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1. 发明申请

WO2002077558A3 SURFACES HAVING PARTICLE STRUCTURES WITH BROAD RANGE RADIATION ABSORPTIVITY 审中-公开
公开(公告)号：WO2002077558A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008858
申请日：2002-03-22
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： YEVIN, Oleg, A. , NUFERT, Thomas, H. , KREIMER, David, I.
IPC分类号： F28D15/00 , E06B7/00
摘要： A heat pipe (105) having particle structures (160, 161) and a polymer (145, 146) thereon.

2. 发明申请

WO2003014697A3 AMPLIFICATION OF ANALYTE DETECTION WITH PASSIVATED ENHANCING SURFACES HAVING RECEPTORS 审中-公开
公开(公告)号：WO2003014697A3
公开(公告)日：2003-02-20
申请号：PCT/US2002/024033
申请日：2002-07-30
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , GINZBURG, Lev, V. , YEVIN, Oleg, A.
IPC分类号： G01N33/543
摘要： This invention comprises devices, compositions and methods for quantitative detecting analytes in complex solutions by Raman spectroscopy. Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing direct interaction between analytes and enhancing surfaces, relatively more selective detection of the analyte can be performed. Analyte receptors can be either highly selective or have lesser selectivity. Reproducible, concentration-dependent Raman spectroscopic analyses can be performed using flow-through cells incorporating passivated substrates. By using receptors having low selectivity, different analytes can be detected simultaneously. Flow cells are provided that permit rapid, and/or continuous monitoring of samples, thereby permitting automated sample analysis.

3. 发明申请

WO2002077647A1 AMPLIFICATION OF ANALYTE DETECTION BY SUBSTRATES HAVING PARTICLE STRUCTURES WITH RECEPTORS 审中-公开
标题翻译：通过具有受体的颗粒结构的基底进行分析物检测的扩增
公开(公告)号：WO2002077647A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/008778
申请日：2002-03-22
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , YEVIN, Oleg, A. , NUFERT, Thomas, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/553 , B01J13/0008 , B82B1/00 , B82Y30/00 , F24S10/90 , F24S70/10 , F28D15/02 , G01N21/65 , G01N21/658 , G01N33/54346 , G01N33/54366 , G01N33/54373 , Y02E10/44
摘要： This invention comprises devices, compositions and methods for detecting analytes in complex solutions. In certain embodiments of this invention, the receptor molecules can be lacking in a Raman signal generating moiety that is present in an analyte molecule, so that binding of the analyte to the receptor provides the array with the Raman signal generating moiety. In other embodiments, binding of a receptor to an analyte is detected by observing an alteration or shift of Raman spectral features upon forming of an analyte-receptor associate. Enzymes can be detected by binding to receptors comprising materials that bind to the active site of the enzyme. Antibodies can be detected by formation of an antibody-antigen complex, wherein the antigen is part of a receptor. Analytes that can be detected using these methods include nucleic acids, proteins, and other molecules that can specifically bind to the arrays. Particle structures are disclosed that enhance the Raman signal produced by an analyte through surface and resonance phenomena. Novel methods are presented for manufacturing particle structures and for attaching receptor molecules to areas of enhanced resonance on the particle structures, thereby producing Raman signals that can be used for highly specific, sensitive assays of biological and other molecules of interest.
摘要翻译：本发明包括用于检测复杂溶液中分析物的装置，组合物和方法。在本发明的某些实施方案中，受体分子可能缺乏存在于分析物分子中的拉曼信号产生部分，使得分析物与受体的结合为阵列提供拉曼信号产生部分。在其它实施方案中，通过在形成分析物 - 受体缔合物时观察拉曼光谱特征的改变或偏移来检测受体与分析物的结合。可以通过结合包含结合酶的活性位点的材料的受体来检测酶。可以通过形成抗体 - 抗原复合物来检测抗体，其中抗原是受体的一部分。可以使用这些方法检测的分析物包括可以特异性结合阵列的核酸，蛋白质和其他分子。公开了通过表面和共振现象增强由分析物产生的拉曼信号的粒子结构。提出了用于制造颗粒结构和将受体分子附着在颗粒结构上增强共振区域的新方法，从而产生可用于生物和其他分子分子的高度特异性，敏感测定的拉曼信号。

