专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO02092776A3 METHODS FOR THE INDENTIFICATION OF INHIBITORS OF 2-HYDROXYISOFLAVONE REDUCTASE EXPRESSION OR ACTIVITY IN PLANTS 审中-公开
标题翻译： 2-羟基磷酸降解酶抑制剂在植物中的表达或活性的鉴定方法
公开(公告)号：WO02092776A3
公开(公告)日：2003-05-30
申请号：PCT/US0215554
申请日：2002-05-16
申请人： BAYER CROPSCIENCE AG , HOFFMAN NEIL , RICE JOHN , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , BOYES DOUGLAS , GORLACH JORN , WOESSNER JEFFREY , HAMILTON CAROL , PHILLIPS KENNETH
发明人： HOFFMAN NEIL , RICE JOHN , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , BOYES DOUGLAS , GORLACH JORN , WOESSNER JEFFREY , HAMILTON CAROL , PHILLIPS KENNETH
IPC分类号： A01N25/00 , C12Q1/26 , G01N33/53 , G01N33/567 , C12Q1/68 , A61K38/00 , C07H21/02 , C12P19/34
CPC分类号： C12Q1/26 , G01N2500/00
摘要： The present invention discloses that 2' hydroxiyisolflavone reductase (IFR) is essential for plant growth. Specifically, the inhibition of IFR gene expression in plant seedlings results in seedlings that fail to produce roots or leaves. Thus, IFR is a useful target for the identification of herbicides. Accordingly, the present invention provides compositions and methods for the identification of compounds that inhibit IFR expression or activity.
摘要翻译：本发明公开了2'羟基异黄酮酮还原酶（IFR）对植物生长至关重要。具体来说，植物幼苗中IFR基因表达的抑制导致不能产生根或叶的幼苗。因此，IFR是鉴定除草剂的有用目标。因此，本发明提供了用于鉴定抑制IFR表达或活性的化合物的组合物和方法。

2. 发明申请

WO2007100919A3 MARKERS FOR ADDICTION 审中-公开
标题翻译：添加标记
公开(公告)号：WO2007100919A3
公开(公告)日：2008-11-06
申请号：PCT/US2007005411
申请日：2007-03-01
申请人： PERLEGEN SCIENCES INC , BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
发明人： BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K49/0004 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/5088 , G01N33/6893 , G01N2500/00
摘要： Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
摘要翻译：提供多态性与成瘾之间的相关性。提供诊断，预后和治疗成瘾的方法。提供了用于诊断，预后和治疗成瘾的系统和试剂盒。还描述了识别成瘾调节剂的方法。

3. 发明申请

WO2007090032A3 RIBOSOMAL PROTEIN S6 AS A PHARMACODYNAMIC MARKER FOR HSP90 INHIBITION 审中-公开
标题翻译：核糖体蛋白S6作为HSP90抑制药物动力学标记物
公开(公告)号：WO2007090032A3
公开(公告)日：2007-11-01
申请号：PCT/US2007061060
申请日：2007-01-25
申请人： SERENEX INC , OTTO JAMES CRANDELL JR , FADDEN PATRICK , RICE JOHN
发明人： OTTO JAMES CRANDELL JR , FADDEN PATRICK , RICE JOHN
IPC分类号： G01N33/50
CPC分类号： G01N33/5011
摘要： The present invention provides methods for identifying inhibitors of heat shock protein 90 (Hsp90), for identifying clinical conditions responsive to Hsp90 inhibitors, and for monitoring clinical efficacy of Hsp90 inhibitors. Methods for identifying Hsp90 inhibitors comprise comparing the level of phosphorylation of ribosomal protein S6 (RPS6) in a sample contacted with a potential Hsp90 inhibitor to the level of phosphorylation of RPS6 in a control sample not exposed to the potential inhibitor. In some embodiments, a test cell is contacted with a putative Hsp90 inhibitor and the level of phosphorylation of RPS6 in the cell is compared to the level of phosphorylation of RPS6 in a control cell not exposed to the putative inhibitor, where a decrease in the level of phosphorylation of RPS6 in the contacted test cell is indicative of inhibition of Hsp90 activity. The invention further provides methods of predicting whether a subject with a tumor or other cellular proliferative disorder will respond to an agent that inhibits Hsp90 activity. Such predictions are based on a comparison of the levels of phosphorylation of RPS6 in test tumor cells or other abnormally proliferating cells contacted with the Hsp90 inhibitor to the level of phosphorylation of RPS6 in control cells not treated with the inhibitor, where a decrease in the level of phosphorylation of RPS6 in the test cells contacted with the Hsp90 inhibitor is predictive of a positive response to the Hsp90 inhibitor. The methods of the invention find use in monitoring clinical efficacy of Hsp90 inhibitors.
摘要翻译：本发明提供了用于鉴定热休克蛋白90（Hsp90）的抑制剂，用于鉴定对Hsp90抑制剂有响应的临床病症以及用于监测Hsp90抑制剂的临床功效的方法。鉴定Hsp90抑制剂的方法包括比较与潜在Hsp90抑制剂接触的样品中核糖体蛋白S6（RPS6）的磷酸化水平与未暴露于潜在抑制剂的对照样品中RPS6的磷酸化水平。在一些实施方案中，将测试细胞与推定的Hsp90抑制剂接触，并将细胞中RPS6的磷酸化水平与未暴露于推定抑制剂的对照细胞中RPS6的磷酸化水平进行比较，其中水平接触的测试细胞中RPS6的磷酸化指示Hsp90活性的抑制。本发明进一步提供了预测患有肿瘤或其他细胞增殖性病症的受试者是否会对抑制Hsp90活性的试剂起反应的方法。这样的预测是基于RPS6在测试肿瘤细胞或与Hsp90抑制剂接触的其他异常增殖细胞中的磷酸化水平与未用抑制剂处理的对照细胞中RPS6磷酸化水平的比较，其中水平降低在与Hsp90抑制剂接触的测试细胞中RPS6磷酸化可预测对Hsp90抑制剂的阳性反应。本发明的方法可用于监测Hsp90抑制剂的临床功效。

