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1. 发明申请

WO1990002751A1 PEPTIDE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：肽衍生物及其用途
公开(公告)号：WO1990002751A1
公开(公告)日：1990-03-22
申请号：PCT/JP1989000926
申请日：1989-09-08
申请人： ASAHI GLASS COMPANY LTD. , OHBA, Masataka , KUMAGAI, Hiromichi , HARIE, Shunsaku , UCHIDA, Keiichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C07K05/12
CPC分类号： C07K5/126 , A61K38/00 , C07K14/75 , C07K14/78 , Y02P20/55
摘要： The invention provides peptide derivatives comprising synthetic cyclic peptides represented by formula (I), or salts thereof, wherein R represents an amino acid residue or an oligo- or polypeptide residue, and a pharmaceutical agent containing said derivative as an active ingredient and inhibiting adhesion of animal cells to a substrate. The peptide derivatives are stable to hydrolysis by enzymes, and the pharmaceutical agent is effective in inhibiting adhesion of animal cells to a substrate, depressing metastasis of cancer cells, and inhibiting agglutination of platelets.

2. 发明申请

WO1996023890A1 SECRETORY SIGNAL GENE AND EXPRESSION VECTOR HAVING THE SAME 审中-公开
标题翻译：秘密信号基因和表达载体
公开(公告)号：WO1996023890A1
公开(公告)日：1996-08-08
申请号：PCT/JP1996000198
申请日：1996-02-01
申请人： ASAHI GLASS COMPANY LTD. , HAMA, Yuko , TOHDA, Hideki , TSUKAMOTO, Hiroko , NIKAIDO, Kiyokazu , KUMAGAI, Hiromichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C12N15/81
CPC分类号： C12N15/815 , C07K14/39 , C07K2319/02
摘要： A secretory signal gene which comprises a base sequence encoding a polypeptide capable of serving as a secretory signal in a fission yeast Schizosaccharomyces pombe; an expression vector having this gene and a heterogenous protein structural gene; a multicloning vector having the above secretory signal gene and being useful in the construction of the above expression vector; and the secretory production of this heterogenous protein structural gene product at a high efficiency in S. pombe, etc.
摘要翻译：一种分泌信号基因，其包含编码能够在裂殖酵母裂殖酵母中分泌信号的多肽的碱基序列; 具有该基因的表达载体和异源蛋白质结构基因; 具有上述分泌信号基因并可用于构建上述表达载体的多克隆载体; 在异源蛋白质结构基因产物中高效率分泌生产S.pombe等。

3. 发明申请

WO1995009914A1 MULTICLONING VECTOR, EXPRESSION VECTOR, AND PRODUCTION OF FOREIGN PROTEIN WITH EXPRESSION VECTOR 审中-公开
标题翻译：多分支向量，表达载体和表达载体生产外源蛋白
公开(公告)号：WO1995009914A1
公开(公告)日：1995-04-13
申请号：PCT/JP1994001657
申请日：1994-10-04
申请人： ASAHI GLASS COMPANY LTD. , TOHDA, Hideki , HAMA, Yuko , KUMAGAI, Hiromichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C12N15/09
CPC分类号： C07K14/5412 , C07K14/4721 , C07K14/765 , C12N9/12 , C12N9/78 , C12N15/815
摘要： An expression vector capable of expressing in a fission yeast Schizosaccharomyces pombe; a multicloning vector for constructing the expression vector; a method of constructing the expression vector; a transformant holding the expression vector; and a process for producing a foreign protein by using the transformant. The multicloning vector has a sequence of -ACATGT- starting with the 5' side at the tip of the multicloning site as the restriction enzyme recognition site for introducing a structural gene of a foreign protein. An expression vector is constructed by introducing a structural gene of a foreign protein by using the above recognition site in such a manner that the tip of the structural gene will have a sequence of -ACATGN- (N being an arbitrary base) starting with the 5' side and that the ATG region of the sequence will function as a translation initiation site of the structural gene. Since it is possible to use an arbitrary base as the N in the sequence of ATGN of the expression vector, it becomes possible to introduce a structural gene of any foreign protein and to express the structural gene to a high level.
摘要翻译：能够在裂殖酵母裂殖酵母中表达的表达载体; 用于构建表达载体的多克隆载体; 构建表达载体的方法; 持有表达载体的转化子; 以及通过使用转化体生产外来蛋白质的方法。多克隆载体具有-ACATGT序列，从多碱基位点末端的5'侧开始作为引入外源蛋白质结构基因的限制酶识别位点。通过使用上述识别位点引入外源蛋白质的结构基因，构建表达载体，使得结构基因的末端将具有以5的顺序开始的-ACATGN-（N为任意碱基）并且序列的ATG区域将用作结构基因的翻译起始位点。由于可以使用任意碱作为表达载体的ATGN的序列中的N，因此可以引入任何外来蛋白质的结构基因并将结构基因表达到高水平。

