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1. 发明申请

WO2010039920A2 BOLDINE COMPOUNDS FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨生长的BOLDINE化合物
公开(公告)号：WO2010039920A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059172
申请日：2009-10-01
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/16 , A61P19/10 , A61K31/438 , A61P35/00
CPC分类号： A61K31/16 , A61K31/438
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了一种通过向对象施用治疗有效量的式I化合物来促进有此需要的对象中的骨生长的方法。本发明还提供了用于治疗肾脏疾病和癌症。

2. 发明申请

WO2010025135A2 TRIMEPRAZINE AND ETHOPROPAZINE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的三溴嘧啶和乙酰胆碱衍生物
公开(公告)号：WO2010025135A2
公开(公告)日：2010-03-04
申请号：PCT/US2009/054887
申请日：2009-08-25
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/5415 , A61P19/10 , A61K33/06 , A61P1/02 , A61P13/12 , A61P35/00
CPC分类号： A61K45/06 , A61K31/5415 , A61K31/59 , A61K31/663 , A61K38/23 , A61K39/395 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。本发明还提供了治疗肾脏疾病和癌症的方法。

3. 发明申请

WO2010002835A2 VINPOCETINE AND EBURNAMONINE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的VINPOCETINE和EBURNAMONINE衍生物
公开(公告)号：WO2010002835A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049168
申请日：2009-06-30
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
CPC分类号： A61K31/4375 , A61L27/54 , A61L2300/412 , A61L2430/02
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。化合物包括其盐，水合物和异构体。本发明还提供了治疗肾病和癌症的方法。

4. 发明申请

WO2010080756A2 HARMINE DERIVATIVES FOR REDUCING BODY WEIGHT 审中-公开
标题翻译：用于减少身体重量的助剂衍生物
公开(公告)号：WO2010080756A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020117
申请日：2010-01-05
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/437 , A61P3/04 , A61P3/00
CPC分类号： A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来减轻有需要的受试者体重的方法。本发明还提供了治疗与肥胖有关的肥胖症和障碍的方法，以及高于推荐的身体脂肪百分比，如II型糖尿病。

5. 发明申请

WO2010019549A2 INDOPROFEN DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨生长的吲哚布洛芬衍生物
公开(公告)号：WO2010019549A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053372
申请日：2009-08-11
申请人： OSTEOGENEX INC , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/404 , A61P19/10 , A61P35/00
CPC分类号： A61K31/404
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了一种通过向对象施用治疗有效量的式I化合物来促进有此需要的对象中的骨生长的方法。本发明还提供了用于治疗肾脏疾病和癌症。

6. 发明申请

WO2009129225A1 COMPOUNDS AND METHODS FOR ALTERING BONE GROWTH 审中-公开
标题翻译：用于改变骨生长的化合物和方法
公开(公告)号：WO2009129225A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040497
申请日：2009-04-14
申请人： OSTEOGENEX, INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A01N43/64 , A61K31/53
CPC分类号： A61K9/0085 , A61K9/0019 , A61K9/0048 , A61K9/0078 , A61K9/0095 , A61K31/53
摘要： The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I. In Formula I, R 1 and R 2 are each H or C 1-6 alkyl. X is C 1-6 alkylene. R 3 is H, -OR 4 , OC(O)R 4 , OC(O)NR 4 R 5 , OC(O)OR 4 , OP(O)(OR 4 ) 2 or OC(O)(CH 2 ) 2 C(O)OH. R 4 and R 5 are each independently H or C 1-20 alkyl. The compounds also include salts, hydrates and isomers of the compounds.
摘要翻译：本发明提供用于促进骨生长的化合物，组合物和方法。可用于本发明方法的化合物包括式I化合物。在式I中，R 1和R 2各自为H或C 1-6烷基。 X是C 1-6亚烷基。 R3是H，-OR4，OC（O）R4，OC（O）NR4R5，OC（O）OR4，OP（O）（OR4）2或OC（O）（CH2）2C（O） R 4和R 5各自独立地为H或C 1-20烷基。化合物还包括化合物的盐，水合物和异构体。

