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1. 发明申请

WO1998002189A2 METHOD FOR PREPARING BIOACTIVE POLYMERS 审中-公开
标题翻译：制备生物活性聚合物的方法
公开(公告)号：WO1998002189A2
公开(公告)日：1998-01-22
申请号：PCT/IL1997000239
申请日：1997-07-14
申请人： BAR ILAN UNIVERSITY , MARGEL, Shlomo , BURDYGIN, Irene
发明人： BAR ILAN UNIVERSITY
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： A method to prepare a bioactive polymer by covalently binding at least one amino group containing ligand to at least one polymer containing a plurality of free hydroxyl groups, said method comprising the following steps: (i) reacting the at least one polymer with an appropriate activating agent; (ii) reacting the resultant activated polymer in aqueous solution with desired amino group containing ligands; (iii) blocking by reaction or removing by hydrolysis residual polymer bound-ligand unreacted, activating groups; and wherein the said activating agent and/or leaving by-products formed by step (i) and/or by step (ii) and/or by step (iii), are swelling agents of the support polymer.
摘要翻译：本发明涉及一种方法，用于制备生物活性聚合物，由共价连接的含胺的配体，一种或多种含多个羟基的聚合物，所述方法包括以下步骤：（i）反应，或者所述用合适的活化剂的聚合物，（ii）所述聚合物反应活化导致与含配体的所需的胺组的水溶液，（iii）通过水解反应，或通过除去残留的未反应的聚合物的活化基团的阻挡配体结合。根据该方法，所述活化剂和/或步骤的残余副产物（i）和/或步骤（ii）和/或步骤（iii）是从聚合物载体发泡剂。

2. 发明申请

WO1996015236A1 BIOACTIVE CONJUGATES OF POLYHYDROXY-POLYMERS WITH AMINES 审中-公开
标题翻译：具有氨基的聚羟基聚合物的生物结合
公开(公告)号：WO1996015236A1
公开(公告)日：1996-05-23
申请号：PCT/US1995014716
申请日：1995-11-09
申请人： BAR ILAN UNIVERSITY , LICHTENSTEIN, Joseph , MARGEL, Shlomo , STURCHAK, Sophia
发明人： BAR ILAN UNIVERSITY , LICHTENSTEIN, Joseph
IPC分类号： C12N11/10
CPC分类号： C12N11/00 , A61L15/32 , C12N11/14
摘要： An article comprising immobilized protein which has been manufactured from at least one polymer containing a plurality of free hydroxy groups which is selected from the group consisting of cellulose and its functional derivatives, polysaccharides other than cellulose and their functional derivatives, and other polymers containing a plurality of free hydroxy groups, the at least one polymer being conjugated with at least one amine function of a biologically active protein which is cross-linked, provided that said manufacture includes the sequential steps of: contacting the at least one polymer in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound; derivatizing the at least one polymer by reaction with at least one reactant for free hydroxy groups in the polymer, such that the resultant derivative is reactive with the at least one amine function; reacting the resultant derivative with at least one amine function in a non-cross-linked protein to form polymer-non-cross-linked protein conjugate; and cross-linking the polymer-conjugated protein in presence of non-conjugated protein by reacting conjugated and non-conjugated protein together in at least one step with cross-linking agent; further provided that the at least one amine function of a cross-linked biologically active protein includes at least one N-H bond, and still further provided that the contacting step is effected for a period of time sufficient to increase the capacity of the at least one polymer for reaction with the at least one reactant, in comparison with an analogous sequence of steps in which the contacting step is omitted.
摘要翻译：一种包含固定化蛋白质的制品，其由至少一种选自纤维素及其功能性衍生物，纤维素及其功能衍生物以外的多糖及其功能性衍生物组成的组中选出的含有多个游离羟基的聚合物制成，的游离羟基，所述至少一种聚合物与交联的生物活性蛋白质的至少一种胺官能团共轭，条件是所述制备包括以下顺序步骤：在不存在反应物的情况下使所述至少一种聚合物接触羟基与至少一个N-杂环化合物反应; 通过与聚合物中的游离羟基的至少一种反应物反应来衍生至少一种聚合物，使得所得衍生物与至少一种胺官能团反应; 将所得衍生物与至少一种胺官能团在非交联蛋白质中反应以形成聚合物 - 非交联蛋白质缀合物; 并在非共轭蛋白存在下通过使至少一个步骤中的共轭和非共轭蛋白与交联剂反应而交联聚合物共轭蛋白; 进一步规定交联的生物活性蛋白质的至少一种胺官能团包括至少一个NH键，并且还进一步规定，所述接触步骤进行足以增加所述至少一种聚合物的能力的时间与其中省略了接触步骤的类似的步骤序列相比，与至少一种反应物反应。

3. 发明申请

WO1997025053A1 PLANT PROTECTION USING FISH OIL 审中-公开
标题翻译：使用鱼油的植物保护
公开(公告)号：WO1997025053A1
公开(公告)日：1997-07-17
申请号：PCT/US1997000493
申请日：1997-01-10
申请人： BAR ILAN UNIVERSITY , FRIEDMAN, Mark, M. , COHEN, Yigal
发明人： BAR ILAN UNIVERSITY , FRIEDMAN, Mark, M.
IPC分类号： A61K35/60
CPC分类号： A01N37/06 , A01N63/00 , A01N63/02 , A01N37/02 , A01N2300/00
摘要： A composition for protecting a crop against fungal diseases which includes one or more fish oils used in association with an agriculturally acceptable diluent and, preferably, with a metal salt. Also provided is a method for protecting a crop against fungal diseases which includes applying to the seed or foliage of a crop or its locus, a fish oil in an amount sufficient to induce the local and/or systemic resistance of the crop to control the fungal disease.
摘要翻译：一种用于保护作物免受真菌疾病的组合物，其包括与农业上可接受的稀释剂结合使用的一种或多种鱼油，优选用金属盐。还提供了一种保护作物免受真菌疾病的方法，其包括向作物或其基因座的种子或叶子施用足以诱导作物的局部和/或全身抗性以控制真菌的鱼油疾病。

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