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1. 发明申请

WO2006078610A1 DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS OR TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 审中-公开
标题翻译：作为有利于预防或治疗进展性多发性白血病的5-HT2A丝氨酸受体的调节剂的二元和尿苷尿素衍生物
公开(公告)号：WO2006078610A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001516
申请日：2006-01-17
申请人： ARENA PHARMACEUTICALS, INC. , UNETT, David J. , TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , LI, Hongmei , STRAH-PLEYNET, Sonja , DOSA, Peter I.
发明人： UNETT, David J. , TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , LI, Hongmei , STRAH-PLEYNET, Sonja , DOSA, Peter I.
IPC分类号： A61K31/415 , A61P25/28
CPC分类号： A61K31/415
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of progressive multifocal leukoencephalopathy.
摘要翻译：本发明涉及式（I）的某些吡唑衍生物及其药物组合物，其调节5-HT2A 5-羟色胺受体的活性。化合物及其药物组合物涉及可用于预防或治疗进行性多灶性脑白质脑病的方法。

2. 发明申请

WO2006055734A2 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5-HT2A丝氨酸受体的调节剂的3-苯基 - 吡唑衍生物
公开(公告)号：WO2006055734A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/041726
申请日：2005-11-17
申请人： ARENA PHARMACEUTICALS, INC. , TEEGARDEN, Bradley , XIONG, Yifeng , STRAH-PLEYNET, Sonja , JAYAKUMAR, Honnappa , DOSA, Peter I. , FEICHTINGER, Konrad , CASPER, Martin , LEHMANN, Juerg , JONES, Robert M. , UNETT, David J.
发明人： TEEGARDEN, Bradley , XIONG, Yifeng , STRAH-PLEYNET, Sonja , JAYAKUMAR, Honnappa , DOSA, Peter I. , FEICHTINGER, Konrad , CASPER, Martin , LEHMANN, Juerg , JONES, Robert M. , UNETT, David J.
CPC分类号： C07D231/12 , A61K31/5377 , C07D231/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D487/08
摘要： The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT 2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT 2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：本发明涉及式（Ia）的某些3-苯基 - 吡唑衍生物及其药物组合物，其调节5-HT 2A / 5-羟色胺受体的活性。化合物及其药物组合物涉及可用于治疗血小板凝集，冠状动脉疾病，心肌梗死，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘或其症状，激动或症状，行为障碍，药物诱导的精神病，兴奋性精神病，吉列斯图雷特综合征，躁狂症，有机或非精神病精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，以及睡眠障碍，睡眠障碍，糖尿病相关病症，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT 2A 5-羟色胺受体介导的病症的方法。

3. 发明申请

WO2005012254A1 DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO 审中-公开
标题翻译：作为有利于预防和治疗相关疾病的5-HT2A丝氨酸蛋白受体的调节剂的二元和尿苷尿素衍生物
公开(公告)号：WO2005012254A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/023488
申请日：2004-07-21
申请人： ARENA PHARMACEUTICALS, INC. , TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , LI, Hongmei , STRAH-PLEYNET, Sonja , DOSA, Peter, Ian
发明人： TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , LI, Hongmei , STRAH-PLEYNET, Sonja , DOSA, Peter, Ian
IPC分类号： C07D231/16
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D231/16 , C07D401/12 , C07D405/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT 2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders and the like. The present invention also relates to the method of prophylaxis or treatment of 5-HT 2A serotonin receptor mediated disorders in combination with a dopamine D2 receptor antagonist such as haloperidol, administered separately or together.
摘要翻译：本发明涉及式（I）的某些吡唑衍生物及其药物组合物，其调节5-HT2A 5-羟色胺受体的活性。化合物及其药物组合物涉及可用于预防或治疗血小板凝集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘或其症状的方法，激动或症状，行为障碍，药物诱导的精神病，兴奋性精神病，吉列斯图雷特综合征，躁狂症，有机或NOS精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症和精神分裂症以及相关疾病和睡眠障碍，睡眠障碍，糖尿病相关疾病等。本发明还涉及与单独或一起施用的多巴胺D2受体拮抗剂如氟哌啶醇组合预防或治疗5-HT2A 5-羟色胺受体介导的病症的方法。

