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1. 发明申请

WO2008005752A2 MODIFICATION OF SURFACES OF POLYMERIC ARTICLES BY MICHAEL ADDITION REACTION 审中-公开
标题翻译：通过MICHAEL添加反应改性聚合物的表面
公开(公告)号：WO2008005752A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072119
申请日：2007-06-26
申请人： BAUSCH & LOMB INCORPORATED , SALAMONE, Joseph, C. , YAN, Wenyan , LAI, Yu-chin , LANG, Weihong
发明人： SALAMONE, Joseph, C. , YAN, Wenyan , LAI, Yu-chin , LANG, Weihong
IPC分类号： G02B1/04 , A61L31/10
CPC分类号： G02B1/043 , A61L27/34 , A61L2400/18 , C08L39/06
摘要： A medical device having an increased surface hydrophilicity comprises a coating polymer comprising units of a polymerizable hydrophilic compound that is attached to the surface of the medical device via the Michael addition reaction. The coating polymer can be applied to a medical device comprising a hydrogel material. The attachment of the coating polymer may be enhanced by increasing the population of the medical-device surface functional groups before contacting the medical device with the coating polymer.
摘要翻译：具有增加的表面亲水性的医疗装置包括涂覆聚合物，其包含通过迈克尔加成反应附着到医疗装置的表面上的可聚合亲水性化合物的单元。涂层聚合物可以应用于包含水凝胶材料的医疗装置。涂层聚合物的附着可以通过在接触医疗器械与涂层聚合物之前增加医疗器械表面官能团的数量来增强。

2. 发明申请

WO2009079245A2 BIOMEDICAL DEVICES 审中-公开
标题翻译：生物医学设备
公开(公告)号：WO2009079245A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/085792
申请日：2008-12-08
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong
发明人： LAI, Yu-chin , LANG, Weihong
IPC分类号： C08F220/22 , G02B1/04 , C08F220/08 , C08F220/26
CPC分类号： C08F220/22 , C08F220/18 , C08F220/26 , C08F226/10 , C08F230/08 , G02B1/043 , Y10S524/916
摘要： Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine- containing monomers; and (b) a biomedical device-forming comonomer.
摘要翻译：本文提供了由混合物的聚合产物形成的生物医学装置，所述混合物包含（a）一种或多种可聚合多元醇与一种或多种可聚合含氟单体的反应产物的共聚物; 和（b）生物医学装置形成共聚单体。

3. 发明申请

WO2009005954A3 NOVEL POLYMERIZABLE SURFACE ACTIVE MONOMERS WITH BOTH FLUORINE-CONTAINING GROUPS AND HYDROPHILIC GROUPS 审中-公开
公开(公告)号：WO2009005954A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/066279
申请日：2008-06-09
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong
发明人： LAI, Yu-chin , LANG, Weihong
IPC分类号： C07C69/65 , C08F30/08 , G02B1/04
摘要： Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having polymerizable functionality that is complimentary to polymerizable hydrophilic polymers.

4. 发明申请

WO2009045886A1 NOVEL POLYMERIZABLE SURFACE ACTIVE MONOMERS WITH BOTH FLUORINE-CONTAINING GROUPS AND HYDROPHILIC GROUPS 审中-公开
标题翻译：新型可聚合表面活性单体，含有两个含氟基团和疏水基团
公开(公告)号：WO2009045886A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/077825
申请日：2008-09-26
申请人： BAUSCH & LOMB INCORPORATED , LANG, Weihong , LAI, Yu-chin
发明人： LANG, Weihong , LAI, Yu-chin
IPC分类号： C07C67/08 , C07C227/02 , C07C229/12 , C08F290/06 , C08F290/14 , G02B1/04
CPC分类号： C08F290/067 , C07C219/08 , C08F290/147 , G02B1/043 , C08L43/04 , C08L33/14
摘要： Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.
摘要翻译：提供由具有与表面改性聚合物互补的反应性官能团的一种或多种富马酸或含衣康酸的预聚物形成的表面改性隐形眼镜。

5. 发明申请

WO2008005753A2 HYDROPHILIC MACROMONOMERS HAVING α, β -CONJUGATED CARBOXYLIC TERMINAL GROUP AND MEDICAL DEVICES INCORPORATING SAME 审中-公开
标题翻译：具有α，β-共轭羧基末端基团的亲水大分子单体和包含该单体的医疗器械
公开(公告)号：WO2008005753A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072120
申请日：2007-06-26
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong
发明人： LAI, Yu-chin , LANG, Weihong
CPC分类号： C08F290/06 , C08F290/061 , C08F290/068 , C08J7/047 , C08J2433/00 , G02B1/043 , C08L51/085
摘要： A macromonomer comprises an α,β-conjugated terminal carboxylic group and a plurality of hydrophilic groups. Polymeric materials comprise such a macromonomer are used advantageously to provide a hydrophilic or lubricious (or both) coating on medical devices. Such polymeric materials can comprise units of other hydrophilic monomers.
摘要翻译：大分子单体包含α，β-共轭末端羧基和多个亲水基团。包含这种大分子单体的聚合物材料有利地用于在医疗装置上提供亲水或光滑（或两者）涂层。这种聚合物材料可以包含其他亲水单体的单元。