4. 发明申请

WO2007100919A8 MARKERS FOR ADDICTION 审中-公开
标题翻译：添加标记
公开(公告)号：WO2007100919A8
公开(公告)日：2007-11-22
申请号：PCT/US2007005411
申请日：2007-03-01
申请人： PERLEGEN SCIENCES INC , BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
发明人： BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K49/0004 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/5088 , G01N33/6893 , G01N2500/00
摘要： Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
摘要翻译：提供多态性与成瘾之间的相关性。提供诊断，预后和治疗成瘾的方法。提供了用于诊断，预后和治疗成瘾的系统和试剂盒。还描述了识别成瘾调节剂的方法。

5. 发明申请

WO2006044994A2 PRIMERS, PROBES AND METHODS FOR NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：用于核酸扩增的引物，探针和方法
公开(公告)号：WO2006044994A2
公开(公告)日：2006-04-27
申请号：PCT/US2005037667
申请日：2005-10-17
申请人： UNIV BRANDEIS , WANGH LAWRENCE J , RICE JOHN , SANCHEZ AQUILES J , PIERCE KENNETH , SALK JESSE , REIS ARTHUR
发明人： WANGH LAWRENCE J , RICE JOHN , SANCHEZ AQUILES J , PIERCE KENNETH , SALK JESSE , REIS ARTHUR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6844 , C12Q1/6851 , C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2545/114 , C12Q2531/107 , C12Q2527/107 , C12Q2561/113
摘要： Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit "single-tube" processing.
摘要翻译：使用荧光DNA染料和间接可激发标记的引物和探针进行PCR扩增或优化LATE-PCR之后或之后的均质检测，提高了重现性和定量。在非对称PCR扩增期间或之后的低温均相检测，优选LATE-PCR，利用荧光DNA染料和间接可激发标记的错配耐受性探针允许分析复杂的靶标。 LATE-PCR扩增后的测序样品制备方法降低了复杂性并允许“单管”处理。

6. 发明申请

WO9830141A3 DEVICES FOR TISSUE REPAIR AND METHODS FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：用于组织修复的装置及其制备和使用方法
公开(公告)号：WO9830141A3
公开(公告)日：1998-11-26
申请号：PCT/US9800414
申请日：1998-01-08
申请人： COHESION TECH INC , CHU GEORGE H , YEUNG JEFFREY E , CASSIDY JAMES J , SCHROEDER JACQUELINE A , BROWN MELISSA K C , SHENOY VIVEK N , RICE JOHN
发明人： CHU GEORGE H , YEUNG JEFFREY E , CASSIDY JAMES J , SCHROEDER JACQUELINE A , BROWN MELISSA K C , SHENOY VIVEK N , RICE JOHN
IPC分类号： A61F2/00 , A61F2/08 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/04 , A61L31/12 , B29C47/70 , A61B1/07
CPC分类号： B29C47/702 , A61B17/0401 , A61B2017/00526 , A61B2017/00898 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0445 , A61F2/0811 , A61F2310/00365 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/044 , A61L31/127 , A61L31/129 , A61L2430/02 , B29C47/0023 , B29C47/003 , C08L89/06
摘要： Disclosed herein are uniformly shaped swellable devices comprising polymeric materials, as well as apparatuses and processes for their manufacture. In one embodiment, the present invention relates to load bearing implant devices for use in tissue repair. The implants consist of a resorbable, swellable implant body which is formed from a dehydrated cross-linked biocompatible polymer. As such, the implants are capable of swelling after insertion to become anchored in place. The implants function to enhance the structural integrity of the hard tissue into which they are placed, and thereby improve the load bearing capacity of such tissues. The implants are particularly well suited for use in attaching a second (hard or soft) tissue to the first (hard) tissue into which the implant is inserted. They may also be used as a site for attachment of a surgical device such as a screw, rod or pin.