4. 发明申请

WO2007136680A2 ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：其他作为5-HT2A丝氨酸受体调节剂的二级氨基酸和衍生物，用于治疗与相关疾病有关的疾病
公开(公告)号：WO2007136680A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011789
申请日：2007-05-17
申请人： ARENA PHARMACEUTICALS, INC. , TEEGARDEN, Bradley , CHAPMAN, Dennis , DECAIRE, Marc , DOSA, Peter, I. , FEICHTINGER, Konrad , JAYAKUMAR, Honnappa , STRAH-PLEYNET, Sonja , TRAN, Thuy-Anh , XU, Jingdong
发明人： TEEGARDEN, Bradley , CHAPMAN, Dennis , DECAIRE, Marc , DOSA, Peter, I. , FEICHTINGER, Konrad , JAYAKUMAR, Honnappa , STRAH-PLEYNET, Sonja , TRAN, Thuy-Anh , XU, Jingdong
IPC分类号： C07D413/12 , C07D231/12 , C07D231/16 , C07D403/12 , C07D411/12 , A61K31/42 , A61K31/4192 , A61K31/427
CPC分类号： C07D231/12 , A61K31/415 , C07D207/335 , C07D207/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：本发明涉及某些调节5-HT2A 5-羟色胺受体活性的式（Ia）化合物及其药物组合物。化合物及其药物组合物涉及可用于治疗血小板凝集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，血块形成，哮喘或其症状，躁动或其症状的方法，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，睡眠障碍，睡眠障碍，糖尿病性精神病，精神病，精神病，精神病，相关疾病，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT2A 5-羟色胺受体相关疾病的方法。

5. 发明申请

WO2004058722A1 DIARYLAMINE AND ARYLHETEROARYLAMINE PYRAZOLE DERIVATIVES AS MODULATORS OF 5HT2A 审中-公开
标题翻译：作为5HT2A的调节剂的二胺和芳基胺胺吡唑衍生物
公开(公告)号：WO2004058722A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/040844
申请日：2003-12-22
申请人： ARENA PHARMACEUTICALS, INC. , TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , STRAH-PLEYNET, Sonja
发明人： TEEGARDEN, Bradley , JAYAKUMAR, Honnappa , STRAH-PLEYNET, Sonja
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： One aspect of the present invention relates to certain diarylamine and arylheteroarylamine pyrazole derivatives of Formula (A) and pharmaceutical compositions that modulate the activity of the human 5HT2A serotonin receptor. Compounds and pharmaceutical compositions are directed to methods useful in the prophylaxis or treatment of reducing platelet aggreagation, sleep disorders, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia and NOS schizophrenia and related disorders. Another aspect of the present invention is directed to the method of prophylaxis or treatment of 5HT2A serotonin receptor mediated disorders in combination with a dopamine D2 receptor antagonist such as haloperidol, administered separately or together.
摘要翻译：本发明的一个方面涉及式（A）的某些二芳基胺和芳基杂芳基胺吡唑衍生物以及调节人5HT2A血清素受体活性的药物组合物。化合物和药物组合物涉及可用于预防或治疗减少血小板凝集，睡眠障碍，冠状动脉疾病，心肌梗死，短暂性脑缺血发作，心绞痛，中风，心房颤动，减少血块形成风险，哮喘或症状，激动或症状，行为障碍，药物诱发的精神病，兴奋性精神病，吉列斯图雷特综合征，躁狂症，有机或NOS精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症和NOS精神分裂症及相关疾病。本发明的另一方面涉及与多巴胺D2受体拮抗剂如氟哌啶醇组合施用以分别或一起施用的5HT2A 5-羟色胺受体介导的病症的方法。

6. 发明申请

WO2008054748A2 INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5-HT2A丝氨酸受体有用的调节剂的吲哚衍生物
公开(公告)号：WO2008054748A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/022921
申请日：2007-10-30
申请人： ARENA PHARMACEUTICALS, INC. , FEICHTINGER, Konrad , XIONG, Yifeng , CHOI, Jin Sun, Karoline , SMITH, Brian, M. , STRAH-PLEYNET, Sonja , TEEGARDEN, Bradley
发明人： XIONG, Yifeng , CHOI, Jin Sun, Karoline , SMITH, Brian, M. , STRAH-PLEYNET, Sonja , TEEGARDEN, Bradley
CPC分类号： C07D231/56 , C07D403/06
摘要： Indazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT 2A receptor. Formula (Ia) Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de Ia Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：式（Ia）的吲唑衍生物及其药物组合物，其调节5-羟色胺5HT 2A受体的活性。式（Ia）化合物及其药物组合物涉及可用于治疗失眠和相关睡眠障碍，血小板聚集，冠状动脉疾病，心肌梗死，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血液风险的方法凝块形成，哮喘或其症状，激动或其症状，行为障碍，药物诱导的精神病，兴奋性精神病，Gilles de Ia Tourette综合征，躁狂症，有机或NOS精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，糖尿病相关疾病，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT2A 5-羟色胺受体介导的病症的方法。

7. 发明申请

WO2006060762A3 PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
公开(公告)号：WO2006060762A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/043893
申请日：2005-12-01
申请人： ARENA PHARMACEUTICALS, INC. , STRAH-PLEYNET, Sonja , TEEGARDEN, Bradley , UNETT, David J.
发明人： STRAH-PLEYNET, Sonja , TEEGARDEN, Bradley , UNETT, David J.
IPC分类号： C07D231/38 , C07D401/12 , A61K31/415 , A61P25/00
摘要： The present invention relates to certain pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.

