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1. 发明申请

WO2018025242A2 METHODS FOR DIAGNOSING AND TREATING ESOPHAGEAL CANCER 审中-公开
标题翻译：诊断和治疗食管癌的方法
公开(公告)号：WO2018025242A2
公开(公告)日：2018-02-08
申请号：PCT/IB2017/054800
申请日：2017-08-04
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , MIYOSHI, Jinsei
IPC分类号： A61K48/00 , C12Q1/68
摘要： The current disclosure relates to therapeutic treatments and diagnostic methods for esophageal cancer based on the expression level of biomarker miRNAs. Aspects of the disclosure relate to a method of treating esophageal cancer (EC) in a patient, said method comprising: diagnosing the patient with esophageal cancer when the patient is determined to have an elevated or decreased level of expression of one or more miRNAs selected from mir- 15b, miR-17, mir-18a, mir-21, mir-23a, mir-24-2, mir-25, mir-27a, mir-93, mir-103, mir- 106b, mir-129-2, mir-139, mir-146b, mir-148a, mir-151, miR-155, mir-181a-1, mir-181a, mir-181b-1, mir-181b, mir-182, mir-183, mir-192, mir-194-1, mir-194-2, mir-196a-1, mir- 196a-2, mir-196b, mir-205, mir-215, mir-223, mir-224, mir-335, mir-338, mir-375, mir-421, mir-484, mir-505, mir-769, mir-944, mir-1468, mir-3648, and let-7i in a sample from a patient relative to the expression level of the one or more miRNAs in a control sample; and administering an effective amount of an esophageal treatment to the diagnosed patient.
摘要翻译：目前的公开涉及基于生物标志物miRNA的表达水平的用于食管癌的治疗性处理和诊断方法。本公开的方面涉及治疗患者中的食管癌（EC）的方法，所述方法包括：当确定患者具有选自以下的一种或多种miRNA的升高或降低的表达水平时诊断患有食管癌的患者： mir-15b，miR-17，mir-18a，mir-21，mir-23a，mir-24-2，mir-25，mir-27a，mir-93，mir-103，mir-106b，mir-129- 2 mir-139 mir-146b mir-148a mir-151 miR-155 mir-181a-1 mir-181a mir-181b-1 mir-181b mir-182 mir-183 mir- mir-192，mir-194-1，mir-194-2，mir-196a-1，mir-196a-2，mir-196b，mir-205，mir-215，mir-223，mir-224，mir- 335，mir-338，mir-375，mir-421，mir-484，mir-505，mir-769，mir-944，mir-1468，mir-3648和let-7i。对照样品中一种或多种miRNA的表达水平; 并对所诊断的患者施用有效量的食管治疗。

2. 发明申请

WO2016164303A1 METHODS FOR DIAGNOSING AND TREATING COLORECTAL CANCER USING snoRNA 审中-公开
标题翻译：使用snoRNA诊断和治疗彩色癌的方法
公开(公告)号：WO2016164303A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/025857
申请日：2016-04-04
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , OKUGAWA, Yoshinaga , YOSHIDA, Kazuhiro
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/00 , C12N2310/10 , C12Q1/68 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The current disclosure relates to therapeutic treatments and diagnostic methods for colorectal cancer based on the expression level of snoRNA expression. Aspects of the current disclosure relate to a method for treating a patient for early or advanced colorectal cancer comprising: treating the patient for advanced colorectal cancer after the patient is determined to have a high elevated level of snoRNA expression in a biological sample from the patient; and treating the patient for early colorectal cancer after the patient is determined to have a low elevated level of snoRNA expression in a biological sample from the patient.
摘要翻译：目前的公开涉及基于snoRNA表达的表达水平的结肠直肠癌的治疗治疗和诊断方法。本公开的方面涉及用于治疗早期或晚期结直肠癌患者的方法，其包括：在确定患者在来自患者的生物样品中具有高水平的snoRNA表达水平之后，对所述患者进行晚期结肠直肠癌治疗; 并且在确定患者在来自患者的生物样品中具有低水平的snoRNA表达水平之后，对患者进行早期结肠直肠癌治疗。

