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1. 发明申请

WO2002080920A1 ARYLACETAMIDO-KETOBENZOXAZOLE AS CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译： ARYLACETAMIDO-KETOBENZOXAZOLE作为CYSTEINE PROTEASE INHIBITORS
公开(公告)号：WO2002080920A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/011234
申请日：2002-04-08
申请人： AXYS PHARMACEUTICALS, INC. , SETTI, Eduardo , VENKATRAMAN, Shankar
发明人： SETTI, Eduardo , VENKATRAMAN, Shankar
IPC分类号： A61K31/49
CPC分类号： C07D263/56 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention thus provides compounds of Formula (I) pharmaceutical compositions comprising compounds (s) of Formula (I) and methods of treating diseases associated with cysteine protease activity using pharmaceutical compositions comprising compounds of Formula (I).
摘要翻译：因此，本发明提供了包含式（I）化合物的式（I）药物组合物的化合物和使用包含式（I）化合物的药物组合物治疗与半胱氨酸蛋白酶活性相关的疾病的方法。

2. 发明申请

WO2020243519A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY 审中-公开
公开(公告)号：WO2020243519A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035249
申请日：2020-05-29
申请人： IFM DUE, INC. , VENKATRAMAN, Shankar , KATZ, Jason , ROUSH, William R.
发明人： VENKATRAMAN, Shankar , KATZ, Jason , ROUSH, William R.
IPC分类号： C07D209/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D513/04 , A61P35/00 , A61K31/404 , A61K31/433 , A61K31/437 , A61K31/4427 , A61K31/506
摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

3. 发明申请

WO2009134747A1 METHOD AND APPARATUS FOR SPECTRALLY EFFICIENT LINK ADAPTATION USING HARQ IN OFDMA SYSTEMS 审中-公开
标题翻译：在OFDMA系统中使用HARQ的频谱效率链路适配的方法和装置
公开(公告)号：WO2009134747A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/041899
申请日：2009-04-28
申请人： NORTEL NETWORKS LIMITED , NAMMI, Sairamesh , VENKATRAMAN, Shankar , CHHEDA, Ashvin
发明人： NAMMI, Sairamesh , VENKATRAMAN, Shankar , CHHEDA, Ashvin
IPC分类号： H04L12/26
CPC分类号： H04W72/04 , H04B7/024 , H04B7/0452 , H04J11/005 , H04L5/0023 , H04L5/0037
摘要： A method increases spectral efficiency in a communication system. The communication system includes at least one mobile station and is capable of transmitting messages encoded according to a plurality of available modulation coding schemes ("MCSs"). Each available MCS includes a modulation scheme and an effective coding rate. The MCSs are indexed according to increasing complexity. A signal-to-interference ratio ("SINR") is determined which is sufficient to satisfy a predetermined frame error rate ("FER"). A first MCS and a corresponding amount of transmissions needed to satisfy the predetermined FER at the SINR using the first MCS are determined. The first MCS has a higher effective coding rate than a second MCS. The second MCS sufficiently satisfies the predetermined FER at the SINR in a single transmission. A message encoded according to the first MCS is transmitted through the communication system using hybrid automatic repeat request ("HARQ")
摘要翻译：一种方法提高了通信系统中的频谱效率。通信系统包括至少一个移动站，并且能够发送根据多个可用调制编码方案（“MCS”）编码的消息。每个可用的MCS包括调制方案和有效的编码率。 MCS随着复杂性的增加而被索引。确定信号干扰比（“SINR”），其足以满足预定的帧错误率（“FER”）。确定使用第一MCS在SINR处满足预定FER所需的第一MCS和相应的传输量。第一MCS具有比第二MCS更高的有效编码率。第二MCS在单个传输中足够满足SINR下的预定FER。根据第一MCS编码的消息通过使用混合自动重传请求（“HARQ”）的通信系统被发送，

