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1. 发明申请

WO2011154941A3 MULTIPLE-LAYER IMMUNE BARRIER FOR DONOR CELLS 审中-公开
标题翻译：多层免疫障碍细胞
公开(公告)号：WO2011154941A3
公开(公告)日：2012-03-29
申请号：PCT/IL2011000445
申请日：2011-06-06
申请人： BETA O2 TECHNOLOGIES LTD , BARKAI URIEL , ROTEM AVI , BREMER YEHEZKEL , NEUFELD TOVA
发明人： BARKAI URIEL , ROTEM AVI , BREMER YEHEZKEL , NEUFELD TOVA
IPC分类号： A61F2/00 , A01N63/00
CPC分类号： A61L27/34 , A01N1/0231 , A61K9/0024 , A61K9/1652 , A61K9/5073 , A61K35/39 , A61L27/00 , A61L27/20 , A61L27/36 , A61L27/505 , A61L27/56 , A61L2400/18 , A61L2420/02 , A61L2420/08 , A61L2430/40 , C12N5/0012 , C12N5/0676 , Y10S623/915
摘要： A system (20) is provided, comprising a plurality of donor cells and a first alginate structure (26) that encapsulates the plurality of donor cells (24). The first alginate structure (26) has a guluronic acid concentration of between 64% and 74%. The system additionally comprises a second alginate structure (28) that surrounds the first alginate structure (26), the second alginate structure (28) having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane (30) is coupled at least in part to the second alginate structure (28). Other embodiments are also described.
摘要翻译：提供了一种系统（20），包括多个供体细胞和封装多个供体细胞（24）的第一藻酸盐结构（26）。第一藻酸盐结构（26）的古罗糖醛酸浓度为64％至74％。该系统还包括环绕第一藻酸盐结构（26）的第二藻酸盐结构（28），第二藻酸盐结构（28）具有52％至60％之间的甘露糖醛酸浓度。选择性渗透膜（30）至少部分地与第二藻酸盐结构（28）连接。还描述了其它实施例。

2. 发明申请

WO2011024178A1 OXYGEN SUPPLY FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的氧气供应
公开(公告)号：WO2011024178A1
公开(公告)日：2011-03-03
申请号：PCT/IL2010/000712
申请日：2010-08-30
申请人： BETA-O2 TECHNOLOGIES LTD. , STERN, Jacob , ROTEM, Avi , EVRON, Yoav , BERMER, Yehezkel
发明人： STERN, Jacob , ROTEM, Avi , EVRON, Yoav , BERMER, Yehezkel
IPC分类号： A61K9/22
CPC分类号： A61M39/0208 , A61M5/1582 , A61M2005/006 , A61M2039/0211 , A61M2039/0217 , A61M2202/0208 , A61M2209/045
摘要： A method for replenishing gas in a subcutaneously implanted medical device containing functional cells comprising: inserting at least one needle, adopted to penetrate the skin and connecting a subcutaneously implanted medical device; connecting said inserted at least one needle to a gas replenishing apparatus; extracting gas from a gas reservoir in said implanted device into said gas replenishing apparatus; sensing oxygen level in said extracted gas; calculating the amount of gas needed for replenishing oxygen in said reservoir based on said sensed oxygen level in said extracted gas; and supplying gas from a gas tank in said gas replenishing apparatus to said gas reservoir in said implanted device.
摘要翻译：一种在含有功能细胞的皮下植入的医疗装置中补充气体的方法，包括：插入至少一个针，用于穿透皮肤并连接皮下植入的医疗装置; 将所述插入的至少一个针连接到气体补充装置; 将来自所述植入装置中的气体储存器的气体提取到所述气体补充装置中; 检测所述提取气体中的氧含量; 基于所述提取的气体中的所述感测氧水平计算在所述储存器中补充氧气所需的气体量; 以及将气体从所述气体补充装置中的气罐供给到所述植入装置中的所述气体储存器。