3. 发明申请

WO2023023123A1 COMPOSITIONS AND METHODS FOR CELL-FREE DNA EPIGENETIC GASTROINTESTINAL CANCER DETECTION AND TREATMENT 审中-公开
公开(公告)号：WO2023023123A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/040555
申请日：2022-08-17
申请人： CITY OF HOPE , BAYLOR RESEARCH INSTITUTE D/B/A BAYLOR SCOTT & WHITE RESEARCH INSTITUTE , BAYLOR COLLEGE OF MEDICINE , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GOEL, Ajay , LI, Wei , XU, Jianfeng
IPC分类号： C12Q1/6886 , C12Q1/6883 , G01N33/574
摘要： Provided herein are, inter alia, methods of detecting DNA methylation levels in patients at risk of developing a gastrointestinal cancer, methods of diagnosing a patient with a gastrointestinal cancer based on DNA methylation levels, methods of monitoring DNA methylation levels in patients at risk of developing a gastrointestinal cancer, and methods of treating patients having a gastrointestinal cancer.

4. 发明申请

WO2020132494A3 METHODS FOR PROGNOSING, DIAGNOSING, AND TREATING GASTRIC CANCER 审中-公开
公开(公告)号：WO2020132494A3
公开(公告)日：2020-06-25
申请号：PCT/US2019/067942
申请日：2019-12-20
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , SHIMURA, Tadanobu
IPC分类号： C12Q1/6886 , G01N33/50 , A61B5/145 , A61P35/00
摘要： The current disclosure provides an miRNA signature for detecting gastric cancer. Aspects of the disclosure relate to a method for treating, evaluating, prognosing, and/or diagnosing a patient for treating a patient with gastric cancer, the method comprising treating the patient for gastric cancer after the expression level of miR-30a-5p, miR-134-5p, miR-337-3p, miR-659-3p, and miR-3917 has been determined in a sample from the patient.

5. 发明申请

WO2014151551A1 ULCERATIVE COLITIS (UC)-ASSOCIATED COLORECTAL NEOPLASIA MARKERS 审中-公开
标题翻译：综合分析（UC）分析的彩色神经元标记
公开(公告)号：WO2014151551A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/025976
申请日：2014-03-13
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , TOIYAMA, Yuji , BOLAND, C., Richard , OKUGAWA, Yoshinaga
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61B1/31 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B10/04 , C12Q2600/154
摘要： Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.
摘要翻译：实施例提供了通过检测和分析来自UC患者的样品中miR-1，-9，-124，miR-137和/或miR-34b / c的甲基化状态来检测溃疡性结肠炎患者的瘤形成的方法和组合物。

6. 发明申请

WO2012158385A1 DETECTING DNA MISMATCH REPAIR-DEFICIENT COLORECTAL CANCERS 审中-公开
标题翻译：检测DNA错配修复缺陷性癌症
公开(公告)号：WO2012158385A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/036801
申请日：2012-05-07
申请人： BAYLOR RESEARCH INSTITUTE , GOEL, Ajay , BOLAND, C., Richard , NAGASAKA, Takeshi
发明人： GOEL, Ajay , BOLAND, C., Richard , NAGASAKA, Takeshi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Use of a CAT25 mononucleotide marker in a novel tetraplex PCR for the detection of MSH6-defective colorectal cancers (CRCs) is described herein. The tetraplex PCR of the present invention offers a facile, robust, less expensive (compared to the original pentaplex assay), highly sensitive, and specific assay for the identification of micros atellite instability (MSI) in CRCs.
摘要翻译：本文描述了在新型四倍体PCR中用于检测MSH6缺陷型结肠直肠癌（CRC）的CAT25单核苷酸标记物的用途。本发明的四倍体PCR提供了简便，鲁棒，较便宜（与原始五倍体测定相比），用于鉴定CRC中微卫星不稳定性（MSI）的高度灵敏和特异性测定。