4. 发明申请

WO2009134742A1 METHOD AND APPARATUS FOR CANDIDATE LIST GENERATION FOR UPLINK V-MIMO 审中-公开
标题翻译：用于UPLINK V-MIMO的候选列表生成的方法和装置
公开(公告)号：WO2009134742A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/041893
申请日：2009-04-28
申请人： NORTEL NETWORKS LIMITED , VENKATRAMAN, Shankar , CHEEDA, Ashvin , DEANE, Peter, Michael , CHEONG, Patrick, Lie, Chin
发明人： VENKATRAMAN, Shankar , CHEEDA, Ashvin , DEANE, Peter, Michael , CHEONG, Patrick, Lie, Chin
IPC分类号： H04J11/00
CPC分类号： H04W72/04 , H04B7/024 , H04B7/0452 , H04J11/005 , H04L5/0023 , H04L5/0037
摘要： A method selects mobile station candidates for use with virtual multiple-input multiple-output ("V-MIMO") in a communication system. The communication system includes at least one base station and a plurality of mobile stations. At least one downlink metric is determined for a first mobile station. The at least one downlink metric is used to determine eligibility for uplink V-MIMO candidate list selection. Responsive to determining that the first mobile station is eligible for uplink V-MIMO candidate list selection, the first mobile station is paired with a second mobile station eligible for uplink V-MIMO candidate list selection.
摘要翻译：一种方法选择在通信系统中使用虚拟多输入多输出（“V-MIMO”）的移动台候选。通信系统包括至少一个基站和多个移动台。为第一移动站确定至少一个下行链路度量。使用至少一个下行链路度量来确定上行链路V-MIMO候选列表选择的合格性。响应于确定第一移动台符合上行链路V-MIMO候选列表选择的条件，第一移动台与符合上行链路V-MIMO候选列表选择的第二移动台配对。

5. 发明申请

WO2005051915A1 PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN 审中-公开
标题翻译：用于治疗神经痛疼痛的吡啶-4-YLAMINE化合物
公开(公告)号：WO2005051915A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/038669
申请日：2004-11-18
申请人： MERCK & CO., INC. , LIM, Jongwon , BOUERES, Julia, K. , MUNOZ, Benito , PRACITTO, Richard , STOCK, Nicholas , VENKATRAMAN, Shankar
发明人： LIM, Jongwon , BOUERES, Julia, K. , MUNOZ, Benito , PRACITTO, Richard , STOCK, Nicholas , VENKATRAMAN, Shankar
IPC分类号： C07D215/00
CPC分类号： C07D219/12 , C07D215/46
摘要： The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α 2 δ-1 subunit of Ca channels.
摘要翻译：本发明涉及使用三唑并哒嗪化合物治疗神经性疼痛的方法。本发明还涉及三唑并 - 哒嗪化合物在治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症，双相性精神障碍和恐慌）以及治疗疼痛方面的应用，帕金森病疾病，认知功能障碍，癫痫，昼夜节律和睡眠障碍 - 如转移工作诱导的睡眠障碍和时差，吸毒成瘾，药物滥用，戒毒等疾病。本发明还涉及选择性结合Ca通道的α2dta-1亚基的新型三唑并哒嗪化合物。

