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1. 发明申请

WO2011114148A1 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 4H- [1,2,4]三唑并[5,1-B]嘧啶-1-酮衍生物作为CCR2B受体拮抗剂
公开(公告)号：WO2011114148A1
公开(公告)日：2011-09-22
申请号：PCT/GB2011/050515
申请日：2011-03-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BENGTSSON, Boel, Ase , BLACKABY, Wesley , CUMMING, John , FAULL, Alan, Wellington , LARSSON, Joakim , NASH, Ian, Alun , OLDHAM, Keith , PAPE, Andrew
发明人： BENGTSSON, Boel, Ase , BLACKABY, Wesley , CUMMING, John , FAULL, Alan, Wellington , LARSSON, Joakim , NASH, Ian, Alun , OLDHAM, Keith , PAPE, Andrew
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00 , A61P9/10 , A61P19/02
CPC分类号： C07D487/04
摘要： The present invention relates to novel compounds for use in the compositions, to processes for their preparation, to intermediates useful in their preparation and to their use as therapeutic agents. The present invention also relates to pharmaceutical compositions, which comprise compounds that act via antagonism of the CCR2b receptor for which MCP-1 is one of the known ligands and so may be used to treat inflammatory disease, atherosclerosis, diabetes, obesity, cancer, chronic obstructive pulmonary disease (COPD) rheumatoid arthritis and/or neuropathic pain, which is mediated by these receptors.
摘要翻译：本发明涉及用于组合物的新化合物，其制备方法，可用于其制备的中间体及其作为治疗剂的用途。本发明还涉及药物组合物，其包含通过CCR2b受体的拮抗作用的化合物，其中MCP-1是已知配体之一，因此可用于治疗炎性疾病，动脉粥样硬化，糖尿病，肥胖症，癌症，慢性阻塞性肺疾病（COPD）类风湿性关节炎和/或由这些受体介导的神经性疼痛。

2. 发明申请

WO2006051270A1 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS 审中-公开
标题翻译： 5-HETEROARYL THIAZOLES及其作为P13K抑制剂使用
公开(公告)号：WO2006051270A1
公开(公告)日：2006-05-18
申请号：PCT/GB2005/004268
申请日：2005-11-07
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BENGTSSON, Malena , LARSSON, Joakim , NIKITIDIS, Grigorios , STORM, Peter , BAILEY, John, Peter , GRIFFEN, Edward, Jolyon , ARNOULD, Jean-Claude , BIRD, Thomas, Geoffrey, Colerick
发明人： BENGTSSON, Malena , LARSSON, Joakim , NIKITIDIS, Grigorios , STORM, Peter , BAILEY, John, Peter , GRIFFEN, Edward, Jolyon , ARNOULD, Jean-Claude , BIRD, Thomas, Geoffrey, Colerick
IPC分类号： C07D417/04 , C07D417/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R 1 , R 2 and R 3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
摘要翻译：本发明提供式（I）的噻唑衍生物或其药学上可接受的盐，其中环A，R 1，R 2和R 3，如规范中所定义; 其准备过程; 含有它们的药物组合物; 以及它们在治疗中的用途，例如用于治疗由PI3K酶和/或mTOR激酶介导的疾病。

3. 发明申请

WO2008002246A1 A PHARMACEUTICAL COMPOSITION COMPRISING AN IKK2 INHIBITOR AND A SECOND ACTIVE INGRDIENT. 审中-公开
标题翻译：包含IKK2抑制剂和第二活性成分的药物组合物。
公开(公告)号：WO2008002246A1
公开(公告)日：2008-01-03
申请号：PCT/SE2007/000622
申请日：2007-06-26
申请人： ASTRAZENECA AB , ANDERSSON, Paul , BÖRJESSON, Lena , ERIKSSON, Christina , LARSSON, Joakim
发明人： ANDERSSON, Paul , BÖRJESSON, Lena , ERIKSSON, Christina , LARSSON, Joakim
IPC分类号： A61K31/381 , A61P11/00 , A61P11/06
CPC分类号： A61K31/381 , A61K45/06 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising an IKK2 inhibitor and a second active ingredient, and their use in therapy.
摘要翻译：本发明提供包含IKK2抑制剂和第二活性成分的药物组合物及其在治疗中的用途。

4. 发明申请

WO2002092571A1 NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES 审中-公开
标题翻译：新型4-苯胺基喹啉-3-羧酰胺
公开(公告)号：WO2002092571A1
公开(公告)日：2002-11-21
申请号：PCT/SE2002/000875
申请日：2002-05-06
申请人： ASTRAZENECA AB , LARSSON, Joakim , SJÖ, Peter
发明人： LARSSON, Joakim , SJÖ, Peter
IPC分类号： C07D215/54
CPC分类号： C07D231/12 , C07D215/54 , C07D215/56 , C07D233/56 , C07D249/08 , C07D401/12 , C07D409/12 , C07D491/04
摘要： The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及新的式（IA）化合物，其为JAK3激酶抑制剂，其制备方法和包含它们的药物组合物。

5. 发明申请

WO2004043924A1 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE 审中-公开
标题翻译：作为中性弹性蛋白酶抑制剂的2-吡啶酮衍生物
公开(公告)号：WO2004043924A1
公开(公告)日：2004-05-27
申请号：PCT/SE2003/001739
申请日：2003-11-11
申请人： ASTRAZENECA AB , BLADH, Håkan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
发明人： BLADH, Håkan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
IPC分类号： C07D211/86
CPC分类号： C07D213/64 , C07D213/82 , C07D239/557 , C07D241/24 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R¿1?, R¿4?, R¿5?, G¿1?, G¿2?, X, L, Y¿1?, Y¿2? and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译：提供式（I）的新化合物，其中R 1，R 4，R 5，G 1，G 2，X，L，Y 1，Y 2，和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。

