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1. 发明申请

WO2006074765A1 MOLECULAR BIOLOGY METHOD 审中-公开
标题翻译：分子生物学方法
公开(公告)号：WO2006074765A1
公开(公告)日：2006-07-20
申请号：PCT/EP2005/013107
申请日：2005-12-07
申请人： BIOINVENT INTERNATIONAL AB , DANIELSSON, Lena , NECKMAR, Linda , BJÖRK, Stephan , STEPPA, Jessica , CARLSSON, Roland
发明人： DANIELSSON, Lena , NECKMAR, Linda , BJÖRK, Stephan , STEPPA, Jessica , CARLSSON, Roland
IPC分类号： C12N15/10 , C40B50/00
CPC分类号： C12N15/1034 , C12N15/102 , C12N15/1027 , C12N15/1031
摘要： The invention relates to a method for assembling a composite poly nucleotide sequence and for producing a library of different composite polynucleotide sequences. In particular, the invention relates to a method for assembling polynucleotide sequences encoding immunoglobulin variable regions and for identi f3 , ing immunoglobulin variable regions with desired characteristics.
摘要翻译：本发明涉及一种用于组装复合多核苷酸序列并用于制备不同复合多核苷酸序列的文库的方法。具体地，本发明涉及用于组装编码免疫球蛋白可变区的多核苷酸序列的方法，并且用于鉴定具有所需特征的免疫球蛋白可变区。

2. 发明申请

WO2008075038A1 BINDING AGENTS TO THE INTEGRIN ALPHA-11 SUBUNIT 审中-公开
标题翻译：绑定代理到集成ALPHA-11子
公开(公告)号：WO2008075038A1
公开(公告)日：2008-06-26
申请号：PCT/GB2007/004875
申请日：2007-12-18
申请人： BIOINVENT INTERNATIONAL AB , FRENDÉUS, Björn , CARLSSON, Roland , JANSSON, Bo
发明人： FRENDÉUS, Björn , CARLSSON, Roland , JANSSON, Bo
IPC分类号： C07K16/28 , A61K39/395 , A61K47/48 , A61K51/10 , A61P19/02 , A61P37/00
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to an antibody, or antigen-binding fragment thereof, with binding specificity for an integrin α11 subunit, or a heterodimer thereof, or a variant, fusion, derivative or polypeptide chain thereof, or a fusion of a said variant or derivative thereof, which retains the binding specificity of the parent antibody wherein the antibody or antigen-binding fragment, or variant, fusion, derivative or polypeptide chain thereof, comprises the following amino acid sequences of SEQ ID NOS: 1 to 6. In particular, the invention relates to antibodies or antigen-binding fragments, or variants, fusions or derivatives thereof, with efficacy in the treatment of inflammatory disorders such as arthritic diseases ( e.g. RA and OA). The invention further provides pharmaceutical compositions and kits comprising the same.
摘要翻译：本发明涉及对整联蛋白a11亚基或其异源二聚体或其变体，融合，衍生物或多肽链或所述变体或衍生物的融合物具有结合特异性的抗体或其抗原结合片段其保留亲本抗体的结合特异性，其中抗体或抗原结合片段或其变体，融合物，衍生物或多肽链包含SEQ ID NO：1至6的以下氨基酸序列。特别地，本发明涉及在治疗诸如关节炎疾病（例如RA和OA）的炎症性疾病中有效的抗体或抗原结合片段或变体，融合物或其衍生物。本发明还提供药物组合物和包含该组合物的试剂盒。

3. 发明申请

WO2007025781A3 IMMUNOTHERAPEUTIC TREATMENT FOR INDUCING THE REGRESSION OF ATHEROSCLEROTIC PLAQUES 审中-公开
公开(公告)号：WO2007025781A3
公开(公告)日：2007-03-08
申请号：PCT/EP2006/008594
申请日：2006-09-04
申请人： BIOINVENT INTERNATIONAL AB , CARLSSON, Roland , NILSSON, Jan
发明人： CARLSSON, Roland , NILSSON, Jan
IPC分类号： C07K16/18 , A61K39/395 , A61K39/00 , A61P9/10 , A61K31/33 , G01N33/68 , G01N33/53
摘要： The use of immunotherapy against oxidised LDL to induce regression of preexisting atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.

