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1. 发明申请

WO2010022391A3 INTEGRATED, AUTOMATED SYSTEM FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
公开(公告)号：WO2010022391A3
公开(公告)日：2010-02-25
申请号：PCT/US2009/054781
申请日：2009-08-24
申请人： AZTE ARIZONA TECHNOLOGY ENTERPRISES , THE UNIVERSITY OF WASHINGTON , HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
发明人： HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
IPC分类号： G01N33/48 , G01N35/00 , C12Q1/68
摘要： The present invention provides for an automated, high-throughput, multi-parameter integrated analysis system to monitor, in parallel, cellular parameters descriptive of cell function and associated physiology both singly and in interactions with other cells in tissues. Parameters may be measured with cell or tissue samples confined in arrays of chambers microfabricated in cassettes. System variants provide for cell or tissue harvesting for (optionally destructive) further analysis. The present invention relates to a system for biological laboratory automation, providing for full automation of cell manipulation using capillary micropipettes and associated robotics. This invention provides a robust and flexible technology that can be deployed in research and corporate laboratories, enabling new experimental protocols. Applications include microinjection and high-throughput, single- to multi-cell, multi-parameter monitoring of parameters such as respiration rates, moiety of interest concentrations, metabolic fluxes, chemotactic gradients, gene expression and transcription, translation to proteins (intracellular, membrane, and extracellular), membrane integrity, and cellular ion gradients.

2. 发明申请

WO2010062654A2 DEVICE AND METHOD FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：用于细胞和组织功能研究的装置和方法
公开(公告)号：WO2010062654A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/062380
申请日：2009-10-28
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
发明人： HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
IPC分类号： C12Q1/02 , G01N33/48
CPC分类号： C12M23/16 , C12M23/12 , C12M23/22 , C12M23/38 , C12M41/46
摘要： A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.
摘要翻译：用于分析活细胞的室装置。腔室装置包括底座和盖子，当可逆地按压时，盖子产生一个腔室。基底配置有光学透明的孔以容纳至少一个细胞。盖子的宽度大于基座，并被配置成包含至少一个传感器。盖子进一步配置有唇部，当在盖子和基座之间被按压时，唇部产生不可渗透的密封。底座和盖被构造成使得当关闭并且在使用中时，传感器在空间上保持与至少一个单元隔开。

3. 发明申请

WO2004038758A2 FLEXIBLE INTEGRATED HEAD-STAGE FOR NEURAL INTERFACE 审中-公开
标题翻译：用于神经接口的柔性整合头阶段
公开(公告)号：WO2004038758A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/022655
申请日：2003-07-21
申请人： ARIZONA BOARD OF REGENTS acting for and on behalf of ARIZONA STATE UNIVERSITY , HE, Jiping , ZHU, Haixin , JENNINGS, Christopher
发明人： HE, Jiping , ZHU, Haixin , JENNINGS, Christopher
IPC分类号： H01L
CPC分类号： A61N1/0529
摘要： An electrode (30) implants into live tissue. The electrode has a first layer with a first silicon portion (50) forming a tip of the electrode and a second benzocyclobutene (BCB) portion (52) disposed adjacent to the first portion. A second BCB layer (56) is disposed over the first layer. A third BCB layer (58) is disposed over the second layer. The first layer further includes a third silicon portion (54) disposed adjacent to the second portion. A head-stage (40) has a connector (38) coupled for receiving the electrical signals from the electrode. A flexible substrate (90) has conductors for transmitting the electrical signals. A stiffener (94) supports a portion of the flexible substrate. An electronic circuit (96) is disposed on the flexible substrate above the stiffener and receives the electrical signals. A connector (12) is supported by the stiffener and coupled to an output of the electronic circuit.
摘要翻译：电极（30）植入活组织。电极具有第一层，其具有形成电极尖端的第一硅部分（50）和邻近第一部分设置的第二苯并环丁烯（BCB）部分（52B）。第二BCB层（56）设置在第一层上。第三BCB层（58）设置在第二层上。第一层还包括邻近第二部分设置的第三硅部分（54）。头级（40）具有连接器（38），其连接用于接收来自电极的电信号。柔性基板（90）具有用于传输电信号的导体。加强件（94）支撑柔性基板的一部分。电子电路（96）设置在加强件上方的柔性基板上并接收电信号。连接器（12）由加强件支撑并耦合到电子电路的输出端。

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