6. 发明申请

WO2011123696A1 SYSTEM AND METHOD FOR PERFORMANCE ENHANCEMENT IN HETEROGENEOUS WIRELESS ACCESS NETWORKS 审中-公开
标题翻译：异构无线接入网络性能提升的系统与方法
公开(公告)号：WO2011123696A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030807
申请日：2011-03-31
申请人： POWERWAVE TECHNOLOGIES, INC. , SHEIKH, Khurram, P. , VENKATRAMAN, Shankar
发明人： SHEIKH, Khurram, P. , VENKATRAMAN, Shankar
IPC分类号： H04W52/00
CPC分类号： H04W52/143 , H04W52/08 , H04W52/226 , H04W52/228 , H04W52/243 , H04W52/245 , H04W52/267
摘要： A system and method for dynamically optimizing the transmission power levels for downlink voice and data signal transmitted from a base station (10) to user equipment (201 ) is disclosed. The user equipment (201 ) measures the strength and quality of the downlink signal, and transmits this downlink signal information to a control unit (96). The control unit (96) analyzes the downlink information and employs an adaptive self-learning traffic algorithm which determines optimized power levels for the downlink signals. The control unit (96) may optimize only one carrier signal or a subset of the multi-carrier signals in a preferred embodiment. The values of the optimized power levels are sent to the base station (10) which then increases or decreases the downlink transmission power of one or more carrier signals based on this level. As a result, the area associated with dead spots is reduced and the quality of the downlink signals is enhanced.
摘要翻译：公开了一种用于动态优化从基站（10）发送到用户设备（201）的下行语音和数据信号的发送功率电平的系统和方法。用户设备（201）测量下行链路信号的强度和质量，并将该下行链路信号信息发送到控制单元（96）。控制单元（96）分析下行链路信息，并采用自适应自学习业务算法，其确定下行链路信号的优化功率电平。在优选实施例中，控制单元（96）可以优化仅一个载波信号或多载波信号的子集。优化的功率电平的值被发送到基站（10），基站（10）基于该电平而增加或减少一个或多个载波信号的下行链路传输功率。结果，与死点相关的区域减少，并且下行链路信号的质量得到提高。

7. 发明申请

WO2010088167A1 BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：桥联化合物作为HIV整合抑制剂
公开(公告)号：WO2010088167A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/021920
申请日：2010-01-25
申请人： MERCK SHARP & DOHME CORP. , VENKATRAMAN, Shankar , WAI, John, S. , THOMPSON, Wayne , KIM, Boyoung , ISAACS, Richard C.A. , LOUGHRAN, H. Marie , SU, Dai-Shi , LIM, John , EMBREY, Mark, W. , WILLIAMS, Peter, D.
发明人： VENKATRAMAN, Shankar , WAI, John, S. , THOMPSON, Wayne , KIM, Boyoung , ISAACS, Richard C.A. , LOUGHRAN, H. Marie , SU, Dai-Shi , LIM, John , EMBREY, Mark, W. , WILLIAMS, Peter, D.
IPC分类号： A01N43/46 , A61K31/55
CPC分类号： C07D487/18 , C07D471/18 , C07D491/18
摘要： Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X 1 , X 2 , χ 3 , Y, Z, R 1 , R 2 and R 3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I化合物是HIV整合酶和HIV复制抑制剂的抑制剂：Q中的星号*表示与化合物其余部分的连接点; 并且n，L1，L2，X1，X2，... 3，Y，Z，R1，R2和R3在本文中定义。该化合物可用于预防或治疗艾滋病毒感染，并预防，治疗或延迟艾滋病的发病或进展。该化合物用作抗体作为化合物本身（或其水合物或溶剂化物）或以药学上可接受的盐形式的HIV感染和AIDS。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

8. 发明申请

WO2009158481A2 INCLUDING FEEDBACK INFORMATION REGARDING AN INDIVIDUAL SUBBAND OF A WIRELESS CHANNEL 审中-公开
标题翻译：包括有关无线通道的个人分支的反馈信息
公开(公告)号：WO2009158481A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048629
申请日：2009-06-25
申请人： NORTEL NETWORKS LIMITED , NAMMI, Sairamesh , VENKATRAMAN, Shankar , HEMRAJANI, Gaurav , CHHEDA, Ashvin , TEE, Lai-king , WANG, Neng , SIVANESAN, Kathiravetpillai
发明人： NAMMI, Sairamesh , VENKATRAMAN, Shankar , HEMRAJANI, Gaurav , CHHEDA, Ashvin , TEE, Lai-king , WANG, Neng , SIVANESAN, Kathiravetpillai
IPC分类号： H04B7/155 , H04W72/08
CPC分类号： H04B7/0417 , H04B7/0619 , H04B7/063 , H04L5/0096 , H04W4/20 , H04W72/0413
摘要： To report feedback information regarding a wireless channel, a mobile station determines whether a predefined condition is satisfied. In response to determining that the predefined condition is satisfied, feedback information regarding an individual one of plural subbands of the wireless channel is included in a first report to be sent to a base station. In response to determining that the predefined condition is not satisfied, aggregate feedback information regarding the plural subbands is included in a second report to be sent to the base station.
摘要翻译：为了报告关于无线信道的反馈信息，移动台确定是否满足预定条件。响应于确定满足预定条件，关于无线信道的多个子带中的各个子带的反馈信息被包括在要发送到基站的第一报告中。响应于确定不满足预定义条件，关于多个子带的聚合反馈信息被包括在要发送到基站的第二报告中。