4. 发明申请

WO2008104194A1 OXIDIZED LDL AND ANTIBODIES THERETO FOR THE TREATMENT OF ATHEROSCLEROTI C PLAQUES 审中-公开
标题翻译：氧化低密度脂蛋白和治疗甲状腺功能亢进症的抗体
公开(公告)号：WO2008104194A1
公开(公告)日：2008-09-04
申请号：PCT/EP2007/001723
申请日：2007-02-28
申请人： BIOINVENT INTERNATIONAL AB , NILSSON, Jan , CARLSSON, Roland
发明人： NILSSON, Jan , CARLSSON, Roland
IPC分类号： A61K39/395 , C07K16/18 , A61P9/10
CPC分类号： A61K39/0012 , C07K14/775 , C07K16/18 , C07K2317/565 , C07K2317/622
摘要： The use of immunotherapy against oxidised LDL to induce regression of pre-existing atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.
摘要翻译：使用针对氧化LDL的免疫治疗来诱导个体中先前存在的动脉粥样硬化病变的消退。免疫治疗可以是使用与氧化的LDL上存在的表位结合的抗体的免疫治疗，或使用疫苗组合物的活性免疫治疗来诱导针对氧化的LDL上存在的表位的免疫应答。

5. 发明申请

WO2006089678A2 PEPTIDES AND USES THEREOF 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2006089678A2
公开(公告)日：2006-08-31
申请号：PCT/EP2006/001404
申请日：2006-02-13
申请人： BIOINVENT INTERNATIONAL AB , CARLSSON, Roland , STENBERG, Yvonne , SONESSON, Elisabeth , GOLDSTEIN, Gideon
发明人： CARLSSON, Roland , STENBERG, Yvonne , SONESSON, Elisabeth , GOLDSTEIN, Gideon
CPC分类号： C07K16/1072 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to an immunoglobulin variable domain comprising all or a fragment or variant of each of peptide sequences SEQ ID No 2,3 and 4. Generally the invention relates to compositions useful for assaying or treating human immunodeficiency virus- 1(HIV-I) infection. There is also provided antibodies and polypeptides comprising immunoglobulin variable domains, polynucleotides, vectors, host cells encoding immunoglobulin variable domains, pharmaceutical compositions comprising and uses of immunoglobulin variable domains.
摘要翻译：本发明涉及包含肽序列SEQ ID No.2,2和4的全部或片段或变体的免疫球蛋白可变结构域。本发明一般涉及用于测定或治疗人类免疫缺陷病毒-1（HIV-1 ）感染。还提供了包含免疫球蛋白可变结构域，多核苷酸，载体，编码免疫球蛋白可变结构域的宿主细胞，包含免疫球蛋白可变结构域和用途的药物组合物的抗体和多肽。

6. 发明申请

WO2007068485A2 BIOLOGICAL MATERIALS AND USES THEREOF 审中-公开
标题翻译：生物材料及其用途
公开(公告)号：WO2007068485A2
公开(公告)日：2007-06-21
申请号：PCT/EP2006/012065
申请日：2006-12-08
申请人： BIOINVENT INTERNATIONAL AB , FRENDÉUS, Björn , CARLSSON, Roland
发明人： FRENDÉUS, Björn , CARLSSON, Roland
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.
摘要翻译：本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞凋亡。还提供了用于凋亡诱导的方法和药物组合物及其用途。

7. 发明申请

WO2004060350A1 IMMOBILISATION OF DNA-LABELLED LIPID VESICLES ON DNA ARRAYS 审中-公开
标题翻译： DNA标记的脂质体在DNA阵列上的免疫
公开(公告)号：WO2004060350A1
公开(公告)日：2004-07-22
申请号：PCT/EP2003/000272
申请日：2003-01-06
申请人： BIOINVENT INTERNATIONAL AB
发明人： PFEIFFER, Indriati , HÖÖK, Fredrik , SVEDHEM, Sofia , LARSSON, Charlotte , CARLSSON, Roland
IPC分类号： A61K9/127
CPC分类号： G01N33/5432 , C12Q1/6816 , C12Q1/6837 , C12Q2563/161
摘要： The present invention relates to a use of a lipid vesicle having bound thereto a targeting polynucleotide and a protein, polypeptide or peptide, which targeting polynucleotide is complementary to a region of a scaffold polynucleotide, to spatially distribute the protein, polypeptide or peptide at a defined position relative to the scaffold polynucleotide.
摘要翻译：本发明涉及结合有靶向多核苷酸和蛋白质，多肽或肽的脂质囊泡的用途，所述靶向多核苷酸靶向多核苷酸与支架多核苷酸区域互补，以将所述蛋白质，多肽或肽空间分布在所定义的相对于支架多核苷酸的位置。