4. 发明申请

WO1992009627A1 PEPTIDE WITH ACTIVITY OF INHIBITING CANCER CELL INFILTRATION, COMPOSITE THEREOF, AND CANCER METASTASIS INHIBITOR 审中-公开
标题翻译：具有抑制癌细胞浸润活性的肽，其复合物，以及癌症METASTASIS抑制剂
公开(公告)号：WO1992009627A1
公开(公告)日：1992-06-11
申请号：PCT/JP1991001648
申请日：1991-11-29
申请人： ASAHI GLASS COMPANY LTD. , ISOAI, Atsushi , HAMA, Yuko , KUMAGAI, Hiromichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C07K07/06
CPC分类号： C07K14/52 , A61K38/00 , A61K47/61 , C07K2319/00
摘要： A peptide having an activity of inhibiting cancer cell infiltration and containing 5 to 20 amino acid residues, preferably any of those having amino acid sequences (1) to (13); and a cancer metastasis inhibitor containing the peptide as the active ingredient. A peptide composite comprising a peptide having an activity of inhibiting cancer cell infiltration and a biopolymer chemically bonded thereto, wherein the peptide is preferably any of those having amino acid sequences (1) to (14) and the biopolymer is preferably a protein such as albumin or globulin; and a cancer metastasis inhibitor containing the peptide composite as the active ingredient. The amino acid sequences (1) to (14) wherein, Glx represents Glu or Gln, and Asx represents Asn or Asp.

5. 发明申请

WO1984004917A1 7-FLUOROPROSTAGLANDINS AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译： 7-FLORORROSTAGLANDINS及其制备方法
公开(公告)号：WO1984004917A1
公开(公告)日：1984-12-20
申请号：PCT/JP1984000294
申请日：1984-06-07
申请人： ASAHI GLASS COMPANY LTD. , YASUDA, Arata , KATO, Masao , YAMABE, Masaaki , UCHIDA, Keiichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C07C177/00
CPC分类号： C07D307/937 , C07C405/00 , Y02P20/55
摘要： 7-Fluoroprostaglandins represented by formula (I), wherein R1 represents H or C1-10 alkyl, R2, R3, and R4 each represents H or the same or different protective group, and R5 represents C3-7, straight-chain, branched or cyclic alkyl.

