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1. 发明申请

WO1995020984A3 VENTRICULAR ASSIST DEVICE WITH VALVED BLOOD CONDUIT AND METHOD OF MAKING 审中-公开
公开(公告)号：WO1995020984A3
公开(公告)日：1995-08-10
申请号：PCT/US1995001596
申请日：1995-02-06
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , WOODARD, John, C. , GREENBERG, Sheldon, I. , NESS, Ronald, A. , ROMLEY, Ronald, M. , NGUYEN, Than , CHEN, Herbert
IPC分类号： A61M01/10

2. 发明申请

WO1991014408A1 MECHANICAL HEART VALVE WITH COMPLIANT SEWING RING 审中-公开
标题翻译：机械式心脏瓣膜配合缝合环
公开(公告)号：WO1991014408A1
公开(公告)日：1991-10-03
申请号：PCT/US1991002033
申请日：1991-03-26
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , WIETING, David, W. , NGUYEN, Than , STOBIE, Robert , LAM, Hung, L. , KAFESJIAN, Ralph
IPC分类号： A61F02/24
CPC分类号： A61F2/2409
摘要： A mechanical heart valve (11) having one or more leaflets (17) pivotally fitted in a substantially cylindrical shaped valve body (19) formed from a resiliently deformable material. A stiffening member (25) formed from substantially nonresilient material fit about the valve body exterior wall to provide structural integrity to the valve body (19). Stresses which are normally applied to the heart valve body during the opening and closing of the valve are absorbed or cushioned by the incorporation of a rubber-like body (26) between the stiffening member (25) and the retainer member (33). Further cushioning is provided by incorporating another rubber-like body (28) in the sewing ring (13). This second body extends out from the exterior surface of the valve body. Finally, a length of fabric (15) is positioned about the retainer (33) and shock absorbing bodies (26). This design provides a precisely calibrated rotational torque which allows for optimum orientation of the leaflets by the implanting surgeon.

3. 发明申请

WO1995001419A1 MICROVESSEL CELL ISOLATION METHOD AND APPARATUS 审中-公开
标题翻译： MICROVESSEL细胞分离方法和装置
公开(公告)号：WO1995001419A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007503
申请日：1994-07-01
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , HU, Can, B. , MA, Minh, T. , NGUYEN, Than , RHEE, Richard , MYERS, Keith
IPC分类号： C12M03/00
CPC分类号： C12M45/09 , A61F2/062 , A61M2202/08 , A61M2202/097 , C12M45/05 , A61M2230/005 , A61M2202/0071
摘要： A processing vessel for isolating microvessel endothelial cells from liposuctioned fat tissues includes a fat-receiving basket defined by polyester screen material. Fat tissue removed from a patient by liposuction is received into the basket and is rinsed and digested with an enzymatic solution. The freed microvessel endothelial cells from the fat tissues are separated from the fat cells, and from blood cells and other materials which may be present in the basket by centrifuging. A bottom chamber of the processing vessel is configured to define a "pellet" of isolated endothelial cells which may be removed from the processing vessel for deposition on the inner lumenal surface of a synthetic graft which the fat-donor patient is to receive.
摘要翻译：用于从脂肪抽吸的脂肪组织分离微血管内皮细胞的处理容器包括由聚酯筛网材料限定的脂肪接收篮。通过吸脂从患者中取出的脂肪组织被接收到篮中并用酶溶液冲洗和消化。来自脂肪组织的释放的微血管内皮细胞从脂肪细胞以及血细胞和其它可能通过离心存在于筐中的物质中分离出来。处理容器的底部室被配置为限定分离的内皮细胞的“沉淀”，其可以从处理容器中移除，以沉积在供体患者将要接收的合成移植物的内腔表面上。

