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1. 发明申请

WO2011044262A2 THERMAL TRANSFORMER 审中-公开
标题翻译：热变压器
公开(公告)号：WO2011044262A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051667
申请日：2010-10-06
申请人： BAKER, David , LANE, Fred
发明人： BAKER, David , LANE, Fred
IPC分类号： F25B27/00 , F25B27/02 , F25B30/02 , F25B49/02
CPC分类号： F25B29/003 , F25B27/002 , F25B2700/21171 , Y02A30/272 , Y02B10/20 , Y02B10/24
摘要： A system for providing a thermal transformer to provide heating and cooling to enclosed structures, most generally a building using solar power combined with geothermal storage and a heat powered heat pump to raise or lower the temperature of the stored energy to a useful temperature as needed. The system also has an electrical generation embodiment to provide electricity in addition to the heating and cooling. The system will collect and store solar energy and supply heated or cooled water to the building's existing HVAC system while consuming no fossil fuels and emitting no greenhouse gases. The system may also be used in one embodiment to supply power for the pumps/fans used to circulate the heated or cooled air or water throughout the building.
摘要翻译：一种用于提供热变压器以向封闭结构提供加热和冷却的系统，最通常是使用与地热存储结合的太阳能发电的建筑物和热功率热泵，以根据需要将储存的能量的温度升高或降低到有用温度。该系统还具有除了加热和冷却之外还提供电力的发电实施例。该系统将收集和存储太阳能，并向建筑物现有的HVAC系统供应加热或冷却水，同时不消耗化石燃料并且不排放温室气体。该系统也可以用于一个实施例中，为用于在整个建筑物内循环加热或冷却的空气或水的泵/风扇供电。

2. 发明申请

WO2012018907A3 POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION 审中-公开
公开(公告)号：WO2012018907A3
公开(公告)日：2012-02-09
申请号：PCT/US2011/046414
申请日：2011-08-03
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , BAKER, David , WHITEHEAD, Timothy, A. , FLEISHMAN, Sarel
发明人： BAKER, David , WHITEHEAD, Timothy, A. , FLEISHMAN, Sarel
IPC分类号： A61K38/10 , A61K38/16
摘要： The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection.

3. 发明申请

WO2010107472A2 HEAT EXCHANGER CONNECTOR ASSEMBLY 审中-公开
标题翻译：热交换器连接器总成
公开(公告)号：WO2010107472A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/000719
申请日：2010-03-10
申请人： SMITHS MEDICAL ASD, INC. , ANDERSEN, Eric , BAKER, David , HUGHES, Gregory , O'SHEA, Liam , SEARLE, Gary
发明人： ANDERSEN, Eric , BAKER, David , HUGHES, Gregory , O'SHEA, Liam , SEARLE, Gary
IPC分类号： F28F9/26 , A61F7/00 , A61H39/06 , F28F9/00
CPC分类号： F28F9/0246 , A61M5/44 , A61M39/10 , A61M39/105 , A61M2039/1072 , Y10S604/905
摘要： A connector assembly for a heat exchanger has a fitting and a mount to which the fitting couples. The fitting has an elongate body having a proximal portion and a distal portion. At the proximal portion there is a crossbar, and at the distal portion there are an inlet and an outlet that protrude away from the body. Two wings extend from the body in a direction opposite to that of the inlet and outlet. There is formed on each of the wings a locking protrusion. The mount has a top portion where there is a groove dimensioned to accept the crossbar of the fitting. A longitudinal channel is formed orthogonal to the groove in the mount. Two sidewalls extend from the mount each for accepting a corresponding one of the wings, when the fitting is coupled to the mount. Apertures are provided at the sidewalls to engage the protrusion at the wings so that, once the fitting is coupled to the mount, it is secured thereto, until a force is exerted to compress the wings towards each other to disengage the protrusions from the apertures. To couple the fitting to the mount, a user first positions the crossbar of the fitting onto the groove of the mount, with the body of the fitting at an angle relative to the mount. With the crossbar resting on the groove, a pivot point is established between the fitting and the mount, so that the body of the fitting can be pivotally positioned within the channel of the mount. At that time the inlet and outlet of the fitting are mated to an output port and an input port, respectively, of the mount; and the protrusions at the wings of the fitting are engaged to the apertures at the sidewalls of the mount. An infusate line and a heat exchanger are connected to the proximal end and distal end, respectively, of the fitting.
摘要翻译：用于热交换器的连接器组件具有配件和配件相配合的安装件。配件具有细长体，其具有近端部分和远端部分。在近端部分处有横杆，并且在远侧部分处具有远离身体突出的入口和出口。两个翼沿着与入口和出口相反的方向从身体延伸。在每个翼上形成有锁定突起。安装座具有顶部，其中有一个凹槽的尺寸以接受配件的横杆。纵向通道形成为与安装件中的凹槽正交。当配件联接到安装座时，两个侧壁从每个安装件延伸以接收相应的一个翼。孔设置在侧壁处以与翼部处的突起接合，使得一旦接头联接到安装件上，其被固定到其上，直到施加力以将翼片朝向彼此压缩以使突起与孔分离。为了将配件联接到安装座，用户首先将配件的横杆定位在安装件的凹槽上，使配件的主体相对于安装座成一角度。在横杆搁置在凹槽上，在配件和安装件之间建立枢轴点，使得配件的主体可以枢转地定位在安装件的通道内。此时，配件的入口和出口分别与安装座的输出端口和输入端口配合; 并且配件的翼部处的突起接合到安装件的侧壁处的孔。输液管线和热交换器分别连接到配件的近端和远端。