6. 发明申请

WO2006071479A1 HYDROGEL COPOLYMERS FOR BIOMEDICAL DEVICES 审中-公开
标题翻译：用于生物医学装置的水凝胶共聚物
公开(公告)号：WO2006071479A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/044289
申请日：2005-12-08
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T. , RUSCIO, Dominic, V.
发明人： LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T. , RUSCIO, Dominic, V.
IPC分类号： C08G18/61 , C08G18/67 , C08F290/06 , C08F290/14 , G02B1/04 , A61L27/16 , A61L27/52
CPC分类号： C08G18/10 , A61L27/165 , A61L27/18 , A61L27/52 , C08F290/06 , C08F290/14 , C08G18/672 , C08G18/8016 , C08G2210/00 , C08L53/00 , G02B1/043 , C08L33/02 , C08L39/06 , C08L33/26 , C08L83/04 , C08L39/04 , C08L51/085 , C08G18/3206 , C08G18/61 , C08L51/08 , C08L2666/02
摘要： Hydrogel copolymers which are hydrated polymerization products of monomeric mixtures comprising polysiloxane prepolymers and hydrophilic comonomers are useful for forming biomedical devices, particularly ophthalmic devices including contact lenses, intraocular lenses and ophthalmic implants. The copolymers have a desirable combination of oxygen permeability, tensile modulus, and water content, especially for soft contact lenses.
摘要翻译：作为包含聚硅氧烷预聚物和亲水共聚单体的单体混合物的水合聚合产物的水凝胶共聚物可用于形成生物医学装置，特别是包括隐形眼镜，眼内透镜和眼科植入物的眼科装置。共聚物具有氧渗透性，拉伸模量和含水量的所需组合，特别是对于软性隐形眼镜。

7. 发明申请

WO2006071388A1 POLYSILOXANE PREPOLYMERS FOR BIOMEDICAL DEVICES 审中-公开
标题翻译：用于生物医学设备的聚硅氧烷预聚物
公开(公告)号：WO2006071388A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/041540
申请日：2005-11-14
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T.
发明人： LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T.
IPC分类号： C08G18/61
CPC分类号： G02B1/043 , A61L27/18 , A61L2430/16 , C08F283/12 , C08F290/06 , C08G18/10 , C08G18/61 , C08G18/672 , C08G18/755 , C08G2210/00 , C08L53/00 , Y10T428/31663 , C08L51/085 , C08L51/08 , C08L83/04 , C08L2666/02
摘要： A polysiloxane prepolymer that is useful for forming biomedical devices has the formula (I): M(*Dii* PS)x *Dii*M wherein: each M is independently a polymerizable ethylenically unsaturated radical; each Dii is independently a diradical residue of a diisocyanate; each PS is independently a diradical residue of a polysiloxane-diol or a polysiloxane-diamine; each * is independently -NH-CO-NH-, -NH-COO- or -OCO-NH-; and x is at least 2.
摘要翻译：可用于形成生物医学装置的聚硅氧烷预聚物具有式（I）：M（* Dii * PS）x * Dii * M其中：每个M独立地是可聚合的烯键式不饱和基团; 每个Dii独立地是二异氰酸酯的双基残基; 每个PS独立地是聚硅氧烷 - 二醇或聚硅氧烷 - 二胺的双基残基; 每个*独立地是-NH-CO-NH-，-NH-COO-或-OCO-NH-; x至少为2。

8. 发明申请

WO2009055226A1 SILICONE HYDROGELS WITH AMINO SURFACE GROUPS 审中-公开
标题翻译：硅胶水凝胶与氨基表面组合
公开(公告)号：WO2009055226A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/078568
申请日：2008-10-02
申请人： BAUSCH & LOMB INCORPORATED , LANG, Weihong , LAI, Yu-chin
发明人： LANG, Weihong , LAI, Yu-chin
IPC分类号： C08L83/04 , C08J7/04 , G02B1/04
CPC分类号： C08J7/047 , C08J2383/08 , C08J2400/104 , C08J2400/105 , C08J2433/24 , C08L83/10 , G02B1/043 , C08L101/14
摘要： A silicone hydrogel comprising monomeric units of one or more amino monomers. Examples of the one or more amino monomers include dimethylaminoethyl (meth)acrylate, diethylaminoethyl (meth)acrylate, diisopropylaminoethyl (meth)acrylate, dibutylaminoethyl (meth)acrylate, dimethyl aminobutyl (meth)acrylate, diethylaminohexyl (meth)acrylate, t- butylaminoethyl (meth)acrylate, isobutylamino-butyl (meth)acrylate, isobutylamino-propyl (meth)acrylate, isobutylamino-ethyl (meth)acrylate, octylamino-ethyl (meth)acrylate isohexylaminoethyl (meth)acrylate, (N-propyl-N-methyl) amino-ethyl (meth)acrylate, t- utylamino-ethyl vinyl acetate, t-butylamino-ethyl crotonate, t-butylamino-ethyl isocrotonate, N,N-dimethylamino-ethyl crotonate, N,N-diethylamino-ethyl isocrotonate, and the quaternization products of each of these compounds.
摘要翻译：包含一个或多个氨基单体的单体单元的硅氧烷水凝胶。一种或多种氨基单体的实例包括（甲基）丙烯酸二甲基氨基乙酯，（甲基）丙烯酸二乙基氨基乙酯，（甲基）丙烯酸二异丙基氨基乙酯，（甲基）丙烯酸二丁基氨基乙酯，（甲基）丙烯酸二甲基氨基丁酯，（甲基）丙烯酸二乙基氨基己酯，（甲基）丙烯酸异丁基氨基 - 丙酯，（甲基）丙烯酸异丁基氨基 - 丙酯，（甲基）丙烯酸异丁基氨基乙酯，（甲基）丙烯酸异丁基氨基乙酯，（甲基）氨基乙基（甲基）丙烯酸酯，叔丁氨基乙基乙酸乙烯酯，叔丁基氨基乙基巴豆酸酯，叔丁基氨基乙基异巴豆酸酯，N，N-二甲基氨基乙基巴豆酸酯，N，N-二乙基氨基 - 乙基异巴豆酸酯，每种化合物的季铵化产物。

