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1. 发明申请

WO2012091832A2 MODULATION OF DYNEIN IN SKIN 审中-公开
标题翻译：皮肤调节DYNEIN
公开(公告)号：WO2012091832A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/062279
申请日：2011-11-29
申请人： AVON PRODUCTS, INC. , ZHENG, Qian , LYGA, John W. , WYBORSKI, Russell J.
发明人： ZHENG, Qian , LYGA, John W. , WYBORSKI, Russell J.
IPC分类号： A61K8/97 , C12Q1/68 , A61K8/46 , A61K8/49 , G01N33/573 , A61K8/368 , A61Q19/08 , A61Q19/00 , A61Q19/02
CPC分类号： C12Q1/6883 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/494 , A61K8/97 , A61K2800/74 , A61Q19/08 , C12Q1/6876 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , G01N33/5044 , G01N33/5088
摘要： Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate dynein expression in the skin. Also provided are methods for screening for substances which modulate dynein expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.
摘要翻译：提供了预防，改善或减少皮肤老化症状的方法，其使用调节皮肤中动力蛋白表达的活性剂。还提供了筛选调节动力蛋白表达水平的物质的方法以及使用筛选方案鉴定的活性剂治疗皮肤的方法。

2. 发明申请

WO2012005876A2 COMPOSITIONS AND METHODS FOR STIMULATING MAGP-1 TO IMPROVE THE APPEARANCE OF SKIN 审中-公开
标题翻译：用于刺激MAGP-1以改善皮肤外观的组合物和方法
公开(公告)号：WO2012005876A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/040157
申请日：2011-06-13
申请人： AVON PRODUCTS, INC. , ZHENG, Qian , CHEN, Siming W. , SANTHANAM, Uma , LYGA, John W.
发明人： ZHENG, Qian , CHEN, Siming W. , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K8/97 , A61K8/49 , A61Q19/00
CPC分类号： A61K8/97 , A61K8/466 , A61K8/49 , A61K31/5377 , A61K36/185 , A61K36/39 , A61K36/53 , A61K36/74 , A61K45/06 , A61K2800/20 , A61Q19/00 , A61Q19/08
摘要： The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
摘要翻译：本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的方法，特别是通过施用一种或其组合来治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹刺激MAGP-1表达的天然化合物或提取物，并改善老化和/或光损伤皮肤的外观。本发明的组合物局部施用于皮肤，或通过定向方式递送至有效改善皮肤状况和美观外观的量的有需要的部位。

3. 发明申请

WO2012005872A1 COSMETIC USE OF N-SUBSTITUTED SOLFONYLOXYBENZYLAMINES AND RELATED COMPOUNDS 审中-公开
标题翻译： N-取代的苯甲酰氧基苯甲酰胺及其相关化合物的化学应用
公开(公告)号：WO2012005872A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/040141
申请日：2011-06-13
申请人： AVON PRODUCTS, INC. , PTCHELINTSEV, Dmitri S. , LYGA, John W. , WYBORSKI, Russell , ZHENG, Qian , HWANG, Cheng S.
发明人： PTCHELINTSEV, Dmitri S. , LYGA, John W. , WYBORSKI, Russell , ZHENG, Qian , HWANG, Cheng S.
IPC分类号： C07D233/00
CPC分类号： C07C309/66 , A61K8/466 , A61K8/4973 , A61Q19/00 , A61Q19/08 , C07D307/52 , Y10S514/827 , Y10S514/828 , Y10S514/848
摘要： Cosmetic compositions comprising N-substituted sulfonyloxybenzylamines and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The N-substituted sulfonyloxybenzylamines are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含N-取代磺酰氧基苄基胺的化妆品组合物和使用这些组合物给皮肤赋予抗老化效果的方法。认为N-取代的磺酰氧基苄胺具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性。

