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    • 6. 发明申请
    • TOPICAL LIGHTENING COMPOSITION AND USES THEREOF
    • 主题亮点组合物及其用途
    • WO2011082044A1
    • 2011-07-07
    • PCT/US2010/061688
    • 2010-12-22
    • AVON PRODUCTS, INC.LYGA, John W.SANTHANAM, UmaWELSH, William J.
    • LYGA, John W.SANTHANAM, UmaWELSH, William J.
    • A61K31/74
    • A61K31/74A61K8/46A61Q19/02
    • The disclosure relates to novel topical lightening compositions a tyrosinase inhibitor and a vehicle. There is provided a topical lightening composition comprising a 2-substituted-thio-4-substitued-4-oxobutanoic acid, ester or amide tyrosinase inhibitor, and a vehicle. The tyrosinase inhibitors of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The tyrosinase inhibitors of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically- acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.
    • 本公开涉及新型局部减轻组合物酪氨酸酶抑制剂和载体。 提供了包含2-取代 - 硫代-4-取代-4-氧代丁酸,酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。 本公开的酪氨酸酶抑制剂可以原样使用或作为药学上可接受的盐使用,包括常规无毒盐,其包括金属盐或碱土金属盐,铵盐或有机碱盐。 本公开的酪氨酸酶抑制剂可以并入通常用于局部应用的任何美容,皮肤病学或化妆品可接受的载体或载体中。 本公开的组合物和方法有效地减轻皮肤,头发,嘴唇和/或指甲。