8. 发明申请

WO2006088740A3 METHODS AND COMPOSITIONS FOR IMPAIRING MULTIPLICATION OF HIV-1 审中-公开
公开(公告)号：WO2006088740A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/004782
申请日：2006-02-13
申请人： THYMON, L.L.C. , GOLDSTEIN, Gideon , CARLSSON, Roland , SONESSON, Elisabeth , STENBERG, Yvonne , STRANDBERG, Leif
发明人： GOLDSTEIN, Gideon , CARLSSON, Roland , SONESSON, Elisabeth , STENBERG, Yvonne , STRANDBERG, Leif
IPC分类号： C07K16/10 , A61K39/42
摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-I Tat protein displayed in multiple strains and subtypes of HIV-I. This "pan-epitope" antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-I infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-I based on a measurement of the amount of Tat protein in a biological sample.

9. 发明申请

WO2011157291A1 METHOD AND DEVICE FOR SINR ESTIMATION 审中-公开
标题翻译： SINR估计的方法和装置
公开(公告)号：WO2011157291A1
公开(公告)日：2011-12-22
申请号：PCT/EP2010/058452
申请日：2010-06-16
申请人： TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) , SAHLIN, Henrik , CARLSSON, Roland , MÄLLO, Aare
发明人： SAHLIN, Henrik , CARLSSON, Roland , MÄLLO, Aare
IPC分类号： H04B17/00
CPC分类号： H04W24/06 , H04B17/336 , H04B17/373 , H04B17/382
摘要： A method (200) for a transceiver in a mobile system for determining the SINR for signals from at least two User Equipments during a future time interval, comprising arranging the transceiver to receive (205) transmissions from User Equipments in the mobile system on one radio channel per User Equipment, choosing (210) the at least two User Equipments from User Equipments which have data to transmit to the transceiver. The method comprises determining (220) the radio channel characteristics during the future time interval for the at least two User Equipments,emulating (230) at least one receiver type available to the transceiver during said future time interval in order to determine a post demodulation channel for the at least two User Equipments, in which emulation the determined radio channel characteristics,and determining (235) an SINR in the transceiver for the at least two User Equipments using the post demodulation channel.
摘要翻译：一种用于在未来时间间隔期间用于确定来自至少两个用户设备的信号的SINR的用于移动系统中的收发器的方法（200），包括：设置所述收发器以在一个无线电中接收（205）来自所述移动系统中的用户设备的传输每个用户设备的通道，从用户设备中选择（210）至少两个用户设备，其中具有要发送到收发器的数据。该方法包括确定（220）在至少两个用户设备的未来时间间隔期间的无线电信道特性，在所述未来时间间隔期间模拟（230）可用于收发器的至少一个接收机类型，以便确定后解调信道对于至少两个用户设备，其中仿真确定的无线电信道特性，以及使用后解调信道确定（235）用于至少两个用户设备的收发器中的SINR。

10. 发明申请

WO2011025978A2 METHODS OF TREATMENT USING ANTI-OXIDIZED LDL ANTIBODIES 审中-公开
标题翻译：使用抗氧化低密度脂蛋白抗体的治疗方法
公开(公告)号：WO2011025978A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/047030
申请日：2010-08-27
申请人： BUNTING, Stuart , BULLENS, Sherron , CARLSSON, Roland , FRENDEUS, Björn , GLAZER, Steven , GROVE, Kevin , VAN BRUGGEN, Nick
发明人： BUNTING, Stuart , BULLENS, Sherron , CARLSSON, Roland , FRENDEUS, Björn , GLAZER, Steven , GROVE, Kevin , VAN BRUGGEN, Nick
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/94
摘要： The present invention relates to methods and compositions for increasing insulin sensitivity comprising the administration of anti-oxidized LDL antibodies.
摘要翻译：本发明涉及用于增加胰岛素敏感性的方法和组合物，其包括施用抗氧化的LDL抗体。

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