3. 发明申请

WO2009031154A2 AIR GAP FOR SUPPORTING CELLS 审中-公开
标题翻译：支持细胞的空气隙
公开(公告)号：WO2009031154A2
公开(公告)日：2009-03-12
申请号：PCT/IL2008/001204
申请日：2008-09-07
申请人： BETA O2 TECHNOLOGIES LTD. , STERN, Yaki , ROZY, Yoram
发明人： STERN, Yaki , ROZY, Yoram
IPC分类号： H01M12/02 , C12M3/00
CPC分类号： A61F2/022 , C12M21/02 , C12M21/08 , C12M23/24 , C12M25/06 , C12M31/10
摘要： Apparatus is provided, including a housing (60), configured for insertion into a body of a subject, one or more photosynthetic oxygen supplies (24), disposed within the housing (60), and at least one layer (70 and 74) of functional cells, disposed within the housing (60). The at least one layer (70 and 74) of functional cells is configured to receive oxygen from the one or more oxygen supplies (24). The housing (60) also includes a gas (40 and 43) configured to permit passage therethrough of the oxygen from the one or more oxygen supplies (24) to the cells (70 and 74). The gas (40) is disposed at least in part between the layer (70 and 74) of functional cells and at least one of the oxygen supplies (24). Other embodiments are also described.
摘要翻译：提供了一种设备，包括：壳体（60），其被配置为插入到受试者的身体中，设置在所述壳体（60）内的一个或多个光合氧供应装置（24），以及至少一个层（70和74）设置在壳体（60）内的功能单元。功能单元的至少一层（70和74）被配置为从一个或多个氧气供应（24）接收氧气。壳体（60）还包括气体（40和43），其构造成允许氧气从一个或多个氧气供应（24）通过到电池（70和74）。气体（40）至少部分地设置在功能单元的层（70和74）与至少一个氧气供应（24）之间。还描述了其它实施例。

4. 发明申请

WO2017175065A3 IMPLANTABLE DEVICE FOR IMPLANTATION OF CELLS HAVING ANTI-INFLAMMATORY AND VASCULARIZATION CAPABILITIES AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：植入具有抗炎和血管形成能力的细胞的可植入装置及其制造方法
公开(公告)号：WO2017175065A3
公开(公告)日：2017-10-12
申请号：PCT/IB2017/000461
申请日：2017-04-04
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , ZIMERMAN, Baruch , BARKAI, Uriel , MAIMON, Shiri
IPC分类号： A61K35/12 , A61P1/18 , A61K9/00
摘要： A method includes spreading a solution including a polyether and a photoinitiator onto a hydrophilic porous membrane, impregnating hydrophilic the porous membrane with the solution, and curing the solution located within the hydrophilic porous membrane by exposure to ultraviolet light to produce a composite membrane.
摘要翻译：一种方法包括将包含聚醚和光引发剂的溶液涂布到亲水性多孔膜上，用溶液浸渍亲水性多孔膜，并通过暴露于紫外线下使位于亲水性多孔膜内的溶液固化生产出复合膜。

5. 发明申请

WO2017175065A2 IMPLANTABLE DEVICE FOR IMPLANTATION OF CELLS HAVING ANTI-INFLAMMATORY AND VASCULARIZATION CAPABILITIES AND METHODS OF MAKING THEREOF 审中-公开
公开(公告)号：WO2017175065A2
公开(公告)日：2017-10-12
申请号：PCT/IB2017/000461
申请日：2017-04-04
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , ZIMERMAN, Baruch , BARKAI, Uriel , MAIMON, Shiri
IPC分类号： B29C35/18
摘要： A method includes spreading a solution including a polyether and a photoinitiator onto a hydrophilic porous membrane, impregnating hydrophilic the porous membrane with the solution, and curing the solution located within the hydrophilic porous membrane by exposure to ultraviolet light to produce a composite membrane.

