专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007073283A1 SUBSTITUTED CINNOLINE DERIVATIVES AS GABAA-RECEPTOR MODULATORS AND METHOD FOR THEIR SYNTHESIS 审中-公开
标题翻译：作为GABAA受体调节剂的取代的CINNOLINE衍生物及其合成方法
公开(公告)号：WO2007073283A1
公开(公告)日：2007-06-28
申请号：PCT/SE2006/001433
申请日：2006-12-18
申请人： ASTRAZENECA AB , CHAPDELAINE, Marc , OHNMACHT, Cyrus , BECKER, Christopher , CHANG, Hui-Fang , DEMBOFSKY, Bruce
发明人： CHAPDELAINE, Marc , OHNMACHT, Cyrus , BECKER, Christopher , CHANG, Hui-Fang , DEMBOFSKY, Bruce
IPC分类号： C07D237/28 , A61K31/497 , A61K31/502 , A61K31/506 , A61P25/22 , A61P25/24 , A61P25/28 , C07D401/10 , C07D403/10
CPC分类号： C07D237/28 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04
摘要： This invention relates to novel Cinnoline -based compounds and their pharmaceutically acceptable salts, tautomers or in vivo- hydrolysable precursors, compositions and methods of use thereof . These novel compounds provide a treatment or prophylaxis of dementia due to Parkinson's disease, dementia due to Alzheimer's disease as well as anxiety disorders, cognitive disorders, and/or mood disorders.
摘要翻译：本发明涉及新颖的噌啉类化合物及其药学上可接受的盐，互变异构体或体内可水解的前体，组合物及其使用方法。这些新化合物提供治疗或预防由于帕金森病导致的痴呆，由于阿尔茨海默病引起的痴呆以及焦虑障碍，认知障碍和/或情绪障碍。

2. 发明申请

WO2004031154A1 NOVEL LACTAMS AND USES THEREOF 审中-公开
标题翻译：新款LACTAMS及其用途
公开(公告)号：WO2004031154A1
公开(公告)日：2004-04-15
申请号：PCT/SE2003/001534
申请日：2003-10-02
申请人： ASTRAZENECA AB , BECKER, Christopher , DEMBOFSKY, Bruce , JACOBS, Robert , KANG, James , OHNMACHT, Cyrus , ROSAMOND, James , SHENVI, Ashokkumar, Bhikkappa , SIMPSON, Thomas , WOODS, James
发明人： BECKER, Christopher , DEMBOFSKY, Bruce , JACOBS, Robert , KANG, James , OHNMACHT, Cyrus , ROSAMOND, James , SHENVI, Ashokkumar, Bhikkappa , SIMPSON, Thomas , WOODS, James
IPC分类号： C07D223/16
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ß protein production and neurological disorders such as Alzheimer's disease.. These compounds inhibit γ secretase and thereby inhibit the production of amyloid ß protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译：具有式（I）的化合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白产生和神经障碍如阿尔茨海默病相关的神经障碍的方法。这些化合物抑制γ-分泌酶，从而抑制淀粉样蛋白ss的产生蛋白质，从而起到防止淀粉样蛋白神经沉积的形成的作用。

3. 发明申请

WO2004098600A1 POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
标题翻译： NICOTINIC乙酰胆碱受体的阳性调节剂
公开(公告)号：WO2004098600A1
公开(公告)日：2004-11-18
申请号：PCT/GB2004/001934
申请日：2004-05-04
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BECKER, Christopher , COMSTOCK, Jeanne , MICHNE, William, F , MURPHY, Megan , PHILLIPS, Eifion , ROSAMOND, James, D , SIMPSON, Thomas, R
发明人： BECKER, Christopher , COMSTOCK, Jeanne , MICHNE, William, F , MURPHY, Megan , PHILLIPS, Eifion , ROSAMOND, James, D , SIMPSON, Thomas, R
IPC分类号： A61K31/47
CPC分类号： A61K31/4709 , A61K31/47
摘要： Compounds of Formula (I) or Formula (II) wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
摘要翻译：式（I）或式（II）的化合物，其中R 1，X和Ar如说明书中所述，其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是治疗条件与烟碱传播减少有关。

