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1. 发明申请

WO2008063815A2 OPTIMIZING STATIC DICTIONARY USAGE FOR SIGNAL HYPERTEXT TRANSFER PROTOCOL AND BYTECODE COMPRESSION IN A WIRELESS NETWORK 审中-公开
标题翻译：优化静态字典用于信号超文本传输协议和无线网络中的保护性压缩
公开(公告)号：WO2008063815A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/082469
申请日：2007-10-25
申请人： AT & T MOBILITY II LLC , STAFFORD, Matthew , KWONG, Kennie, Y. , WUTHNOW, Mark, S. , ROSENBERG, William
发明人： STAFFORD, Matthew , KWONG, Kennie, Y. , WUTHNOW, Mark, S. , ROSENBERG, William
CPC分类号： H04L67/06 , H04L65/1006 , H04L67/02 , H04L67/24 , H04L67/28 , H04L67/34 , H04L69/04 , H04W28/06 , H04W88/18
摘要： Methods and apparatus including a virtual machine and a compression network platform are provided especially for improving the application of compression algorithms and unique identifiers for bytecode and bytecode packages including associated static dictionaries utilized to advantage in wireless networks. In particular, a given virtual machine need only identify to a receiving virtual machine the unique package identifier for one or more of an algorithm, a static dictionary or a hash for decompressing a received data signal. The receiving virtual machine may advertise what it has locally available to it so that no uploading is necessary. The actuation of bytecode by identifier may be requested at a given destination within the parameters set by RFC 3320. Universal decompressor virtual machines may receive uploaded compression algorithms, bytecode identifiers, package identifiers or static dictionary identifiers and the like from proxy call session control functions of a wireless network, the compressing machine or a compression network platform resource which in one embodiment may comprise an IANA database. The methods and apparatus may find particular application in improving the efficiency of presence/group list management.
摘要翻译：提供了包括虚拟机和压缩网络平台的方法和装置，其特别是用于改进压缩算法的应用和用于字节码和字节码包的唯一标识符，包括在无线网络中利用的相关联的静态字典。特别地，给定的虚拟机仅需要向接收虚拟机识别用于解压缩接收到的数据信号的算法，静态字典或散列中的一个或多个的唯一包标识符。接收虚拟机可以向其发布本地可用的虚拟机，以便不需要上传。可以在由RFC 3320设置的参数内的给定目的地请求标识符的字节码的激活。通用解压缩器虚拟机可以从代理呼叫会话控制功能接收上传的压缩算法，字节码标识符，包标识符或静态字典标识符等无线网络，压缩机器或压缩网络平台资源，其在一个实施例中可以包括IANA数据库。方法和装置可以在提高存在/组列表管理的效率方面发现特别的应用。

2. 发明申请

WO2010039920A2 BOLDINE COMPOUNDS FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨生长的BOLDINE化合物
公开(公告)号：WO2010039920A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059172
申请日：2009-10-01
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/16 , A61P19/10 , A61K31/438 , A61P35/00
CPC分类号： A61K31/16 , A61K31/438
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了一种通过向对象施用治疗有效量的式I化合物来促进有此需要的对象中的骨生长的方法。本发明还提供了用于治疗肾脏疾病和癌症。

3. 发明申请

WO2006009702A3 LIVER DISEASE-RELATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：WO2006009702A3
公开(公告)日：2006-01-26
申请号：PCT/US2005/021002
申请日：2005-06-15
申请人： BAYER HEALTHCARE LLC , VOLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef , THIEL, Robert, P. , PETRY, Christoph , ROSENBERG, William
发明人： VOLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef , THIEL, Robert, P. , PETRY, Christoph , ROSENBERG, William
IPC分类号： A01N1/02 , A61K31/765 , C12M1/00 , G01N31/00 , G01N33/53 , G01N35/00
摘要： The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.

4. 发明申请

WO2010025135A2 TRIMEPRAZINE AND ETHOPROPAZINE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的三溴嘧啶和乙酰胆碱衍生物
公开(公告)号：WO2010025135A2
公开(公告)日：2010-03-04
申请号：PCT/US2009/054887
申请日：2009-08-25
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/5415 , A61P19/10 , A61K33/06 , A61P1/02 , A61P13/12 , A61P35/00
CPC分类号： A61K45/06 , A61K31/5415 , A61K31/59 , A61K31/663 , A61K38/23 , A61K39/395 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。本发明还提供了治疗肾脏疾病和癌症的方法。

5. 发明申请

WO2010002835A2 VINPOCETINE AND EBURNAMONINE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的VINPOCETINE和EBURNAMONINE衍生物
公开(公告)号：WO2010002835A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049168
申请日：2009-06-30
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
CPC分类号： A61K31/4375 , A61L27/54 , A61L2300/412 , A61L2430/02
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。化合物包括其盐，水合物和异构体。本发明还提供了治疗肾病和癌症的方法。

