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1. 发明申请

WO2010115758A2 FUNGICIDAL COMPOUNDS 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO2010115758A2
公开(公告)日：2010-10-14
申请号：PCT/EP2010054113
申请日：2010-03-29
申请人： BASF SE , RHEINHEIMER JOACHIM , NAVE BARBARA , KREMZOW DORIS , REDLICH STEFAN , PILGER CHRISTIAN , ROSENBAUM CLAUDIA , KLEEMANN AXEL , SAUTER HUBERT , GRAMMENOS WASSILIOS
发明人： RHEINHEIMER JOACHIM , NAVE BARBARA , KREMZOW DORIS , REDLICH STEFAN , PILGER CHRISTIAN , ROSENBAUM CLAUDIA , KLEEMANN AXEL , SAUTER HUBERT , GRAMMENOS WASSILIOS
IPC分类号： C07C259/14
CPC分类号： C07C259/14 , C07C327/58 , C07C2601/02
摘要： Compounds of the formula (I) in which the substituents have the meaning given in the description, processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi.
摘要翻译：式（I）化合物，其中取代基具有在说明书中给出的含义，制备这些化合物的方法，包含它们的组合物及其用于控制有害真菌的用途。

2. 发明申请

WO2005095404A3 6-(2-FLUOROPHENYL)-TRIAZOLOPYRIMIDINES, METHOD FOR PRODUCING THEM, THEIR USE FOR CONTROLLING PARASITIC FUNGI AND AGENTS CONTAINING THE SAME 审中-公开
标题翻译： 6-（2-氟苯基） - 三唑并嘧啶，防治有害真菌和代理CONTAINING生产和使用方法
公开(公告)号：WO2005095404A3
公开(公告)日：2006-04-06
申请号：PCT/EP2005003208
申请日：2005-03-26
申请人： BASF AG , BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
发明人： BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
IPC分类号： C07D487/04 , A01N43/90
CPC分类号： A01N43/90 , C07D487/04
摘要： The invention relates to the 6-(2-fluorophenyl)-triazolopyrimidines of formula (I), wherein the substituents are defined as follows: R
摘要翻译：本申请公开了式-6-（2-氟苯基） - 三唑并嘧啶予其中的取代基具有下列含义：R t

3. 发明申请

WO2005095405A3 6-(2,6-DICHLOROPHENYL)-TRIAZOLOPYRIMIDINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF FOR CONTROLLING PATHOGENIC FUNGI, AND AGENTS CONTAINING THE SAME 审中-公开
标题翻译： 6-（2,6-二氯 - 苯基） - 三唑并嘧啶，防治有害真菌和代理CONTAINING生产和使用方法
公开(公告)号：WO2005095405A3
公开(公告)日：2005-12-22
申请号：PCT/EP2005004187
申请日：2005-03-29
申请人： BASF AG , BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
发明人： BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
IPC分类号： A01N43/90 , C07D487/04
CPC分类号： A01N43/90 , C07D487/04
摘要： The invention relates to 6-(2,6-dichlorophenyl)-triazolopyrimidines of formula (I) wherein the substituents have the following designations: R and R represent hydrogen, alkyl, halogenalkyl, cycloalkyl, halogencycloalkyl, alkenyl, halogenalkenyl, cycloalkenyl, halogencycloalkenyl, alkinyl, halogenalkinyl or phenyl, naphthyl, or a five-membered or six-membered saturated, partially unsaturated or aromatic heterocycle containing between one and four heteroatoms from the group containing O, N or S; R and R can also form, together with the nitrogen atom to which they are bound, a five-membered or six-membered heterocycle or heteroaryl which is bound by N and contains between one and three other heteroatoms from the group containing O, N and S as a cyclic member and is substituted according to the description; and X represents alkyl, cyano, alkoxy, halogenalkoxy, alkenyloxy or halogenalkenyloxy, but does not represent C1-C4 alkyl when R and R together represent piperidin-1-yl or 4-methylpiperidin-1-yl. The invention also relates to a method for producing said compounds, agents containing the same, and the use thereof for controlling plant pathogenic fungi.
摘要翻译： 6-（2,6-二氯苯基） - 三唑并嘧啶的式（I）的其中取代基具有以下含义：R t <1>，R <2>是氢，烷基，卤代烷基，环烷基，卤代环烷基，烯基，卤代烯基，环烯基，卤代环烯基基，炔基，卤代炔基，或苯基，萘基，或含有选自O，N，或S，R <1>和R <2>也可以，一起一至四个杂原子的五元或六元饱和，部分不饱和或芳族杂环形成一个五元或六元杂环基或杂芳基的氮原子与它们所连接，这是经N个附接和选自O，N和S的一至三个另外的杂原子作为环成员，并且可以根据该描述被取代; X为烷基，氰基，烷氧基，卤代烷氧基，烯氧基或卤代链烯氧基，其中X不为C1-C4烷基，当R <1>和R <2>是常见的哌啶-1-基或4-甲基 - 哌啶-1-基; 一种用于制备这些化合物，含有它们和它们在防治植物病原性有害真菌的用途的组合物的过程。

