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1. 发明申请

WO2010036052A3 COMPOSITION CONTAINING 4-O-METHYLHONOKIOL FOR TREATING OR PREVENTING AMYLOID- RELATED DISEASES 审中-公开
标题翻译：含有4-O-甲基羟基木酚醇的组合物用于治疗或预防淀粉样蛋白相关性疾病
公开(公告)号：WO2010036052A3
公开(公告)日：2010-07-22
申请号：PCT/KR2009005485
申请日：2009-09-25
申请人： BIOLAND LTD , KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , KIM KYOUNG TAE , HAN CHANG SUNG , LEE SANG IL
发明人： KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , KIM KYOUNG TAE , HAN CHANG SUNG , LEE SANG IL
IPC分类号： A61K31/085 , A23L1/29 , A23L1/30 , A61K31/05 , A61P25/28
CPC分类号： A61K31/085 , A23L2/52 , A23L33/105 , A61K31/05 , A61K36/575
摘要： The present invention relates to a composition for treating or preventing amyloid-related diseases, said composition containing 4-O-methylhonokiol as an active ingredient. More particularly, the present invention relates to a pharmaceutical composition which contains as an active ingredient and which is useful in treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorders, memory impairment, amyloidosis, etc. The inventors of the present invention first found that 4-O-methylhonokiol of the present invention inhibits the formation of beta-amyloid, and it is evidenced that 4-O-methylhonokiol can be used in the treatment and prevention of amyloid-related diseases. The inventors of the present invention have performed animal tests such as a water maze test, a passive avoidance test, and the like using experimental rats to find that 4-O-methylhonokiol is effective in the treatment or prevention of amyloid-related diseases such as Alzheimer's disease, cognitive disorders, memory impairment, amyloidosis, etc. The inventors of the prevent invention further have performed an acetylcholinesterase activity inhibition test using the cortex and hippocampus of the brain of a rat to find that 4-O-methylhonokiol is significantly effective in the treatment or prevention of Alzheimer's disease specifically from among the amyloid-related diseases.
摘要翻译：本发明涉及用于治疗或预防淀粉样蛋白相关疾病的组合物，所述组合物含有4-O-甲基和厚朴酚作为活性成分。更具体地说，本发明涉及含有作为活性成分并可用于治疗或预防淀粉样蛋白相关疾病如阿尔茨海默病，认知障碍，记忆障碍，淀粉样变性等的药物组合物。本发明的发明人首先发现本发明的4-O-甲基和厚朴酚抑制β-淀粉样蛋白的形成，并且证明4-O-甲基和厚朴酚可用于治疗和预防淀粉样蛋白相关疾病。本发明的发明人使用实验大鼠进行了水迷宫试验，被动回避试验等动物试验，结果发现4-O-甲基和厚朴酚有效治疗或预防淀粉样蛋白相关疾病，例如阿尔茨海默病，认知障碍，记忆障碍，淀粉样变性等。本发明的发明人进一步使用大鼠脑的皮质和海马进行了乙酰胆碱酯酶活性抑制试验，发现4-O-甲基和厚朴酚在特别是从淀粉样蛋白相关疾病中治疗或预防阿尔茨海默病。

2. 发明申请

WO2011013909A9 COMPOSITION CONTAINING OLIGO-HYALURONIC ACID FOR PROMOTING THE STEMNESS OF SKIN CELLS AND FOR STIMULATING DIFFERENTIATION 审中-公开
标题翻译：含有OLIGO-HYALURONIC酸的组合物，用于促进皮肤细胞的粘连和刺激分化
公开(公告)号：WO2011013909A9
公开(公告)日：2011-05-12
申请号：PCT/KR2010004185
申请日：2010-06-28
申请人： BIOLAND LTD , KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , PARK SUN HEE , CHOI HYE RYUNG
发明人： KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , PARK SUN HEE , CHOI HYE RYUNG
IPC分类号： A61K31/728 , A61P17/00
CPC分类号： A61K31/728
摘要： The present invention relates to a composition containing oligo-hyaluronic acid for promoting the stemness of skin cells and for stimulating differentiation, and more specifically, to a composition containing oligo-hyaluronic acid as an active ingredient for promoting the stemness of skin cells and for stimulating differentiation, and to a method for stimulating the differentiation of adult skin stem cells using same. According to the present invention, unlike existing hyaluronic acid, oligo-hyaluronic acid exhibits the effects of stimulating differentiation in epidermal cells and enhancing the function of epidermal cells by increasing the expression of markers of the epidermal stem cells in skin tissue to restore the stemness of the epidermal cells.
摘要翻译：本发明涉及含有低透明质酸的组合物，其用于促进皮肤细胞的干性和刺激分化，更具体地，涉及含有低聚透明质酸作为活性成分的组合物，用于促进皮肤细胞的干性和刺激性以及使用其刺激成体皮肤干细胞分化的方法。根据本发明，与现有的透明质酸不同，低透明质酸通过增加皮肤组织中表皮干细胞的标志物的表达，表现出刺激表皮细胞分化和增强表皮细胞功能的作用，以恢复表皮细胞的干性表皮细胞。

3. 发明申请

WO2011013909A3 COMPOSITION CONTAINING OLIGO-HYALURONIC ACID FOR PROMOTING THE STEMNESS OF SKIN CELLS AND FOR STIMULATING DIFFERENTIATION 审中-公开
标题翻译：含有低聚果糖酸的组合物用于促进皮肤细胞的干细胞和促进分化
公开(公告)号：WO2011013909A3
公开(公告)日：2011-06-30
申请号：PCT/KR2010004185
申请日：2010-06-28
申请人： BIOLAND LTD , KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , PARK SUN HEE , CHOI HYE RYUNG
发明人： KIM KI HO , KIM KI SOO , KIM YOUNG HEUI , KIM JIN GUK , PARK SUN HEE , CHOI HYE RYUNG
IPC分类号： A61K31/728 , A61P17/00
CPC分类号： A61K31/728
摘要： The present invention relates to a composition containing oligo-hyaluronic acid for promoting the stemness of skin cells and for stimulating differentiation, and more specifically, to a composition containing oligo-hyaluronic acid as an active ingredient for promoting the stemness of skin cells and for stimulating differentiation, and to a method for stimulating the differentiation of adult skin stem cells using same. According to the present invention, unlike existing hyaluronic acid, oligo-hyaluronic acid exhibits the effects of stimulating differentiation in epidermal cells and enhancing the function of epidermal cells by increasing the expression of markers of the epidermal stem cells in skin tissue to restore the stemness of the epidermal cells.
摘要翻译：本发明涉及一种含有用于促进皮肤细胞的干度和促进分化的寡聚透明质酸的组合物，更具体地，涉及一种含有寡聚透明质酸作为活性成分的组合物，所述活性成分用于促进皮肤细胞的干燥和刺激分化的方法，以及使用该方法刺激成体皮肤干细胞分化的方法。根据本发明，与现有透明质酸不同，寡透明质酸通过增加皮肤组织中表皮干细胞的标记物的表达来显示刺激表皮细胞分化和增强表皮细胞功能的作用，以恢复皮肤干细胞表皮细胞。

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