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1. 发明申请

WO03049765A2 ENVELOPED VIRUS VACCINE AND METHOD FOR PRODUCTION 审中-公开
标题翻译：发展中的病毒疫苗和生产方法
公开(公告)号：WO03049765A2
公开(公告)日：2003-06-19
申请号：PCT/EP0214009
申请日：2002-12-10
申请人： BAXTER HEALTHCARE SA , KISTNER OTFIRED , REITER MANFRED , BRUEHMANN AXEL , BARRETT NOEL , MUNDT WOLFGANG , DORNER FRIEDRICH
发明人： KISTNER OTFIRED , REITER MANFRED , BRUEHMANN AXEL , BARRETT NOEL , MUNDT WOLFGANG , DORNER FRIEDRICH
IPC分类号： A61K39/12 , C12N7/01 , C12N7/02 , C12N7/00
CPC分类号： A61K39/12 , A61K39/42 , A61K2039/5252 , A61K2039/55505 , C07K16/1081 , C12N7/00 , C12N2770/36051 , C12N2770/36134 , C12N2770/36151
摘要： The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus RRV antigens, and vaccines comprising purified, inactived Ross River Virus RRV antigen.
摘要翻译：本发明提供了纯化的包膜病毒抗原的生产方法。特别地，它提供了纯化的罗斯河病毒RRV抗原和包含纯化的，灭活的罗斯河病毒RRV抗原的疫苗。

2. 发明申请

WO03049767A2 METHOD OF LARGE SCALE PRODUCTION OF HEPATITIS A VIRUS 审中-公开
标题翻译：大规模生产乙型肝炎病毒的方法
公开(公告)号：WO03049767A2
公开(公告)日：2003-06-19
申请号：PCT/EP0214012
申请日：2002-12-10
申请人： BAXTER HEALTHCARE SA , MEYER HEIDI , REITER MANFRED , MUNDT WOLFGANG , BARRETT NOEL , DORNER FRIEDRICH
发明人： MEYER HEIDI , REITER MANFRED , MUNDT WOLFGANG , BARRETT NOEL , DORNER FRIEDRICH
IPC分类号： A61K39/29 , C12N5/06 , C12N7/01 , C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K2039/5252 , C12N2770/32434 , C12N2770/32451
摘要： The present invention provides methods of large scale production of Hepatitis A Virus (HAV) on VERO cells bound to microcarrier. The invention also provides for methods of isolation of HAV from the cell culture supernatant of HAV infected VERO cells.
摘要翻译：本发明提供了在与微载体结合的VERO细胞上大规模生产甲型肝炎病毒（HAV）的方法。本发明还提供从HAV感染的VERO细胞的细胞培养物上清液中分离HAV的方法。

3. 发明申请

WO03050275A8 METHOD OF ISOLATION AND PURIFICATION OF TRYPSIN FROM PRONASE AND USE THEREOF 审中-公开
标题翻译：从PRONASE分离和纯化TRYPSIN的方法及其用途
公开(公告)号：WO03050275A8
公开(公告)日：2004-05-21
申请号：PCT/EP0214005
申请日：2002-12-10
申请人： BAXTER HEALTHCARE SA , MITTERER ARTUR , TAUER CHRISTA , REITER MANFRED , MUNDT WOLFGANG
发明人： MITTERER ARTUR , TAUER CHRISTA , REITER MANFRED , MUNDT WOLFGANG
IPC分类号： C12N5/06 , C12N7/00 , C12N7/01 , C12N7/02 , C12N9/76 , C12P21/02 , C12R1/465 , C07K1/22
CPC分类号： C12N9/6427 , C07K14/36 , C12N7/00 , C12N2760/16051 , C12N2760/16151 , C12N2770/32451
摘要： The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from pronase in a single affinity chromatography step and uses of the purified SGT.
摘要翻译：本发明提供了在单一亲和色谱步骤中从链霉蛋白酶分离和纯化灰色链霉菌胰蛋白酶（SGT）的方法以及纯化的SGT的用途。