4. 发明申请

WO2007041245A2 BIOMARKERS FOR MULTIPLE SCLEROSIS AND METHODS OF USE THEREOF 审中-公开
标题翻译：多发性硬化症的生物标志物及其使用方法
公开(公告)号：WO2007041245A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/037924
申请日：2006-09-29
申请人： PPD BIOMARKER DISCOVERY SCIENCES LLC , KANTOR, Aaron, B. , GOELZ, Susan , DENG, Jun , LIN, Hua , BECKER, Christopher
发明人： KANTOR, Aaron, B. , GOELZ, Susan , DENG, Jun , LIN, Hua , BECKER, Christopher
IPC分类号： G01N33/53
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/5023 , G01N33/5047 , G01N33/564 , G01N2500/00 , G01N2500/10 , G01N2800/285 , G01N2800/52
摘要： Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing MS, relapse of MS patients and disease progression in MS patients.
摘要翻译：提供了用于识别多发性硬化症（MS）患者治疗和监测治疗的生物标志物，以及其鉴定方法，MS诊断方法，MS患者复发和MS患者疾病进展。

5. 发明申请

WO2002081752A2 METHODS AND KITS USEFUL FOR THE SIMPLIFICATION OF COMPLEX PEPTIDE MIXTURES 审中-公开
标题翻译：用于简化复合肽混合物的方法和工具
公开(公告)号：WO2002081752A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/010463
申请日：2002-04-03
申请人： THERMO FINNIGAN CORPORATION , BECKER, Christopher
发明人： BECKER, Christopher
IPC分类号： C12Q1/68
CPC分类号： G01N33/58 , B01J2219/005 , B01J2219/00725 , C12Q1/37 , C40B70/00 , G01N30/7233 , G01N33/532 , G01N33/54326 , G01N33/54353 , G01N33/6842 , G01N33/6848 , G01N2333/976 , G01N2458/15 , Y10S436/824 , Y10T436/24
摘要： Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The simplified sample can be easier to analyze than the original peptide sample yet it is representative of all or nearly all of the proteins present in the mixed protein sample from which the original and more complex peptide sample was derived. The methods entail the use of tagging moieties that include an amino-acid-specific reactive group (R). The tagging moieties "tag" peptides or proteins at specific amino acids (e.g., by reacting with an amino acid to form a covalent bond), ultimately allowing the isolation of peptides that contain those specific amino acids. Other methods entail the used of a reactive moiety (R p ) that comprises a reagent that selectively interacts with selected proteins, either covalently or noncovalently. For example, R p can be a natural ligand for a receptor that is to be taged or a protein that interacts with a second protein that is to be tagged. It can be an enzymatic substrate or other element of molecular recognition such as an antibody, ATP, GTP, NAD, NADP, NADH, NADPH, ubiquitin, or structural analogs thereof.
摘要翻译：公开了从含有多个肽的样品中获得肽的简化混合物的方法和试剂。简化的样品可以比原始肽样品更容易分析，但它代表了衍生原始和更复杂的肽样品的混合蛋白样品中存在的全部或几乎全部蛋白质。所述方法需要使用包括氨基酸特异性反应性基团（R）的标记部分。标签部分在特定氨基酸“标记”肽或蛋白质（例如通过与氨基酸反应以形成共价键），最终允许分离含有那些特定氨基酸的肽。其他方法需要使用包含与所选蛋白质共价或非共价选择性相互作用的试剂的反应性部分（R p）。例如，Rp可以是待受体的受体的天然配体或与被标记的第二种蛋白质相互作用的蛋白质。其可以是酶底物或分子识别的其它元件，例如抗体，ATP，GTP，NAD，NADP，NADH，NADPH，泛素或其结构类似物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式