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1. 发明申请

WO2003011386A1 FLOW CYTOMETER 审中-公开
标题翻译：流量计
公开(公告)号：WO2003011386A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023892
申请日：2002-07-29
申请人： BIOMED SOLUTIONS, LLC , CONNELLY, Patrick, R. , MACDONALD, Stuart, G. , GRAY, Robert, W. , GEBERT, Carol
发明人： CONNELLY, Patrick, R. , MACDONALD, Stuart, G. , GRAY, Robert, W. , GEBERT, Carol
IPC分类号： A61M37/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/076 , A61B5/145 , A61B5/150015 , A61B5/150221 , A61B5/150229 , A61B5/417 , A61F2/82 , A61M1/3621 , A61M1/3679 , A61M1/3687 , A61M1/38 , G01N15/10 , G01N2015/1006 , G01N2015/149
摘要： A flow cytometer (44) containing a device for sampling cellular material within a body, comprising a detector (86), controller (88), light source (84) and injector (96). The flow cytometer (44) is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, and to maintain the sorted cells in a viable state.
摘要翻译：一种流式细胞仪（44），其包含用于在体内采样细胞材料的装置，包括检测器（86），控制器（88），光源（84）和注射器（96）。流式细胞仪（44）适于用标记物标记体液中的细胞以产生标记的细胞，分析标记的细胞，对体液内的细胞进行分类以产生分选的细胞，并将分选的细胞维持在可行的州。

2. 发明申请

WO2003011385A1 FLOW CYTOMETER SHUNT 审中-公开
标题翻译：流量计流量计
公开(公告)号：WO2003011385A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023780
申请日：2002-07-29
申请人： BIOMED SOLUTIONS, LLC , CONNELLY, Patrick, R. , MACDONALD, Stuart, G. , GRAY, Robert, W. , GEBERT, Carol
发明人： CONNELLY, Patrick, R. , MACDONALD, Stuart, G. , GRAY, Robert, W. , GEBERT, Carol
IPC分类号： A61M37/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/076 , A61B5/145 , A61B5/15003 , A61B5/155 , A61F2/82 , A61M1/3621 , A61M1/3679 , A61M1/3687 , A61M1/38 , G01N15/1456 , G01N2015/1006 , G01N2015/149
摘要： A flow cytometer (300) containing a device for sampling cellular material (306) within a body. The flow cytometer is adapted to mark cells within bodily fluid (306) with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, to maintain the sorted cells in a viable state, and to remove the marker from the marked cells. Two marker removal devices (320, 324) are used in the flow cytometer.
摘要翻译：流式细胞仪（300），其包含用于在体内采样细胞材料（306）的装置。流式细胞仪适于用标记物标记体液（306）中的细胞以产生标记的细胞，分析标记的细胞，对体液内的细胞进行分类以产生分选的细胞，以将分选的细胞维持在可行状态并从标记的细胞中去除标记物。在流式细胞仪中使用两个标记物去除装置（320,324）。

3. 发明申请

WO2003031561A1 HYBRID NUCLEIC ACID ASSEMBLY 审中-公开
标题翻译：混合核酸组件
公开(公告)号：WO2003031561A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/032231
申请日：2002-10-09
申请人： BIOMED SOLUTIONS, LLC , WEINER, Michael, L. , CONNELLY, Patrick, R. , GEBERT, Carol , GRAY, Robert, W.
发明人： WEINER, Michael, L. , CONNELLY, Patrick, R. , GEBERT, Carol , GRAY, Robert, W.
IPC分类号： C12M1/34
CPC分类号： C12Q1/68 , C12Q1/6816 , C12Q1/6818 , C12Q2565/101 , C12Q2563/155 , C12Q2563/113
摘要： A detection device containing a hybrid nucleic acid assembly. The device contains a nucleic acid polymer, a first complementary oligonucleotide annealed to a first consensus sequence on the nucleic acid polymer, a second complementary oligonucleotide annealed to a second consensus sequence on the nucleic acid polymer, a first nanoparticle conjugated with the first complementary oligonucleotide, a second nanoparticle conjugated with the second complementary oligonucleotide, means for introducing energy into the first nanoparticle, means for withdrawing energy from the second nanoparticle, means for detecting the withdrawal of energy from the second nanoparticle, and means for determining a physical property of the nucleic acid polymer while energy is introduced into the first nanoparticle.
摘要翻译：一种含有杂交核酸组件的检测装置。该装置含有核酸聚合物，退火于核酸聚合物上的第一共有序列的第一互补寡核苷酸，退火至核酸聚合物上的第二共有序列的第二互补寡核苷酸，与第一互补寡核苷酸缀合的第一纳米颗粒，与第二互补寡核苷酸缀合的第二纳米颗粒，用于将能量引入第一纳米颗粒的装置，用于从第二纳米颗粒中提取能量的装置，用于检测来自第二纳米颗粒的能量抽出的装置，以及用于确定核酸的物理性质的装置酸性聚合物，同时将能量引入第一纳米颗粒。

