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1. 发明申请

WO2010032242A1 OPTIMIZATION OF ALGINATE ENCAPSULATION OF ISLETS FOR TRANSPLANTATION 审中-公开
标题翻译：用于运输的离心机的铝酸盐包封的优化
公开(公告)号：WO2010032242A1
公开(公告)日：2010-03-25
申请号：PCT/IL2009/000905
申请日：2009-09-16
申请人： BETA O2 TECHNOLOGIES LTD. , BARKAI, Uriel , ROTEM, Avi , AZAROV, Dimitry , NEUFELD, Tova , GENDLER, Zohar
发明人： BARKAI, Uriel , ROTEM, Avi , AZAROV, Dimitry , NEUFELD, Tova , GENDLER, Zohar
IPC分类号： A61F2/04 , A01N65/03 , A61K36/02 , C12N11/10
CPC分类号： A61L27/52 , A61L27/20 , A61L27/26 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3834 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N5/0677 , C12N11/04 , C12N11/10
摘要： Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
摘要翻译：提供了包括多个胰岛的设备，以及被配置为将所述多个胰岛大包封的水凝胶。水凝胶可植入在受试者的肾脏（22）的囊下空间（21）中并且被成形为限定平面构型。还描述了其它应用。

2. 发明申请

WO2011154941A2 MULTIPLE-LAYER IMMUNE BARRIER FOR DONOR CELLS 审中-公开
标题翻译：多层免疫障碍细胞
公开(公告)号：WO2011154941A2
公开(公告)日：2011-12-15
申请号：PCT/IL2011/000445
申请日：2011-06-06
申请人： BETA-O2 TECHNOLOGIES LTD. , BARKAI, Uriel , ROTEM, Avi , BREMER, Yehezkel , NEUFELD, Tova
发明人： BARKAI, Uriel , ROTEM, Avi , BREMER, Yehezkel , NEUFELD, Tova
IPC分类号： A61K9/00 , A61K35/12 , A61K35/39 , A61P1/18 , A61J3/06
CPC分类号： A61L27/00 , A01N1/0231 , A61K9/0024 , A61K9/1652 , A61K9/5073 , A61K35/39 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/505 , A61L27/56 , A61L2400/18 , A61L2420/02 , A61L2420/08 , A61L2430/40 , C12N5/0012 , C12N5/0676 , Y10S623/915
摘要： A system (20) is provided, comprising a plurality of donor cells and a first alginate structure (26) that encapsulates the plurality of donor cells (24). The first alginate structure (26) has a guluronic acid concentration of between 64% and 74%. The system additionally comprises a second alginate structure (28) that surrounds the first alginate structure (26), the second alginate structure (28) having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane (30) is coupled at least in part to the second alginate structure (28). Other embodiments are also described.
摘要翻译：提供了一种系统（20），其包括多个供体细胞和封装多个供体细胞（24）的第一藻酸盐结构（26）。第一藻酸盐结构（26）的古罗糖醛酸浓度为64％至74％。该系统另外包含围绕第一藻酸盐结构（26）的第二藻酸盐结构（28），第二藻酸盐结构（28）具有52％至60％之间的甘露糖醛酸浓度。选择性渗透膜（30）至少部分地与第二藻酸盐结构（28）连接。还描述了其它实施例。