4. 发明申请

WO2002077558A2 SURFACES HAVING PARTICLE STRUCTURES WITH BROAD RANGE RADIATION ABSORPTIVITY 审中-公开
标题翻译：具有广泛范围辐射吸收性的颗粒结构的表面
公开(公告)号：WO2002077558A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008858
申请日：2002-03-22
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： YEVIN, Oleg, A. , NUFERT, Thomas, H. , KREIMER, David, I.
IPC分类号： F28D15/00
CPC分类号： G01N33/54346 , F28D15/02 , F28F13/18 , F28F2245/06
摘要： A heat pipe (105) having particle structures (160, 161) and a polymer (145, 146) thereon.
摘要翻译：具有颗粒结构（160,161）和其上的聚合物（145,146）的热管（105）。

5. 发明申请

WO2003083480A1 METHODS FOR MANUFACTURING NANOPARTICLE STRUCTURES USING HYDROPHOBIC OR CHARGED SURFACES 审中-公开
标题翻译：使用疏水性或充电表面制造纳米结构的方法
公开(公告)号：WO2003083480A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/009655
申请日：2003-03-28
申请人： ARRAY BIOSCIENCE CORPORATION , KREIMER, David, I. , NUFERT, Thomas, H. , GINZBURG, Lev , YEVIN, Oleg, A.
发明人： KREIMER, David, I. , NUFERT, Thomas, H. , GINZBURG, Lev , YEVIN, Oleg, A.
IPC分类号： G01N33/553
CPC分类号： G01N33/54346 , G01N33/54393 , G01N33/553
摘要： The invention provides methods for manufacturing nanoparticle structures using surfaces onto which the nonoparticles can aggregate to form nanoparticle structures. The surfaces suitable include gas-liquid interfaces (bubbles), beads, plastics, glasses, oil-water emulsions and films. The nanoparticle structures so obtained have improved Raman signal enhancement an improved radiation absorptivity and emmissivity.
摘要翻译：本发明提供了使用非颗粒可以聚集形成纳米颗粒结构的表面来制造纳米颗粒结构的方法。合适的表面包括气 - 液界面（气泡），珠，塑料，玻璃，油水乳液和薄膜。如此获得的纳米颗粒结构具有改善的拉曼信号增强，改善的辐射吸收率和辐射率。

6. 发明申请

WO2003027619A2 DEVICES AND METHODS FOR VERIFYING MEASUREMENT OF ANALYTES BY RAMAN SPECTROSCOPY AND SURFACE PLASMON RESONANCE 审中-公开
标题翻译：用于通过拉曼光谱和表面等离子体共振来验证分析物测量的装置和方法
公开(公告)号：WO2003027619A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/029766
申请日：2002-09-19
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , YEVIN, Oleg, A.
IPC分类号： G01J
CPC分类号： G01N21/553 , G01N21/554 , G01N21/658
摘要： Embodiments of devices and methods are provided that permit validation of analyte detection using both surface enhanced Raman spectroscopy (SERS) and surface plasmon resonance (SPR). In specific embodiments, a substrate having a surface suitable for SPR is provided, along with a source of electromagnetic radiation to interact with the surface and thereby elicit surface plasmon resonance characteristic of the analyte under study. In some embodiments, surface enhancing structures are also provided on the substrate, and analytes under study are associated with enhancing structures. Another source of electromagnetic radiation is directed at the analyte on the enhancing structures to produce surface enhanced Raman scattering. In certain embodiments, data obtained by these two methods are compared, thereby providing an internally consistent and self-validating method for analyte detection.
摘要翻译：提供了允许使用表面增强拉曼光谱学（SERS）和表面等离子体共振（SPR）验证分析物检测的装置和方法的实施例。在具体的实施方案中，提供具有适用于SPR的表面的基底以及与表面相互作用的电磁辐射源，从而引起正在研究的分析物的表面等离子体共振特性。在一些实施例中，表面增强结构也被提供在衬底上，并且正在研究的分析物与增强结构相关。电磁辐射的另一个来源是指向增强结构上的分析物以产生表面增强拉曼散射。在某些实施方案中，比较由这两种方法获得的数据，由此提供用于分析物检测的内部一致且自我验证的方法。

7. 发明申请

WO2003042403A3 BIOCHIPS FOR CHARACTERIZING BIOLOGICAL PROCESSES 审中-公开
公开(公告)号：WO2003042403A3
公开(公告)日：2003-05-22
申请号：PCT/US2002/036630
申请日：2002-11-14
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , NUFERT, Thomas, H. , GINZBURG, Lev , YEVIN, Oleg, A.
IPC分类号： C12Q1/68
摘要： This invention includes biochips (Figure 18d) for analysis of a variety of molecules, cell components and cells. Embodiments of this invention include devices and methods for parallel and/or nearly parallel processing of biological analytes. Biochips can comprise a substrate, Raman signal-enhancing structures, and receptors selective and/or specific for the analyte(s) to be assayed. Biochips can be read using a Raman reader and can provide for rapid, sensitive, direct assays for physiological and/or pathophysiological conditions of interest.