4. 发明申请

WO2005110080A2 FUNGICIDAL MIXTURES AND NOVEL TRIAZOLOPYRIMIDINES 审中-公开
标题翻译：杀真菌剂混合物及新三唑
公开(公告)号：WO2005110080A2
公开(公告)日：2005-11-24
申请号：PCT/EP2005005070
申请日：2005-05-11
申请人： BASF AG , BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
发明人： BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
IPC分类号： A01N20060101 , A01N43/90 , A01N
CPC分类号： A01N43/90 , A01N59/06 , A01N59/02 , A01N57/12 , A01N47/38 , A01N47/34 , A01N47/24 , A01N47/04 , A01N43/50 , A01N43/76 , A01N43/653 , A01N43/36 , A01N43/40 , A01N43/32 , A01N37/48 , A01N37/46 , A01N37/38 , A01N37/34 , A01N2300/00
摘要： The invention relates to fungicidal mixtures containing in the form of active components 1) 5-methyl-7-amino-triazolopyrimidine of formula (I), wherein R is alkyl, halogenalkyl, alkenyl or cyclopentyl, R is hydrogen or alkyl, R and R together with the nitrogen atom to which they are bound may form a piperidinyl cycle substitutable by a methyl group, L is fluorine or chlorine, L , L are independently from each other hydrogen, fluorine or chlorine and 2) at least one type of active substance selected from groups A) azoles, B) strobilurins, C) acyl alanines, D) amine derivatives, E) anilinopyrimidines; F) dicarboximides; G) cinnamic acid amides and analogues thereof, H) antibiotics, K) dithiocarbamates, L) heterocyclic compounds, M) sulphur and copper fungicides, N) nitrophenyl derivatives, O) phenylpyrroles, P) sulfenic acid derivatives, Q) other fungicides and R) growth retardants according to the descriptions, wherein said mixtures contain the compounds in a synergically efficient amount. Novel triazolopyrimidines, methods for controlling pathogenic fungi using the mixtures of the compound (I) with active substances of the groups A) and R), the use the compounds (I) with the active substances of the groups A) and R) for producing said mixtures and agents containing said mixtures are also disclosed.
摘要翻译：一种杀真菌混合物，其包含作为活性组分：1）式（I）的5-甲基-7-氨基三唑并嘧啶，其中R <1>是烷基，卤代烷基，链烯基或环戊基; [R <2>是氢或烷基; [R <1>和R <2>也可以与氮原子一起与它们所连接的形式，其可以由甲基取代的哌啶环; →<1>是氟或氯; →<2>，L <3>独立地是氢，氟或氯; 和2）选自组A）唑类中的至少一种活性化合物; B）嗜球果伞素; C）酰基丙氨酸类; D）胺衍生物; E）苯胺基嘧啶; F）二甲酰亚胺; G）肉桂酸和类似物; 1H）抗生素; K）二硫代氨基甲酸酯; L）杂环化合物; M）硫和铜杀真菌剂; N）硝基苯基衍生物; O）苯基吡咯; P）Sulfensäurederivate; Q）其他杀菌剂; R）Wachstumsretardantien; 根据描述; 在协同有效量; 新的三唑并嘧啶，用于控制使用I化合物的混合物与基团A），以R的活性成分）包含这些混合物的有害真菌及其制造这样的混合物使用I化合物与基团A）至R）的活性成分和组合物的方法，

