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1. 发明申请

WO2004098497A2 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
标题翻译： CD4 +人类乳头状瘤病毒（HPV）表位
公开(公告)号：WO2004098497A2
公开(公告)日：2004-11-18
申请号：PCT/US2004012652
申请日：2004-04-23
申请人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA , GENENCOR INT
发明人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
IPC分类号： A61K20060101 , A61K39/12 , A61K39/295 , C07K14/025 , C12N15/37 , C12Q1/68 , G01N33/50 , A61K
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供了来自人乳头瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。在一些优选的实施方案中，本发明提供了开发HPV疫苗的手段，特别是用于预防高风险HPV毒株感染的多价疫苗。在另外的实施方案中，本发明提供了用于开发针对高风险HPV类型的治疗性疫苗的手段，所述高风险HPV类型阻止感染个体发展良性和/或恶性肿瘤。本发明还提供了适用于预防性和治疗性疫苗的表位。

2. 发明申请

WO2004105681A3 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
标题翻译： CD4 +人乳头瘤病毒（HPV）病毒
公开(公告)号：WO2004105681A3
公开(公告)日：2005-03-24
申请号：PCT/US2004012650
申请日：2004-04-23
申请人： INNOGENETICS NV , BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
发明人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
IPC分类号： A61K20060101 , A61K39/12 , A61K39/295 , C07K14/025 , C12N15/37 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供来自人乳头瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。在另外的实施方案中，本发明提供了用于开发针对预防感染个体中良性和/或恶性肿瘤发展的高风险HPV类型的治疗性疫苗的手段。本发明还提供了适用于预防和治疗疫苗的表位。

3. 发明申请

WO2005119259A3 POPULATION BASED PREDICTION METHODS FOR IMMUNE RESPONSE DETERMINATIONS AND METHODS FOR VERIFYING IMMUNOLOGICAL RESPONSE DATA 审中-公开
标题翻译：基于人群的预测方法，用于免疫应答确定和验证免疫应答数据的方法
公开(公告)号：WO2005119259A3
公开(公告)日：2007-03-15
申请号：PCT/US2005014182
申请日：2005-04-25
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： G01N33/50 , G01N33/564
CPC分类号： G01N33/505 , G01N33/5047
摘要： The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations, wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based on their relative immunogenicity. In further embodiments, the present invention provides means for verifying immunological response data, as well as means for predicting immune responses directed against any antigen/immunogen. In addition, the present invention provides means to create proteins with reduced immunogenicity for use in various applications.
摘要翻译：本发明提供了评估群体的免疫应答谱的方法。特别地，本发明提供了定性评估人群免疫应答的方法，其中分析针对任何目标蛋白的免疫应答。本发明还提供了基于其相对免疫原性对蛋白质进行排序的方法。在进一步的实施方案中，本发明提供用于验证免疫应答数据的手段，以及用于预测针对任何抗原/免疫原的免疫应答的手段。此外，本发明提供了用于产生用于各种应用的具有降低的免疫原性的蛋白质的方法。

4. 发明申请

WO0240997A9 PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：产生改变的免疫应答的蛋白质及其制备和使用方法
公开(公告)号：WO0240997A9
公开(公告)日：2002-07-25
申请号：PCT/US0130062
申请日：2001-09-26
申请人： GENENCOR INT , ESTELL DAVID A , HARDING FIONA A
发明人： ESTELL DAVID A , HARDING FIONA A
IPC分类号： G01N33/53 , C12N9/56 , C12N9/64 , G01N33/50 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/505
摘要： The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.
摘要翻译：本发明涉及用于生产高过敏和低过敏性组合物的新方法和组合物。具体而言，本发明包括中和或降低T细胞识别表位并因此防止个体对蛋白质敏化的能力。或者，T细胞表位突变以产生增加的免疫原性反应。

5. 发明申请

WO03073068A2 POPULATION BASED ASSESSMENTS AND MEANS TO RANK THE RELATIVE IMMUNOGENICITY OF PROTEINS 审中-公开
标题翻译：基于人群的评估和手段来排除蛋白质的相对免疫原性
公开(公告)号：WO03073068A2
公开(公告)日：2003-09-04
申请号：PCT/US0305670
申请日：2003-02-26
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： G01N33/53 , C12N9/56 , C12Q1/02 , G01N33/50 , G01N33/566 , G01N33/567 , G01N
CPC分类号： G01N33/505 , C12N9/54 , G01N2333/96433
摘要： The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based on their relative immunogenicity. In addition, the present invention provides means to create proteins with reduced immunogenicity for use in various applications.
摘要翻译：本发明提供了评估群体的免疫应答谱的方法。特别地，本发明提供了定性评估人群免疫应答的方法，其中分析针对任何目标蛋白的免疫应答。本发明还提供了基于其相对免疫原性对蛋白质进行排序的方法。此外，本发明提供了在各种应用中产生具有降低的免疫原性的蛋白质的方法。

6. 发明申请

WO2006116292A3 METHODS FOR REDUCING THE IMMUNOGENICITY OF CYTOKINES AND REMOVAL OF CELL SURFACE MARKERS 审中-公开
标题翻译：降低细胞因子免疫球蛋白和细胞表面标记物去除的方法
公开(公告)号：WO2006116292A3
公开(公告)日：2007-03-01
申请号：PCT/US2006015441
申请日：2006-04-24
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： C07K14/52 , C07K14/54 , C07K14/705 , C07K14/73
CPC分类号： C07K14/5406 , C07K14/52 , C07K14/54 , C07K14/5434 , C07K14/5437
摘要： The present invention provides means to assess the comparative allergenicity of proteases. In particular, the present invention provides means to qualitatively assess the potential for any protease to induce an allergic response in humans. In addition, the present invention provides means to select proteases with reduced allergenicity for use in various applications.
摘要翻译：本发明提供了评估蛋白酶的比较变应原性的方法。特别地，本发明提供了定性评估任何蛋白酶诱导人类过敏反应的潜力的方法。此外，本发明提供了选择具有降低的变应原性的蛋白酶用于各种应用的方法。

