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1. 发明申请

WO2011003945A1 METHODS FOR ANALYZING POLAR METABOLITES OF THE ENERGY METABOLISM 审中-公开
标题翻译：用于分析能量代谢的极性代谢物的方法
公开(公告)号：WO2011003945A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059740
申请日：2010-07-07
申请人： BASF PLANT SCIENCE COMPANY GMBH , BLACKE, Gerd , WALK, Tilmann B. , DOSTLER, Martin , LOOSER, Ralf , CARVALHO, Susan
发明人： BLACKE, Gerd , WALK, Tilmann B. , DOSTLER, Martin , LOOSER, Ralf , CARVALHO, Susan
IPC分类号： G01N33/50 , G01N30/02
CPC分类号： G01N33/5038 , G01N30/7233 , G01N33/5091
摘要： The present invention is concerned with the analysis of polar metabolites and provides methods for analyzing polar metabolites comprising extracting a biological sample with a ex- traction buffer comprising a phase separator and a volatile neutral ammonium salt under conditions which allow for immediate disruption of cells comprised by the biological sample, separating the polar metabolites comprised by the extract by chromatography, and analyzing the separated polar metabolites. Moreover, a method for quenching a biological sample comprising cellular material is contemplated.
摘要翻译：本发明涉及极性代谢物的分析，并提供了分析极性代谢物的方法，其中包括在包含相分离器和挥发性中性铵盐的提取缓冲液中提取生物样品的条件下，允许立即破坏由生物样品，通过色谱分离由提取物组成的极性代谢物，并分析分离的极性代谢物。此外，考虑了包含多孔材料的生物样品的淬灭方法。

2. 发明申请

WO2011048007A2 VERFAHREN ZUR ERZEUGUNG VON BIOMARKER-REFERENZPATTERN 审中-公开
标题翻译：用于生产生物标志物参考模式
公开(公告)号：WO2011048007A2
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065450
申请日：2010-10-14
申请人： BASF PLANT SCIENCE COMPANY GMBH , PROKOUDINE, Alexandre , WALK, Tilmann, B. , WIEMER, Jan, C. , LOOSER, Ralf , HEROLD, Michael, Manfred , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke
发明人： PROKOUDINE, Alexandre , WALK, Tilmann, B. , WIEMER, Jan, C. , LOOSER, Ralf , HEROLD, Michael, Manfred , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke
IPC分类号： G06F19/18
CPC分类号： G06F19/18
摘要： Die vorliegende Erfindung betrifft Verfahren zur Auswertung von Biomarkern. Insbesondere betrifft die Erfindung ein Verfahren zur Erstellung mindestens eines Patterns für mindestens einen vorgegebenen Effektor mit mindestens einer bestimmbaren Wirkung auf ein biologisches System, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen und ein Verfahren zur Identifikation mindestens einer Wirkung eines vorgegebenen Effektors sowie ein Computerprogramm und einen Computer, die zur Durchführung dieser Verfahren eingerichtet sind.
摘要翻译：本发明涉及一种用于生物标志物的分析方法。特别地，本发明涉及一种用于至少与生物系统，用于创建Effektorenklasse到预定动作的方法在至少一个可确定的效果的预定执行创建至少一个图案或一组操作，用于创建Effektorenklasse到预定的方法效果或效果集和用于识别一个给定执行器的至少一个效果和一种计算机程序和其适合用于执行这些方法的计算机的方法。