9. 发明申请

WO2005041971A1 TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN 审中-公开
标题翻译：三唑并吡啶化合物及其衍生物可用于治疗神经性疼痛
公开(公告)号：WO2005041971A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034466
申请日：2004-10-15
申请人： MERCK & CO., INC. , LEBSACK, Alec D. , MUNOZ, Benito , PRACITTO, Richard , VENKATRAMAN, Shankar , WANG, Bowei , GUNZNER, Janet
发明人： LEBSACK, Alec D. , MUNOZ, Benito , PRACITTO, Richard , VENKATRAMAN, Shankar , WANG, Bowei , GUNZNER, Janet
IPC分类号： A61K31/5025
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α 2 δ-1 subunit of Ca channels.
摘要翻译：本发明涉及使用三唑并哒嗪化合物治疗神经性疼痛的方法。本发明还涉及三唑并 - 哒嗪化合物在治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症，双相性精神障碍和恐慌）以及治疗疼痛中的应用，帕金森病疾病，认知功能障碍，癫痫，昼夜节律和睡眠障碍 - 如转移工作诱导的睡眠障碍和时差，吸毒成瘾，药物滥用，戒毒等疾病。本发明还涉及选择性结合Ca通道的α2dta-1亚基的新的三唑并哒嗪化合物。

10. 发明申请

WO2012138769A1 SYSTEM AND METHOD FOR PERFORMANCE ENHANCEMENT IN HETEROGENEOUS WIRELESS ACCESS NETWORK EMPLOYING DISTRIBUTED ANTENNA SYSTEM 审中-公开
标题翻译：使用分布式天线系统进行异构无线接入网络性能提升的系统与方法
公开(公告)号：WO2012138769A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032184
申请日：2012-04-04
申请人： POWERWAVE TECHNOLOGIES, INC. , VENKATRAMAN, Shankar , SHEIKH, Khurram, P.
发明人： VENKATRAMAN, Shankar , SHEIKH, Khurram, P.
IPC分类号： H04B1/00
CPC分类号： H04W52/265 , H04W24/06 , H04W52/143 , H04W52/244 , H04W52/267 , H04W52/40 , H04W52/42 , H04W84/045
摘要： A system and method for dynamically optimizing the performance of indoor distributed antenna systems (8) which communicate to user equipment (16) is disclosed. The user equipment measures information describing the downlink signals such as the downlink data rates, the quality of the received signal, and the location of the user equipment. A service module (30) collects this information and determines an optimized power level for each of the antenna units (20). The service module (30) may optimize only one antenna unit power level or a subset of the antenna units within the distributed antenna system (8) in a preferred embodiment. One or more of the antenna units (20) then transmits downlink signals with the optimized power levels. The optimized power level may be less than the initial power level in a preferred embodiment. In a further aspect, the system enhances performance for multi-carrier base stations (300).
摘要翻译：公开了一种用于动态优化与用户设备（16）通信的室内分布式天线系统（8）的性能的系统和方法。用户设备测量描述下行链路信号的信息，例如下行链路数据速率，接收信号的质量和用户设备的位置。服务模块（30）收集该信息并确定每个天线单元（20）的优化功率电平。在优选实施例中，服务模块（30）可以仅优化分布式天线系统（8）内的天线单元功率电平或天线单元的子集。一个或多个天线单元（20）然后发送具有优化的功率电平的下行链路信号。优选的功率水平可以小于优选实施例中的初始功率水平。在另一方面，该系统增强了多载波基站（300）的性能。

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