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1. 发明申请

WO0031051B1 QUINOLINE AND QUINOXALINE COMPOUNDS AS PDGF-RECEPTOR AND/OR LCK TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：喹啉和喹啉化合物作为PDGF受体和/或LCK酪氨酸激酶抑制剂
公开(公告)号：WO0031051B1
公开(公告)日：2000-08-27
申请号：PCT/US9927825
申请日：1999-11-23
申请人： AVENTIS PHARM PROD INC , MYERS MICHAEL R , HE WEI , SPADA ALFRED P , MAGUIRE MARTIN P
发明人： MYERS MICHAEL R , HE WEI , SPADA ALFRED P , MAGUIRE MARTIN P
IPC分类号： A61F2/84 , A61K31/47 , A61K31/495 , A61K31/498 , A61K31/5377 , A61M25/00 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/08 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D215/20 , C07D215/38 , C07D241/42 , C07D241/44 , C07D241/52 , C07D241/54 , C07D403/04 , C07D405/10 , C07D405/12 , C07D453/06 , C07D471/08 , A61K31/50
CPC分类号： C07D215/38 , C07D215/20 , C07D241/42 , C07D241/44 , C07D241/52 , C07D241/54 , C07D403/04 , C07D405/12 , C07D453/06
摘要： This invention is directed to quinoline/quinoxaline compounds of formula (I), which inhibit platelet-derived growth factor or p56 tyrosine kinase activity, to pharmaceutical compositions comprising theses compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
摘要翻译：本发明涉及抑制血小板衍生生长因子或p56酪氨酸激酶活性的式（I）的喹啉/喹喔啉化合物，包括这些化合物的药物组合物，以及这些化合物用于治疗患者的用途来自或受到涉及细胞分化，增殖，细胞外基质产生或介体释放和/或T细胞活化和增殖的病症/病症的影响。

2. 发明申请

WO0107436A3 Substituted oxoazaheterocyclyl compounds. 审中-公开
标题翻译：取代的含氮杂环基化合物。
公开(公告)号：WO0107436A3
公开(公告)日：2001-08-23
申请号：PCT/IB0001156
申请日：2000-07-26
申请人： AVENTIS PHARM PROD INC , EWING WILLIAM R , BECKER MICHAEL R , CHOI SLEDESKI YONG MI , PAULS HEINZ W , HE WEI , CONDON STEPHEN M , DAVIS RODERICK S , HANNEY BARBARA A , SPADA ALFRED P , BURNS CHRISTOPHER J , JIANG JOHN Z , LI AIWEN , MYERS MICHAEL R , LAU WAN F , POLI GREGORY B
发明人： EWING WILLIAM R , BECKER MICHAEL R , CHOI-SLEDESKI YONG MI , PAULS HEINZ W , HE WEI , CONDON STEPHEN M , DAVIS RODERICK S , HANNEY BARBARA A , SPADA ALFRED P , BURNS CHRISTOPHER J , JIANG JOHN Z , LI AIWEN , MYERS MICHAEL R , LAU WAN F , POLI GREGORY B
IPC分类号： C07D241/08 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P9/02 , A61P9/04 , A61P9/10 , A61P19/02 , A61P25/28 , A61P35/00 , A61P41/00 , A61P43/00 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D491/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D471/04 , Y02P20/582
摘要： This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.

3. 发明申请

WO2005038465A3 ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：使用特异性酪氨酸激酶抑制剂的抗血管和抗增殖方法，治疗和组合
公开(公告)号：WO2005038465A3
公开(公告)日：2005-09-15
申请号：PCT/EP2004012185
申请日：2004-10-07
申请人： GENCELL SAS , AVENTIS PHARMA INC , NESBIT MARK , SPADA ALFRED P , HE WEI , MYERS MICHAEL R
发明人： NESBIT MARK , SPADA ALFRED P , HE WEI , MYERS MICHAEL R
IPC分类号： A61K31/498 , G01N33/50 , G01N33/74 , A61P9/00 , A61P35/00
CPC分类号： A61K31/498 , G01N33/5011 , G01N2333/71
摘要： This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature vasculature within chemotherapeutic refractory tumors, pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cell proliferation, and particularly treatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer, and human leukemias, such as CML, AML or ALL.
摘要翻译：本发明涉及蛋白酪氨酸激酶的单独或与抗血管生成剂或化学治疗剂联合用于废除化疗难治性肿瘤内的成熟脉管系统的有效抑制剂，包含这些化合物的药物组合物，以及这些化合物用于治疗患有来自或受到涉及细胞增殖的疾病/病症，特别是脑癌，卵巢癌，胰腺癌前列腺癌和人类白血病例如CML，AML或ALL的治疗。