3. 发明申请

WO2003041835A1 VERFAHREN ZUR EXTRAKTION UND ANALYSE VON INHALTSSTOFFEN AUS ORGANISCHEM MATERIAL 审中-公开
标题翻译：提取及原料来自有机材料的分析
公开(公告)号：WO2003041835A1
公开(公告)日：2003-05-22
申请号：PCT/EP2002/012552
申请日：2002-11-11
申请人： METANOMICS GMBH & CO. KGAA , HEROLD, Michael, Manfred , DOSTLER, Martin , LOOSER, Ralf , WALK, Tilmann, B. , FEGERT, Achim , KLUTTIG, Martin , LEHMANN, Britta , HEIDEMANN, Silke , HENNIG, Annette , KOPKA, Joachim
发明人： HEROLD, Michael, Manfred , DOSTLER, Martin , LOOSER, Ralf , WALK, Tilmann, B. , FEGERT, Achim , KLUTTIG, Martin , LEHMANN, Britta , HEIDEMANN, Silke , HENNIG, Annette , KOPKA, Joachim
IPC分类号： B01D11/02
CPC分类号： B01D11/0288 , Y10T436/255
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Isolation von Inhaltsstoffen aus organischem Material, das folgende Verfahrensschritte umfasst: (a) Gefriertrocknen des organischen Materials; (b) Extrahieren der Inhaltsstoffe mit einem polaren Lösungsmittel oder Lösungsmittelgemisch (A) und einem organischen Lösungsmittel oder Lösungsmittelgemisch (B), wobei die Extrakte aus dem Extrahieren mit (A) und (B) eine Phase bilden können; (c) Vereinen der Extrakte (A) und (B) zu einer Phase; und (d) Durchführen einer Veresterung/Umesterung in der unpolaren Phase mit einem Alkohol, wobei die Veresterung/Umesterung in Gegenwart einer flüchtigen Säure durchgeführt wird; wobei das Verfahren ein Hochdurchsatzverfahren ist.
摘要翻译：本发明涉及一种方法，用于从有机材料中分离组分，其包括以下步骤：（a）冷冻干燥的有机材料的; （B）提取用极性溶剂或溶剂混合物（A）和有机溶剂或溶剂混合物（B）的组分，该提取物可以形成具有（A）和（B）在提取的一个相; （C）提取物（A）和（B）组合以相位; 和（d）进行在非极性相中的酯化/酯交换与醇，酯化/酯交换是在挥发性酸的存在下进行; 其中所述方法是高通量方法。

4. 发明申请

WO2003041834A1 VERFAHREN ZUR EXTRAKTION VON INHALTSSTOFFEN AUS ORGANISCHEM MATERIAL 审中-公开
标题翻译：工艺配料，从有机材料的提取
公开(公告)号：WO2003041834A1
公开(公告)日：2003-05-22
申请号：PCT/EP2002/012551
申请日：2002-11-11
申请人： METANOMICS GMBH & CO. KGAA , HEROLD, Michael, Manfred , DOSTLER, Martin , LOOSER, Ralf , WALK, Tilmann, B. , FEGERT, Achim , KLUTTIG, Martin , LEHMANN, Britta , HEIDEMANN, Silke , HENNIG, Annette , KOPKA, Joachim
发明人： HEROLD, Michael, Manfred , DOSTLER, Martin , LOOSER, Ralf , WALK, Tilmann, B. , FEGERT, Achim , KLUTTIG, Martin , LEHMANN, Britta , HEIDEMANN, Silke , HENNIG, Annette , KOPKA, Joachim
IPC分类号： B01D11/00
CPC分类号： C11B1/10 , B01D11/0215 , B01D11/0288 , Y10T436/255
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Extraktion von Inhaltsstoffen aus organischem Material, umfassend den Schritt Extrahieren mit einem einphasigen Gemisch aus 50 Vol.-% bis 90 Vol.-% Methanol und 50 bis 10 Vol.-% Wasser und optional 0 Vol.-% bis 40 Vol.-% eines weiteren Lösungsmittels oder Lösungsmittelgemisches.
摘要翻译：本发明涉及一种方法，用于从有机材料中提取的组分，其包括具有50％（体积）单相混合物中提取到90体积％甲醇和50至10体积％水的步骤和任选的0体积％至40体积百分比的另一溶剂或溶剂混合物的％。