6. 发明申请

WO2017137842A1 SYSTEMS AND METHODS FOR PROVIDING OXYGEN TO TRANSPLANTED CELLS 审中-公开
标题翻译：用于提供氧到移植细胞的系统和方法
公开(公告)号：WO2017137842A1
公开(公告)日：2017-08-17
申请号：PCT/IB2017/000175
申请日：2017-02-07
申请人： BETA-O2 TECHNOLOGIES LTD.
发明人： ROTEM, Avi , AVNI, Yuval
IPC分类号： A01N1/00 , A61K33/00 , A61L27/36 , A61L27/52 , C12N5/00 , C12M1/04 , C12M3/06
CPC分类号： A61L27/3804 , A61F2/022 , A61K35/39 , A61K2035/126 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/56 , A61L2300/64 , A61M1/1678 , A61M1/1698 , A61M39/0208 , A61M2202/0208
摘要： A device containing transplanted tissue includes a housing, having a chamber configured for insertion into a body of a subject and protecting the transplanted tissue from the subject's immune system. The housing includes an oxygen supply container, a hydrogel layer, a port, and an access port. The oxygen supply container has a chamber defined by top and bottom surfaces and sides, disposed within the chamber of the housing. The top surface and the bottom surface of the oxygen supply container include a gas-permeable membrane. The hydrogel layer has inner and outer surfaces. The inner surface of the hydrogel layer contacts the top surface of the oxygen supply container or the bottom surface of the oxygen supply container. The port is configured to deliver oxygen to the oxygen supply container. The access port is configured to receive an exogenous supply of gas and is fluidly connected to the port.
摘要翻译：包含移植组织的装置包括壳体，所述壳体具有配置用于插入受试者体内并保护移植组织免受受试者免疫系统影响的腔室。外壳包括氧气供应容器，水凝胶层，端口和进入端口。氧气供应容器具有由顶部和底部表面和侧面限定的腔室，该腔室设置在壳体的腔室内。氧气供应容器的顶部表面和底部表面包括透气膜。水凝胶层具有内表面和外表面。水凝胶层的内表面接触氧气供应容器的顶部表面或氧气供应容器的底部表面。该端口被配置为将氧气输送到氧气供应容器。接入端口被配置为接收外源气体并与端口流体连接。

7. 发明申请

WO2008062417A3 PROTECTING ALGAE FROM BODY FLUIDS 审中-公开
标题翻译：保护身体液体
公开(公告)号：WO2008062417A3
公开(公告)日：2009-04-16
申请号：PCT/IL2007001447
申请日：2007-11-22
申请人： BETA O2 TECHNOLOGIES LTD , ROTEM AVI , SCHNEIDER CHANAN , NEUFELD TOVA , EVRON YOAV
发明人： ROTEM AVI , SCHNEIDER CHANAN , NEUFELD TOVA , EVRON YOAV
IPC分类号： A61K9/22
CPC分类号： A61F2/022 , A61K35/39 , A61L27/38
摘要： Apparatus (20) is provided for implantation into a body of a subject, including isolated functional cells (28). At least one first barrier (22) having a first molecular weight cutoff is disposed with respect to the functional cells so as to protect the functional cells from components disposed within body fluid of the subject having molecular weights higher than the first cutoff. Photosynthetic elements (26) are disposed with respect to the functional cells so as to provide oxygen thereto. At least one second barrier (24) has a second molecular weight cutoff that is lower than the first cutoff. The second barrier is disposed with respect to the photosynthetic elements so as to protect the photosynthetic elements from components disposed within the body fluid of the subject having molecular weights higher than the second cutoff. Other embodiments are also described.
摘要翻译：提供装置（20）用于植入受试者的身体，包括分离的功能细胞（28）。相对于功能性细胞设置具有第一分子量截留值的至少一个第一屏障（22），以便保护功能细胞免受配对在具有高于第一截止值的分子量的受检者体液内的组分。相对于功能单元设置光合元件（26），以向其提供氧气。至少一个第二屏障（24）具有低于第一截止值的第二分子量截止值。第二屏障相对于光合元件设置，以便保护光合元件免受被配置在受试者体液中的分子量高于第二截止值的组分。还描述了其它实施例。

8. 发明申请

WO2015145264A3 IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2015145264A3
公开(公告)日：2016-03-03
申请号：PCT/IB2015001093
申请日：2015-03-24
申请人： BETA O2 TECHNOLOGIES LTD
发明人： ROTEM AVI , BARKAI URIEL , ZIMERMAN BARUCH , GENDLER ZOHAR
IPC分类号： A61M37/00
CPC分类号： A61M39/0208 , A61F2/022 , A61M5/14276 , A61M2005/14204 , A61M2039/0211 , A61M2202/0007 , A61M2202/0208 , A61M2202/0225 , A61M2209/045
摘要： An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.
摘要翻译：一种可植入医疗系统，其包括用于供应基本为氧的气体的气体单元和被配置为从气体单元接收氧气的至少一个功能单元单元，以便将细胞维持在可行状态。电池单元是灵活的。公开了几个实施例。

