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1. 发明申请

WO2008153608A2 MICRODEVICE ARRAYS FORMED BY MAGNETIC ASSEMBLY 审中-公开
标题翻译： MICRODEVICE阵列由磁性组件形成
公开(公告)号：WO2008153608A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/001021
申请日：2008-01-23
申请人： ARRAYOMICS, INC. , HEROLD, Christopher D. , ROTHWARF, David , NGUYEN, Bao
发明人： HEROLD, Christopher D. , ROTHWARF, David , NGUYEN, Bao
IPC分类号： C40B60/14 , C40B40/00 , C40B50/00
CPC分类号： B01J19/0046 , B01J2219/00497 , B01J2219/00549 , B01J2219/00563 , B01J2219/00585 , B01J2219/00655 , B01J2219/00709 , C40B40/00 , C40B50/00 , G01N33/54326 , G01N33/54366 , G06K19/06187
摘要： Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 10 2 , 10 3 , 10 6 or even 10 10 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.
摘要翻译：包含预定的磁化优选轴的微器件设置在具有谨慎区域的阵列中。在磁场的影响下，微器件可以具有至少十二个离散取向，并且可以有利地在适当位置上翻翻。可以以支持至少102,103,106甚至1010或更多选择的编码空间的方式对微器件进行编码，并且可以包括一个或多个化学反应位点。这些区域可以由长条和短条定义，其中微型设备跨越长条之间的间隙，较短的条测量小于这种间隙的60％。还提供了优选实施例以产生用于基于磁性组件的排列的微加工微型器件。

2. 发明申请

WO2013142716A1 LIPID ARRAYS ON FABRICATED DEVICES AND USES THEREOF 审中-公开
标题翻译：织物装置上的脂质阵列及其用途
公开(公告)号：WO2013142716A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033348
申请日：2013-03-21
申请人： ARRAYOMICS, INC. , CASTELLANA, Edward T. , NGUYEN, Bao , ROTHWARF, David
发明人： CASTELLANA, Edward T. , NGUYEN, Bao , ROTHWARF, David
IPC分类号： G01N33/92 , G01N33/58 , G01N33/48
CPC分类号： G01N21/6458 , B01J19/0046 , B01J2219/00463 , B01J2219/00466 , B01J2219/00468 , B01J2219/00475 , B01J2219/00502 , B01J2219/00533 , B01J2219/00547 , B01J2219/00563 , B01J2219/00596 , B01J2219/00637 , B01J2219/00655 , B01J2219/00734 , B01J2219/0074 , G01N21/6428 , G01N2201/067
摘要： Systems and methods for arranging microdevices on an array substrate are described. Each microdevice contains a lipid bilayer region and a patterned magnetic material that has a predetermined preferential axis of magnetization. The microdevices are located at specific locations on the arraying substrate and a magnetic field is used to orient the microdevices to facilitate the study of lipids and lipid-associated moieties. The bilayer region can also contain a fluorescent reagent, which can be monitored during exposure to an excitation source. The fluorescent reagent can also be photobleached and monitored for fluorescence recovery.
摘要翻译：描述了在阵列基板上布置微器件的系统和方法。每个微器件都含有一个脂质双层区域和一个具有预定优先磁化轴的图案化磁性材料。微器件位于排列衬底上的特定位置，并且使用磁场来定向微器件以促进脂质和脂质相关部分的研究。双层区域还可以含有荧光试剂，其可以在暴露于激发源期间被监测。荧光试剂也可以进行光漂白并监测荧光恢复。

3. 发明申请

WO2017019754A1 SYSTEMS, APPARATUS, AND METHODS FOR ELECTRO-ANATOMICAL MAPPING OF A CATHETER WITH ELECTODE CONTACT ASSESSMENT AND ROTOR PROJECTION 审中-公开
标题翻译：用于电子接触评估和转子投影的电导率的电解分析系统，装置和方法
公开(公告)号：WO2017019754A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044228
申请日：2016-07-27
申请人： KESSMAN, Paul , EDWARDS, Jerome , NGUYEN, Bao
发明人： KESSMAN, Paul , EDWARDS, Jerome , NGUYEN, Bao
IPC分类号： A61B5/0452 , G06F19/00
CPC分类号： A61B5/0452 , A61B5/0422 , A61B5/061 , A61B8/0883 , A61B8/12 , A61B8/4254 , G06F19/00
摘要： A system includes a pair of external body electrodes, a first control unit and a second control unit. The first control unit is arranged to provide a constant current at a first frequency across the pair of external body electrodes coupled to a body of a patient. The first control unit further arranged to provide a constant voltage circuit across the body of the patient at a second frequency different from the first frequency. The second control unit is arranged to measure a voltage of an internal electrode located within a chamber of a heart of the patient in the first frequency. The second control unit further arranged to measure a voltage of the internal electrode in the second frequency to determine a voltage change.
摘要翻译：一种系统包括一对外部主体电极，第一控制单元和第二控制单元。第一控制单元布置成在耦合到患者身体的一对外部主体电极上以第一频率提供恒定电流。所述第一控制单元还被布置成以不同于所述第一频率的第二频率在所述患者的身体上提供恒定电压电路。第二控制单元被布置成以第一频率测量位于患者心脏的腔室内部电极的电压。第二控制单元还被布置成测量第二频率中的内部电极的电压以确定电压变化。