4. 发明申请

WO2009137146A9 METHOD FOR PRODUCING CONTINUOUS CELL LINES 审中-公开
标题翻译：生产连续细胞系的方法
公开(公告)号：WO2009137146A9
公开(公告)日：2010-01-14
申请号：PCT/US2009034732
申请日：2009-02-20
申请人： BAXTER INT , BAXTER HEALTHCARE SA , REITER MANFRED , MUNDT WOLFGANG , FEIGL SIMONE , VON FIRCKS SIMONE
发明人： REITER MANFRED , MUNDT WOLFGANG , FEIGL SIMONE , VON FIRCKS SIMONE
IPC分类号： C12N5/00
CPC分类号： C12N5/0603 , C12N7/00 , C12N15/01 , C12N2510/04 , C12N2710/24151 , C12N2760/16051 , C12N2760/16151 , C12N2770/24151 , C12R1/91
摘要： The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
摘要翻译：本发明涉及一种生产连续细胞系的方法，包括提供动物或人的活细胞，用紫外线照射所述细胞，增殖所述细胞并选择倍增细胞作为连续细胞系的细胞。

5. 发明申请

WO2008135229A2 FORMULATION OF SUGAR SOLUTIONS FOR CONTINUOUS ULTRACENTRIFUGATION FOR VIRUS PURIFICATION 审中-公开
标题翻译：用于连续超声造影用于病毒纯化的糖溶液的配方
公开(公告)号：WO2008135229A2
公开(公告)日：2008-11-13
申请号：PCT/EP2008003531
申请日：2008-04-30
申请人： BAXTER INT , BAXTER HEALTHCARE SA , REITER MANFRED , GRILLBERGER LEOPOLD , MUNDT WOLFGANG , MITTERER ARTUR , SCHAFHAUSER HORST
发明人： REITER MANFRED , GRILLBERGER LEOPOLD , MUNDT WOLFGANG , MITTERER ARTUR , SCHAFHAUSER HORST
IPC分类号： C07K14/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , C12N2750/14351 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/16234 , C12N2760/16251 , C12N2760/16252
摘要： The present invention provides a method for purification of a virus or virus antigen comprising providing a virus preparation and centrifugation of said virus preparation in a gradient of a sugar established by the addition of two or more buffered sugar layers of different concentration. The method leads to higher yields and reduces unwanted aggregation of the virus or virus antigen by increasing the volume of the peak pool.
摘要翻译：本发明提供了一种病毒或病毒抗原的纯化方法，包括提供病毒制剂，并通过加入两种或多种不同浓度的缓冲糖层确定的糖的梯度离心所述病毒制剂。该方法导致更高的产量，并通过增加峰池的体积来减少病毒或病毒抗原的不想要的聚集。

6. 发明申请

WO03050275A2 METHOD OF ISOLATION AND PURIFICATION OF TRYPSIN FROM PRONASE AND USE THEREOF 审中-公开
标题翻译：从PRONASE分离和纯化TRYPSIN的方法及其用途
公开(公告)号：WO03050275A2
公开(公告)日：2003-06-19
申请号：PCT/EP0214005
申请日：2002-12-10
申请人： BAXTER HEALTHCARE SA , MITTERER ARTUR , TAUER CHRISTA , REITER MANFRED , MUNDT WOLFGANG
发明人： MITTERER ARTUR , TAUER CHRISTA , REITER MANFRED , MUNDT WOLFGANG
IPC分类号： C12N5/06 , C12N7/00 , C12N7/01 , C12N7/02 , C12N9/76 , C12P21/02 , C12R1/465 , C12N9/00
CPC分类号： C12N9/6427 , C07K14/36 , C12N7/00 , C12N2760/16051 , C12N2760/16151 , C12N2770/32451
摘要： The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from pronase in a single affinity chromatography step and uses of the purified SGT.
摘要翻译：本发明提供了在单一亲和色谱步骤中从链霉蛋白酶分离和纯化灰色链霉菌胰蛋白酶（SGT）的方法以及纯化的SGT的用途。

7. 发明申请

WO2009137146A3 METHOD FOR PRODUCING CONTINUOUS CELL LINES 审中-公开
标题翻译：生产连续细胞系的方法
公开(公告)号：WO2009137146A3
公开(公告)日：2010-03-25
申请号：PCT/US2009034732
申请日：2009-02-20
申请人： BAXTER INT , BAXTER HEALTHCARE SA , REITER MANFRED , MUNDT WOLFGANG , FEIGL SIMONE , VON FIRCKS SIMONE
发明人： REITER MANFRED , MUNDT WOLFGANG , FEIGL SIMONE , VON FIRCKS SIMONE
IPC分类号： C12N15/01 , C12N15/85
CPC分类号： C12N5/0603 , C12N7/00 , C12N15/01 , C12N2510/04 , C12N2710/24151 , C12N2760/16051 , C12N2760/16151 , C12N2770/24151 , C12R1/91
摘要： The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
摘要翻译：本发明涉及生产连续细胞系的方法，其包括提供动物或人的活细胞，用UV光照射所述细胞，使所述细胞增殖并选择倍增细胞作为连续细胞系的细胞。

