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    • 1. 发明申请
    • METAL-ASSISTED AND MICROWAVE-ACCELERATED EVAPORATIVE CRYSTALLIZATION
    • 金属辅助和微波加速蒸发结晶
    • WO2013055859A1
    • 2013-04-18
    • PCT/US2012/059660
    • 2012-10-11
    • ASLAN, Kadir
    • ASLAN, Kadir
    • C07C227/00
    • C07H1/06C07B2200/13C07C227/42C30B7/005C30B28/06C30B29/58C07C229/08
    • The present invention relates to methods for rapid crystallization of amino acids, drug molecules, proteins and DNA/peptides. One method for rapid crystallization of functional group-containing molecules selected from the group consisting of amino acids, drug molecules, proteins and DNA/peptides includes (A) providing at least one metal or metal oxide in particulate or thin film form to provide (a) selective nucleation sites for crystallization of the functional group-containing molecules due to interactions of their functional groups and metal surfaces or engineered metal surfaces and (b) a microwave-transparent medium to create a thermal gradient between the metal surfaces or engineered metal surfaces and a warmer solution containing functional group-containing molecules to be crystallized, and (B) conducting microwave heating to cause the functional group-containing molecules to be crystallized.
    • 本发明涉及氨基酸,药物分子,蛋白质和DNA /肽快速结晶的方法。 选自氨基酸,药物分子,蛋白质和DNA /肽的含官能团分子的快速结晶的一种方法包括(A)提供至少一种颗粒或薄膜形式的金属或金属氧化物以提供(a )由于其官能团和金属表面或工程金属表面的相互作用而使含官能团的分子结晶的选择性成核位点和(b)微波透明介质以在金属表面或工程金属表面之间产生热梯度,以及 含有待结晶的含有官能团的分子的较暖的溶液,(B)进行微波加热使含官能团的分子结晶。