4. 发明申请

WO2013033116A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：WO2013033116A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052704
申请日：2012-08-28
申请人： IRM LLC , LIU, Xiaodong , LI, Xiaolin , LOREN, Jon , MOLTENI, Valentina , NABAKKA, Juliet , NGUYEN, Bao , PETRASSI, Hank Michael James , YEH, Vince
发明人： LIU, Xiaodong , LI, Xiaolin , LOREN, Jon , MOLTENI, Valentina , NABAKKA, Juliet , NGUYEN, Bao , PETRASSI, Hank Michael James , YEH, Vince
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P11/00 , A61P17/00 , A61P29/00
CPC分类号： C07D471/04 , A61K31/4245 , C07F9/6561
摘要： The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的式（I）和（II）化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRa，PDGFRβ）激酶异常活化的疾病或病症的方法。

5. 发明申请

WO2010120741A1 COMPOSITIONS AND METHODS FOR MODULATING RETINOL BINDING TO RETINOL BINDING PROTEIN 4 (RBP4) 审中-公开
标题翻译：用于调节RETINOL结合蛋白质结合蛋白4（RBP4）的组合物和方法
公开(公告)号：WO2010120741A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030843
申请日：2010-04-13
申请人： IRM LLC , PETRASSI, Hank Michael James , TULLY, David C. , MASICK, Brian T. , NGUYEN, Bao
发明人： PETRASSI, Hank Michael James , TULLY, David C. , MASICK, Brian T. , NGUYEN, Bao
IPC分类号： C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D417/06 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61P27/02
CPC分类号： C07D277/30 , C07D261/08 , C07D263/32 , C07D271/06 , C07D417/06
摘要： The present invention relates to compositions and methods for modulating retinol binding to retinol binding protein 4 (RBP4). In particular, the present invention provides compounds having Formula (1) or (2) (Formulae (1), (2)); wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Y 1 , Y 2 , Y 3 , Y 4 and m are as defined above.
摘要翻译：本发明涉及调节视黄醇与视黄醇结合蛋白4（RBP4）结合的组合物和方法。特别地，本发明提供具有式（1）或（2）（式（1），（2））的化合物; 其中R1，R2，R3，R4，R5，R6，Y1，Y2，Y3，Y4和m如上所定义。

6. 发明申请

WO2006050142A2 KNOWLEDGE DISCOVERY SYSTEM 审中-公开
标题翻译：知识发现系统
公开(公告)号：WO2006050142A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039035
申请日：2005-10-28
申请人： EAGLEFORCE ASSOCIATES , MAREN, Alianna, J. , CAMPBELL, Stanley , PERRY, Dennis , NGUYEN, Bao
发明人： MAREN, Alianna, J. , CAMPBELL, Stanley , PERRY, Dennis , NGUYEN, Bao
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30943 , G06N5/025
摘要： A knowledge discovery apparatus and method that extracts both specifically desired as well as pertinent and relevant information to query from a corpus of multiple elements that can be structured, unstructured, and/or semi-structured, along with imagery, video, speech, and other forms of data representation, to generate a set of outputs with a confidence metric applied to the match of the output against the query. The invented apparatus includes a multi-level architecture, along with one or more feedback loop(s) from any level n to any lower level n-1 so that a user can control the output of this knowledge discovery method via providing inputs to the utility function.
摘要翻译：一种知识发现设备和方法，其从具有结构化，非结构化和/或半结构化的多个元素的语料库中提取具体需要的以及相关和相关的信息以供查询，以及图像，视频，语音和其他形式的数据表示，以生成一组输出，其中置信度度量应用于输出与查询的匹配。本发明的装置包括多级架构，以及从任何级别n到任何较低级别n-1的一个或多个反馈环路，以便用户可以通过向效用函数提供输入来控制这种知识发现方法的输出。

7. 发明申请

WO2013033167A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：WO2013033167A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052802
申请日：2012-08-29
申请人： IRM LLC , MOLTENI, Valentina , PETRASSI, Hank Michael James , LI, Xiaolin , LIU, Xiaodong , LOREN, Jon , NABAKKA, Juliet , NGUYEN, Bao , YEH, Vince
发明人： MOLTENI, Valentina , PETRASSI, Hank Michael James , LI, Xiaolin , LIU, Xiaodong , LOREN, Jon , NABAKKA, Juliet , NGUYEN, Bao , YEH, Vince
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P17/00 , A61P11/00 , A61P29/00
CPC分类号： C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要： The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的式（I）和（II）的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防病症的方法与异常或失调的激酶活性有关。在一些实施方案中，本发明提供了使用这些化合物来治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFRβ）激酶异常活化的疾病或病症的方法。

