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1. 发明申请

WO1992020363A1 TREATMENT OF LIVER CANCER 审中-公开
标题翻译：肝癌治疗
公开(公告)号：WO1992020363A1
公开(公告)日：1992-11-26
申请号：PCT/US1992003916
申请日：1992-05-11
申请人： BIOMEASURE, INC. , ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： BIOMEASURE, INC. , ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BODGEN, Arthur, E. , COY, David, H. , KIM, Sun, Hyuk , MOREAU, Jacques-Pierre
IPC分类号： A61K37/02
CPC分类号： A61K38/105 , Y02A50/395 , Y10S514/894 , Y10S530/828
摘要： A method of treating liver cancer involving administration to the subject a therapeutically effective amount of a bombesin analog.
摘要翻译：一种治疗肝癌的方法，涉及向受试者施用治疗有效量的铃蟾肽类似物。

2. 发明申请

WO1998021298A1 SYNTHESIS OF A LOW TRANS-CONTENT EDIBLE OIL, NON-EDIBLE OIL OR FATTY ACID IN A SOLID POLYMER ELECTROLYTE REACTOR 审中-公开
标题翻译：在固体聚合物电解质反应器中合成低转化可食用油，不可食用油或脂肪酸
公开(公告)号：WO1998021298A1
公开(公告)日：1998-05-22
申请号：PCT/US1997019842
申请日：1997-11-12
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , PINTAURO, Peter, N. , AN, Weidong
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
IPC分类号： C11C03/12
CPC分类号： C11C3/12 , C25B3/04
摘要： An electrochemical catalytic process for hydrogenating an unsaturated fatty acid, mixtures of two or more fatty acids having different degrees of unsaturation, or the unsaturated fatty acid constituents of an edible or non-edible oil's triglycerides is performed using a solid polymer electrolyte reactor. The anode and cathode catalyst materials are used to fabricate membrane electrode assemblies consisting of a cation exchange membrane onto which porous anode and cathode electrodes are attached. As the electrodes are permeable, reactant and products enter and leave the membrane/cathode and membrane/anode reaction zones via the back sides of the electrodes. During the electrochemical oil hydrogenation process, hydrogen is generated in situ by the electroreduction of protons that are formed at the anode and which migrate through the ion exchange membrane for reaction with the unsaturated fatty acids. A novel partially hydrogenated oil product selected from the group consisting of a partially hydrogenated fatty acid, a partially hydrogenated triglyceride, or mixtures thereof is produced by the disclosed process.
摘要翻译：使用固体聚合物电解质反应器进行用于使不饱和脂肪酸氢化，具有不同不饱和度的两种或更多种脂肪酸的混合物或可食用或不可食用油的甘油三酸酯的不饱和脂肪酸组分的电化学催化方法。阳极和阴极催化剂材料用于制造由阳极交换膜组成的膜电极组件，多孔阳极和阴极电极连接在阳离子交换膜上。由于电极是可渗透的，反应物和产物经由电极的背面进入和离开膜/阴极和膜/阳极反应区。在电化学油加氢过程中，通过电解还原在阳极处形成的质子并且通过离子交换膜迁移以与不饱和脂肪酸反应，原位产生氢。通过所公开的方法制备选自部分氢化的脂肪酸，部分氢化的甘油三酸酯或其混合物的新型部分氢化油产物。

3. 发明申请

WO1990005540A1 MONOCLONAL ANTIBODIES SPECIFIC FOR TUMOR ANTIGENS 审中-公开
标题翻译：肿瘤抗原特异性单克隆抗体
公开(公告)号：WO1990005540A1
公开(公告)日：1990-05-31
申请号：PCT/US1989005208
申请日：1989-11-22
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , HENDERSON, Lee, A.
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K38/00
摘要： The present invention relates to tumor-specific monoclonal antibodies that recognize antigenic determinants of a membrane component characteristic of squamous cell carcinoma, and to hybridomas producing same. The invention further relates to a diagnostic kit comprising the tumor-specific antibodies. The invention also relates to the use of the tumor-specific antibodies in determining the presence of squamous carcinoma cells in a biological sample.
摘要翻译：本发明涉及识别鳞状细胞癌特征性膜组分的抗原决定簇的肿瘤特异性单克隆抗体以及产生其的杂交瘤。本发明还涉及包含肿瘤特异性抗体的诊断试剂盒。本发明还涉及肿瘤特异性抗体在确定生物样品中鳞状细胞癌细胞存在的用途。

4. 发明申请

WO1993004081A1 PEPTIDES HAVING GROWTH HORMONE RELEASING ACTIVITY 审中-公开
标题翻译：具有生长激素释放活性的肽
公开(公告)号：WO1993004081A1
公开(公告)日：1993-03-04
申请号：PCT/US1992007026
申请日：1992-08-20
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BOWERS, Cyril, Y. , COY, David
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
IPC分类号： C07K07/06
CPC分类号： C07K14/60
摘要： Novel peptides of the formula A1-A2-C1-C2-C3-A5 are disclosed which promote the release of growth hormone when administered to animals. These peptides can be used therapeutically.
摘要翻译：公开了式A1-A2-C1-C2-C3-A5的新型肽，其在施用于动物时促进生长激素的释放。这些肽可用于治疗。