9. 发明申请

WO2010143176A1 SUBMERGED PLANAR ILLUMINATION DEVICE 审中-公开
标题翻译：提出的平面照明装置
公开(公告)号：WO2010143176A1
公开(公告)日：2010-12-16
申请号：PCT/IL2010/000375
申请日：2010-05-11
申请人： BETA-O2 TECHNOLOGIES LTD. , EISEN, Leon , STERN, Jacob , ROTEM, Abraham , EVRON, Yoav
发明人： EISEN, Leon , STERN, Jacob , ROTEM, Abraham , EVRON, Yoav
IPC分类号： F21V7/10
CPC分类号： G02B6/0036 , F21W2121/00 , G02B6/0061
摘要： A submerged planar illumination device for providing specified, substantially uniform distribution of light in liquid from one or few light sources such as LED. The device comprises a light guiding plate having an entrance edge to which the LEDs are fixed, a collimator for redirecting the light and forming substrate light which is coupled to a light guiding plate having at least one light extracting surface. Light extracting surface are optionally on both large surfaces of the light guiding plate. Each light extracting surface is covered with a pattern of light extracting and scattering elements capable of collecting, scattering and extracting light propagating in the light guiding plate into the liquid ambient medium in which the device is submerged. A cover, sealed to the entrance edge of the light guiding plate, protects the light emitting element from the liquid ambient medium.
摘要翻译：一种浸没式平面照明装置，用于从一个或几个光源（例如LED）提供指定的，基本均匀的光分布在液体中。该装置包括具有固定LED的入口边缘的导光板，用于重定向光并形成衬底光的准直器，该衬底光耦合到具有至少一个光提取表面的导光板。光提取表面可选地在导光板的两个大表面上。每个光提取表面被提取和散射元件的图案覆盖，能够将在导光板中传播的光聚集，散射和提取到装置浸没的液体环境介质中。密封到导光板的入口边缘的盖子保护发光元件免受液体环境介质的影响。

10. 发明申请

WO2008062417A2 PROTECTING ALGAE FROM BODY FLUIDS 审中-公开
标题翻译：保护身体液体
公开(公告)号：WO2008062417A2
公开(公告)日：2008-05-29
申请号：PCT/IL2007/001447
申请日：2007-11-22
申请人： BETA O2 TECHNOLOGIES LTD. , ROTEM, Avi , SCHNEIDER, Chanan , NEUFELD, Tova , EVRON, Yoav
发明人： ROTEM, Avi , SCHNEIDER, Chanan , NEUFELD, Tova , EVRON, Yoav
IPC分类号： C12M3/00
CPC分类号： A61F2/022 , A61K35/39 , A61L27/38
摘要： Apparatus (20) is provided for implantation into a body of a subject, including isolated functional cells (28). At least one first barrier (22) having a first molecular weight cutoff is disposed with respect to the functional cells so as to protect the functional cells from components disposed within body fluid of the subject having molecular weights higher than the first cutoff. Photosynthetic elements (26) are disposed with respect to the functional cells so as to provide oxygen thereto. At least one second barrier (24) has a second molecular weight cutoff that is lower than the first cutoff. The second barrier is disposed with respect to the photosynthetic elements so as to protect the photosynthetic elements from components disposed within the body fluid of the subject having molecular weights higher than the second cutoff. Other embodiments are also described.
摘要翻译：提供装置（20）用于植入受试者的身体，包括分离的功能细胞（28）。相对于功能性细胞设置具有第一分子量截留值的至少一个第一屏障（22），以便保护功能细胞免受配对在具有高于第一截止值的分子量的受检者体液内的组分。相对于功能单元设置光合元件（26），以向其提供氧气。至少一个第二屏障（24）具有低于第一截止值的第二分子量截止值。第二屏障相对于光合元件设置，以便保护光合元件免受被配置在受试者体液中的分子量高于第二截止值的组分。还描述了其它实施例。

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