8. 发明申请

WO2007127500A2 METHOD AND APPARATUS TO PERFORM PERSISTENCE TESTS IN A NETWORK 审中-公开
标题翻译：在网络中执行持续测试的方法和设备
公开(公告)号：WO2007127500A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/060184
申请日：2007-01-05
申请人： QUALCOMM Incorporated , CHIN, Tom , NGUYEN, Bao
发明人： CHIN, Tom , NGUYEN, Bao
IPC分类号： H04W52/02 , H04W74/08
CPC分类号： H04W74/0816 , H04W52/0261 , H04W74/0866 , Y02D70/142 , Y02D70/146
摘要： A method and apparatus to perform persistence tests for a mobile station in a network are described. The apparatus includes a random number generator, a timer module, and a processor coupled to the random number generator and the timer module. A counter for the random number generator configured to count access slots is initialized. One or more random numbers are successively generated, until a value of a generated random number is lower than a first predetermined value. At the same time, the counter is successively incremented based on the number of generated random numbers. When the counter value is higher than or equal to a second predetermined value of successive iterations, or, in the alternative, when the value of the generated random number is lower than the first predetermined value, the mobile station is deactivated for a predetermined number of access slots equal to the counter value. A timer interrupt further runs subsequent to the expiration of the predetermined number of access slots. Finally, if an access probe needs to be transmitted to the network, the timer interrupt is disabled and a random access number is generated in preparation for transmission of the access probe to enable access to the network.
摘要翻译：描述了对网络中的移动台执行持久性测试的方法和装置。该装置包括随机数发生器，定时器模块和耦合到随机数发生器和定时器模块的处理器。被配置为对接入时隙进行计数的随机数发生器的计数器被初始化。连续产生一个或多个随机数，直到生成的随机数的值低于第一预定值。同时，计数器依据生成的随机数的顺序依次递增。当计数器值高于或等于连续迭代的第二预定值时，或者替代地，当生成的随机数的值低于第一预定值时，移动站停用预定数量的访问时隙等于计数器值。在预定数量的接入时隙到期之后，定时器中断进一步运行。最后，如果接入探测器需要发送到网络，则定时器中断被禁用，随机接入号码被准备用于传输接入探测器以便能够访问网络。

9. 发明申请

WO2006023929A1 METHOD AND APPARATUS FOR RECEIVING A CONTROL CHANNEL DATA IN A WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：用于在无线通信系统中接收控制信道数据的方法和装置
公开(公告)号：WO2006023929A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/029988
申请日：2005-08-22
申请人： QUALCOMM INCORPORATED , HANG, Ling , NGUYEN, Bao
发明人： HANG, Ling , NGUYEN, Bao
IPC分类号： H04L1/00
CPC分类号： H04L1/0061 , H04L1/0045 , H04L1/0072
摘要： A higher layer at a base station generates and passes messages to Layer 2, which generates and appends a CRC value to each message. The messages are encapsulated in frames at the physical layer, which generates and appends a CRC value to each frame. The base station transmits the frames on a control channel. The physical layer at a wireless device processes the control channel and decodes each received frame to obtain a decoded frame. The physical layer forwards the decoded frame to Layer 2, regardless of whether the frame passes or fails a CRC test. Layer 2 processes the decoded frame, even if the decoded frame fails the CRC test, to extract messages sent in the decoded frame. Layer 2 checks each extracted message based on its CRC value and forwards each message that passes the CRC test to the higher layer.
摘要翻译：基站的较高层生成消息并将消息传递给第2层，其向每个消息生成CRC并附加CRC值。消息被封装在物理层的帧中，该帧生成CRC并附加到每个帧。基站在控制信道上发送帧。无线设备的物理层处理控制信道并解码每个接收到的帧以获得解码的帧。物理层将解码的帧转发到第2层，而不管帧是否通过或CRC测试失败。即使解码的帧失败了CRC测试，二层处理解码的帧，以提取在解码帧中发送的消息。层2基于其CRC值检查每个提取的消息，并将通过CRC测试的每个消息转发到较高层。

10. 发明申请

WO2015175487A1 COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS 审中-公开
标题翻译：化合物和组合物，用于诱导CHENDROGENESIS
公开(公告)号：WO2015175487A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030303
申请日：2015-05-12
申请人： NOVARTIS AG , CHOI, Ha-Soon , LAJINESS, James Paul , NATALA, Srinivasa Reddy , NGUYEN, Bao , PETRASSI, Hank Michael James , WANG, Zhicheng
发明人： CHOI, Ha-Soon , LAJINESS, James Paul , NATALA, Srinivasa Reddy , NGUYEN, Bao , PETRASSI, Hank Michael James , WANG, Zhicheng
IPC分类号： C07D491/18 , C07D493/08 , A61K31/352 , A61K31/44 , A61K31/415 , A61K31/4245 , A61K31/506 , A61P19/02
CPC分类号： A61K31/443 , A61K31/34 , A61K31/351 , A61K31/4155 , A61K31/416 , A61K31/4245 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L2300/412 , A61L2430/06 , C07D491/18 , C07D493/08 , C12N5/0655 , C12N2501/999 , C12N2506/1346
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用这些化合物治疗哺乳动物的关节损伤或关节损伤以及诱导间充质干细胞分化为软骨细胞的方法。

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