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1. 发明申请

WO1994002163A1 NEUROMEDIN B RECEPTOR ANTAGONISTS 审中-公开
标题翻译：神经母细胞B受体拮抗剂
公开(公告)号：WO1994002163A1
公开(公告)日：1994-02-03
申请号：PCT/US1993007036
申请日：1993-07-27
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BIOMEASURE, INC.
发明人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BIOMEASURE, INC. , COY, David, H. , TAYLOR, John, E.
IPC分类号： A61K37/00
CPC分类号： C07K14/6555 , A61K38/31
摘要： A method of selectively inhibiting biochemical activity of cells induced by neuromedin B. The method includes the step of contacting cells which contain neuromedin B receptor with a cyclic octapeptide, D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2, or an analog thereof.
摘要翻译：一种选择性抑制由神经介肽B诱导的细胞的生化活性的方法。该方法包括使含有神经介肽B受体的细胞与环状八肽D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys- Nal-NH 2或其类似物。

2. 发明申请

WO1989004666A1 TREATMENT OF CANCER WITH SOMATOSTATIN AND ANALOGS THEREOF 审中-公开
标题翻译：用SOMATOSTATIN治疗癌症及其类似物
公开(公告)号：WO1989004666A1
公开(公告)日：1989-06-01
申请号：PCT/US1988004126
申请日：1988-11-18
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , TAYLOR, John, E. , BOGDEN, Arthur, E. , MOREAU, Jacques-Pierre , COY, David, H.
IPC分类号： A61K37/24
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 mug/kg/day.

3. 发明申请

WO1990003980A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1990003980A1
公开(公告)日：1990-04-19
申请号：PCT/US1989004616
申请日：1989-10-13
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E. , KIM, Sun, Hyuk
IPC分类号： C07K07/02
CPC分类号： C07K14/57572 , A61K38/00 , C07K7/02 , C07K7/086
摘要： In general, the invention features a linear (i.e., non-cyclic) bombesin analog of biologically active mammalian gastrin-releasing peptide (GRP) and amphibian bombesin, having an active site and a binding site responsable for the binding of the peptide to a receptor on a target cell; cleavage of a peptide bond in the active site of naturally occuring bombesin or GRP is unnecessary for in vivo bilogical activity. The analog has one of the following modifications: (a) a deletion of a residue within the active site and a modification of a residue outside of the active site, or (b) a remplacement of one or two residues within the active site with a synthetic amino acid. The analog is capable of binding to the receptor and acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of one of the modifications, failing to exhibit the in vivo biological activity of the naturally occurring peptide.
摘要翻译：通常，本发明的特征在于具有生物活性的哺乳动物胃泌素释放肽（GRP）和两栖动物铃蟾肽的线性（即非环状）铃蟾肽类似物，具有活性位点和对肽结合受体负责的结合位点在目标细胞上天然存在的铃蟾肽或GRP的活性位点中肽键的切割对于体内生物活性是不必要的。类似物具有以下修改之一：（a）活性位点内的残基的缺失和活性位点之外的残基的修饰，或（b）活性位点内的一个或两个残基的置换，合成氨基酸。类似物能够结合受体并且通过与受体结合而作为天然存在的肽的竞争性抑制剂，并且通过其中一个修饰，不能显示天然存在的肽的体内生物活性。

4. 发明申请

WO1989009231A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1989009231A1
公开(公告)日：1989-10-05
申请号：PCT/US1989001259
申请日：1989-03-27
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E. , KIM, Sun, Hyuk
IPC分类号： C07K07/18
CPC分类号： C07K7/086 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/57572 , C07K14/685 , Y10S514/803
摘要： Bradykinin analogs containing a non-peptide bond; some of the analogs exhibit antagonist activity rendering useful therapeutically, e.g., for the relief of vasodilation - induced swelling and/or itching.
摘要翻译：含有非肽键的缓激肽类似物; 一些类似物表现出拮抗剂活性，其治疗有用，例如用于缓解血管舒张引起的肿胀和/或瘙痒。

5. 发明申请

WO1989009230A1 THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽
公开(公告)号：WO1989009230A1
公开(公告)日：1989-10-05
申请号：PCT/US1989001216
申请日：1989-03-22
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , COY, David, H. , MOREAU, Jacques-Pierre , TAYLOR, John, E.
IPC分类号： C07K07/18
CPC分类号： C07K14/57572 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/685
摘要： Bradykinin analogs containing a non-peptide bond; some of the analogs exhibit antagonist activity rendering useful therapeutically, e.g., for the relief of vasodilation - induced swelling and/or itching.

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