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1. 发明申请

WO2010062654A2 DEVICE AND METHOD FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：用于细胞和组织功能研究的装置和方法
公开(公告)号：WO2010062654A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/062380
申请日：2009-10-28
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
发明人： HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
IPC分类号： C12Q1/02 , G01N33/48
CPC分类号： C12M23/16 , C12M23/12 , C12M23/22 , C12M23/38 , C12M41/46
摘要： A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.
摘要翻译：用于分析活细胞的室装置。腔室装置包括底座和盖子，当可逆地按压时，盖子产生一个腔室。基底配置有光学透明的孔以容纳至少一个细胞。盖子的宽度大于基座，并被配置成包含至少一个传感器。盖子进一步配置有唇部，当在盖子和基座之间被按压时，唇部产生不可渗透的密封。底座和盖被构造成使得当关闭并且在使用中时，传感器在空间上保持与至少一个单元隔开。

2. 发明申请

WO2010022391A3 INTEGRATED, AUTOMATED SYSTEM FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
公开(公告)号：WO2010022391A3
公开(公告)日：2010-02-25
申请号：PCT/US2009/054781
申请日：2009-08-24
申请人： AZTE ARIZONA TECHNOLOGY ENTERPRISES , THE UNIVERSITY OF WASHINGTON , HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
发明人： HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
IPC分类号： G01N33/48 , G01N35/00 , C12Q1/68
摘要： The present invention provides for an automated, high-throughput, multi-parameter integrated analysis system to monitor, in parallel, cellular parameters descriptive of cell function and associated physiology both singly and in interactions with other cells in tissues. Parameters may be measured with cell or tissue samples confined in arrays of chambers microfabricated in cassettes. System variants provide for cell or tissue harvesting for (optionally destructive) further analysis. The present invention relates to a system for biological laboratory automation, providing for full automation of cell manipulation using capillary micropipettes and associated robotics. This invention provides a robust and flexible technology that can be deployed in research and corporate laboratories, enabling new experimental protocols. Applications include microinjection and high-throughput, single- to multi-cell, multi-parameter monitoring of parameters such as respiration rates, moiety of interest concentrations, metabolic fluxes, chemotactic gradients, gene expression and transcription, translation to proteins (intracellular, membrane, and extracellular), membrane integrity, and cellular ion gradients.

3. 发明申请

WO2016073967A1 TAMPER RESISTANT SYSTEM FOR CREATING ZONES AND MANIPULATING COMPUTING DEVICES 审中-公开
标题翻译：用于创建区域和操纵计算设备的防篡体系统
公开(公告)号：WO2016073967A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059635
申请日：2015-11-07
申请人： ASHILI, Shashanka
发明人： ASHILI, Shashanka
IPC分类号： G06F15/16
CPC分类号： H04M1/72577 , G06F21/629 , G06F21/86 , G06F2221/2111 , H04M1/6091 , H04M1/72572 , H04W4/021 , H04W4/046 , H04W4/40
摘要： A system for selectively manipulating a mobile device when the mobile device is present within one or more defined zones within an area. The system comprises a control device transmitting a signal, with the signal having a decreasing signal strength as distance from the control device increases. The system additional comprises one or more profiles stored in a memory for determining the one or more defined zones based on one or more values, each value corresponding to a particular signal strength of the signal, and at least one software application executing on the mobile device. The application is configured for accessing the profiles from a memory and receiving, from the mobile device, an indication of the signal received at the mobile device and a signal strength of the received signal, and selectively manipulating the mobile device as a function of the signal strength and the one or more profiles.
摘要翻译：一种用于当移动设备存在于区域内的一个或多个限定区域内时选择性地操纵移动设备的系统。该系统包括传输信号的控制装置，随着距离控制装置的距离增加，信号具有降低的信号强度。该系统附加包括存储在存储器中的一个或多个简档，用于基于一个或多个值来确定一个或多个定义的区域，每个值对应于信号的特定信号强度，以及在移动设备上执行的至少一个软件应用。应用被配置用于从存储器访问简档并从移动设备接收在移动设备处接收到的信号的指示和接收到的信号的信号强度，并且根据信号选择性地操纵移动设备强度和一个或多个轮廓。

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