4. 发明申请

WO2007079214A3 PROKINETICIN 2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： PROKINETICIN 2受体拮抗剂
公开(公告)号：WO2007079214A3
公开(公告)日：2007-08-30
申请号：PCT/US2006049560
申请日：2006-12-28
申请人： JANSSEN PHARMACEUTICA NV , COATS STEVEN J , DYATKIN ALEXEY B , HE WEI , LISKO JOSEPH , MISKOWSKI TAMARA A , RALBOVSKY JANET L , SCHULZ MARK
发明人： COATS STEVEN J , DYATKIN ALEXEY B , HE WEI , LISKO JOSEPH , MISKOWSKI TAMARA A , RALBOVSKY JANET L , SCHULZ MARK
IPC分类号： A61K31/506 , A61K31/53 , A61P1/00 , A61P35/00
CPC分类号： A61K31/506 , A61K31/53
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及用于治疗促动蛋白原2或原激素2受体介导的病症的方法。

5. 发明申请

WO2005118145A3 INDUSTRY STANDARD MULTI-WELL PLATES WITH INCREASED CAPACITY AND EFFICIENCY PER WELL 审中-公开
标题翻译：行业标准的多层板具有提高的能力和效率
公开(公告)号：WO2005118145A3
公开(公告)日：2006-10-12
申请号：PCT/US2005017829
申请日：2005-05-20
申请人： INGENIOUS TARGETING LAB INC , CHEN ELLEN , HE WEI , WENG WEI
发明人： CHEN ELLEN , HE WEI , WENG WEI
IPC分类号： B01L3/00 , B01L9/00
CPC分类号： B01L3/50853 , B01L3/5085 , B01L2300/0809 , B01L2300/0829
摘要： The invention provides for improved multi-well plates and platforms that comprise a plurality of wells having increased volume capacity and clustered in a standard multi-well plate format and dimensions, said multi-well plate format being compatible with auxiliary equipment currently used and designed for the particular multi-well plate format. More particularly, the invention provides improved multi-well plates comprising a base to improve wells having one or more said wells having rectangular configuration, better retention of working materials and tissue culture ingredients than observed in conventional round-shaped wells. A cover is provided for protecting the assembly and cell cultures.
摘要翻译：本发明提供了改进的多孔板和平台，其包括具有增加的体积容量并且以标准多孔板格式和尺寸聚集的多个孔，所述多孔板格式与目前使用和设计的辅助设备兼容特定的多孔板格式。更具体地，本发明提供了改进的多孔板，其包括基底，以改进具有一个或多个所述孔的孔，所述孔具有矩形构型，比常规圆形孔中观察到的具有更好的保留作业材料和组织培养成分。提供了一种保护组装和细胞培养的盖子。