6. 发明申请

WO1998012175A1 FLUORINATED PROSTAGLANDIN DERIVATIVES AND MEDICINES 审中-公开
标题翻译：氟化衍生物衍生物和药物
公开(公告)号：WO1998012175A1
公开(公告)日：1998-03-26
申请号：PCT/JP1997003236
申请日：1997-09-12
申请人： ASAHI GLASS COMPANY LTD. , SANTEN PHARMACEUTICAL CO., LTD. , SHIRASAWA, Eiichi , KAGEYAMA, Masaaki , MORI, Nobuaki , SAKATA, Kazuhisa , NAKANO, Takashi , MATSUMURA, Yasushi , MORIZAWA, Yoshitomi
发明人： ASAHI GLASS COMPANY LTD. , SANTEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07C405/00
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0033 , C07C405/0041 , C07D313/00
摘要： Fluorinated prostaglandin derivatives represented by general formula (1) or salts thereof; and medicines containing the same as the active ingredient, particularly ones to be used for preventing or treating eye diseases. In said formula A represents vinylene, ethylene, ethynylene, etc.; R represents aryloxyalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, etc.; R and R represent each hydrogen, acyl, etc.; Z represents -OR , -NHCOR , -NHSO2R , -SR (wherein R , R , R and R represent each hydrogen, alkyl, etc.); and the combination of the solid line with the broken line represents a single bond, a cis double bond or a trans double bond. The medicines are excellent as a medicine for eye diseases with high pharmacological effects and low side effects.
摘要翻译：由通式（1）表示的氟化前列腺素衍生物或其盐; 和含有与活性成分相同的药物，特别是用于预防或治疗眼睛疾病的药物。所述式A表示亚乙烯基，亚乙基，亚乙炔基等; R 1表示芳氧基烷基，烷基，烯基，炔基，环烷基，芳烷基等; R 2和R 3各自代表氢，酰基等; Z表示-OR 4，-NHCOR 5，-NHSO 2 R 6，-SR 7（其中R 4，R 5，R 6和R 7各自表示氢，烷基等）; 并且实线与虚线的组合表示单键，顺式双键或反式双键。该药物作为一种具有高药理作用和低副作用的眼部疾病药物是优异的。

7. 发明申请

WO1998004406A1 TRANSPARENT CONDUCTIVE FILM AND METHOD FOR FORMING TRANSPARENT ELECTRODE 审中-公开
标题翻译：透明导电膜和形成透明电极的方法
公开(公告)号：WO1998004406A1
公开(公告)日：1998-02-05
申请号：PCT/JP1997002545
申请日：1997-07-23
申请人： ASAHI GLASS COMPANY LTD. , TAKAKI, Satoru , SATO, Kazuo , MIYAZAKI, Masami , KAWAMURA, Yuki , NISHIMURA, Hiromichi
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： B32B07/02
CPC分类号： C23F1/30 , C23C14/086 , G02F1/13439 , H01J2211/225
摘要： A transparent conductive film constituted by alternately piling transparent oxide layers composed of an oxide containing ZnO and In, with the amount of In being adjusted within the range of 9-98 at. % against the total amount of Zn and In, and metallic layers containing Ag one upon another in (2n+1) layers (n: an integer not smaller than 1) in that order from the base, and a method for forming a transparent electrode.
摘要翻译：通过交替堆叠由含有ZnO和In的氧化物构成的透明氧化物层而构成的透明导电膜，其中In的量被调节在9-98at。的范围内。相对于Zn和In的总量的含量，以及从基底按顺序在（2n + 1）层（n：1以上的整数）中含有Ag的金属层，以及形成透明电极的方法。