5. 发明申请

WO2012140603A1 METHOD FOR PROFILING PHYTOHORMONE LEVELS IN PLANT TISSUE 审中-公开
标题翻译：在植物组织中分析植物酮水平的方法
公开(公告)号：WO2012140603A1
公开(公告)日：2012-10-18
申请号：PCT/IB2012/051818
申请日：2012-04-13
申请人： BASF PLANT SCIENCE COMPANY GMBH , BASF (CHINA) COMPANY LIMITED , FUCHS, Regine , DOSTLER, Martin , WAHL, Maria , HENTSCHEL, Benjamin , LOOSER, Ralf
发明人： FUCHS, Regine , DOSTLER, Martin , WAHL, Maria , HENTSCHEL, Benjamin , LOOSER, Ralf
IPC分类号： G01N30/62 , G01N30/60 , A01N65/00
CPC分类号： G01N33/74 , G01N30/06 , G01N30/7233 , G01N30/7266 , G01N2030/009 , G01N2030/062 , G01N2030/8813 , Y10T436/141111 , Y10T436/145555 , Y10T436/147777 , Y10T436/201666 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/255
摘要： The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms, which method comprises the following steps: i. extraction of particulate tissue material of the plastid containing organism, in particulate tissue material of plants, with a liquid extractant, which is a mixture of at least one water miscible neutral organic solvent having from 1 to 3 carbon atoms and 1 heteroatom selected from O and N with water containing from 0.1 to 5% by weight, based on the extractant, of at least one acid, whereby a first liquid extract is obtained; ii. contacting the liquid extract obtained in step i. with a solid absorbent having a hydrophobically modified surface and removing the solid absorbent to obtain a second liquid extract; iii. evaporating the solvent from the second extract and then re-dissolving the obtained residue in a solvent mixture of at least one water miscible neutral organic solvent having from 1 to 3 carbon atoms and 1 heteroatom selected from O and N with water containing from 0.1 to 5% by weight, based on the solvent mixture, of at least one acid to obtain a reconstituted extract; iv. purification of the reconstituted extract by contacting it with a solid absorbent having a hydrophobically modified surface to obtain a purified reconstituted extract (eluate); and v. determining the relative concentrations of at least two, frequently at least 4, in particular at least 6, especially at least 8 or at least 10 phyto, e.g. from 2 to 60, frequently from 4 to 50, in particular from 6 to 45, especially from 8 to 40 or from 10 to 30 plant hormones (phytohormones) in the purified reconstituted extract obtained in step iv. by directly subjecting the purified reconstituted extract to an analyzing unit comprising a separation unit for separation the phytohormones and an analyzer for identifying the phytohormones which separation unit is coupled to the analyzer.
摘要翻译：本发明提供了用于在植物组织或其他含有质体的生物体的组织中分析植物激素水平的方法，即用于同时测定植物组织或其他含有物质的生物体的组织中的大量植物激素水平的方法，该方法包括以下步骤：我在植物的颗粒组织材料中用液体萃取剂萃取含有质体的生物体的颗粒组织材料，其是至少一种具有1至3个碳原子的水混溶性中性有机溶剂和1个选自O和O的杂原子的混合物， N，其中含有0.1至5重量％的基于萃取剂的至少一种酸，由此获得第一液体提取物; II。使步骤i中获得的液体提取物接触。具有疏水改性表面的固体吸收剂并除去固体吸收剂以获得第二液体提取物; III。从第二提取物蒸发溶剂，然后将得到的残余物重新溶解在至少一种具有1至3个碳原子的水混溶性中性有机溶剂和1个选自O和N的杂原子的溶剂混合物中，所述溶剂混合物含有0.1至5 基于溶剂混合物的至少一种酸重量以获得重构的提取物; IV。通过使其与具有疏水改性表面的固体吸收剂接触来纯化重构的提取物，以获得纯化的重构提取物（洗脱液）; 和v。确定至少两个，经常至少4个，特别是至少6个，特别是至少8个或至少10个植物的相对浓度。在步骤iv中获得的纯化的再提取的提取物中，从2至60，通常为4至50，特别是6至45，特别是8至40或10至30种植物激素（植物激素）。通过将纯化的重构提取物直接经受包含用于分离植物激素的分离单元的分析单元和用于鉴定分离单元与分析仪结合的植物激素的分析器。