7. 发明申请

WO2012064978A2 COMPOSITIONS, METHODS, AND KITS FOR DETECTING AND IDENTIFYING MYCOBACTERIA 审中-公开
标题翻译：用于检测和鉴定杆状病毒的组合物，方法和试剂盒
公开(公告)号：WO2012064978A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060224
申请日：2011-11-10
申请人： UNIV BRANDEIS , WANGH LAWRENCE J , RICE JOHN
发明人： WANGH LAWRENCE J , RICE JOHN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/689 , C12Q2600/106 , C12Q2600/16 , C12Q2527/107 , C12Q2537/101 , C12Q2537/143
摘要： Provided herein are methods for detecting and identifying strains of mycobacteria, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided for the detection and differentiation of mycobacteria based on, for example, pathogenicity, species, and antibiotic resistance or sensitivity. Compositions and methods are provided herein to identify and differentiate mycobacteria in mixtures of different mycobacteria and mycobacteria and non-mycobacteria.
摘要翻译：本文提供了用于检测和鉴定分枝杆菌菌株的方法，以及用于执行此类方法的组合物和试剂盒。具体而言，基于例如致病性，物种和抗生素抗性或敏感性，提供用于检测和分化分枝杆菌的核酸扩增和荧光检测方法。本文提供组合物和方法以鉴别和区分不同分枝杆菌和分枝杆菌和非分枝杆菌混合物中的分枝杆菌。

8. 发明申请

WO2006084367A3 BRACKET AND BRIDGING MEMBER FOR METAL STUD WALL 审中-公开
标题翻译：金属墙壁支架和桥梁构件
公开(公告)号：WO2006084367A3
公开(公告)日：2006-09-28
申请号：PCT/CA2006000188
申请日：2006-02-13
申请人： BAILEY METAL PRODUCTS LTD , RICE JOHN
发明人： RICE JOHN
IPC分类号： E04B2/00 , E04B1/38 , E04B2/58 , E04C5/18
CPC分类号： E04B2/763 , E04B2/7457
摘要： A bracket for use in a metal stud wall having internal bridging members for tying the metal studs and bridging members together. The bracket comprises an L shaped bracket having a leg for overlying the bridging member joined to an upright for overlying the metal stud. The outside corners of the leg and upright of the L shaped bracket are truncated so that the bracket may be inserted within the channel of a metal stud and rotated to the proper position for attaching to the bridging member and metal stud. In an aspect of the invention, the bridging member being provided with openings at regular intervals along its length thereof to aid in spacing of the studs in the metal stud partition wall. The bracket is provided with a downwardly extending tab at the junction of the leg and the upright sized to fit within an opening of the bridging member.
摘要翻译：用于金属螺柱壁的支架，其具有用于将金属螺柱和桥接构件捆绑在一起的内部桥接构件。支架包括一个L形支架，该支架具有用于覆盖桥接构件的腿部，该桥接构件连接到用于覆盖金属支柱的立柱上。腿部的外角和L形支架的直立部分被截断，使得支架可以插入金属螺柱的通道内并且旋转到适当的位置以附接到桥接构件和金属螺柱。在本发明的一个方面，桥接构件沿着其长度设置有规则间隔的开口，以有助于螺柱在金属螺柱分隔壁中的间隔。支架在腿部和立柱的接合部处设置有向下延伸的突出部，其尺寸适于配合在桥接构件的开口内。

9. 发明申请

WO03104483A2 METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF MODULATORS OF DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE ACTIVITY 审中-公开
标题翻译：去氧霉素5-磷酸酯合成酶活性调节剂的鉴定方法和组合
公开(公告)号：WO03104483A2
公开(公告)日：2003-12-18
申请号：PCT/US0124993
申请日：2001-08-09
申请人： PARADIGM GENETICS INC , RICE JOHN , KLOTI ANDREAS S , CRAWFORD JOHN , LANNING BETH , STEWART SANDY
发明人： RICE JOHN , KLOTI ANDREAS S , CRAWFORD JOHN , LANNING BETH , STEWART SANDY
IPC分类号： C12N1/21 , C12Q1/25 , C12Q1/00
CPC分类号： C12Q1/25
摘要： The invention is directed to methods and compositions for the determination of deoxyxylulose 5-phosphate synthase (DXPS) activity. The methods and compositions of the invention are amenable to high throughput screening assays for the identification of inhibitors and enhancers of DXPS activity. Such compounds have use in the modulation of plant and microbial growth. The compositions of the invention are DXPS fragments and chimeric polypeptides that have increased solubility as compared to the wild type DXPS polypeptide. These DXPS fragments and chimeric polypeptides, or variants thereof, can be recombinantly expressed and purified in quantities suitable for high throughput screening assays. The assays of the invention are based on the detection of substrates of DXPS that remain after a DXPS reaction.
摘要翻译：本发明涉及用于测定脱氧纤维素-5-磷酸合成酶（DXPS）活性的方法和组合物。本发明的方法和组合物适于用于鉴定DXPS活性的抑制剂和增强剂的高通量筛选测定。这些化合物可用于植物和微生物生长的调节。本发明的组合物是与野生型DXPS多肽相比具有增加的溶解度的DXPS片段和嵌合多肽。这些DXPS片段和嵌合多肽或其变体可以以适于高通量筛选测定的量重组表达和纯化。本发明的测定是基于在DXPS反应后残留的DXPS底物的检测。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式