8. 发明申请

WO1996024560A1 SCRATCH-RESISTANT GLASS 审中-公开
标题翻译：防刮玻璃
公开(公告)号：WO1996024560A1
公开(公告)日：1996-08-15
申请号：PCT/JP1996000301
申请日：1996-02-13
申请人： ASAHI GLASS COMPANY LTD. , SEHGAL, Jeetendra , KASE, Junichiro , TAKADA, Akira , TAKAHASHI, Hideo , NAKAO, Yasumasa , ITO, Seturo
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： C03C03/091
CPC分类号： C03C3/078 , C03C3/085 , C03C3/089 , C03C3/091
摘要： A scratch-resistant glass essentially comprising the following components and having a density of 2.43 g/cc or less as determined at room temperature: SiO2 74 - 85.5 wt.%, B2O3 0.5 - 5 wt.%, SiO2+B2O3 76 - 88 wt.%, RO 1 - 9 wt.%, R'2O 10 - 23 wt.%, RO+R'2O 11 - 24 wt.%, Al2O3 0 - 5 wt.%, RO/R'2O by weight 0.6 or less, wherein R represents at least one of Mg and Ca; R' represents at least one of Li, Na and K.
摘要翻译：一种耐刮擦玻璃，其基本上包括以下组分，并且在室温下测定的密度为2.43g / cc或更低：SiO 2 74-85.5wt。％，B 2 O 3 0.5-5wt。％，SiO 2 + B 2 O 3 76-88wt ％，RO 1-9重量％，R'2O 10-23重量％，RO + R'2O 11-24重量％，Al2O3 0-5重量％，RO / R'2O按重量计0.6或较少，其中R表示Mg和Ca中的至少一种; R'表示Li，Na和K中的至少一种。

9. 发明申请

WO1995023996A1 DISPLAY DEVICE 审中-公开
标题翻译：显示设备
公开(公告)号：WO1995023996A1
公开(公告)日：1995-09-08
申请号：PCT/JP1995000321
申请日：1995-03-01
申请人： ASAHI GLASS COMPANY LTD. , OZEKI, Masao , HIRAI, Yoshinori , OOI, Yoshiharu
发明人： ASAHI GLASS COMPANY LTD.
IPC分类号： G02F01/1335
CPC分类号： G02F1/133526 , G02F1/1334 , G02F1/133555 , G02F1/133615 , G02F2001/13756
摘要： The display device using a transparent-scattering type liquid crystal element has such a structure that the light quantity to an observer is controlled as possible when a black image (transparent state) is provided, and a high efficiency of light is maintained when a white image (scattering state) is provided. A prism array (12) is disposed at the back surface of the transparent-scattering type display element so that a sawteeth-like surface of the prism array (12) faces the display element (11) and a light absorber (13) is disposed at the back surface of the prism array. A light source (14) can be disposed at a side face of the prism array (12), with a reflector (16) at the opposite side of the light source (14) with respect to the prism array (12). A display device having high contrast ratio is obtainable.
摘要翻译：使用透明散射型液晶元件的显示装置具有这样的结构，即当设置黑色图像（透明状态）时可以控制观察者的光量，并且当白色图像保持高效率的光时（散射状态）。棱镜阵列（12）设置在透明散射型显示元件的背面，使得棱镜阵列（12）的锯齿状表面面向显示元件（11）并设置光吸收体（13）在棱镜阵列的后表面。光源（14）可以设置在棱镜阵列（12）的侧面，反射器（16）相对于棱镜阵列（12）位于光源（14）的相对侧。可以获得具有高对比度的显示装置。

10. 发明申请

WO1992004339A1 NOVEL PROSTAGLANDIN I2 DERIVATIVES 审中-公开
标题翻译：新型PROSTAGLANDIN I2衍生物
公开(公告)号：WO1992004339A1
公开(公告)日：1992-03-19
申请号：PCT/JP1991001185
申请日：1991-09-05
申请人： ASAHI GLASS COMPANY LTD. , DAINIPPON PHARMACEUTICAL CO., LTD. , ASAI, Tomoyuki , MORIZAWA, Yoshitomi , YASUDA, Arata , YAMAMOTO, Taku , FUJITANI, Buichi , HOSOKI, Kanoo
发明人： ASAHI GLASS COMPANY LTD. , DAINIPPON PHARMACEUTICAL CO., LTD.
IPC分类号： C07D307/937
CPC分类号： C07D307/937
摘要： A novel prostaglandin I2 derivative selected from a prostaglandin I2 having a halogen atom on the carbon atom corresponding to the 7-position of natural prostaglandin I2 and having a cycloalkylene group in the α-chain, and its esters and salts.

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