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1. 发明申请

WO2019046091A3 HIGH POWERED LASERS FOR WESTERN BLOTTING 审中-公开
公开(公告)号：WO2019046091A3
公开(公告)日：2019-03-07
申请号：PCT/US2018/047701
申请日：2018-08-23
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , SWIHART, Steve
IPC分类号： G01N21/01 , G01N33/52 , A61K49/10 , H01S5/06 , H01S5/0625
摘要： Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.

2. 发明申请

WO2015035001A1 DOUBLE FOLD OPTICS 审中-公开
标题翻译：双重折射光学
公开(公告)号：WO2015035001A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054017
申请日：2014-09-04
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , PEREZ, Evelio , SWIHART, Steve
IPC分类号： G02B5/08 , G02B5/18 , G02B7/182
CPC分类号： G02B21/361 , G01N21/00 , G01N21/76 , G02B17/023 , G02B21/0008 , G03B15/00 , G03B17/17
摘要： An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.
摘要翻译：用于观察，成像和分析凝胶或其它基底中的生物，化学和/或生物化学样品的成像组件，其中可调节的相机和透镜模块，反射镜和焦平面镜配置成弯曲或折叠光路以便对目标区域进行成像，并且其中可以沿非正交角度反射光路。成像组件被配置为由于反射镜和相机和透镜组件相对于彼此定位的角度而减小成像装置的总体尺寸，这允许在目标区域中对较大样本进行成像。

3. 发明申请

WO2021231205A1 ILLUMINATOR SYSTEMS HAVING LIGHT EMITTING DIODES WITH UV ACTIVATION 审中-公开
公开(公告)号：WO2021231205A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/031267
申请日：2021-05-07
申请人： BIO-RAD LABORATORIES, INC.
发明人： SWIHART, Stephen , THRUSH, Evan , MCDONALD, Kevin
IPC分类号： G01N33/53 , G01N21/00 , G01N21/17 , G01N21/33 , G01N21/64 , G01N27/447
摘要： An imaging system including an illuminator apparatus or an epi-illumination apparatus that has LEDs for illuminations is provided for stain-free gel activation and fluorescent sample visualization. The illuminator apparatus includes a housing, a light source array disposed on at least one side surface of the housing and including at least one plurality of LEDs having each LED individually operable to output light of a predetermined color within a range of wavelengths, and a controller for controlling ranges of operational parameters of the at least one plurality of LEDs. The light emitted from the light source array incidents upon a sample having a gel that includes a product of UV light induced reaction between tryptophan and a haloalkane and the light emitted from the light source array includes ultraviolet (UV) light to excite a fluorescent response of the sample.

4. 发明申请

WO2021113240A1 ELECTRONIC COMPONENT ASSEMBLY WITH THERMALLY CONDUCTIVE STRUCTURES FOR IMAGE SENSORS 审中-公开
公开(公告)号：WO2021113240A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/062706
申请日：2020-12-01
申请人： BIO-RAD LABORATORIES, INC.
发明人： SWIHART, Stephen , LU, Li , JAMESON, Wade , THRUSH, Evan , GRIFFIN, Michael , PEREZ, Evelio
IPC分类号： H01L27/146
摘要： An electronic component assembly having thermal pads with thermal vias coupling an image sensor and a camera board fab is provided for heat dissipation. The electronic component assembly can include: a circuit board having at least one thermal pad disposed on a top surface of the circuit board; and an image sensor disposed on the top surface of the circuit board, having at least one conductive pad disposed at at least one corner of the image sensor. The at least one thermal pad is coupled to the at least one conductive pad of the image sensor and the at least one thermal pad is formed with a plurality of first thermal vias penetrating the thermal pad and the circuit board for transfer of heat of the image sensor.

5. 发明申请

WO2019046091A2 HIGH POWERED LASERS FOR WESTERN BLOTTING 审中-公开
公开(公告)号：WO2019046091A2
公开(公告)日：2019-03-07
申请号：PCT/US2018/047701
申请日：2018-08-23
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , SWIHART, Steve
IPC分类号： G01N21/64 , G02B5/02
摘要： Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.

