基本信息:
- 专利标题: METHODS FOR DIAGNOSING AND TREATING COLORECTAL CANCER USING snoRNA
- 专利标题(中):使用snoRNA诊断和治疗彩色癌的方法
- 申请号:PCT/US2016/025857 申请日:2016-04-04
- 公开(公告)号:WO2016164303A1 公开(公告)日:2016-10-13
- 发明人: GOEL, Ajay , OKUGAWA, Yoshinaga , YOSHIDA, Kazuhiro
- 申请人: BAYLOR RESEARCH INSTITUTE
- 申请人地址: 3310 Live Oak Street, Suite 501 Dallas, TX 75204 US
- 专利权人: BAYLOR RESEARCH INSTITUTE
- 当前专利权人: BAYLOR RESEARCH INSTITUTE
- 当前专利权人地址: 3310 Live Oak Street, Suite 501 Dallas, TX 75204 US
- 代理机构: STELLMAN, Laurie
- 优先权: US62/308,724 20160315; US62/143,647 20150406
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; C12Q1/68
摘要:
The current disclosure relates to therapeutic treatments and diagnostic methods for colorectal cancer based on the expression level of snoRNA expression. Aspects of the current disclosure relate to a method for treating a patient for early or advanced colorectal cancer comprising: treating the patient for advanced colorectal cancer after the patient is determined to have a high elevated level of snoRNA expression in a biological sample from the patient; and treating the patient for early colorectal cancer after the patient is determined to have a low elevated level of snoRNA expression in a biological sample from the patient.
摘要(中):
目前的公开涉及基于snoRNA表达的表达水平的结肠直肠癌的治疗治疗和诊断方法。 本公开的方面涉及用于治疗早期或晚期结直肠癌患者的方法,其包括:在确定患者在来自患者的生物样品中具有高水平的snoRNA表达水平之后,对所述患者进行晚期结肠直肠癌治疗; 并且在确定患者在来自患者的生物样品中具有低水平的snoRNA表达水平之后,对患者进行早期结肠直肠癌治疗。