4. 发明申请

WO1993002640A1 FLEXIBLE SUTURE GUIDE AND HOLDER 审中-公开
标题翻译：柔性指南和支架
公开(公告)号：WO1993002640A1
公开(公告)日：1993-02-18
申请号：PCT/US1992006312
申请日：1992-07-30
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , COSGROVE, Delos, M. , NGUYEN, Than
IPC分类号： A61F02/24
CPC分类号： A61F2/2448 , A61B17/0482 , A61B17/11 , A61B50/20 , A61F2/2466
摘要： An assembly (12) for holding a substantially flexible suture guide (10) of predetermined length in a substantially taut position used to achieve a suture line having a dimension equal to the length of the suture guide (10), such as the circumference about a heart valve annulus. The assembly (12) includes a rigid suture guide holder (20) having a surface against which the length of suture guide (10) is releasably positioned. The guide holder (20) can have a shape or geometry, such as a circumference or circumferential segment, equivalent to the shape or geometry of the intended suture line. The shape of the guide holder (20) can therefore be selected to hold the suture guide (10) in the shape most advantageous to placing the desired suture line. The assembly (12) further includes a mechanism (39, 48, 49) for releasably binding the suture guide (10) to the surface of the holder (20) and a detachable handle (40) extendibly attached to the holder (20) by means of a lanyard (100) so that the handle (42) can be detached to afford an unobstructed view of the surgical site, but cannot be removed from the surgical site until the holder (20) has also been removed.
摘要翻译：一种用于将基本上柔性的缝合线引导件（10）保持在基本上紧紧的位置，用于实现具有等于缝合线引导件（10）的长度的尺寸的缝合线的组件（12），例如围绕心脏瓣膜环。组件（12）包括刚性缝合线引导保持器（20），其具有可释放地定位缝合线引导件（10）的长度的表面。引导保持器（20）可以具有等同于预期缝合线的形状或几何形状的形状或几何形状，例如圆周或周向段。因此，可以选择引导保持器（20）的形状以将缝线引导件（10）保持为最有利于放置所需缝合线的形状。组件（12）还包括用于将缝合线引导件（10）可释放地装配到保持器（20）的表面的机构（39,48,49），以及可拆卸的手柄（40），其通过挂绳（100）的装置，使得手柄（42）可以被拆卸以提供手术部位的无障碍视图，但是在保持器（20）也被移除之前不能从外科手术部位移除。

5. 发明申请

WO1992019199A1 METHOD AND DEVICE FOR TESTING VENOUS VALVES 审中-公开
标题翻译：用于测试VENOUS阀的方法和装置
公开(公告)号：WO1992019199A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003353
申请日：1992-04-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NGUYEN, Than , NASHEF, Aws , ABOLFATHI, Amir, H. , WIETING, David, H. , LEE, Denis
IPC分类号： A61F20/24
CPC分类号： A61F2/2472 , A61B2017/00707
摘要： A method and device for testing artificial or natural venous valves. The device comprises chamber (10), a sample for mounting a test valve (V) on a liquid flow path and a muscle pump component (16) and/or respiratory pump component (50) and/or capacitance reservoir (58) and/or vertical hydrostatic column component (102) fluidly connected to the flow path to mimic the muscle pump, respiratory pump, capacitance and hydrostatic impedance effects on venous circulation in the mammalian body. Included in the invention are methods of testing venous valves by mimicking known hemodynamic flow conditions within a mammalian body.

6. 发明申请

WO1991001697A1 FLEXIBLE ANNULOPLASTY RING AND HOLDER 审中-公开
标题翻译：灵活的手术环和保持架
公开(公告)号：WO1991001697A1
公开(公告)日：1991-02-21
申请号：PCT/US1990004132
申请日：1990-07-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , COSGROVE, Delos, M. , NGUYEN, Than
IPC分类号： A61F02/24
CPC分类号： A61F2/2448 , A61B50/20 , A61B90/00 , A61F2/2466
摘要： An assembly for holding a substantially flexible lenticular shaped annuloplasty ring in a substantially taunt position for suturing about a valve annulus. The assembly includes a portion which is formed with a surface against which the annuloplasty ring is positioned and held in a shape substantially equivalent to at least a portion of the valve annulus. The assembly further includes a mechanism for releasably binding the annuloplasty ring to this surface.
摘要翻译：用于将基本上柔性的透镜状环形成形术环保持在基本上ta unt位置以用于缝合围绕瓣膜环的组件。组件包括形成有表面的部分，瓣环成形术环被定位在该表面上并保持在基本上等同于瓣膜环的至少一部分的形状。组件还包括用于将瓣膜成形术环可释放地结合到该表面的机构。