4. 发明申请

WO2009111066A1 LARGE-SCALE PRODUCTION OF SOLUBLE HYALURONIDASE 审中-公开
标题翻译：大规模生产可溶性羟丙基纤维素酶
公开(公告)号：WO2009111066A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001455
申请日：2009-03-06
申请人： HALOZYME, INC. , BAKER, David , BOOKBINDER, Louis
发明人： BAKER, David , BOOKBINDER, Louis
IPC分类号： C12N9/26
CPC分类号： C12N9/2408 , C12Y302/01035 , C12Y302/01036
摘要： Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium.
摘要翻译：提供制备可溶性透明质酸酶大规模制剂的方法。该方法使用含有编码可溶性透明质酸酶的多种核酸活性拷贝的细胞和多种饲料和温度变化，从而将编码的可溶性透明质酸酶分泌到细胞培养基中。

5. 发明申请

WO2009076655A2 SYNTHETIC ENZYMES DERIVED FROM COMPUTATIONAL DESIGN 审中-公开
标题翻译：由计算设计衍生的合成酶
公开(公告)号：WO2009076655A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/086715
申请日：2008-12-12
申请人： UNIVERSITY OF WASHINGTON , BAKER, David , ZANGHELLINI, Alexandre , JIANG, Lin , WOLLACOTT, Andrew , GRABS-ROTHLISBERGER, Daniela , ALTHOFF, Eric
发明人： BAKER, David , ZANGHELLINI, Alexandre , JIANG, Lin , WOLLACOTT, Andrew , GRABS-ROTHLISBERGER, Daniela , ALTHOFF, Eric
IPC分类号： C12N9/14
CPC分类号： C12N9/88 , G06F19/24
摘要： Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.
摘要翻译：这里公开了用于计算设计酶的技术。这些技术可用于设计天然存在的酶的变体，以及不具有天然对应物的新酶。这些技术基于首先确定促进所需反应所需的功能反应位点。然后，使用散列算法来识别能够支持所需功能位点的潜在蛋白质骨架结构（即支架）。这些技术被用于设计32种表现出醛醇缩合反应催化功能的不同蛋白质序列，其中31种在序列表中定义。提供了这31种不同合成醛缩酶的细节，包括如何将这种合成醛缩酶与天然存在的醛缩酶分开的描述。