6. 发明申请

WO0233828A8 A DIGITAL DATA TRANSFORMING METHOD 审中-公开
标题翻译：一种数字数据转换方法
公开(公告)号：WO0233828A8
公开(公告)日：2002-08-08
申请号：PCT/CN0100615
申请日：2001-04-26
申请人： UNIV JIAOTONG SOUTHWEST , HE DAKE , HE WEI
发明人： HE DAKE , HE WEI
IPC分类号： G06F17/22 , H03M7/04 , H03M7/30 , H03M7/00
CPC分类号： H03M7/04 , G06F17/2217
摘要： The present invention discloses a digital data transforming method. The method solves the problems of low encoding efficiency and increasing the network load when prepared to transmit enciphered e-mails or any 8-bit data sequence. The key technology is designing a "base-91 encoding" general bit strings to printable ASCII characters which is also referred to base91 encoding or Radix-91 encoding. Combined with Internet standard SMTP, MIME, S/MIME etc., the present invention can reduce 7.7 % of transmitted data or storage demand in place of Base64 encoding; and reduce 58.97 % of transmitted data or storage demand in place of QP encoding which processes the byte data with the high bit being 1. The present invention is applied in enciphering the Internet e-mails and transmitting or storing the compressed data.
摘要翻译：本发明公开了一种数字数据变换方法。该方法解决了编写传输加密电子邮件或任何8位数据序列时编码效率低和增加网络负载的问题。关键技术是设计一个“base-91编码”通用位串到可打印的ASCII字符，这也被称为base91编码或Radix-91编码。结合互联网标准SMTP，MIME，S / MIME等，本发明可以减少传输数据或存储需求的7.7％来代替Base64编码; 并且代替处理高位为1的字节数据的QP编码，减少了传输数据或存储需求的58.97％。本发明应用于对互联网电子邮件进行加密并传输或存储压缩数据。

7. 发明申请

WO2012135564A2 AIR DEFLECTOR FOR A VEHICLE A-PILLAR AND SIDE VIEW MIRROR 审中-公开
标题翻译：用于车辆A支柱和侧视镜的空气调节器
公开(公告)号：WO2012135564A2
公开(公告)日：2012-10-04
申请号：PCT/US2012031343
申请日：2012-03-30
申请人： VOLVO GROUP NORTH AMERICA LLC , SORRELLS MICHAEL , HEINECKE MATHEW FREDERICK , HE WEI , HOMER ROB , BALICKI BRIAN D , ANDERSON IAN P , HAUGH GLYN COLIN
发明人： SORRELLS MICHAEL , HEINECKE MATHEW FREDERICK , HE WEI , HOMER ROB , BALICKI BRIAN D , ANDERSON IAN P , HAUGH GLYN COLIN
IPC分类号： B62D37/02
CPC分类号： B62D35/008 , B60R1/0605
摘要： An air deflector for a vehicle A -pillar and side view mirror is formed as a unitary structure including an A-pillar vane and tipper and lower support arms. The vane is formed as a longitudinally elongated panel curved in a lateral direction. The vane is mountable adjacent to and spaced from a vehicle A-pillar with a concave surface facing the A-pillar. An upper arm extends laterally from a top end of the vane and encases a vehicle mirror upper support and a lower arm extends laterally from a bottom end of the vane and encases a vehicle mirror lower support. The vane is configured to control a flow air past the A-pillar and the upper arm and lower arms are shaped to guide an air flow around the mirror supports.
摘要翻译：用于车辆的导风板A柱和侧视镜形成为包括A柱叶片和自卸车以及下支撑臂的整体结构。叶片形成为沿横向方向弯曲的纵向细长板。叶片可以靠近车辆A柱并与其间隔开，并且具有面向A柱的凹面。上臂从叶片的顶端横向延伸并且包围车辆镜面上支撑件，并且下臂从叶片的底端横向延伸并且包围车辆后视镜下支撑件。叶片构造成控制流过A柱的流动空气，并且上臂和下臂成形为引导反射镜支撑件周围的空气流。