8. 发明申请

WO2007077217A3 OLIGOPEPTIDE-FREE CELL CULTURE MEDIA 审中-公开
标题翻译：无细胞免疫细胞培养基
公开(公告)号：WO2007077217A3
公开(公告)日：2007-11-08
申请号：PCT/EP2007000027
申请日：2007-01-03
申请人： BAXTER INT , BAXTER HEALTHCARE SA , GRILLBERGER LEOPOLD , REITER MANFRED , MUNDT WOLFGANG , MITTERER ARTUR
发明人： GRILLBERGER LEOPOLD , REITER MANFRED , MUNDT WOLFGANG , MITTERER ARTUR
IPC分类号： C12N5/00
CPC分类号： C07K14/755 , C12N5/0018 , C12N5/005 , C12N7/00 , C12N2500/05 , C12N2500/10 , C12N2500/20 , C12N2500/24 , C12N2500/32 , C12N2500/38 , C12N2500/46 , C12N2500/50 , C12N2710/24151
摘要： The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine. The invention also relates to methods for expressing at least one protein in a medium comprising at least 0.5 mg/L of a polyamine and to methods for producing at least one virus in a medium comprising at least 0.5 mg/L of a polyamine.
摘要翻译：本发明涉及包含至少0.5mg / L多胺的无寡肽的细胞培养基和用于在包含至少0.5mg / L多胺的所述不含寡肽的细胞培养基中培养细胞的方法。本发明还涉及用于在包含至少0.5mg / L多胺的培养基中表达至少一种蛋白质的方法以及在包含至少0.5mg / L多胺的培养基中产生至少一种病毒的方法。

9. 发明申请

WO2011012725A8 METHOD OF PRODUCING A POLYPEPTIDE OR VIRUS OF INTEREST IN A CONTINUOUS CELL CULTURE 审中-公开
标题翻译：在连续细胞培养中产生多肽或病毒的方法
公开(公告)号：WO2011012725A8
公开(公告)日：2011-05-05
申请号：PCT/EP2010061191
申请日：2010-08-02
申请人： BAXTER HEALTHCARE SA , BAXTER INT , GRILLBERGER LEOPOLD , REITER MANFRED , FLEISCHHANDERL DANIEL
发明人： GRILLBERGER LEOPOLD , REITER MANFRED , FLEISCHHANDERL DANIEL
IPC分类号： C12M3/00 , C12N5/00
CPC分类号： C12N7/00 , C12N9/6489 , C12N2710/00052 , C12P21/02 , Y02P20/52
摘要： Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to improve the culturing of mammalian cells, e.g., genetically modified cells, particularly in serum-free or chemically-defined media. The continuous culture system described herein involves culturing mammalian cells in a continuous cell culture system, which comprises a cell retention device, wherein the cell culture system has a dilution rate (D) of less than about 2 d-1, and a cell density of less than about 2X107 cell/mL. Also described herein is a method for producing a polypeptide and/or virus of interest in a continuous cell culture, the method comprising culturing mammalian cells expressing the polypeptide and/or virus of interest in a continuous cell culture system, which comprises a cell retention device, wherein the cell culture system has a dilution rate (D) of less than about 2 d-1, and a cell density of less than about 2X107 cell/mL; and recovering the polypeptide and/or virus of interest from medium of the cell culture system.
摘要翻译：本文描述了一种恒化器样连续细胞培养系统，其组合了灌注开放系统和恒化器开放系统的某些优点，以改善哺乳动物细胞例如遗传修饰细胞的培养，特别是在无血清或化学成分确定的培养基中。本文所述的连续培养系统包括在包含细胞保留装置的连续细胞培养系统中培养哺乳动物细胞，其中所述细胞培养系统具有小于约2d-1的稀释率（D），和细胞密度小于约2×10 7个细胞/ mL。本文还描述了用于在连续细胞培养物中产生感兴趣的多肽和/或病毒的方法，所述方法包括在连续细胞培养系统中培养表达感兴趣的多肽和/或病毒的哺乳动物细胞，其包含细胞保留装置其中所述细胞培养系统具有小于约2d-1的稀释率（D）和小于约2×10 7个细胞/ mL的细胞密度; 并从细胞培养系统的培养基中回收感兴趣的多肽和/或病毒。

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