7. 发明申请

WO2010036567A2 HARMINE COMPOUNDS FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的助剂化合物
公开(公告)号：WO2010036567A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/057417
申请日：2009-09-18
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/437 , A61P19/10 , A61P13/12 , A61P35/00
CPC分类号： C07K16/2875 , A61K9/0024 , A61K31/437 , A61K31/59 , A61K31/663 , A61K38/23 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。本发明还提供了治疗肾脏疾病和癌症的方法。

8. 发明申请

WO2010022201A2 FOLINIC ACID DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨生长的弗林酸衍生物
公开(公告)号：WO2010022201A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/054396
申请日：2009-08-20
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： C07D487/04 , C07D487/02 , A61K31/4985 , A61P3/14 , A61P19/08
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/4985 , A61K31/59 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了一种通过向对象施用治疗有效量的式I化合物来促进有此需要的对象中的骨生长的方法。本发明还提供了用于治疗肾脏疾病和癌症。

9. 发明申请

WO2010107704A2 ELLIPTICINE COMPOUNDS FOR TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的化合物
公开(公告)号：WO2010107704A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/027337
申请日：2010-03-15
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/4738 , A61K31/47 , A61P3/04 , A61P3/00
CPC分类号： A61K31/475
摘要： The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I : In Formula I, R 1 is H, C 1-6 alkyl, or C 1-6 alkyl-aryl. Each of R 2 and R 4 of Formula I are independently H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, OR 2a , SR 2a , C(O)R 2a , C(O)OR 2a , C(O)NR 2a R 2b , NR 2a R 2b , C 1-6 alkyl NR 2a R 2b , N(R 2a )C(O)R 2b , N(R 2a )C(O)OR 2b , N(R 2a )C(O)NR 2a R 2b , OP(O)(OR 2a ) 2 , S(O) 2 OR 2a , S(O) 2 NR 2a R 2b , -CN, -NO 2 , cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each of R 2a and R 2b of Formula I are independently H, C 1-6 alkyl, C 1-10 heteroalkyl or C 1-6 alkyl-aryl. R 3 of Formula I is absent, C 1-6 alkyl or N-oxide. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.
摘要翻译：本发明提供了一种通过向受试者施用治疗有效量的式I化合物来减少有需要的受试者的体重的方法：在式I中，R 1是H，C 1-6烷基或C 1-6 烷基 - 芳基。式I的R 2和R 4各自独立地为H，卤素，C 1-6烷基，C 1-6卤代烷基，C 2-6烯基，C 2-6炔基，C 1-6卤代烷氧基，OR 2 a，SR 2 a，C（O）R 2a，C （O）OR2a，C（O）NR2aR2b，NR2aR2b，C1-6烷基NR2aR2b，N（R2a）C（O）R2b，N（R2a）C（O）OR2b，N（R2a）C（O）NR2aR2b，OP （O）（OR 2 a）2，S（O）2 OR 2 a，S（O）2 NR 2 R 2b，-CN，-NO 2，环烷基，杂环烷基，芳基或杂芳基。式I的R2a和R2b各自独立地为H，C1-6烷基，C1-10杂烷基或C1-6烷基 - 芳基。式I的R 3不存在，C 1-6烷基或N-氧化物。化合物包括其盐，水合物和异构体。本发明还提供了治疗与肥胖相关的肥胖症和高于推荐的体脂肪百分比（例如II型糖尿病）的方法。

10. 发明申请

WO2010011599A2 PIMETHIXENE DERIVATIVES FOR PROMOTING BONE GROWTH 审中-公开
标题翻译：用于促进骨骼生长的PIMETHIXENE衍生物
公开(公告)号：WO2010011599A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051142
申请日：2009-07-20
申请人： OSTEOGENEX INC. , ELLIES, Debra , ROSENBERG, William
发明人： ELLIES, Debra , ROSENBERG, William
IPC分类号： A61K31/382 , A61P19/10 , A61P1/02 , A61P35/00
CPC分类号： A61K45/06 , A61K31/445 , A61K31/497 , A61K2300/00
摘要： The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的式I化合物来促进有需要的受试者的骨生长的方法。本发明还提供了治疗肾脏疾病和癌症的方法。

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