5. 发明申请

WO2005121146A3 1, 2, 4-TRIAZOLO[1,5A]PYRIMIDINES AND USE THEREOF FOR CONTROLLING PLANT-PATHOGENIC FUNGI 审中-公开
标题翻译： 1，2，4-三唑并[1,5-α]嘧啶和它们用于防治植物病原真菌
公开(公告)号：WO2005121146A3
公开(公告)日：2006-02-16
申请号：PCT/EP2005006171
申请日：2005-06-08
申请人： BASF AG , BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
发明人： BLETTNER CARSTEN , GEWEHR MARKUS , GRAMMENOS WASSILIOS , GROTE THOMAS , HUENGER UDO , MUELLER BERND , NIEDENBRUECK MATTHIAS , RHEINHEIMER JOACHIM , SCHAEFER PETER , SCHIEWECK FRANK , SCHWOEGLER ANJA , WAGNER OLIVER , RACK MICHAEL , NAVE BARBARA , SCHERER MARIA , STRATHMANN SIEGFRIED , SCHOEFL ULRICH , STIERL REINHARD
IPC分类号： C07D487/04 , A01N43/647 , A01N43/90 , C07D487/00
CPC分类号： A01N43/90 , C07D487/04
摘要： The invention relates to triazolopyrimidines of formula (I), wherein the index n and the substituents R, R
摘要翻译：本发明涉及下式的三唑并嘧啶I，其中索引n和取代基R，R

6. 发明申请

WO2006079556A2 SUBSTITUTED 5-PHENYL PYRIMIDINES I IN THERAPY 审中-公开
标题翻译：取代的5-苯基吡啶在治疗中
公开(公告)号：WO2006079556A2
公开(公告)日：2006-08-03
申请号：PCT/EP2006000774
申请日：2006-01-30
申请人： BASF AG , RHEINHEIMER JOACHIM , GROTE THOMAS , MUELLER BERND , NAVE BARBARA , SCHIEWECK FRANK , SCHWOEGLER ANJA , JABS THORSTEN , BLETTNER CARSTEN
发明人： RHEINHEIMER JOACHIM , GROTE THOMAS , MUELLER BERND , NAVE BARBARA , SCHIEWECK FRANK , SCHWOEGLER ANJA , JABS THORSTEN , BLETTNER CARSTEN
IPC分类号： A61K31/506 , A61K31/505 , C07D239/42 , C07D239/48 , C07D401/04 , C07D403/04 , C07D417/04
CPC分类号： C07D239/48 , C07D239/42 , C07D401/04 , C07D403/04 , C07D417/04
摘要： The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR 1 R 2 , OR 1a or SR 1a , in which R 1 , R 2 , independently of each other, denote hydrogen, C 1 -C 10 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 10 -haloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 ; or the radical NR 1 R 2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR 1 R 2 , in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C 1 -C 4 -alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 as defined in claim 1, R 1a has one of the meanings given for R 1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, C 3 -C 4 -alkenyloxy, C 3 -C 4 -alkynyloxy, C 1 -C 6 -alkylthio, di-(C 1 -C 6 -alkyl)amino or C 1 -C 6 -alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C 1 -C 2 -alkoxy or C 1 -C 4 -alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.
摘要翻译：本发明涉及取代的5-苯基嘧啶I，其在嘧啶环的4-位上携带基团X，嘧啶环的6-位的基团Y，基团X表示式NR的基团其中R 1，R 2，R 2，R 1，R 2， R 2彼此独立地表示氢，C 1 -C 10 - 烷基，C 2 - C 6 - 烯基，C 2 -C 6 - 炔基，C 1 -C 10 - C 1 -C 3烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 卤代烷基，C 3 -C 8 - 苯基或含有1,2,3或4个氮原子或1,2或3个氮原子和一个硫或氧原子作为环成员的5-或6-元杂芳基或5-或6-元杂环基，该基团可以未被取代或可以携带1,2,3或4个基团R a1a; 或自由基NR 1 R 2还可以形成含有1,2,3或4个氮原子或1,2或2个氮原子的5或6元任选取代的杂环或3个氮原子和一个硫或氧原子作为环成员，其与NR 1 R 2 O 2的氮不相邻，其中两个相邻的C原子或一个 N原子和一个相邻的C原子可以通过C 1 -C 4 - 亚烷基链连接，并且其中杂环可以是未取代的或可以携带1,2,3 或如权利要求1所定义的4个基团R a1，其中R 1a除了氢之外具有R 1给出的含义之一; 基团Y选自卤素，氰基，C 1 -C 4 - 亚烷基，C 2 -C 3 - 烷基， 4 - 烯基，C 2 -C 4 - 炔基，C 3 -C 6 - 环烷基，C 1 -C 4 - 烷氧基，C 3 -C 4 - 炔基氧基，C 1 -C 4 - 3-C 4 - 炔基氧基，C 1 -C 6 - 烷硫基，二 - （C 1 -C 6） C 1 -C 6 - 烷基）氨基或C 1 -C 6 - 烷基氨基，其中Y的烷基，烯基和炔基可以被卤素，氰基，硝基取代，C 1 -C 2 - 烷氧基或C 1 -C 4 - - 烷氧基; 并且其中嘧啶基团还可以携带2-位上与氢不同的基团，其中嘧啶环的5-位上的苯环可以是未取代的或携带1,2,3,4或5个基团L，其为不同于氢，以及用于治疗，特别是治疗或治疗癌性疾病的药学上可接受的盐取代的5-苯基嘧啶。