7. 发明申请

WO2019178217A1 METHODS AND COMPOSITIONS FOR TREATING, DIAGNOSING, AND PROGNOSING CANCER 审中-公开
公开(公告)号：WO2019178217A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022036
申请日：2019-03-13
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , KANDIMALLA, Raju
IPC分类号： A61P3/04 , A61P35/00 , C12Q1/68 , G01N33/53 , G01N33/574
摘要： The current disclosure relates to methods and compositions for the treatment of cancers in a patient with a particular biomarker profile. Aspects of the disclosure relate to a method for evaluating a patient comprising measuring the level of expression in a biological sample from the patient of one or more of the listed biomarkers: FTO, METTL3, WTAP, ALKBH5, METTL14, YTHDF1, or YTHDF2. Further aspects of the disclosure relate to a method comprising measuring in a biological sample from a cancer patient the levels of expression of the following biomarkers FTO, METTL3, WTAP, ALKBH5, METTL14, YTHDF1 and YTHDF2.

8. 发明申请

WO2019178215A1 METHODS AND COMPOSITIONS FOR TREATING, PROGNOSING, AND DIAGNOSING ESOPHAGEAL CANCER 审中-公开
公开(公告)号：WO2019178215A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022033
申请日：2019-03-13
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , YAMAMURA, Kensuke
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
摘要： Methods and compositions are provided using the level of F. nucleatum in cancer patients. In certain embodiments, the levels of F. nucleatum are used to evaluate esophageal cancer patients and the risk of relapse.

9. 发明申请

WO2012128904A1 LONG INTERSPERSED NUCLEAR ELEMENTS (LINE-1) AND ALU HYPOMETHYLATION AS BIOMARKERS FOR COLORECTAL CANCER METASTASIS 审中-公开
标题翻译：长度相互影响的核素元素（LINE-1）和ALU HYPOMETHYLATION作为生物标记物进行色素沉积
公开(公告)号：WO2012128904A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/027145
申请日：2012-02-29
申请人： BAYLOR RESEARCH INSTITUTE , GOEL, Ajay , BOLAND, C., Richard , HUR, Keun
发明人： GOEL, Ajay , BOLAND, C., Richard , HUR, Keun
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： A method for determining a colorectal cancer metastasis in a human subject suffering from a primary colorectal cancer (CRC) is described herein. The method of the present invention comprises the steps of: i) identifying the human subject suffering from the primary CRC, ii) obtaining one or more biological samples from the human subject, iii) detecting a methylation level of Alu, LINE-1, or both in the one or more biological samples, and iv) increasing the level of the colorectal metastatic stage in the human subject when the methylation level of Alu, LINE-1 is lower compared to a corresponding control methylation level of Alu, LINE-l.
摘要翻译：本文描述了在患有原发性结肠直肠癌（CRC）的人类受试者中确定结肠直肠癌转移的方法。本发明的方法包括以下步骤：i）鉴定患有原发性CRC的人类受试者，ii）从人类受试者获得一种或多种生物样品，iii）检测Alu，LINE-1或在一个或多个生物样品中，以及iv）当Alu，LINE-1的甲基化水平与Alu，LINE-1的相应对照甲基化水平相比较时，增加人类受试者的结肠直肠转移期水平。

10. 发明申请

WO2012128902A1 CHANGES IN THE EXPRESSION OF MIR-200C/141 CLUSTER OF MICRORNAS AS BIOMARKERS FOR EPITHELIAL-TO-MESENCHYMAL TRANSITION IN HUMAN COLORECTAL CANCER METASTASIS 审中-公开
标题翻译： MIR-200C / 141微生物群落在人类癌细胞中的上皮转移到生物标志物的表达变化
公开(公告)号：WO2012128902A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/027131
申请日：2012-02-29
申请人： BAYLOR RESEARCH INSTITUTE , GOEL, Ajay , BOLAND, C., Richard , HUR, Keun
发明人： GOEL, Ajay , BOLAND, C., Richard , HUR, Keun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention includes methods, kits and biomarkers for detecting and determining the development of colorectal cancer (CRC) metastasis based on changes in the expression pattern of one or more microRNAs (miR) or miR clusters that include the miR-200/141 family.
摘要翻译：本发明包括用于基于包括miR-200/141家族的一个或多个微小RNA（miR）或miR簇的表达模式的变化来检测和确定结肠直肠癌（CRC）转移发展的方法，试剂盒和生物标志物。

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