8. 发明申请

WO2003014697A2 AMPLIFICATION OF ANALYTE DETECTION WITH PASSIVATED ENHANCING SURFACES HAVING RECEPTORS 审中-公开
标题翻译：具有受体的钝化增强表面的分析检测的扩增
公开(公告)号：WO2003014697A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/024033
申请日：2002-07-30
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , GINZBURG, Lev, V. , YEVIN, Oleg, A.
IPC分类号： G01N
CPC分类号： B82Y30/00 , B01J13/0008 , B01J13/0043 , B82B1/00 , F24S10/90 , F24S70/10 , F28D15/02 , F28F2245/02 , F28F2245/04 , G01N21/05 , G01N21/35 , G01N21/3577 , G01N21/64 , G01N21/658 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N33/553 , Y02E10/44
摘要： This invention comprises devices, compositions and methods for quantitative detecting analytes in complex solutions by Raman spectroscopy. Passivating agents associated with enhancing surfaces can decrease direct, non-specific interaction between analytes and the enhancing surface. By decreasing direct interaction between analytes and enhancing surfaces, relatively more selective detection of the analyte can be performed. Analyte receptors can be either highly selective or have lesser selectivity. Reproducible, concentration-dependent Raman spectroscopic analyses can be performed using flow-through cells incorporating passivated substrates. By using receptors having low selectivity, different analytes can be detected simultaneously. Flow cells are provided that permit rapid, and/or continuous monitoring of samples, thereby permitting automated sample analysis.
摘要翻译：本发明包括用于通过拉曼光谱定量检测复杂溶液中分析物的装置，组合物和方法。与增强表面相关的钝化剂可减少分析物与增强表面之间的直接非特异性相互作用。通过减少分析物与增强表面之间的直接相互作用，可以进行相对更多的分析物选择性检测。分析物受体可以是高度选择性的或具有较低的选择性。可重复的浓度依赖性拉曼光谱分析可使用掺入钝化基质的流通池进行。通过使用具有低选择性的受体，可以同时检测不同的分析物。提供的流通池允许对样品进行快速和/或连续监测，从而实现样品自动分析。

9. 发明申请

WO2002063259A1 SYSTEMS AND METHODS FOR FILTER BASED SPECTROGRAPHIC ANALYSIS 审中-公开
标题翻译：基于滤波器的光谱分析系统与方法
公开(公告)号：WO2002063259A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/003745
申请日：2002-02-07
申请人： ARRAY BIOSCIENCE CORPORATION
发明人： KREIMER, David, I. , YEVIN, Oleg, A. , WEBER, Robert
IPC分类号： G01J3/44
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/024 , G01J3/0291 , G01J3/0294 , G01J3/32 , G01J3/36 , G01J3/44 , G01J2003/1213 , G01N21/31 , G01N21/6428 , G01N21/658 , G01N2021/3137 , G01N2021/3177 , G01N2021/6484 , G01N2021/656
摘要： Systems and methods for filter based spectrographic analysis are provided that permit rapid analysis of bioanalytes. Systems include devices for illuminating a sample with electromagnetic radiation and capturing radiation emitted from the sample. Emitted radiation can be collected by a plurality of waveguides (406) each associated with a filter (408) for a particular wavelength of radiation. Radiation captured by waveguides can then be transmitted to a remote detector (400), which can determine the intensity of radiation for each waveguide. The use of plurality of filters having different band pass characteristics can permit the simultaneous detection of a plurality of different wavelengths of radiation emitted by a sample, thereby providing spectrographic information about the sample under study. Systems can include computers (411) for storing acquired spectrographic information, addressable arrays of samples, and information security measures. Spectrographic information of samples can be diagnostic tools for identifying and quantifying a variety of different materials, including bioanalytes.
摘要翻译：提供了基于过滤器的光谱分析的系统和方法，可以快速分析生物分析物。系统包括用于用电磁辐射照射样品并捕获从样品发射的辐射的装置。发射的辐射可以由与用于特定波长的辐射的滤波器（408）相关联的多个波导（406）收集。然后可以将由波导捕获的辐射传输到远程检测器（400），这可以确定每个波导的辐射强度。使用具有不同带通特性的多个滤光器可以允许同时检测由样品发射的多个不同波长的辐射，从而提供关于正在研究的样品的光谱信息。系统可以包括用于存储获取的光谱信息的计算机（411），可寻址的样本阵列和信息安全措施。样品的光谱信息可以是用于识别和量化各种不同材料（包括生物分析物）的诊断工具。

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