6. 发明申请

WO2009153139A2 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
IPC分类号： G01N33/68 , G01N33/82 , G01N33/92 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

7. 发明申请

WO2013038341A1 MEANS AND METHODS FOR ASSESSING HEMATOPOIETIC TOXICITY 审中-公开
标题翻译：用于评估血液毒性毒性的手段和方法
公开(公告)号：WO2013038341A1
公开(公告)日：2013-03-21
申请号：PCT/IB2012/054731
申请日：2012-09-12
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED , WALK, Tilmann B. , RAVENZWAAY, Bennard van , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WIEMER, Jan C , LOOSER, Ralf , HEROLD, Michael Manfred , PROKOUDINE, Alexandre
发明人： WALK, Tilmann B. , RAVENZWAAY, Bennard van , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WIEMER, Jan C , LOOSER, Ralf , HEROLD, Michael Manfred , PROKOUDINE, Alexandre
IPC分类号： G01N33/50
CPC分类号： G01N33/53 , G01N33/6893 , G01N2500/04 , G01N2800/22 , G01N2800/60 , G01N2800/709
摘要： A method for diagnosing hematopoietic toxicity comprises: a) determining the amount of at least one biomarker in a test sample of a subject suspected to suffer from hematopoietic toxicity, and b) comparing the amounts determined in step a) to a reference, whereby hematopoietic toxicity is to be diagnosed. A method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject, a method of identifying a drug for treating hematopoietic toxicity, a device and a kit for diagnosing hematopoietic toxicity are also disclosed.
摘要翻译：用于诊断造血毒性的方法包括：a）确定疑似患有造血毒性的受试者的测试样品中至少一种生物标志物的量，以及b）将步骤a）中测定的量与参考文献比较，由此造血毒性被诊断。还公开了一种用于确定化合物是否能够在受试者中诱导造血毒性的方法，鉴定用于治疗造血毒性的药物的方法，用于诊断造血毒性的装置和试剂盒。

8. 发明申请

WO2007014825A1 A METHOD FOR PROVIDING AND ANALYZING AN ANIMAL POPULATION HAVING AN ESSENTIALLY IDENTICAL METABOLOME 审中-公开
标题翻译：一种提供和分析具有基本代谢代谢物的动物群体的方法
公开(公告)号：WO2007014825A1
公开(公告)日：2007-02-08
申请号：PCT/EP2006/064053
申请日：2006-07-10
申请人： BASF AKTIENGESELLSCHAFT , RAVENZWAAY, Bennard van , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , LOOSER, Ralf , WALK, Tilmann B. , WIEMER, Jan C. , HAAKE, Volker
发明人： RAVENZWAAY, Bennard van , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , LOOSER, Ralf , WALK, Tilmann B. , WIEMER, Jan C. , HAAKE, Volker
IPC分类号： A01K29/00 , A01K1/03 , A01K67/02
CPC分类号： A01K1/031 , A01K29/00 , A01K67/02
摘要： The present invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping said animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, wherein the food to be fed is essentially free of chemical or micro- bial contaminance, (v) drinking libitum, wherein the drinking liquid is essentially free of chemical or microbial contaminance, (vi) constant illumination period, and providing the animal population after said time period. Further, the present invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the present invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.
摘要翻译：本发明涉及一种用于提供具有基本相同的代谢组的动物群体的方法，其包括编译基本相同年龄的动物群体，在下列住房条件下将所述动物群体保持足够的时间以适应适应环境：（i）恒定温度，（ii）恒定湿度，（iii）动物群体的动物的物理分离，（iv）随意喂食，其中待进食的食物基本上没有化学或微生物污染，（v）自由饮用，其中所述饮用液体基本上不含化学或微生物污染物，（vi）恒定的照射期，并且在所述时间段之后提供所述动物群体。此外，本发明涉及用于鉴定影响动物代谢组合物的化合物的方法，或用于鉴定这些化合物的标记物的方法。此外，本发明包括用于鉴定这样的化合物或其标志物的方法，其包括代谢分析来自动物群体的至少一种动物的样品。