6. 发明申请

WO2005080316A2 MODULATOR 审中-公开
标题翻译： CANNABINOID受体的调节剂
公开(公告)号：WO2005080316A2
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000605
申请日：2005-02-21
申请人： UNIVERSITY COLLEGE LONDON , OKUYAMA, Masahiro , SELWOOD, David , VISINTIN, Cristina , BAKER, David , PRYCE, Gareth
发明人： OKUYAMA, Masahiro , SELWOOD, David , VISINTIN, Cristina , BAKER, David , PRYCE, Gareth
IPC分类号： C07C233/68
CPC分类号： C07C235/42 , A61K31/165 , C07C69/76 , C07C69/78 , C07C233/11 , C07C233/65 , C07C233/66 , C07C233/69 , C07C235/34 , C07C235/78 , C07C235/84 , C07C237/32 , C07C237/38 , C07C237/42 , C07C255/41 , C07C255/44
摘要： The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR 1 or NR 1 R 2 wherein each of R 1 and R 2 is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO 2 -alkyl, alkenyl, CN, NH 2 , hydroxy, halo, alkoxy, CF 3 and nitro; Y is a polar functional group selected from OH, NO 2 , CN, COR 3 , COOR 3 , NR 3 R 4 , CONR 3 R 4 , SO 3 H, SO 2 -R 3 , SO 2 NR 3 R 4 and CF 3 , where each of R 3 and R 4 is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH 2 ) n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X-Y is other than meta -C≡-C-(CH 2 ) 2 CO 2 H, meta -C≡-C-(CH 2 ) 2 OH, meta -C≡C-(CH 2 ) 2 CO 2 Me, meta -(CH 2 ) 4 CO 2 H, ortho -CH 2 CO 2 H, ortho -(CH 2 ) 2 CO 2 H and ortho -(CH 2 ) 4 CO 2 H; and (ii) when A is phenyl, n is 0, and Z is OMe, X-Y is other than meta -C≡C-(CH 2 ) 4 OH. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中Z为OR 1或NR 1 R 2，其中R 1和R 2各自独立地为 H或烃基; X是亚烷基，亚烯基或亚炔基，其各自可以任选地被一个或多个选自烷基，COOH，CO 2 - 烷基，烯基，CN，NH 2，羟基，卤素，烷氧基，CF 3和硝基的取代基取代; Y是选自OH，NO 2，CN，COR 3，COOR 3，NR 3 R 4，CONR 3 R 4，SO 3 H，SO 2 -R 3的极性官能团。，SO 2 NR 3 R 4和CF 3，其中R 3和R 4各自独立地为H或烃基; A是芳基或杂芳基，其各自可以任选被取代; 和B是（CH 2）n，其中n是0,1,2,3,4或5; 条件是：（i）当A是苯基时，n是0，Z是OH，XY不是间位-C = -C-（CH 2）2 CO 2 H，间位C = -C-（CH 2）2 OH，间 - C（C-（CH 2）2 CO 2 Me，间 - （CH 2）4 CO 2 H，邻-CH 2 CO 2 H，邻 - （CH 2）2 CO 2 H和邻 - （CH 2）4 CO 2 H; 和（ii）当A是苯基时，n是0，Z是OMe，X-Y不是间位C = C-（CH 2）4 OH。本发明的其它方面涉及这些化合物在制备用于治疗肌肉疾病，胃肠道疾病或用于控制痉挛或震颤的药物中的用途。

7. 发明申请

WO2005013504A1 COMMUNICATIONS SYSTEMS AND METHODS 审中-公开
标题翻译：通信系统与方法
公开(公告)号：WO2005013504A1
公开(公告)日：2005-02-10
申请号：PCT/GB2004/003147
申请日：2004-07-19
申请人： ARTIMI LTD , BAKER, David , MOORE, Mark, Justin
发明人： BAKER, David , MOORE, Mark, Justin
IPC分类号： H04B1/69
CPC分类号： H04B1/71637 , H04B1/7174 , H04B1/7183 , H04B1/719
摘要： This invention generally relates to wired and wireless ultra wideband (UWB) data communications apparatus and methods, and in particular to UWB receiver systems and architectures, and to training and synchronisation systems therefore. An ultra wideband (UWB) receiver system comprising: a front end to receive a UWB signal; a reference signal memory for storing a reference UWB signal; a correlator coupled to said front end and to said reference signal memory to correlate said received UWB signal with said reference UWB signal; and a controller coupled to said reference signal memory and configured to control the storage of a received UWB signal into said reference signal memory as said reference UWB signal.
摘要翻译：本发明一般涉及有线和无线超宽带（UWB）数据通信装置和方法，特别是涉及UWB接收机系统和体系结构，以及训练和同步系统。一种超宽带（UWB）接收机系统，包括：前端，用于接收UWB信号; 用于存储参考UWB信号的参考信号存储器; 耦合到所述前端和所述参考信号存储器的相关器，用于将所述接收的UWB信号与所述参考UWB信号相关; 以及耦合到所述参考信号存储器并被配置为控制将所接收的UWB信号存储到所述参考信号存储器中作为所述参考UWB信号的控制器。