4. 发明申请

WO2011087654A1 PAXILLIN STIMULATING COMPOSITIONS AND COSMETIC USES THEREOF 审中-公开
标题翻译： PAXILLIN刺激组合物及其化妆品用途
公开(公告)号：WO2011087654A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060012
申请日：2010-12-13
申请人： AVON PRODUCTS, INC. , ZHENG, Qian , WYBORSKI, Russell , SANTHANAM, Uma , LYGA, John W. , PTCHELINTSEV, Dmitri S.
发明人： ZHENG, Qian , WYBORSKI, Russell , SANTHANAM, Uma , LYGA, John W. , PTCHELINTSEV, Dmitri S.
IPC分类号： C07D471/00 , C07D471/18 , A61K31/437
CPC分类号： A61K8/97 , A61K8/342 , A61K8/4906 , A61K8/4926 , A61K36/00 , A61Q19/08 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
摘要翻译：公开了包含一种或多种桩蛋白刺激剂的化妆品组合物和使用这些组合物以赋予皮肤抗衰老益处的方法。据信桩蛋白刺激剂及其组合对至少一种与皮肤老化有关的生物化学途径具有调节活性。

5. 发明申请

WO2013062667A1 COMPOSITIONS AND METHODS FOR STIMULATING COLLAGEN SYNTHESIS IN THE SKIN 审中-公开
标题翻译：用于刺激皮肤中胶原蛋白合成的组合物和方法
公开(公告)号：WO2013062667A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/051728
申请日：2012-08-21
申请人： AVON PRODUCTS, INC. , HWANG, Cheng S. , LYGA, John W. , HU, Hong
发明人： HWANG, Cheng S. , LYGA, John W. , HU, Hong
IPC分类号： A01N43/56
CPC分类号： A61K8/49 , A61K8/494 , A61K8/4946 , A61K8/496 , A61K31/4155 , A61K31/496 , A61K31/5377 , A61K2800/78 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： Cosmetic compositions comprising substituted carbamoyl heterocyclic analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted carbamoyl heterocyclic analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含取代的氨基甲酰基杂环类似物的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。认为取代的氨基甲酰基杂环类似物对于涉及皮肤老化的一种或多种生物化学途径具有调节活性。

6. 发明申请

WO2012091824A1 METHOD OF TREATING SKIN WITH microRNA MODULATORS 审中-公开
标题翻译：用microRNA调节剂处理皮肤的方法
公开(公告)号：WO2012091824A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/061656
申请日：2011-11-21
申请人： AVON PRODUCTS, INC. , KHUSIAL, Permanan Raaj , SANTHANAM, Uma , LYGA, John W.
发明人： KHUSIAL, Permanan Raaj , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K31/33 , A61K31/17 , A61K31/12
CPC分类号： C07C311/17 , A61K8/466 , A61K8/4926 , A61K2800/782 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , C12Q2600/178
摘要： Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific microRNAs and the methods of using active agents identified by the screening protocol in the treatment of skin.
摘要翻译：提供了用于预防，改善或减少皮肤老化迹象的方法，其使用抑制或下调真皮成纤维细胞中的microRNA表达的活性剂，导致皮肤中胶原，弹性蛋白和/或原纤维蛋白的产生增加。还提供了用于筛选针对特定微小RNA的活性的方法以及使用筛选方案鉴定的活性剂治疗皮肤的方法。

7. 发明申请

WO2011082044A1 TOPICAL LIGHTENING COMPOSITION AND USES THEREOF 审中-公开
标题翻译：主题亮点组合物及其用途
公开(公告)号：WO2011082044A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/061688
申请日：2010-12-22
申请人： AVON PRODUCTS, INC. , LYGA, John W. , SANTHANAM, Uma , WELSH, William J.
发明人： LYGA, John W. , SANTHANAM, Uma , WELSH, William J.
IPC分类号： A61K31/74
CPC分类号： A61K31/74 , A61K8/46 , A61Q19/02
摘要： The disclosure relates to novel topical lightening compositions a tyrosinase inhibitor and a vehicle. There is provided a topical lightening composition comprising a 2-substituted-thio-4-substitued-4-oxobutanoic acid, ester or amide tyrosinase inhibitor, and a vehicle. The tyrosinase inhibitors of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The tyrosinase inhibitors of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically- acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.
摘要翻译：本公开涉及新型局部减轻组合物酪氨酸酶抑制剂和载体。提供了包含2-取代 - 硫代-4-取代-4-氧代丁酸，酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。本公开的酪氨酸酶抑制剂可以原样使用或作为药学上可接受的盐使用，包括常规无毒盐，其包括金属盐或碱土金属盐，铵盐或有机碱盐。本公开的酪氨酸酶抑制剂可以并入通常用于局部应用的任何美容，皮肤病学或化妆品可接受的载体或载体中。本公开的组合物和方法有效地减轻皮肤，头发，嘴唇和/或指甲。