9. 发明申请

WO2013038369A1 MEANS AND METHODS FOR ASSESSING KIDNEY TOXICITY 审中-公开
标题翻译：用于评估KIDNEY毒性的方法和方法
公开(公告)号：WO2013038369A1
公开(公告)日：2013-03-21
申请号：PCT/IB2012/054790
申请日：2012-09-14
申请人： BASF SE , BASF (China) Company Limited , KAMP, Hennicke , WALK, Tilmann B. , RAVENZWAAY, Bennard van , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WIEMER, Jan C. , LOOSER, Ralf , HEROLD, Michael, Manfred , PROKOUDINE, Alexandre
发明人： KAMP, Hennicke , WALK, Tilmann B. , RAVENZWAAY, Bennard van , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WIEMER, Jan C. , LOOSER, Ralf , HEROLD, Michael, Manfred , PROKOUDINE, Alexandre
IPC分类号： G01N33/53
CPC分类号： G01N33/5014 , G01N33/62 , G01N33/6893 , G01N33/70 , G01N33/92 , G01N2500/04 , G01N2800/347 , Y10T436/171538 , Y10T436/173845 , Y10T436/24
摘要： The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it discloses a method for diagnosing kidney toxicity. It also discloses a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention discloses a device and a kit for diagnosing kidney toxicity.
摘要翻译：本发明涉及用于化学化合物的危险分层的肾毒性和毒理学评估的诊断领域。具体地说，它公开了一种诊断肾毒性的方法。它还公开了一种用于确定化合物是否能够在受试者中诱导这种肾毒性的方法以及鉴定用于治疗肾毒性的药物的方法。此外，本发明公开了一种用于诊断肾毒性的装置和试剂盒。

10. 发明申请

WO2012035117A1 EXTRACTION DEVICE AND METHOD FOR EXTRACTING INGREDIENTS FROM A BIOLOGICAL SAMPLE 审中-公开
标题翻译：从生物样品中提取成分的提取装置和方法
公开(公告)号：WO2012035117A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/066044
申请日：2011-09-15
申请人： BASF PLANT SCIENCE COMPANY GMBH , BRABD, Wolfgang , HENN, Karl , MAHLER, Sven , LOOSER, Ralf
发明人： BRABD, Wolfgang , HENN, Karl , MAHLER, Sven , LOOSER, Ralf
IPC分类号： B01D11/02 , G01N1/34
CPC分类号： G01N1/34 , B01D11/0219 , G01N1/4055 , G01N2001/4061
摘要： An extraction device (110) for extracting at least one ingredient from a biological sample (112) is disclosed, specifically for extracting metabolites from a plant specimen. The extraction device (110) has at least one liquid charger (116) which is adapted to be brought in contact with a first side (122) of the sample (112). The liquid charger (116) is adapted to apply an extraction liquid (128), specifically at least one solvent, to the first side (122) of the sample (112). The extraction device (110) further has at least one sampling device (118) which is adapted to be brought in contact with a second side (124) of the sample (112). The sampling device (118) is adapted to collect sample fluid (126) comprising the extraction liquid (128) and the ingredient.
摘要翻译：公开了一种用于从生物样品（112）中提取至少一种成分的提取装置（110），具体用于从植物样品中提取代谢物。提取装置（110）具有至少一个适于与样品（112）的第一侧（122）接触的加液器（116）。加液器（116）适于将提取液体（128），特别是至少一种溶剂施加到样品（112）的第一侧（122）。提取装置（110）还具有至少一个适于与样品（112）的第二侧（124）接触的取样装置（118）。采样装置（118）适于收集包含提取液体（128）和成分的样本流体（126）。

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