9. 发明申请

WO2008076506A1 PACKAGING SOLUTIONS 审中-公开
标题翻译：包装解决方案
公开(公告)号：WO2008076506A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/082176
申请日：2007-10-23
申请人： BAUSCH & LOMB INCORPORATED , LANG, Weihong , LAI, Yu-chin
发明人： LANG, Weihong , LAI, Yu-chin
IPC分类号： A61L12/14 , C11D3/00 , C11D3/22 , G02C13/00
CPC分类号： A61L12/04 , B65B25/008 , C11D3/0078 , C11D3/227
摘要： The present invention is directed to new and improved packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing an ophthalmic device in an aqueous packaging solution comprising hyaluronic acid or a salt thereof. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, thereby preventing dryness and improving lubricity.
摘要翻译：本发明涉及用于存储诸如隐形眼镜的眼科装置的新的和改进的包装系统，以及用于包装这些眼科装置的方法，以提高穿戴期间镜片的舒适度。特别地，本发明涉及用于将眼科装置储存在包含透明质酸或其盐的含水包装溶液中的包装系统。这种溶液长时间保留在未使用的镜片的表面上，导致眼睛中持续的表面改性，这可以显着改善首次使用的新鲜隐形眼镜的润湿性能，此外甚至镜片插入后数小时，从而防止干燥，提高润滑性。

10. 发明申请

WO2006071387A1 POLYSILOXANE PREPOLYMERS FOR BIOMEDICAL DEVICES 审中-公开
标题翻译：用于生物医学设备的聚硅氧烷预聚物
公开(公告)号：WO2006071387A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/041537
申请日：2005-11-14
申请人： BAUSCH & LOMB INCORPORATED , LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T.
发明人： LAI, Yu-chin , LANG, Weihong , QUINN, Edmond, T.
IPC分类号： C08G18/61 , C08G18/67 , C08F299/06 , C08F299/08 , G02B1/04 , C08F290/06 , C08F290/14
CPC分类号： C08G18/61 , A61L27/18 , A61L2430/16 , C08F290/06 , C08F290/067 , C08F290/068 , C08F290/14 , C08F290/147 , C08F290/148 , C08F293/00 , C08F293/005 , C08G18/10 , C08G18/12 , C08G18/3206 , C08G18/672 , C08G18/755 , C08G2210/00 , C08L53/00 , C08L75/16 , G02B1/043 , C08L83/08 , C08L83/04 , C08L2666/02 , C08L51/08
摘要： A polysiloxane prepolymer that is useful for forming biomedical devices comprises blocks (I) and (II) and is terminated at each end with an ethylenic unsaturated radical: (*Dii*Diol*Dii*PS) x (I) (*Dii*PS) y (II) wherein: each Dii is independently a diradical residue of a diisocyanate; each Diol is independently a diradical residue of a diol having 1 to 10 carbon atoms; each PS is independently a diradical residue of a polysiloxane-containing diol or diamine; each * is independently -NH-CO-NH-, -NH-COO- or -OCO-NH-: x represents the number of blocks (I) and is at least 2, and y represents the number of blocks (II) and is at least 1.
摘要翻译：可用于形成生物医学装置的聚硅氧烷预聚物包括嵌段（I）和（II），并且在每一末端用乙烯不饱和基团封端：（* Dii * Diol * Dii * PS）X I）（* Dii * PS）Y（II）其中：每个Dii独立地是二异氰酸酯的双基残基; 每个二醇独立地是具有1至10个碳原子的二元醇的双基残基; 每个PS独立地是含聚硅氧烷的二醇或二胺的双基残基; 每个*独立地是-NH-CO-NH-，-NH-COO-或-OCO-NH-：x表示嵌段（I）的数量并且至少为2，y表示嵌段（II）和至少是1。

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