5. 发明申请

WO1991013911A1 PEPTIDE INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION BLOCKS VIRUS INTERACTIONS WITH A NOVEL CELLULAR RECEPTOR 审中-公开
标题翻译：人类免疫缺陷病毒感染块的肽抑制剂与新型细胞受体的病毒相互作用
公开(公告)号：WO1991013911A1
公开(公告)日：1991-09-19
申请号：PCT/US1991001549
申请日：1991-03-07
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , HENDERSON, Lee, Alan , COY, David, H. , GARRY, Robert, Francis, Jr.
IPC分类号： C07K07/08
CPC分类号： C07K14/005 , A61K38/00 , C07K14/705 , C12N2740/16122
摘要： The present invention relates to methods of inhibiting HIV-mediated cell killing which comprises inhibiting the interaction between the CS3 region and viral gp41 and its receptor on the surface of lymphocytes. The invention provides for methods which employ peptides, peptide derivatives, or antibodies to inhibit the CS3/CS3 receptor interaction. In addition, the invention also relates to the CS3 receptor. The present invention is based in part on the discovery that a CS3 specific cellular receptor is widely distributed on human lymphocytes and forms a 108 kd complex with CS3-HSA peptide conjugate. It was further discovered that CS3 peptide effectively blocks HIV mediated cell infection and killing. Therefore, the present invention provides for methods of treatment and prophylaxis of HIV infection as well as a means for better understanding the physiology of acquired immunodeficiency syndrome (AIDS).
摘要翻译：本发明涉及抑制HIV介导的细胞杀伤的方法，其包括抑制CS3区域和病毒gp41及其淋巴细胞表面受体之间的相互作用。本发明提供了使用肽，肽衍生物或抗体来抑制CS3 / CS3受体相互作用的方法。此外，本发明还涉及CS3受体。本发明部分基于CS3特异性细胞受体广泛分布在人淋巴细胞上并与CS3-HSA肽缀合物形成108kd复合物的发现。进一步发现CS3肽有效阻断HIV介导的细胞感染和杀伤。因此，本发明提供了治疗和预防HIV感染的方法以及更好地了解获得性免疫缺陷综合征（AIDS）的生理学的方法。

6. 发明申请

WO1990003980A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1990003980A1
公开(公告)日：1990-04-19
申请号：PCT/US1989004616
申请日：1989-10-13
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E. , KIM, Sun, Hyuk
IPC分类号： C07K07/02
CPC分类号： C07K14/57572 , A61K38/00 , C07K7/02 , C07K7/086
摘要： In general, the invention features a linear (i.e., non-cyclic) bombesin analog of biologically active mammalian gastrin-releasing peptide (GRP) and amphibian bombesin, having an active site and a binding site responsable for the binding of the peptide to a receptor on a target cell; cleavage of a peptide bond in the active site of naturally occuring bombesin or GRP is unnecessary for in vivo bilogical activity. The analog has one of the following modifications: (a) a deletion of a residue within the active site and a modification of a residue outside of the active site, or (b) a remplacement of one or two residues within the active site with a synthetic amino acid. The analog is capable of binding to the receptor and acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of one of the modifications, failing to exhibit the in vivo biological activity of the naturally occurring peptide.
摘要翻译：通常，本发明的特征在于具有生物活性的哺乳动物胃泌素释放肽（GRP）和两栖动物铃蟾肽的线性（即非环状）铃蟾肽类似物，具有活性位点和对肽结合受体负责的结合位点在目标细胞上天然存在的铃蟾肽或GRP的活性位点中肽键的切割对于体内生物活性是不必要的。类似物具有以下修改之一：（a）活性位点内的残基的缺失和活性位点之外的残基的修饰，或（b）活性位点内的一个或两个残基的置换，合成氨基酸。类似物能够结合受体并且通过与受体结合而作为天然存在的肽的竞争性抑制剂，并且通过其中一个修饰，不能显示天然存在的肽的体内生物活性。

7. 发明申请

WO1989009231A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1989009231A1
公开(公告)日：1989-10-05
申请号：PCT/US1989001259
申请日：1989-03-27
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E. , KIM, Sun, Hyuk
IPC分类号： C07K07/18
CPC分类号： C07K7/086 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/57572 , C07K14/685 , Y10S514/803
摘要： Bradykinin analogs containing a non-peptide bond; some of the analogs exhibit antagonist activity rendering useful therapeutically, e.g., for the relief of vasodilation - induced swelling and/or itching.
摘要翻译：含有非肽键的缓激肽类似物; 一些类似物表现出拮抗剂活性，其治疗有用，例如用于缓解血管舒张引起的肿胀和/或瘙痒。

8. 发明申请

WO1989009230A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1989009230A1
公开(公告)日：1989-10-05
申请号：PCT/US1989001216
申请日：1989-03-22
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E.
IPC分类号： C07K07/18
CPC分类号： C07K14/57572 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/685
摘要： Bradykinin analogs containing a non-peptide bond; some of the analogs exhibit antagonist activity rendering useful therapeutically, e.g., for the relief of vasodilation - induced swelling and/or itching.

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