8. 发明申请

WO2007136875A2 ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5-HT2A硒同位素受体的调节剂的乙酰胺衍生物
公开(公告)号：WO2007136875A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/012230
申请日：2007-05-17
申请人： ARENA PHARMACEUTICALS, INC. , TEEGARDEN, Bradley , FEICHTINGER, Konrad , STRAH-PLEYNET, Sonja , ULMANN, Brett , XIONG, Yifeng
发明人： TEEGARDEN, Bradley , FEICHTINGER, Konrad , STRAH-PLEYNET, Sonja , ULMANN, Brett , XIONG, Yifeng
CPC分类号： C07D231/16 , C07D231/12 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT 2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT 2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：本发明涉及调节5-HT 2A 2 5-羟色胺受体活性的某些式（Ia）化合物及其药物组合物。化合物及其药物组合物涉及可用于治疗血小板凝集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，血块形成，哮喘或其症状，躁动或其症状的方法，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，以及睡眠障碍，睡眠障碍，糖尿病性精神病，精神病性精神病，精神病性精神病，精神病性精神病，相关疾病，进行性多灶性脑白质病等。本发明还涉及与分开或一起施用的其它药剂组合治疗5-HT 2A 5-羟色胺受体相关疾病的方法。

9. 发明申请

WO2008042388A1 PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5-HT2A硒同位素受体的调节剂的吡唑衍生物
公开(公告)号：WO2008042388A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/021182
申请日：2007-10-02
申请人： ARENA PHARMACEUTICALS, INC. , XIONG, Yifeng , CHERRIER, Martin, C. , CHOI, Jin Sun, Karoline , DOSA, Peter, I. , SMITH, Brian, M. , STRAH-PLEYNET, Sonja , ULLMAN, Bret , TEEGARDEN, Bradley
发明人： XIONG, Yifeng , CHERRIER, Martin, C. , CHOI, Jin Sun, Karoline , DOSA, Peter, I. , SMITH, Brian, M. , STRAH-PLEYNET, Sonja , ULLMAN, Bret , TEEGARDEN, Bradley
IPC分类号： C07D231/14 , A61K31/415 , A61P25/00
CPC分类号： C07D231/16 , C07D231/14 , C07D231/54 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04
摘要： Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT 2A receptor. Formula (Ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de Ia Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic- related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT 2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：式（Ia）的吡唑衍生物及其药物组合物，其调节5-羟色胺5HT 2A受体的活性。式（Ia）。化合物及其药物组合物涉及可用于治疗失眠和相关睡眠障碍，血小板聚集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘的方法精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症，精神分裂症和相关疾病，以及其它疾病，或其症状，激动或其症状，行为障碍，药物诱导的精神病，兴奋性精神病，Gilles de Ia Tourette综合征，躁狂症，有机或NOS精神病，精神病，精神病，糖尿病相关疾病，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT 2A 5-羟色胺受体介导的病症的方法。

10. 发明申请

WO2012116277A1 CANNABINOID RECEPTOR MODULATORS 审中-公开
标题翻译： CANNABINOID受体调节剂
公开(公告)号：WO2012116277A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026507
申请日：2012-02-24
申请人： ARENA PHARMACEUTICALS, INC. , THATTE, Jayant , BLACKBURN, Anthony C. , HAN, Sangdon , JONES, Robert M. , JUNG, Jae-Kyu , MONTALBAN, Anthony Garrido , PAL, Biman B. , RUETER, Jaimie Karyn , STRAH-PLEYNET, Sonja , THORESEN, Lars , XIONG, Yifeng , YUE, Dawei , ZHU, Xiuwen
发明人： THATTE, Jayant , BLACKBURN, Anthony C. , HAN, Sangdon , JONES, Robert M. , JUNG, Jae-Kyu , MONTALBAN, Anthony Garrido , PAL, Biman B. , RUETER, Jaimie Karyn , STRAH-PLEYNET, Sonja , THORESEN, Lars , XIONG, Yifeng , YUE, Dawei , ZHU, Xiuwen
IPC分类号： A61K31/416 , A61K45/06 , A61P35/00
CPC分类号： A61K31/675 , A61K31/416 , A61K31/4439 , A61K31/497 , A61K45/06 , A61K2300/00
摘要： Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor.
摘要翻译：提供一些可用于治疗癌症的方法，包括施用调节大麻素CB 2受体活性的式（Ia）化合物及其药物组合物。

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