6. 发明申请

WO2005021509A1 QUINOLINE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE 审中-公开
标题翻译：喹诺酮衍生物作为中性弹性蛋白酶抑制剂及其使用
公开(公告)号：WO2005021509A1
公开(公告)日：2005-03-10
申请号：PCT/SE2004/001226
申请日：2004-08-25
申请人： ASTRAZENECA AB , BLADH, Håkan , LARSSON, Joakim
发明人： BLADH, Håkan , LARSSON, Joakim
IPC分类号： C07D215/54
CPC分类号： C04B35/632 , C07D215/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： There are provided novel compounds of formula (I) wherein R 1 , R 3 , R 4 , R 5 , G 1 , G 2 , L and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译：提供新的式（I）化合物，其中R 1，R 3，R 4，R 5，G 1，G 2，L和n如本说明书中所定义和其光学异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。

7. 发明申请

WO2005021512A1 QUINOXALINE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE 审中-公开
标题翻译：喹诺酮衍生物作为中性弹药酶抑制剂及其使用
公开(公告)号：WO2005021512A1
公开(公告)日：2005-03-10
申请号：PCT/SE2004/001225
申请日：2004-08-25
申请人： ASTRAZENECA AB , BLADH, Håkan , LARSSON, Joakim
发明人： BLADH, Håkan , LARSSON, Joakim
IPC分类号： C07D241/44
CPC分类号： C07D241/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R 1 , R 4 , R 5 , G 1 , G 2 , L and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译：提供了新的式（I）化合物，其中R 1，R 4，R 5，G 1，G 2，L和n如本说明书和光学异构体，外消旋物及其互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。

8. 发明申请

WO2008105696A1 STERILIZATION DEVICE, STERILIZATION PROCESS, VAPORIZING SYSTEM AND USE OF SUCH A VAPORIZING SYSTEM 审中-公开
标题翻译：灭菌装置，灭菌过程，蒸发系统和这种蒸发系统的使用
公开(公告)号：WO2008105696A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000202
申请日：2007-03-01
申请人： GETINGE STERILIZATION AB , LARSSON, Joakim , PEDERSEN, Bjarne , ÅHLUND, Mats-Åke , NILSSON, Stefan
发明人： LARSSON, Joakim , PEDERSEN, Bjarne , ÅHLUND, Mats-Åke , NILSSON, Stefan
IPC分类号： A61L11/00 , A61L9/16 , B01D35/18
CPC分类号： A61L11/00 , A61L2/07 , A61L9/16 , A61L2202/122
摘要： The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.
摘要翻译：本发明公开了一种灭菌装置（1），用于消毒废物的介质，设备和/或去污，所述灭菌装置（1）包括一个室（2），至少一个排放管线（6），布置在所述室）和布置在所述室（2）上的至少一个气体发生器，至少两个串联布置在排气管线（6）中的无菌过滤器（8a，8b），连接到室（2）的至少一个真空装置）通过所述排气管（6）和所述至少两个过滤器（8a，8b）。至少一个加热装置（9）布置在所述两个无菌过滤器（8a，8b）之间的所述排气管线（6）上，以便蒸发在过滤器之间形成的冷凝物。此外，公开了用于消毒废物的介质，设备和/或去污的灭菌方法，灭菌装置的蒸发系统（12）以及在消毒装置中使用这种蒸发系统（12）。

9. 发明申请

WO2012060758A1 A METHOD OF MEASURING A CAPACITANCE AND A USE 审中-公开
标题翻译：测量电容和使用的方法
公开(公告)号：WO2012060758A1
公开(公告)日：2012-05-10
申请号：PCT/SE2011/000192
申请日：2011-10-31
申请人： CAPSENZE , HEDSTRÖM, Martin , ERLANDSSON, Dag , MATTIASSON, Bo , LARSSON, Joakim
发明人： HEDSTRÖM, Martin , ERLANDSSON, Dag , MATTIASSON, Bo , LARSSON, Joakim
IPC分类号： G01N27/22 , G01R27/26
CPC分类号： G01N27/22 , G01N27/228 , G01N27/3276 , G01R27/26 , G01R27/2605
摘要： The invention relates to a method of measuring a capacitance of a sensor with a capacitance (C). The sensor has a working electrode that is coated by an insulating layer and a ligand forming an affinity surface. The method involves the steps of bringing the electrode into contact with an analyte, supplying a constant first current (li), and a constant second current (l2) of opposite direction to the first current (li), and a constant third current (l3) of same direction as the first current (li) during determined time periods to the sensor. Further the method include sampling the potential (V) built up across the sensor, and calculating the capacitance of the sensor by means of the inclination (B, D, F, H) of a potential curve received in response to the current supply. Also, the invention relates to a use of a method for detection of an interaction between a ligand and an analyte.
摘要翻译：本发明涉及一种用电容（C）测量传感器电容的方法。传感器具有由绝缘层和形成亲和表面的配体涂覆的工作电极。该方法包括使电极与分析物接触的步骤，提供恒定的第一电流（li）和与第一电流（li）相反方向的恒定的第二电流（I2）和恒定的第三电流（13 ）与在传感器的确定时间段期间的与第一电流（li）相同的方向。此外，该方法包括对跨传感器建立的电位（V）进行采样，并且通过响应于当前电源接收的电位曲线的倾斜度（B，D，F，H）来计算传感器的电容。此外，本发明涉及用于检测配体和分析物之间的相互作用的方法的用途。

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