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    • 3. 发明申请
    • COMPOSITION CONTAINING 4-O-METHYLHONOKIOL FOR TREATING OR PREVENTING AMYLOID- RELATED DISEASES
    • 含有4-O-甲基羟基木酚醇的组合物用于治疗或预防淀粉样蛋白相关性疾病
    • WO2010036052A3
    • 2010-07-22
    • PCT/KR2009005485
    • 2009-09-25
    • BIOLAND LTDKIM KI HOKIM KI SOOKIM YOUNG HEUIKIM JIN GUKKIM KYOUNG TAEHAN CHANG SUNGLEE SANG IL
    • KIM KI HOKIM KI SOOKIM YOUNG HEUIKIM JIN GUKKIM KYOUNG TAEHAN CHANG SUNGLEE SANG IL
    • A61K31/085A23L1/29A23L1/30A61K31/05A61P25/28
    • A61K31/085A23L2/52A23L33/105A61K31/05A61K36/575
    • The present invention relates to a composition for treating or preventing amyloid-related diseases, said composition containing 4-O-methylhonokiol as an active ingredient. More particularly, the present invention relates to a pharmaceutical composition which contains as an active ingredient and which is useful in treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorders, memory impairment, amyloidosis, etc. The inventors of the present invention first found that 4-O-methylhonokiol of the present invention inhibits the formation of beta-amyloid, and it is evidenced that 4-O-methylhonokiol can be used in the treatment and prevention of amyloid-related diseases. The inventors of the present invention have performed animal tests such as a water maze test, a passive avoidance test, and the like using experimental rats to find that 4-O-methylhonokiol is effective in the treatment or prevention of amyloid-related diseases such as Alzheimer's disease, cognitive disorders, memory impairment, amyloidosis, etc. The inventors of the prevent invention further have performed an acetylcholinesterase activity inhibition test using the cortex and hippocampus of the brain of a rat to find that 4-O-methylhonokiol is significantly effective in the treatment or prevention of Alzheimer's disease specifically from among the amyloid-related diseases.
    • 本发明涉及用于治疗或预防淀粉样蛋白相关疾病的组合物,所述组合物含有4-O-甲基和厚朴酚作为活性成分。 更具体地说,本发明涉及含有作为活性成分并可用于治疗或预防淀粉样蛋白相关疾病如阿尔茨海默病,认知障碍,记忆障碍,淀粉样变性等的药物组合物。本发明的发明人 首先发现本发明的4-O-甲基和厚朴酚抑制β-淀粉样蛋白的形成,并且证明4-O-甲基和厚朴酚可用于治疗和预防淀粉样蛋白相关疾病。 本发明的发明人使用实验大鼠进行了水迷宫试验,被动回避试验等动物试验,结果发现4-O-甲基和厚朴酚有效治疗或预防淀粉样蛋白相关疾病,例如 阿尔茨海默病,认知障碍,记忆障碍,淀粉样变性等。本发明的发明人进一步使用大鼠脑的皮质和海马进行了乙酰胆碱酯酶活性抑制试验,发现4-O-甲基和厚朴酚在 特别是从淀粉样蛋白相关疾病中治疗或预防阿尔茨海默病。
    • 8. 发明申请
    • CERAMIC PRODUCT DECORATED WITH JEWELS, AND METHOD FOR MANUFACTURING SAME
    • 用珠宝装饰的陶瓷制品及其制造方法
    • WO2010126265A3
    • 2011-03-03
    • PCT/KR2010002620
    • 2010-04-27
    • HANKOOK CHINAWARE CO LTDKIM YOUNG MOKYU DEOK SANGJIN SU KYOUNGHONG SUNG BONGKIM KI SOO
    • KIM YOUNG MOKYU DEOK SANGJIN SU KYOUNGHONG SUNG BONGKIM KI SOO
    • B44C5/00B44C3/12C04B33/24
    • B44C5/005
    • The present invention relates to a ceramic product decorated with jewels and to a method for manufacturing same, and provides a ceramic product which is decorated with jewels to increase the value thereof and in which the jewels are prevented from being easily detached from the ceramic product by force applied by an external force, and also provides a method for manufacturing same. The method comprises: a step (S10) of forming images on a ceramic product; a step (S20) of applying an epoxy resin on the points of the surface of the ceramic product having the images and at which the jewels are to be attached; a step (S30) of attaching jewels to the surface of the ceramic where the epoxy resin was applied; a step (S40) of inserting the ceramic product into a heater having an internal temperature of 150 to 200°C, and heating and drying the ceramic product for 30 to 60 minutes so as to heat and dry the epoxy resin which fixes and supports the jewels; and a step (S50) of cooling the hot ceramic product.
    • 本发明涉及用珠宝装饰的陶瓷制品及其制造方法,并提供一种用珠宝装饰以增加其价值的陶瓷制品,并且其中防止珠宝容易与陶瓷制品分离。 通过外力施加的力,并且还提供其制造方法。 该方法包括:在陶瓷制品上形成图像的步骤(S10) 在具有图像的陶瓷制品的表面上涂布环氧树脂的步骤(S20),并且安装珠宝; 将珠宝安装在施加了环氧树脂的陶瓷的表面上的步骤(S30) 将陶瓷制品插入到内部温度为150〜200℃的加热器中的步骤(S40),将陶瓷制品加热干燥30〜60分钟,将固定并支撑陶瓷制品的环氧树脂加热干燥 珠宝; 以及冷却热陶瓷制品的步骤(S50)。