4. 发明申请

WO2007089762A2 DEVICES FOR SELECTIVE RECRUITMENT, ISOLATION, ACTIVATION, AND/OR ELIMINATION OF VARIOUS CELL POPULATIONS 审中-公开
标题翻译：选择性招募，分离，激活和/或消除各种细胞群体的设备
公开(公告)号：WO2007089762A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002505
申请日：2007-01-31
申请人： BIOMED SOLUTIONS, LLC , GOSS, Kendrick , GEBERT, Carol
发明人： GOSS, Kendrick , GEBERT, Carol
IPC分类号： A61K48/00
CPC分类号： A61L27/38
摘要： Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells. The implantable devices can be utilized for selectively removing a particular subset of cells from bodily fluids of a patient. Various non-selective pharmaceutical agents and biological agents can be incorporated into the implantable devices so that cells of interest can be isolated for elimination or for activation/differentiation. Cell-type selectivity is conferred by the presence of cell-type-specific targeting molecules incorporated into the implantable device, preferably at the surface level to permit direct or indirect interaction between the cells of interest and targeting molecules of the implantable device. Related therapeutic methods for utilizing the implantable devices are also provided. These implantable devices can be manufactured as a stent, a catheter, a holding chamber, or any other device, and can be manufactured into any shape, including a conduit, a vessel, and a tubing.
摘要翻译：可植入装置包含至少一种或多种靶向分子，其形成用于选择性募集，分离，活化和/或消除任何目标细胞如T细胞，单核细胞和干细胞的初级包被层。可植入装置可用于从患者的体液中选择性地去除细胞的特定子集。可以将各种非选择性药剂和生物制剂掺入到可植入装置中，使得可以分离感兴趣的细胞用于消除或激活/分化。细胞型选择性由掺入到可植入装置中的细胞型特异性靶向分子的存在赋予，优选在表面水平，以允许感兴趣的细胞和可植入装置的靶向分子之间的直接或间接相互作用。还提供了用于利用可植入装置的相关治疗方法。这些可植入装置可以被制造成支架，导管，保持室或任何其它装置，并且可以制造成任何形状，包括导管，容器和管。

5. 发明申请

WO2005072142A3 HYBRID NUCLEIC ACID ASSEMBLY 审中-公开
公开(公告)号：WO2005072142A3
公开(公告)日：2005-08-11
申请号：PCT/US2005/001252
申请日：2005-01-14
申请人： BIOMED SOLUTIONS, LLC , WEINER, Michael , CONNELLY, Patrick , GEBERT, Carol , GRAY, Robert , CUSTER, Andrew
发明人： WEINER, Michael , CONNELLY, Patrick , GEBERT, Carol , GRAY, Robert , CUSTER, Andrew
IPC分类号： C07H21/04 , C12Q1/00
摘要： A detection device comprised of a hybrid nucleic acid assembly. The device further comprises a nucleic acid polymer, a first nanoparticle conjugated to the nucleic acid polymer, a second nanoparticle conjugated with the nucleic acid polymer, a means for introducing energy into the first nanoparticle, means for detecting energy from the second nanoparticle, and means for determining a physical property of the nucleic acid polymer, wherein the means of introducing energy into the first nanoparticle is a source of mechanical energy.

6. 发明申请

WO2002092161A1 MINIATURIZED PARTICLE ANALYZER 审中-公开
标题翻译：微型颗粒分析仪
公开(公告)号：WO2002092161A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/014253
申请日：2002-05-06
申请人： BIOPHAN, LLC , GEBERT, Carol , GRAY, Robert, W.
发明人： GEBERT, Carol , GRAY, Robert, W.
IPC分类号： A61M37/00
CPC分类号： A61B5/145 , A61B5/076
摘要： A particle analyzer containing a device (12) for acquiring particles of cellular material from a living body, a device (42) for labeling the particles of cellular material to produce labeled particles, a device (82) for analyzing the labeled particles to produce analyzed and labeled particles, a device (118) for sorting the analyzed and labeled particles to produce labeled and sorted particles, and a device (120) for maintaining a portion of the analyzed and labeled particles in a viable state.
摘要翻译：一种粒子分析装置，包括用于从活体获取细胞材料颗粒的装置（12），用于标记细胞材料颗粒以产生标记颗粒的装置（42），用于分析标记颗粒以产生分析的装置（82）和标记的颗粒，用于分选分析和标记的颗粒以产生标记和分选的颗粒的装置（118），以及用于将分析和标记的颗粒的一部分保持在可行状态的装置（120）。

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