6. 发明申请

WO2023069651A1 FLUORESCENCE DETECTION SYSTEM 审中-公开
公开(公告)号：WO2023069651A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047322
申请日：2022-10-20
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , SWIHART, Stephen L. , HEFNER, Eli A. , GRIFFIN, Michael , LU, Li
IPC分类号： G01N21/64 , C12Q1/686 , G01N21/25 , G02B21/06
摘要： A fluorescence detection system, including apparatus and methods, suitable for qPCR and other fluorescence-based analyses. The system may comprise various components, including a stage, an illumination module, a detection module, and an optical relay structure. The stage may be configured to support a sample holder. The illumination module may include one or more discrete light sources configured to produce excitation light. The detection module may be configured to detect fluorescence emission light produced, in response to the excitation light, by a fluorescent sample positioned in the sample holder. The optical relay structure may include a beamsplitter assembly configured to direct the excitation light from the illumination module along an illumination path to the sample holder and to direct the fluorescence emission light from the sample holder along a response path to the imaging module. The system may enhance the quality of excitation light hitting samples in the sample holder, for example, by collimating and/or homogenizing the light.

7. 发明申请

WO2021081194A8 MEASUREMENT OF MOLECULAR INTERACTIONS AT SINGLE MOLECULE LEVEL USING SUBSTRATES THAT ENHANCE FLUORESCENCE DETECTION 审中-公开
公开(公告)号：WO2021081194A8
公开(公告)日：2021-04-29
申请号：PCT/US2020/056849
申请日：2020-10-22
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , LIU, Ning , MARLOWE, Carl , STRONG, William, Bradley
IPC分类号： G01N33/52 , G01N33/53 , G01N21/553 , G01N21/6458 , G01N21/648 , G01N33/68 , G06T2207/30024 , G06T7/0014
摘要： The invention relates to methods for characterizing the binding interactions between binding partners. The invention pertains to methods comprising contacting a first binding partner with a second binding partner that exhibits fast-off rate binding characteristics with the first binding partner to generate the binding interaction between the first binding partner and the second binding partner, wherein the first binding partner is immobilized onto a substrate that is designed to enhance the fluorescence signal of fluorescent molecules located near the substrate's surface, and wherein the second binding partner is a molecule that emits a fluorescent signal or is conjugated to molecule that emits a fluorescent signal. The interactions between the two binding partners can be analyzed based on multiple transient interactions between the two binding partners.

8. 发明申请

WO2015168240A1 SERIES ABSORBANCE GLASS AND INTERFERENCE FILTERS 审中-公开
标题翻译：系列吸收玻璃和干涉滤光片
公开(公告)号：WO2015168240A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028214
申请日：2015-04-29
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , SWIHART, Steve , BHATT, Neeraj
IPC分类号： G01J3/30 , F21V9/00
CPC分类号： G01N21/6456 , G01N21/6486 , G01N2021/6439 , G01N2021/6471 , G01N2021/6482 , G01N2201/062 , G01N2201/0627 , G01N2201/0638 , G01N2201/12
摘要： An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.
摘要翻译：一种成像组件和处理系统，其包括具有可容纳样品的目标区域的样品平台，其中可以用荧光或磷光标记物标记样品。成像组件可以具有靠近样本平台的激发光模块，其发射光以激发标记;以及透镜模块，其定位成接收来自目标区域中的激发标记的发射光。至少一个串联滤波器组件或干涉滤波器可以布置在透镜模块的前面，后面或者两者之间。组件包括光传感器，以及被配置为处理由光传感器捕获的数据的处理器和成像模块。基于来自样品的发射光，通过透镜组件和串联滤光器组件或干涉滤光器滤光而产生样品的图像。

9. 发明申请

WO2015089031A1 NON-DESTRUCTIVE READ OPERATIONS WITH DYNAMICALLY GROWING IMAGES 审中-公开
标题翻译：非破坏性阅读操作与动态增长图像
公开(公告)号：WO2015089031A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069281
申请日：2014-12-09
申请人： BIO-RAD LABORATORIES, INC.
发明人： SWIHART, Steve , THRUSH, Evan , RAN, Boaz
IPC分类号： G01N21/27
CPC分类号： H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
摘要： Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
摘要翻译：本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。使用数字成像设备中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像。在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。然后可以在图形显示中显示捕获的图像。

10. 发明申请

WO2023044017A1 SYSTEM FOR CUMULATIVE IMAGING OF BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2023044017A1
公开(公告)日：2023-03-23
申请号：PCT/US2022/043821
申请日：2022-09-16
申请人： BIO-RAD LABORATORIES, INC.
发明人： THRUSH, Evan , SWIHART, Stephen , MCDONALD, Kevin
IPC分类号： H04N23/10 , G16B20/00
摘要： Aspects of the present disclosure relate to systems and methods for generating a composite image. This can include a western blot imager with a real time camera. One aspect of the present disclosure relates to an imaging system. The imaging system includes a sample plane that can receive and hold a sample, a photon resolving camera, and a lens attached to the photon resolving camera, the photon resolving camera and the lens positioned to image the sample plane.

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