7. 发明申请

WO1996024307A1 METHOD AND APPARATUS FOR SODDING MICROVESSEL CELLS ONTO A SYNTHETIC VASCULAR GRAFT 审中-公开
标题翻译：用于将微血管细胞切割成合成血管细胞的方法和装置
公开(公告)号：WO1996024307A1
公开(公告)日：1996-08-15
申请号：PCT/US1996001367
申请日：1996-02-01
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , HU, Can, B. , MA, Minh, T. , NGUYEN, Than , RHEE, Richard , MYERS, Keith
IPC分类号： A61F02/06
CPC分类号： A61F2/062 , A61L27/507 , Y10S623/921
摘要： An apparatus for sodding onto the inner lumenal surface of a synthetic graft of harvested and concentrated microvessel endothelial cells from liposuctioned fat tissues, which harvested cells are formed into a "pellet" of isolated endothelial cells in loose aggregations, includes a sodding tube having a single rigid outer wall bounding a sodding chamber. A filter pack assembly is provided to communicate the pellet of cells from a processing vessel to the graft. This filter pack assembly includes a series of successively finer filter members cooperatively defining a series of turbulent-flow chambers in which aggregations of cells too large to pass through a particular filter are exposed to liquid flow turbulence which is effective to break up the aggregations. A check valve assembly ensures that liquid flow is unidirectional so that sodding of the cells onto the inner lumenal surface of the graft is not interfered with by possible liquid reflux, and sodded cells are similarly not dislodged from the graft by such liquid reflux.
摘要翻译：将收集的细胞收集和浓缩的微血管内皮细胞的合成移植物的内腔表面上的沉淀物形成为松散聚集的分离的内皮细胞的“沉淀”的装置，包括具有单个刚性外墙围住了一个饮料室。提供过滤器组件以将细胞团从处理容器传递到移植物。该过滤器组件包括一系列相继更细的过滤器构件，其协作地限定一系列湍流室，其中太大而不能通过特定过滤器的单元的聚集物暴露于有效破坏聚集的液体流动湍流。止回阀组件确保液体流动是单向的，使得细胞在移植物的内腔表面上的唾液分解不会被可能的液体回流干扰，并且经过这种液体回流的同样，细胞也不会从移植物移出。

8. 发明申请

WO1990009153A1 SELECTIVELY FLEXIBLE ANNULOPLASTY RING 审中-公开
标题翻译：选择灵活的ANNULOPLASTY环
公开(公告)号：WO1990009153A1
公开(公告)日：1990-08-23
申请号：PCT/US1990000641
申请日：1990-02-01
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , LAM, Hung, L. , NGUYEN, Than , CARPENTIER, Alain
IPC分类号： A61F02/24
CPC分类号： A61F2/2448 , A61F2250/0018
摘要： An annuloplasty ring prosthesis (10) which is formed from a selectively flexible body element (14) having at least one defined length (16) about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element (14) is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element (14) is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material (20) through which sutures can be drawn to suture the prosthesis to the heart valve annulus.
摘要翻译：一种瓣膜成形术假体（10），其由选择性柔性体元件（14）形成，所述弹性体元件围绕其圆周具有至少一个限定的长度（16），其基本上是刚性的。身体元素的其余部分的灵活性逐渐增加。身体元件（14）是被设计成被缝合到心脏瓣膜的环的基本环形的主体元件。身体元件（14）由非腐蚀性的抗磁性材料形成，并且被包裹在材料（20）中，缝合线可通过该材料（20）被缝合以将假体缝合到心脏瓣膜环。

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