获得更高的体内分辨率。

3. 发明申请

WO2016036643A1 SELECTIVE SAMPLING MAGNETIC RESONANCE-BASED METHOD FOR ASSESSING STRUCTURAL SPATIAL FREQUENCIES 审中-公开
标题翻译：用于评估结构空间频率的选择性采样磁共振方法
公开(公告)号：WO2016036643A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/047676
申请日：2015-08-31
申请人： BIOPROTONICS LLC
发明人： CHASE, David, R. , JAMES, Timothy, W. , JAMES, Kristin, E.
IPC分类号： G01R33/56
CPC分类号： G01R33/4818 , A61B5/055 , A61B5/7207 , G01R33/385 , G01R33/4833 , G01R33/54 , G01R33/5616 , G01R33/5617
摘要： The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions.
摘要翻译：所公开的实施例提供了一种用于以分辨率低至几十微米获取MR数据的方法，用于体内诊断和监测病理学，其中精细组织纹理的变化可用作疾病发作和进展的标志。骨病，肿瘤，神经系统疾病和涉及纤维化生长和/或破坏的疾病都是目标病态。此外，该技术可以用于需要非常高分辨率表征精细尺度形态的任何生物或物理系统中。该方法提供在k空间中快速获取所选择的值，并且以定义的组织体积内的微秒数量级的多个连续采集在时间尺度上采集多个k值，以及以这种方式的多个测量的后续组合以使SNR最大化。缩小采集量，并在所选方向上仅在k空间中获取选择值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式