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2. 发明申请

WO2005117843A2 SUSTAINED RELEASE PREPARATIONS 审中-公开
标题翻译：持续发布准备
公开(公告)号：WO2005117843A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/016528
申请日：2005-05-11
申请人： MALLINCKRODT INC. , RAMAN, Siva, N. , CUNNINGHAM, John, P. , LANG, John, F.
发明人： RAMAN, Siva, N. , CUNNINGHAM, John, P. , LANG, John, F.
IPC分类号： A61K9/50
CPC分类号： A61K31/785 , A61K9/0095 , A61K9/5036 , A61K47/585
摘要： Disclosed are sustained release drug particles suitable for forming sustained release oral pharmaceutical compositions. The sustained release drug particles comprise a drug-ion exchange resin complex and a water-permeable, diffusion barrier surrounding at least a portion of the drug-ion exchange resin complex. The diffusion barrier comprises a film-forming polymer and is free or contains no substantial traces of organic solvent. Also disclosed are oral pharmaceutical compositions, for example, oral suspensions, comprising the sustained release drug particles, a method for the controlled administration of a drug to a patient, and a method for manufacturing the sustained release drug particles. The method of manufacturing involves the use of an aqueous coating composition comprising a water-permeable film-forming polymer such as ethylcellulose.
摘要翻译：公开了适于形成缓释口服药物组合物的缓释药物颗粒。缓释药物颗粒包含药物 - 离子交换树脂复合物和围绕药物 - 离子交换树脂复合物的至少一部分的透水的扩散阻挡层。扩散阻挡层包含成膜聚合物，并且不含或不含有实质痕量的有机溶剂。还公开了口服药物组合物，例如包含缓释药物颗粒的口服悬浮液，用于向患者控制施用药物的方法和制备缓释药物颗粒的方法。制造方法涉及使用包含透水性成膜聚合物如乙基纤维素的水性涂料组合物。

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