3. 发明申请

WO2010061387A2 APPARATUS FOR TRANSPORTATION OF OXYGEN TO IMPLANTED CELLS 审中-公开
标题翻译：用于将氧气运输到植入细胞的装置
公开(公告)号：WO2010061387A2
公开(公告)日：2010-06-03
申请号：PCT/IL2009/001114
申请日：2009-11-25
申请人： BETA O2 TECHNOLOGIES LTD. , STERN, Yaki , BARKAI, Uriel , ROTEM, Avi , REINGEWIRTZ, Meir , ROZY, Yoram
发明人： STERN, Yaki , BARKAI, Uriel , ROTEM, Avi , REINGEWIRTZ, Meir , ROZY, Yoram
IPC分类号： A61M37/00
CPC分类号： A61M13/003 , A61F2/022 , A61M2202/0208
摘要： Apparatus is provided which includes a housing (24), configured for insertion into a body of a subject. The apparatus includes functional cells (32) coupled to the housing (24) and a source of oxygen configured to supply oxygen to the functional cells. The apparatus further includes an oxygen delivery interface (27) configured to receive oxygen from the source of oxygen, and to facilitate passage of the oxygen to the functional cells (32), while the housing (24) is disposed within the body of the subject. Other applications are also described.
摘要翻译：提供了包括被配置为插入到受试者的身体中的壳体（24）的装置。该装置包括耦合到壳体（24）的功能单元（32）和被配置为向功能单元供应氧气的氧源。该装置还包括氧输送界面（27），其被配置为从氧源接收氧气，并且有助于氧气通向功能单元（32），同时壳体（24）设置在受试者体内。还描述了其它应用。

4. 发明申请

WO2008065660A3 OXYGEN SUPPLY FOR CELL TRANSPLANT AND VASCULARIZATION 审中-公开
公开(公告)号：WO2008065660A3
公开(公告)日：2008-06-05
申请号：PCT/IL2007/001471
申请日：2007-11-28
申请人： BETA O2 TECHNOLOGIES LTD. , ROTEM, Avi , SCHNEIDER, Chanan , BARKAI, Uriel , EVRON, Yoav , VARDI, Pnina , BLOCH, Konstantin
发明人： ROTEM, Avi , SCHNEIDER, Chanan , BARKAI, Uriel , EVRON, Yoav , VARDI, Pnina , BLOCH, Konstantin
IPC分类号： A61K9/22
摘要： Apparatus is provided, including a housing (22), configured for insertion into a body of a patient; a photosynthetic oxygen supply (24) configured to supply oxygen; and functional cells (30), coupled to the housing (22). The functional cells (30) are adapted to receive the oxygen and to secrete at least one factor that induces vascularization in a vicinity of the housing (22) when the housing (22) is in the body of the patient. Other embodiments are also described.

5. 发明申请

WO2017175065A3 IMPLANTABLE DEVICE FOR IMPLANTATION OF CELLS HAVING ANTI-INFLAMMATORY AND VASCULARIZATION CAPABILITIES AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：植入具有抗炎和血管形成能力的细胞的可植入装置及其制造方法
公开(公告)号：WO2017175065A3
公开(公告)日：2017-10-12
申请号：PCT/IB2017/000461
申请日：2017-04-04
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , ZIMERMAN, Baruch , BARKAI, Uriel , MAIMON, Shiri
IPC分类号： A61K35/12 , A61P1/18 , A61K9/00
摘要： A method includes spreading a solution including a polyether and a photoinitiator onto a hydrophilic porous membrane, impregnating hydrophilic the porous membrane with the solution, and curing the solution located within the hydrophilic porous membrane by exposure to ultraviolet light to produce a composite membrane.
摘要翻译：一种方法包括将包含聚醚和光引发剂的溶液涂布到亲水性多孔膜上，用溶液浸渍亲水性多孔膜，并通过暴露于紫外线下使位于亲水性多孔膜内的溶液固化生产出复合膜。

6. 发明申请

WO2017175065A2 IMPLANTABLE DEVICE FOR IMPLANTATION OF CELLS HAVING ANTI-INFLAMMATORY AND VASCULARIZATION CAPABILITIES AND METHODS OF MAKING THEREOF 审中-公开
公开(公告)号：WO2017175065A2
公开(公告)日：2017-10-12
申请号：PCT/IB2017/000461
申请日：2017-04-04
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , ZIMERMAN, Baruch , BARKAI, Uriel , MAIMON, Shiri
IPC分类号： B29C35/18
摘要： A method includes spreading a solution including a polyether and a photoinitiator onto a hydrophilic porous membrane, impregnating hydrophilic the porous membrane with the solution, and curing the solution located within the hydrophilic porous membrane by exposure to ultraviolet light to produce a composite membrane.

