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1. 发明申请

WO2012018907A3 POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION 审中-公开
公开(公告)号：WO2012018907A3
公开(公告)日：2012-02-09
申请号：PCT/US2011/046414
申请日：2011-08-03
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , BAKER, David , WHITEHEAD, Timothy, A. , FLEISHMAN, Sarel
发明人： BAKER, David , WHITEHEAD, Timothy, A. , FLEISHMAN, Sarel
IPC分类号： A61K38/10 , A61K38/16
摘要： The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection.

2. 发明申请

WO2013138259A2 POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION 审中-公开
标题翻译：用于治疗和/或限制流感病毒感染的多肽
公开(公告)号：WO2013138259A2
公开(公告)日：2013-09-19
申请号：PCT/US2013/030311
申请日：2013-03-12
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： BAKER, David , WHITEHEAD, Timothy, A. , FLEISHMAN, Sarel
IPC分类号： A61K38/16
CPC分类号： C07K14/00 , A61K38/00 , C07K7/08 , G01N33/56983 , G01N2333/11
摘要： The present invention provides polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection.
摘要翻译：本发明提供识别并且是甲型流感血凝素的强结合剂的多肽，并且可以用于例如治疗和/或限制流感感染的发展。本发明还提供了编码本发明多肽的分离的核酸，包含编码本发明多肽的核酸的重组表达载体，其可操作地连接到合适的控制序列，以及包含本发明的重组表达载体的重组宿主细胞。本发明还提供了选择性结合本发明多肽的抗体，以及包含一种或多种本发明多肽和药学上可接受的载体的药物组合物。此外，本发明提供了用于治疗和/或限制流感感染的方法，用于诊断流感感染的方法或监测流感感染的进展，用于鉴定候选流感疫苗的方法，以及用于鉴定候选化合物的方法，用于治疗，限制，和/或诊断流感感染。

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