6. 发明申请

WO2010080756A2 HARMINE DERIVATIVES FOR REDUCING BODY WEIGHT 审中-公开
标题翻译：用于减少身体重量的助剂衍生物
公开(公告)号：WO2010080756A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020117
申请日：2010-01-05
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/437 , A61P3/04 , A61P3/00
CPC分类号： A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来减轻有需要的受试者体重的方法。本发明还提供了治疗与肥胖有关的肥胖症和障碍的方法，以及高于推荐的身体脂肪百分比，如II型糖尿病。

7. 发明申请

WO2010019549A2 INDOPROFEN DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨生长的吲哚布洛芬衍生物
公开(公告)号：WO2010019549A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053372
申请日：2009-08-11
申请人： OSTEOGENEX INC , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/404 , A61P19/10 , A61P35/00
CPC分类号： A61K31/404
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了一种通过向对象施用治疗有效量的式I化合物来促进有此需要的对象中的骨生长的方法。本发明还提供了用于治疗肾脏疾病和癌症。

8. 发明申请

WO2009129225A1 COMPOUNDS AND METHODS FOR ALTERING BONE GROWTH 审中-公开
标题翻译：用于改变骨生长的化合物和方法
公开(公告)号：WO2009129225A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040497
申请日：2009-04-14
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A01N43/64 , A61K31/53
CPC分类号： A61K9/0085 , A61K9/0019 , A61K9/0048 , A61K9/0078 , A61K9/0095 , A61K31/53
摘要： The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I. In Formula I, R 1 and R 2 are each H or C 1-6 alkyl. X is C 1-6 alkylene. R 3 is H, -OR 4 , OC(O)R 4 , OC(O)NR 4 R 5 , OC(O)OR 4 , OP(O)(OR 4 ) 2 or OC(O)(CH 2 ) 2 C(O)OH. R 4 and R 5 are each independently H or C 1-20 alkyl. The compounds also include salts, hydrates and isomers of the compounds.
摘要翻译：本发明提供用于促进骨生长的化合物，组合物和方法。可用于本发明方法的化合物包括式I化合物。在式I中，R 1和R 2各自为H或C 1-6烷基。 X是C 1-6亚烷基。 R3是H，-OR4，OC（O）R4，OC（O）NR4R5，OC（O）OR4，OP（O）（OR4）2或OC（O）（CH2）2C（O） R 4和R 5各自独立地为H或C 1-20烷基。化合物还包括化合物的盐，水合物和异构体。

9. 发明申请

WO2010107704A2 ELLIPTICINE COMPOUNDS FOR TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的化合物
公开(公告)号：WO2010107704A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/027337
申请日：2010-03-15
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/4738 , A61K31/47 , A61P3/04 , A61P3/00
CPC分类号： A61K31/475
摘要： The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I : In Formula I, R 1 is H, C 1-6 alkyl, or C 1-6 alkyl-aryl. Each of R 2 and R 4 of Formula I are independently H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, OR 2a , SR 2a , C(O)R 2a , C(O)OR 2a , C(O)NR 2a R 2b , NR 2a R 2b , C 1-6 alkyl NR 2a R 2b , N(R 2a )C(O)R 2b , N(R 2a )C(O)OR 2b , N(R 2a )C(O)NR 2a R 2b , OP(O)(OR 2a ) 2 , S(O) 2 OR 2a , S(O) 2 NR 2a R 2b , -CN, -NO 2 , cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each of R 2a and R 2b of Formula I are independently H, C 1-6 alkyl, C 1-10 heteroalkyl or C 1-6 alkyl-aryl. R 3 of Formula I is absent, C 1-6 alkyl or N-oxide. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.
摘要翻译：本发明提供了一种通过向受试者施用治疗有效量的式I化合物来减少有需要的受试者的体重的方法：在式I中，R 1是H，C 1-6烷基或C 1-6 烷基 - 芳基。式I的R 2和R 4各自独立地为H，卤素，C 1-6烷基，C 1-6卤代烷基，C 2-6烯基，C 2-6炔基，C 1-6卤代烷氧基，OR 2 a，SR 2 a，C（O）R 2a，C （O）OR2a，C（O）NR2aR2b，NR2aR2b，C1-6烷基NR2aR2b，N（R2a）C（O）R2b，N（R2a）C（O）OR2b，N（R2a）C（O）NR2aR2b，OP （O）（OR 2 a）2，S（O）2 OR 2 a，S（O）2 NR 2 R 2b，-CN，-NO 2，环烷基，杂环烷基，芳基或杂芳基。式I的R2a和R2b各自独立地为H，C1-6烷基，C1-10杂烷基或C1-6烷基 - 芳基。式I的R 3不存在，C 1-6烷基或N-氧化物。化合物包括其盐，水合物和异构体。本发明还提供了治疗与肥胖相关的肥胖症和高于推荐的体脂肪百分比（例如II型糖尿病）的方法。

10. 发明申请

WO2010011599A2 PIMETHIXENE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的PIMETHIXENE衍生物
公开(公告)号：WO2010011599A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051142
申请日：2009-07-20
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/382 , A61P19/10 , A61P1/02 , A61P35/00
CPC分类号： A61K45/06 , A61K31/445 , A61K31/497 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。本发明还提供了治疗肾脏疾病和癌症的方法。

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