8. 发明申请

WO2005013502A1 COMMUNICATIONS SYSTEMS AND METHODS 审中-公开
标题翻译：通信系统与方法
公开(公告)号：WO2005013502A1
公开(公告)日：2005-02-10
申请号：PCT/GB2004/003124
申请日：2004-07-19
申请人： ARTIMI LTD , BAKER, David , MOORE, Mark, Justin
发明人： BAKER, David , MOORE, Mark, Justin
IPC分类号： H04B1/69
CPC分类号： H04B1/71637 , H04B1/7176 , H04B1/719
摘要： This invention generally relates to wired and Wireless ultra wideband (UWB) data communications apparatus and methods, and in particular to UWB receiver systems and architectures, and to correlators therefore. An ultra wideband (UWB) receiver system comprising: a receiver front end to receive a UWB signal having a plurality of multipath components; and a correlator coupled to said receiver front end to correlate said UWB signal with a reference signal; and wherein said UWB signal comprises a plurality of pulses; wherein each said pulse has a plurality of multipath components; wherein said reference signal comprises a plurality of multipath components of a said pulse; and wherein said correlator comprises at least one correlator module configured to correlate a plurality of said multipath components of a said pulse with said reference signal.
摘要翻译：本发明一般涉及有线和无线超宽带（UWB）数据通信装置和方法，特别涉及UWB接收机系统和体系结构，因此涉及相关器。一种超宽带（UWB）接收机系统，包括：接收机前端，用于接收具有多个多径分量的UWB信号; 以及耦合到所述接收器前端的相关器，用于将所述UWB信号与参考信号相关联; 并且其中所述UWB信号包括多个脉冲; 其中每个所述脉冲具有多个多径分量; 其中所述参考信号包括所述脉冲的多个多径分量; 并且其中所述相关器包括至少一个相关器模块，其被配置为将所述脉冲的多个所述多径分量与所述参考信号相关。

9. 发明申请

WO2020018935A2 DE NOVO DESIGN OF PROTEIN SWITCHES 审中-公开
公开(公告)号：WO2020018935A2
公开(公告)日：2020-01-23
申请号：PCT/US2019/042651
申请日：2019-07-19
申请人： UNIVERSITY OF WASHINGTON , LANGAN, Robert A. , BOYKEN, Scott , BAKER, David , NOVAK, Walter , LAJOIE, Marc Joseph , QUIJANO RUBIO, Alfredo
发明人： LANGAN, Robert A. , BOYKEN, Scott , BAKER, David , NOVAK, Walter , LAJOIE, Marc Joseph , QUIJANO RUBIO, Alfredo
IPC分类号： A61K38/00 , C07K14/00
摘要： Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ("off"') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates ("on") the bioactive peptide or binding domain, components of such protein switches, and their use.

10. 发明申请

WO2020018445A1 FRIZZLED SPECIFIC WNT AGONISTS AND ANTAGONISTS 审中-公开
公开(公告)号：WO2020018445A1
公开(公告)日：2020-01-23
申请号：PCT/US2019/041852
申请日：2019-07-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , UNIVERSITY OF WASHINGTON , GARCIA, Kenan Christopher , MIAO, Yi , BAKER, David , PARK, Keunwan , DANG, Luke
发明人： GARCIA, Kenan Christopher , MIAO, Yi , BAKER, David , PARK, Keunwan , DANG, Luke
IPC分类号： A61K38/17 , C07K14/435 , C07K14/47 , C07K16/28
摘要： Wnt signaling antagonist and agonist compositions and methods for their use are provided.

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