8. 发明申请

WO2004111759A3 APPLIED ESTIMATION OF EIGENVECTORS AND EIGENVALUES 审中-公开
标题翻译：应用估计的特征和特征值
公开(公告)号：WO2004111759A3
公开(公告)日：2007-03-08
申请号：PCT/US2004016734
申请日：2004-05-27
申请人： PURDUE RESEARCH FOUNDATION , PRABHU NAGABHUSHANA , HE WEI
发明人： PRABHU NAGABHUSHANA , HE WEI
IPC分类号： G06F7/38 , G06F20060101 , G06F7/00 , G06F17/16 , G06K9/62
CPC分类号： G06F17/16 , G06K9/6232
摘要： Various applications are presented of a vector field method of computing one or more eigenvalues and eigenvectors of a symmetric matrix. The vector field method computes an eigenvector by computing a discrete approximation to the integral curve of a special tangent vector field on the unit sphere. The optimization problems embedded in each iteration of the vector field algorithms admit closed form solutions making the vector field approach relatively efficient. Among the several vector fields discussed is a family of vector fields called the recursive vector fields. Numerical results are presented that suggest that in some embodiments the recursive vector field method yields implementations that are faster than those based on the QR method. Further, the vector field method preserves, and hence can fully exploit the sparseness on the given matrix to speed up computation even further. Preprocessing that contracts the spectral radius of the given matrix further accelerates the systems.
摘要翻译：提出了一种用于计算对称矩阵的一个或多个特征值和特征向量的矢量场方法的各种应用。矢量场方法通过计算单位球上特殊切线矢量场的积分曲线的离散近似来计算特征向量。嵌入在矢量场算法的每次迭代中的优化问题承认封闭形式的解决方案，使得矢量场方法相对有效。在讨论的几个矢量场中，有一系列称为递归矢量场的矢量场。提出了数值结果，表明在一些实施例中，递归矢量场方法产生比基于QR方法的实现更快的实现。此外，矢量场方法保留，因此可以充分利用给定矩阵上的稀疏，进一步加快计算。收缩给定矩阵的光谱半径的预处理进一步加速了系统。

9. 发明申请

WO2004099373A3 BIOCOMPATIBLE RESISTS 审中-公开
标题翻译：生物易燃性
公开(公告)号：WO2004099373A3
公开(公告)日：2005-04-21
申请号：PCT/US2004013383
申请日：2004-04-30
申请人： UNIV NORTH CAROLINA , GONSALVES KENNETH E , HE WEI
发明人： GONSALVES KENNETH E , HE WEI
IPC分类号： C08G63/48 , C08G63/91 , C12N20060101 , G03C1/73 , G03F7/038 , G03F7/039 , G03F7/20 , G03F7/26 , G03F7/30
CPC分类号： G03F7/0392 , G03F7/265
摘要： This invention relates to biomaterials, biocompatible photoresists, and electroactive photoresists, and methods to engineer the interactions between biomaterials and cells. In one aspect, this invention provides for modifying surface topography through micro-patterning techniques that require no organic solvent development to reveal the lithographic patterns. Cells can be cultured on these surfaces directly and exhibit strong cell alignment features.
摘要翻译：本发明涉及生物材料，生物相容性光致抗蚀剂和电活性光致抗蚀剂，以及设计生物材料与细胞之间相互作用的方法。在一个方面，本发明提供了通过不需要有机溶剂开发来显示平版印刷图案的微图案化技术改性表面形貌。可以直接在这些表面上培养细胞并显示出强的细胞对准特征。

10. 发明申请

WO2010003313A8 ICOTINIB HYDROCHLORIDE, SYNTHESIS, CRYSTALLOGRAPHIC FORM, MEDICAL COMBINATION, AND USES THEREOF 审中-公开
标题翻译： ICOTINIB HYDROCHLORIDE，合成，晶体形式，医学组合及其用途
公开(公告)号：WO2010003313A8
公开(公告)日：2010-04-22
申请号：PCT/CN2009000773
申请日：2009-07-07
申请人： ZHEJIANG BETA PHARMA INC , WANG YINXIANG , DING LIEMING , TAN FENLAI , HU YUNYAN , HE WEI , HAN BIN , LONG WEI , LIU YONG
发明人： WANG YINXIANG , DING LIEMING , TAN FENLAI , HU YUNYAN , HE WEI , HAN BIN , LONG WEI , LIU YONG
IPC分类号： C07D491/056 , A61K31/519 , A61P35/00
CPC分类号： C07D491/056 , A61K31/519 , C07B2200/13
摘要： The invention provides the 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline hydrochloride and its new crystallographic form. The invention also provides the preparation method, the medical combination, the clinical treatment method, the relevant intermediates of the compound above.
摘要翻译：本发明提供了4 - [（3-乙炔基苯基）氨基] -6,7-苯并-12-冠-4-喹唑啉盐酸盐及其新的晶体形式。本发明还提供了上述化合物的制备方法，药物组合，临床治疗方法及相关中间体。

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