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1. 发明申请

WO8402704A3 TETRACYCLIC COMPOUNDS 审中-公开
标题翻译：四环化合物
公开(公告)号：WO8402704A3
公开(公告)日：1984-08-02
申请号：PCT/GB8300353
申请日：1983-12-29
申请人： BEECHAM GROUP PLC , CONNELL ANTHONY CHRISTOPHER
发明人： CONNELL ANTHONY CHRISTOPHER
IPC分类号： A61K31/55 , C07C233/07 , C07D223/00 , C07D223/20 , C07D235/00 , C07D243/00 , C07D243/38 , C07D267/00 , C07D267/20 , C07D281/00 , C07D281/14 , C07D281/16 , C07D487/00 , C07D487/04 , C07D498/00 , C07D498/04 , C07D513/00 , C07D513/04
CPC分类号： C07D487/04 , C07C233/07 , C07D223/20 , C07D243/38 , C07D267/20 , C07D281/16 , C07D513/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7 alkyl, C2-5 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl or C1-6 alkyl substituted by C2-7 alkenyl, C2-7alkynyl, C3-7 cycloalkyl, hydroxy, thiol, C1-6 alkoxy, C1-6 alkylthio, carboxy, C1-6 alkoxycarbonyl, C2-7 alkanoyl, amino optionally substituted by one or two C1-4 alkyl or by C4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C1-6 alkyl groups, or benzoyl or phenyl either being optionally ring-substituted by one or two C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl; and one of R4, R5 and R6 is C1-6 alkyl and the other two are independently hydrogen or C1-6 alkyl, having anti-depressant and/or anxiolytic activity, a process for their preparation and their use.

2. 发明申请

WO8402704A2 TETRACYCLIC COMPOUNDS 审中-公开
标题翻译：四环化合物
公开(公告)号：WO8402704A2
公开(公告)日：1984-07-19
申请号：PCT/GB8300353
申请日：1983-12-29
申请人： BEECHAM GROUP PLC
发明人： CONNELL ANTHONY CHRISTOPHER
IPC分类号： A61K31/55 , C07C233/07 , C07D223/00 , C07D223/20 , C07D235/00 , C07D243/00 , C07D243/38 , C07D267/00 , C07D267/20 , C07D281/00 , C07D281/14 , C07D281/16 , C07D487/00 , C07D487/04 , C07D498/00 , C07D498/04 , C07D513/00 , C07D513/04
CPC分类号： C07D487/04 , C07C233/07 , C07D223/20 , C07D243/38 , C07D267/20 , C07D281/16 , C07D513/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7 alkyl, C2-5 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl or C1-6 alkyl substituted by C2-7 alkenyl, C2-7alkynyl, C3-7 cycloalkyl, hydroxy, thiol, C1-6 alkoxy, C1-6 alkylthio, carboxy, C1-6 alkoxycarbonyl, C2-7 alkanoyl, amino optionally substituted by one or two C1-4 alkyl or by C4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C1-6 alkyl groups, or benzoyl or phenyl either being optionally ring-substituted by one or two C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl; and one of R4, R5 and R6 is C1-6 alkyl and the other two are independently hydrogen or C1-6 alkyl, having anti-depressant and/or anxiolytic activity, a process for their preparation and their use.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中：X为CH 2，O，S或NR，其中R为C 1-4烷基; R 1和R 2独立地选自氢，羟基，C 1-4烷基，C 1-4烷氧基，卤素或CF 3; R3是C1-7烷基，C2-5炔基，C3-7环烷基，C4-7环烯基或被C2-7烯基取代的C1-6烷基，C2-7炔基，C3-7环烷基，羟基，硫醇，C1-6烷氧基 C 1-6烷硫基，羧基，C 1-6烷氧基羰基，C 2-7烷酰基，任选被一个或两个C 1-4烷基取代的氨基或任选地含有氧或氮原子的C 4-6二聚亚甲基，任选地被一个或多个N取代的氨基羰基或两个C 1-6烷基，或任选被一个或两个C 1-4烷基，C 1-4烷氧基，卤素或三氟甲基环取代的苯甲酰基或苯基; R 4，R 5和R 6中的一个是C 1-6烷基，另外两个独立地是氢或具有抗抑郁和/或抗焦虑活性的C 1-6烷基，其制备方法和用途。

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