8. 发明申请

WO2013066481A2 COSMETIC USE OF N-HETEROARYLBISAMIDE ANALOGS AND RELATED COMPOUNDS 审中-公开
标题翻译： N-异辛二酰胺类似物及其相关化合物的化学应用
公开(公告)号：WO2013066481A2
公开(公告)日：2013-05-10
申请号：PCT/US2012/052040
申请日：2012-08-23
申请人： AVON PRODUCTS, INC. , PARIMOO, Satish , ILAYA, Nancy T. , LYGA, John W.
发明人： PARIMOO, Satish , ILAYA, Nancy T. , LYGA, John W.
IPC分类号： A61K31/415 , A61K31/5377 , A61Q19/00 , A61Q19/08 , A61P17/02 , A61K8/49
CPC分类号： A61K8/494 , A61K8/49 , A61K9/0014 , A61K31/415 , A61K2800/10 , A61Q19/007 , A61Q19/08
摘要： Cosmetic and dermatological compositions comprising N-heteroarylbisamide analogs and methods of using such compositions to impart anti-aging benefits to the skin and/or improve skin conditions resulting from reduced collagen and hyaluronic acid production are disclosed. The N-heteroarylbisamides are believed to stimulate collagen and hyaluronic acid production and restore or maintain homeostasis for these compounds.
摘要翻译：公开了包含N-杂芳基双酰胺类似物的化妆品和皮肤病学组合物以及使用这些组合物赋予皮肤抗老化益处和/或改善由胶原蛋白和透明质酸产生减少引起的皮肤病症的方法。据信N-杂芳基双酰胺刺激胶原蛋白和透明质酸的产生并恢复或维持这些化合物的体内平衡。

9. 发明申请

WO2013028267A2 COSMETIC USE OF SUBSTITUTED AMINO HETEROCYCLIC CARBAMOYL ANALOGS AND RELATED COMPOUNDS 审中-公开
标题翻译：取代氨基杂环碳酰胺类似物及相关化合物的化学应用
公开(公告)号：WO2013028267A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/045227
申请日：2012-07-02
申请人： AVON PRODUCTS, INC. , LYGA, John W.
发明人： LYGA, John W.
IPC分类号： A61K8/49 , A61Q19/00 , A61Q19/08
CPC分类号： C07D263/34 , A61K8/49 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： Cosmetic compositions comprising substituted amino heterocyclic carbamoyl analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted amino heterocyclic carbamoyl analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含取代的氨基杂环氨基甲酰基类似物的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。认为取代的氨基杂环氨基甲酰基类似物对于涉及皮肤老化的一种或多种生物化学途径具有调节活性。

10. 发明申请

WO2013028266A1 COLLAGEN AND ELASTIN STIMULATING COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：胶原和激素刺激组合物及其用途
公开(公告)号：WO2013028266A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/045217
申请日：2012-07-02
申请人： AVON PRODUCTS, INC. , THORN LEESON, Daniel , SANTHANAM, Uma , LYGA, John W. , CHEN, Siming W. , WYBORSKI, Russell
发明人： THORN LEESON, Daniel , SANTHANAM, Uma , LYGA, John W. , CHEN, Siming W. , WYBORSKI, Russell
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K8/97 , A61K36/19 , A61K36/48 , A61Q19/08 , A61K2300/00
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus , or combinations thereof and a cosmetically acceptable vehicle.
摘要翻译：提供了用于预防，改善或减少老化皮肤病学症状的方法和组合物，其采用了法蒂西娅（Petricia ventricosa）的植物提取物，西葫芦（Archidendron clypearia）或其组合以及美容上可接受的载体。

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