7. 发明申请

WO2006066818A3 7-AMINO-6-HETARYL-1,2,4-TRIAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AND THE USE THEREOF FOR CONTROLLING PATHOGENIC FUNGI 审中-公开
标题翻译： 7-氨基-6-杂芳基-1,2,4-三唑并[1,5-a]嘧啶化合物和它们在防治有害真菌中的用途
公开(公告)号：WO2006066818A3
公开(公告)日：2006-11-02
申请号：PCT/EP2005013577
申请日：2005-12-16
申请人： BASF AG , WAGNER OLIVER , GROTE THOMAS , RHEINHEIMER JOACHIM , NAVE BARBARA , STIERL REINHARD
发明人： WAGNER OLIVER , GROTE THOMAS , RHEINHEIMER JOACHIM , NAVE BARBARA , STIERL REINHARD
IPC分类号： C07D487/04 , A01N43/90
CPC分类号： A01N43/90 , C07D213/55 , C07D237/14 , C07D487/04
摘要： The invention relates to novel 7-amino-6-hetaryl-1,2,4-triazolo[1,5-a]pyrimidine compounds and the salts thereof that can be used in agriculture, the use of the same for controlling pathogenic fungi, and plant protection agents containing at least one such compound as an active constituent. Said novel 7-amino-6-hetaryl-1,2,4-triazolo[1,5-a]pyrimidine compounds correspond to general formula (I) wherein the substituents R 1 , R 2 , Het, X and Y have the following designations: Het represents a six-membered heteroaromatic radical selected from pyridinyl, pyridazinyl, pyrazinyl, 1,2,4-triazinyl and 1,3,5-triazinyl, the six-membered heteroaromatic radical comprising 1, 2 or 3 substituents L which are the same or different, R 1 , R 2 independently represent hydrogen, C 1 -C 8 alkyl, C 1 -C 8 halogenalkyl, C 1 -C 8 alkoxy, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 5 -C 10 bicycloalkyl, C 3 -C 8 halogencycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkenyloxy, C 4 -C 10 alkadienyl, C 2 -C 8 halogenalkenyl, C 3 -C 8 cycloalkenyl, C 3 -C 8 halogencycloalkenyl, C 2 -C 8 alkinyl, C 2 -C 8 alkinyloxy, C 2 -C 8 halogenalkinyl, NH 2, C 1 -C 8 alkylamino, Di-C 1 -C 8 -alkylamino, phenyl, naphthyl, or a five-membered or six-membered saturated, partially unsaturated or aromatic heterocycle, X represents hydrogen, halogen, OH, cyano, C 1 -C 4 alkyl and the like, and Y represents hydrogen, halogen, cyano, C 1 -C 4 alkyl, and the like.
摘要翻译：本发明涉及新颖的7-氨基-6-杂芳基-1,2,4-三唑并[1,5-a]嘧啶化合物及其农业上可接受的盐，以及它们在防治有害真菌中的用途，以及植物保护剂，这些化合物的至少一种作为含有活性成分。新的7-氨基-6-杂芳基-1,2,4-三唑并[1,5-a]嘧啶化合物可通过通式（I）所示，其中取代基R ^{1 来表示，R ^{2 ，（I）的Het，X和Y在式具有以下含义：Het是其选自吡啶基，哒嗪基，吡嗪基的6元杂芳基，1,2,4- 三嗪基和1,3,5-三嗪基，其中所述6元杂芳基1，2或3个相同或不同的取代基L可以包括，R ^{1 ，R ^{2 独立地另一个氢，C _{1 -C _{8 烷基，C _{1 -C _{8 卤代烷基，C _{1 -C _{8 烷氧基，C _{3 -C _{8 环烷基，C _{3 -C _{8 环烷氧基，C _{5 -C _{10 双环，C _{3 -C _{8 卤代环烷基，C _{2 -C _{8 烯基，C _{2 -C _{8 烯，C _{4 -C _{10 链二烯基，C _{2 -C _{8 卤代，C _{3 -C _{8 环烯基，C _{3 -C _{8 卤代环，C _{2 -C _{8 炔基，C _{2 -C _{8 炔氧基，C _{2 -C _{8 卤代炔基，NH _{2 C _{1 -C _{8 烷基氨基，二-C _{1 -C _{8 烷基氨基，苯基，萘基或五 - 或六元饱和，部分不饱和或芳族的杂环，X是氢，卤素，OH，氰基，C < SUB> 1 -C _{4 烷基等，Y是氢，卤素，氰基，C _{1 -C _{4 烷基，等等。}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}