7. 发明申请

WO2005044838A8 CD4+ EPITOPES OF BONE MORPHOGENETIC PROTEINS 审中-公开
标题翻译：骨形成蛋白的CD4 +表位
公开(公告)号：WO2005044838A8
公开(公告)日：2005-10-27
申请号：PCT/US2004034679
申请日：2004-10-21
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： C07K20060101 , C07K14/51 , G01N33/53 , G01N33/567 , G01N33/74
CPC分类号： G01N33/74 , C07K14/51 , G01N2333/51
摘要： The present invention provides CD4+ T-cell epitopes in bone morphogenetic proteins (BMPs). In particular embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14. In some preferred embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14 that are suitable for modification to reduce the immunogenicity of the BMP-7 and BMP-14 proteins.
摘要翻译：本发明提供了骨形态发生蛋白（BMP）中的CD4 + T细胞表位。在具体的实施方案中，本发明提供了BMP-7和BMP-14的CD4 + T细胞表位。在一些优选的实施方案中，本发明提供适合修饰以降低BMP-7和BMP-14蛋白免疫原性的BMP-7和BMP-14的CD4 + T细胞表位。

8. 发明申请

WO0240997A3 PRODUCTION AND USE OF PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE 审中-公开
标题翻译：生产和使用产生改变的免疫应答的蛋白质
公开(公告)号：WO0240997A3
公开(公告)日：2004-08-12
申请号：PCT/US0130062
申请日：2001-09-26
申请人： GENENCOR INT , ESTELL DAVID A , HARDING FIONA A
发明人： ESTELL DAVID A , HARDING FIONA A
IPC分类号： G01N33/53 , C12N9/56 , C12N9/64 , G01N33/50 , G01N33/68 , A01K67/027
CPC分类号： G01N33/6854 , G01N33/505
摘要： The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.
摘要翻译：本发明涉及一种用于生产超低和过敏组合物的新方法和组合物。具体地，本发明包括中和或降低T细胞识别表位的能力，从而防止个体对蛋白质的致敏。或者，T细胞表位突变以产生增加的免疫原性反应。

9. 发明申请

WO02077187A2 PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：产生改变的免疫应答的蛋白质及其制备和使用方法
公开(公告)号：WO02077187A2
公开(公告)日：2002-10-03
申请号：PCT/US0209205
申请日：2002-03-22
申请人： GENENCOR INT , PROCTER & GAMBLE , ESTELL DAVID A , GANSHAW GRANT C , HARDING FIONA A , LARENAS EDMUND A , POULOSE AYROOKARAN J , SIKORSKI ELIZABETH ELLEN , ELLIOTT RUSSEL PHILIP
发明人： ESTELL DAVID A , GANSHAW GRANT C , HARDING FIONA A , LARENAS EDMUND A , POULOSE AYROOKARAN J , SIKORSKI ELIZABETH ELLEN , ELLIOTT RUSSEL PHILIP
IPC分类号： C07H21/04 , A61K8/64 , A61K8/67 , A61K38/00 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C12N9/54 , C12N
CPC分类号： C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
摘要翻译：本发明涉及与亲本蛋白质相比显示出降低的变应原性的新型蛋白质变体。还包括编码新变体的DNA分子，包含DNA的宿主细胞和使蛋白质变得不敏感的方法。

10. 发明申请

WO2007067473A3 PERHYDROLASE EPITOPES 审中-公开
公开(公告)号：WO2007067473A3
公开(公告)日：2007-09-07
申请号：PCT/US2006046203
申请日：2006-12-04
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： C12N9/16 , C11D3/386 , G01N33/50
CPC分类号： C12N9/18 , C11D3/38636 , C12N9/16 , G01N33/505
摘要： The present invention provides perhydrolase enzyme CD4+ T-cell epitopes, as well as variants that exhibit reduced immunogenic responses, as compared to the parental perhydrolase . The present invention further provides DNA molecules that encode perhydrolase variants, and host cells comprising DNA encoding perhydrolase variants, as well as methods for making perhydrolase enzymes less immunogenic. In addition, the present invention provides variou compositions that comprise perhydrolase variants that are less immunogenic than the wild- type perhydrolase. In some specific embodiments, the present invention provides perhydrolase variants with reduced immunogenicity identified and/or characterized using the methods of the present invention. These enzymes find use in cleaning and other applications. In some preferred embodiments, the present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：与亲本过氧化氢酶相比，本发明提供了过水解酶酶CD4 + T细胞表位，以及表现出降低的免疫原性应答的变体。本发明还提供了编码过水解酶变体的DNA分子和包含编码过水解酶变体的DNA的宿主细胞，以及制备过水解酶较少免疫原性的方法。此外，本发明提供了包含与野生型过水解酶相比较少免疫原性的过水解酶变体的变种组合物。在一些具体实施方案中，本发明提供使用本发明的方法鉴定和/或表征的具有降低的免疫原性的过水解酶变体。这些酶可用于清洁和其他应用。在一些优选实施方案中，本发明特别用于涉及清洁，漂白和消毒的应用。

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