7. 发明申请

WO2015145264A2 IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2015145264A2
公开(公告)日：2015-10-01
申请号：PCT/IB2015/001093
申请日：2015-03-24
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , BARKAI, Uriel , ZIMERMAN, Baruch , GENDLER, Zohar
IPC分类号： A61M39/02
CPC分类号： A61M39/0208 , A61F2/022 , A61M5/14276 , A61M2005/14204 , A61M2039/0211 , A61M2202/0007 , A61M2202/0208 , A61M2202/0225 , A61M2209/045
摘要： An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.
摘要翻译：一种可植入医疗系统，其包括用于供应基本上为氧的气体的气体单元和被配置为从所述气体单元接收氧气的至少一个功能单元单元，以便将所述电池维持在可行状态。电池单元是灵活的。公开了几个实施例。

8. 发明申请

WO2008152640A2 THREE DIMENSIONAL BIOCOMPATIBLE SCAFFOLDS FOR EX-VIVO EXPANSION AND TRANSPLANTATION OF STEM CELLS 审中-公开
标题翻译：用于扩张和转移干细胞的三维生物可溶性细胞
公开(公告)号：WO2008152640A2
公开(公告)日：2008-12-18
申请号：PCT/IL2008/000803
申请日：2008-06-12
申请人： PLURISTEM LTD. , MERETZKI, Shai , BARKAI, Uriel , ZIPORI, Dov , KADOURI, Avinoam
发明人： MERETZKI, Shai , BARKAI, Uriel , ZIPORI, Dov , KADOURI, Avinoam
IPC分类号： A61K35/14
CPC分类号： C12N5/0647 , A61K2035/124 , C12N2502/1394 , C12N2533/30 , C12N2533/40
摘要： A method of transplanting undifferentiated hematopoietic stem cells into a recipient is disclosed. The method comprising (a) expanding the undifferentiated hematopoietic stem cells to increase the number of the hematopoietic stem cells by (i) culturing in a stationary phase plug-flow bioreactor stromal cells under continuous flow of a culture medium on a three dimensional biocompatible substrate to thereby generate a three dimensional stromal cell culture; and (ii) seeding undifferentiated hematopoietic stem cells into the stationary phase plug-flow bioreactor including the three dimensional stromal cell culture and under a continuous flow of a culture medium, thereby expanding the undifferentiated hematopoietic stem cells and obtaining a three dimensional stromal cell culture comprising increased number of hematopoietic stem cells; and (b) transplanting the three dimensional stromal cell culture comprising hematopoietic stem cells resulting from (a) into the recipient.
摘要翻译：公开了将未分化的造血干细胞移植到受体中的方法。该方法包括：（a）通过（i）在三维生物相容性底物连续流动的培养基上在固定相插塞生物反应器基质细胞中培养，扩展未分化的造血干细胞以增加造血干细胞的数量，从而产生三维基质细胞培养物; 和（ii）将未分化的造血干细胞接种到包括三维基质细胞培养物的固定相塞子流生物反应器中并在连续流动的培养基下，从而扩增未分化的造血干细胞并获得三维基质细胞培养物，其包含增加造血干细胞的数量; 和（b）将包含（a）产生的造血干细胞的三维基质细胞培养物移植到受体中。

9. 发明申请

WO2009125402A3 BONE-LIKE PROSTHETIC IMPLANTS 审中-公开
公开(公告)号：WO2009125402A3
公开(公告)日：2009-10-15
申请号：PCT/IL2009/000395
申请日：2009-04-07
申请人： BONUS THERAPEUTICS LTD , MERETZKI, Shai , SROUJI, Samer , BARKAI, Uriel
发明人： MERETZKI, Shai , SROUJI, Samer , BARKAI, Uriel
IPC分类号： A61L27/38 , A61L27/56
摘要： A prosthetic implant comprising a biocompatible three-dimensional scaffold and at least two cell types selected from the group consisting of osteoblasts, osteoclasts, and endothelial cells or progenitors thereof.

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