8. 发明申请

WO2008084081A3 2-SUBSTITUTED 5-PHENYLPYRIMIDINES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增殖性疾病的2-取代的5-苯基嘧啶
公开(公告)号：WO2008084081A3
公开(公告)日：2008-10-09
申请号：PCT/EP2008050253
申请日：2008-01-10
申请人： BASF SE , NAVE BARBARA , HARMSEN SVEN , MUELLER BERND , GROTE THOMAS
发明人： NAVE BARBARA , HARMSEN SVEN , MUELLER BERND , GROTE THOMAS
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P35/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/513
摘要： The present invention relates to the use of 2-substituted pyridines of the formulaI and the pharmaceutically acceptable salts of the 2-substituted pyridines of formula I in therapy, in particular in therapy or treatment of cancerous diseases: in which the indices and the substituents are as defined in the claims and the specification.
摘要翻译：本发明涉及式I的2-取代吡啶和式I的2-取代吡啶的药学上可接受的盐在治疗中的用途，特别是在治疗或治疗癌性疾病中的用途：其中指数和取代基是如权利要求和说明书中所限定的。

9. 发明申请

WO0146388A2 PATHOLOGICALLY MODIFIED MYOCARDIAL CELL, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：病理改变的心脏肌肉细胞，生产和使用
公开(公告)号：WO0146388A2
公开(公告)日：2001-06-28
申请号：PCT/EP0013101
申请日：2000-12-21
申请人： MEDIGENE AG , ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
发明人： ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
IPC分类号： C12N15/09 , C12N5/077 , C12Q1/02 , G01N33/50 , C12N5/06 , A61K35/34 , C12N5/08 , C12N5/10
CPC分类号： C12N5/0657 , C12N2501/235 , C12N2501/365 , C12N2501/999 , C12N2503/02 , G01N33/5014 , G01N2500/10
摘要： The invention relates to a pathologically modified myocardial cell which can be produced from healthy cardiac tissue by providing or isolating at least one healthy myocardial cell, by stimulating said isolated myocardial cell using the appropriate hormones, hormone analogues and/or zytokines and by detecting the pathologically modified myocardial cell(s) by localising at least one signal molecule. The invention also relates to a method for producing said pathologically modified myocardial cell and to the use thereof, including a method for detecting or identifying cardioactive substances.
摘要翻译：患病的心脏肌肉细胞，从健康的心脏组织制备通过提供或分离至少一种健康的心脏肌肉细胞，刺激通过适当的激素，激素类似物和/或细胞因子的分离的心脏肌细胞; 通过确定至少一个信号分子的位置，以及它们的制备方法和它们的用途，包括用于检测或鉴定的活性物质心脏的方法的至少一个患病的心肌细胞检测。

10. 发明申请

WO02097128A3 METHOD FOR IDENTIFYING SUBSTANCES DIRECTED AGAINST MYOCARDIAL CELL HYPERTROPHY 审中-公开
标题翻译：一种用于识别物质的侵害心肌肥大
公开(公告)号：WO02097128A3
公开(公告)日：2003-09-12
申请号：PCT/EP0205924
申请日：2002-05-29
申请人： MEDIGENE AG , HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
发明人： HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
IPC分类号： C12N5/077 , C12Q1/68 , C12N5/10
CPC分类号： C12N5/0657 , C12N2510/00 , C12Q1/6897
摘要： The invention relates to a method for the in vitro examination of myocardial cell hypertrophy characterized in that at least one parameter for myocardial cell hypertrophy can be measured by using the expression rate of a heterologous marker protein in at least one myocardial cell containing a nucleic acid that codes for the heterologous marker protein.
摘要翻译：本发明的一个目的是一种用于心肌细胞肥大的体外研究中，其特征在于，用于在异源标志物蛋白的表达的至少一种心肌细胞的速率心肌细胞肥大的至少一个参数的方法中，核酸是异源标记蛋白可测量含有编码。

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